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publications

2012

  • Xu XJ, Boumechache M, Robinson LE, Marschall V, Gorecki DC, Masin M, Murrell-Lagnado R. Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1. . J Cell Sci. In press. DOI 10.1242/jcs.099374
  • Stewart AP, Gómez-Posada JC, McGeorge J, Rouhani MJ, Villarroel A, Murrell-Lagnado RD, Edwardson JM (2012) The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. Journal of Biological Chemistry 287(15):11870-11877 2012
  • M. Masin, C. Young, K. Lim, S.J. Barnes, X.J. Xu, V. Marschall, W. Brutkowski , E.R. Mooney, D.C. Gorecki and R.D. Murrell-Lagnado (2012) Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts. British Journal of Pharmacology165(4):978-993

2011

  • L.S. Antonio, A.P. Stewart, X.J. Xu, W.A. Varanda, R.D. Murrell-Lagnado, J.M. Edwardson (2011) P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. British Journal of Pharmacology 163, 1069-1077.

2010

  • Gomez-Posada J.C, Etxeberria, A., Roura-Ferrer, M., Arerso, P., Masin, M., Murrell-Lagnado, R.D and Villarroel, A. (2010) A Pore Residue of the KCNQ3 Potassium M-Channel Subunit Controls Surface Expression. Journal of Neuroscience 30(27), 9316-23

2009

  • Murrell-Lagnado RD. (2009) More cross talk between purinergic receptors. Journal of Physiology. 587, 2713-2714.
  • Nicke, A, Kuan Y-H, Masin, M., Bender, O., Rettinger, J., Marquez-Klaka, B., Górecki, D.C., Murrell-Lagnado, R.D., and Soto, F. (2009) A functional P2X7 splice variant with an alternative transmembrane domain I escapes gene inactivation in P2X7 KO mice.Journalof Biological Chemistry. doi: 10.1074/jbc.M109.033134
  • Boumechache, M, Masin, M, Edwardson, J.M, Gorecki, D.C. and Murrell-Lagnado, R.D. (2009) Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. Journal of Biological Chemistry. 284, 13446-13454.

2008

  • Murrell-Lagnado R.D. and O. Qureshi. (2008) Assembly and trafficking of P2X purinergic receptors. Mol. Pharmacol.25(4) 321-331.

2007

  • Qureshi, O.S, Paramasivam, A., Yu, J.C.H and Murrell-Lagnado R.D. (2007) Regulation of P2X4 receptors by lysosomal targeting, protection and exocytosis J. Cell. Sci 120, 3838-3849.
  • Guo, C., Masin, M., Qureshi, O.S. and Murrell-Lagnado R.D. (2007) Evidence for functional P2X4 / P2X7 heteromeric receptors. Mol. Pharmacol. 72, 1447-1456.
  • Barrera, N.P., Henderson, R.M., Murrell-Lagnado, R.D. and Edwardson, J.M. (2007) The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Biophys. J. 93, 505-512.

2006

  • Ormond, S.G. Barrera, N.P. Qureshi, O.S. Henderson, R.M., Edwardson J.M. and Murrell-Lagnado, R.D. (2006) An uncharged region within the N-terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum Mol. Pharmacol. 69, 1692-1700.

2005

  • Royle, S.J., Qureshi, O.S., Bobanovic, L.K., Evans, P.R., Owen D.J., and Murrell-Lagnado, R.D. (2005) Non-canonical YXXGΦ endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. J. Cell Sci.118:3073-80.
  • Barrera, N.P, Ormond, S.J., Henderson, R.M. Murrell-Lagnado, R.D. and Edwardson J.M. (2005) Atomic Force Microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J. Biol. Chem. 18;280(11):10759-65

2003

  • Royle S.J. and Murrell-Lagnado, R.D. (2003) Constitutive cycling: a general mechanism to regulate cell surface proteins. BioEssays 25:39-46.

2002

  • Bobanovic, L.K., Royle, S.J. and Murrell-Lagnado, R.D. (2002) Constitutive, dynamin-dependent endocytosis and recycling of the P2X4 receptor. Journal of Neuroscience, 22, 4814-4824.
  • Royle, S.J., Bobanovic, L.K. and Murrell-Lagnado, R.D. (2002) Identification of a non-canonical tyrosine based endocytic motif in an ionotropic receptor. The Journal of Biological Chemistry 277, 35378-35389.
  • Guo, Y, Waldron, G.J. and Murrell-Lagnado, R.D. (2002) A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating. The Journal of Biological Chemistry 277, 48289-48294.