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Publications

2009

  • Higazi, D.R., Fearnley, C.J., Drawnel, F.M., Talasila, A., Corps, E.M., Ritter, O., McDonald, F., Mikoshiba, K., Bootman, M.D. & Roderick, H.L. Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell 33, 472-82 (2009).
  • Harzheim, D., Movassagh, M., Foo, R.S., Ritter, O., Tashfeen, A., Conway, S.J., Bootman, M.D. & Roderick, H.L. Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci U S A 106, 11406-11 (2009).
  • Bootman, M.D., Fearnley, C., Smyrnias, I., Macdonald, F. & Roderick, H.L. An update on nuclear calcium signalling. J Cell Sci 122, 2337-50 (2009).

2008

  • Szado, T. et al. Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc Natl Acad Sci U S A 105, 2427-32 (2008).
  • Roderick, H. L., and Cook, S. J. Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 8, 361-375. (2008).
  • Walker, S., Cunniffe, N., Bootman, M. & Roderick, H.L. Dynamic imaging of calcium and STIM1 in the same cell using wide-field and TIRF microscopy. Biotechniques 45, 347-8 (2008).
  • Rong, Y. P., Aromolaran, A. S., Bultynck, G., Zhong, F., Li, X., McColl, K., Matsuyama, S., Herlitze, S., Roderick, H. L., Bootman, M. D., et al. Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell 31, 255-265. (2008)
  • Thul, R., Bellamy, T.C., Roderick, H.L., Bootman, M.D. & Coombes, S. Calcium oscillations. Adv Exp Med Biol 641, 1-27 (2008).
  • Kockskamper, J., Zima, A. V., Roderick, H. L., Pieske, B., Blatter, L. A., and Bootman, M. D. Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol. (2008).
  • Hanson, C.J., Bootman, M.D., Distelhorst, C.W., Wojcikiewicz, R.J. & Roderick, H.L. Bcl-2 suppresses Ca(2+) release through inositol 1,4,5-trisphosphate receptors and inhibits Ca(2+) uptake by mitochondria without affecting ER calcium store content. Cell Calcium 44, 324-38 (2008).
  • Hanson, C.J., Bootman, M.D., Distelhorst, C.W., Maraldi, T. & Roderick, H.L. The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect. Cell Calcium 44 143-58 (2008).
  • Ewence, A. E., Bootman, M., Roderick, H. L., Skepper, J. N., McCarthy, G., Epple, M., Neumann, M., Shanahan, C. M., and Proudfoot, D. Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells. A Potential Mechanism in Atherosclerotic Plaque Destabilization. Circ Res.103, e28-34(2008).
  • Cuddon, P., Bootman, M.D., Richards, G.R., Smith, A.J., Simpson, P.B. & Roderick, H.L. Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels. Biol Res 41, 183-95 (2008).
  • Bootman, M.D. & Roderick, H.L. Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors? Am J Physiol Heart Circ Physiol 294, H579-81 (2008).
  • Axe, E.L., Walker, S.A., Manifava, M., Chandra, P., Roderick, H.L., Habermann, A., Griffiths, G. & Ktistakis, N.T. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182, 685-701 (2008).

2007

  • Roderick, H.L. et al. Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid. Biochem Soc Trans 35, 957-61 (2007).
  • Roderick, H.L. & Bootman, M.D. Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes. J Physiol 581, 883-4 (2007).
  • McNeill, E., Conway, S.J., Roderick, H.L., Bootman, M.D. & Hogg, N. Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils. Cell Calcium 41, 107-121 (2007).
  • Jones, R.G. et al. The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity 27, 268-80 (2007).
  • Holmes, A.M., Roderick, H.L., McDonald, F. & Bootman, M.D. Interaction between store-operated and arachidonate-activated calcium entry. Cell Calcium 41, 1-12 (2007).
  • Bootman, M.D., Harzheim, D., Smyrnias, I., Conway, S.J. & Roderick, H.L. Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1. Cell Calcium 42, 489-501 (2007).
  • Bello, D. et al. Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate. J Org Chem 72, 5647-59 (2007).

2006

  • Bootman, M.D., Higazi, D.R., Coombes, S. and Roderick, H.L. (2006) Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes. J Cell Sci, 119, 3915-3925.
  • Conway, S.J., Thuring, J.W., Andreu, S., Kvinlaug, B.T., Roderick, H.L., Bootman, M.D. and Holmes, A.B. (2006) The Synthesis of Membrane Permeant Derivatives of myo-Inositol 1,4,5-Trisphosphate. Aust. J. Chem, 59, 887–893.
  • Hong, J.H., Moon, S.J., Byun, H.M., Kim, M.S., Jo, H., Bae, Y.S., Lee, S.I., Bootman, M.D., Roderick, H.L., Shin, D.M. and Seo, J.T. (2006) Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [ca2+]i oscillations in cultured rat cortical astrocytes. J Biol Chem, 281, 13057-13067.
  • Proven, A., Roderick, H.L., Conway, S.J., Berridge, M.J., Horton, J.K., Capper, S.J. and Bootman, M.D. (2006) Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes. J Cell Sci, 119, 3363-3375.
  • Richards, G.R., Smith, A.J., Cuddon, P., Ma, Q.P., Leveridge, M., Kerby, J., Roderick, H.L., Bootman, M.D. and Simpson, P.B. (2006) The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells. J Neurochem, 97, 201-210.
  • Roderick, H.L. and Bootman, M.D. (2006) New ca2+ indicator has freedom to express. Chem Biol, 13, 463-464.

2005

  • Liu, Q., Walker, S.A., Gao, D., Taylor, J.A., Dai, Y.F., Arkell, R.S., Bootman, M.D., Roderick, H.L., Cullen, P.J. and Lockyer, P.J. (2005) CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of ca2+. J Cell Biol, 170, 183-190.
  • Roderick, H.L. and Bootman, M.D. (2005) Redoxing calcium from the ER. Cell, 120, 4-5.
  • Shim, S., Goh, E.L., Ge, S., Sailor, K., Yuan, J.P., Roderick, H.L., Bootman, M.D., Worley, P.F., Song, H. and Ming, G.L. (2005) XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci, 8, 730-735.

2004

  • Chen, R., Valencia, I., Zhong, F., McColl, K.S., Roderick, H.L., Bootman, M.D., Berridge, M.J., Conway, S.J., Holmes, A.B., Mignery, G.A., Velez, P. and Distelhorst, C.W. (2004) Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol, 166, 193-203.
  • Hanson, C.J., Bootman, M.D. and Roderick, H.L. (2004) Cell signalling: IP3 receptors channel calcium into cell death. Curr Biol, 14, R933-935.
  • Kasri, N.N., Holmes, A.M., Bultynck, G., Parys, J.B., Bootman, M.D., Rietdorf, K., Missiaen, L., McDonald, F., De Smedt, H., Conway, S.J., Holmes, A.B., Berridge, M.J. and Roderick, H.L. (2004) Regulation of InsP3 receptor activity by neuronal ca2+-binding proteins. Embo J, 23, 312-321.
  • Mackenzie, L., Roderick, H.L., Berridge, M.J., Conway, S.J. and Bootman, M.D. (2004a) The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci, 117, 6327-6337.
  • Mackenzie, L., Roderick, H.L., Proven, A., Conway, S.J. and Bootman, M.D. (2004b) Inositol 1,4,5-trisphosphate receptors in the heart. Biol Res, 37, 553-557.
  • Peppiatt, C.M., Holmes, A.M., Seo, J.T., Bootman, M.D., Collins, T.J., McDonald, F. and Roderick, H.L. (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem J, 381, 929-939.
  • Russell, S.J., Ruddock, L.W., Salo, K.E., Oliver, J.D., Roebuck, Q.P., Llewellyn, D.H., Roderick, H.L., Koivunen, P., Myllyharju, J. and High, S. (2004) The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association. J Biol Chem, 279, 18861-18869.

2003

  • Berridge, M.J., Bootman, M.D. and Roderick, H.L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol, 4, 517-529.
  • Distelhorst, C.W. and Roderick, H.L. (2003) Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2? Biochem Soc Trans, 31, 958-959.
  • Mackenzie, L., Roderick, H.L., Bootman, M.D. and Proven, A. (2003) Inositol 1,4,5-Trisphosphate Receptors in the Heart. In Poujeol, P. and Petersen, O. (eds.), 3rd FEPS Conference. Monduzzi Editore, Nice (France), pp. 109-115.
  • Peppiatt, C.M., Collins, T.J., Mackenzie, L., Conway, S.J., Holmes, A.B., Bootman, M.D., Berridge, M.J., Seo, J.T. and Roderick, H.L. (2003) 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium, 34, 97-108.
  • Roderick, H.L., Berridge, M.J. and Bootman, M.D. (2003a) Calcium-induced calcium release. Curr Biol, 13, R425.
  • Roderick, H.L., Berridge, M.J. and Bootman, M.D. (2003b) The Endoplasmic Reticulum: A Central Player in Cell Signalling and Protein Synthesis. In Falcke, M. and Malchow, D. (eds.), Understanding Calcium Dynamics: Experiments and Theory. Springer, Vol. 13, pp. 17-35.
  • Roderick, H.L. and Bootman, M.D. (2003a) Calcium influx: is homer the missing link? Curr Biol, 13, R976-978.
  • Roderick, H.L. and Bootman, M.D. (2003b) Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors. Biochem Soc Trans, 31, 950-953.

2002 - 1997

  • Bootman, M.D., Berridge, M.J. and Roderick, H.L. (2002a) Calcium signalling: more messengers, more channels, more complexity. Curr Biol, 12, R563-565.
  • Bootman, M.D., Berridge, M.J. and Roderick, H.L. (2002b) Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate. Proc Natl Acad Sci U S A, 99, 7320-7322.
  • Bootman, M.D., Collins, T.J., Mackenzie, L., Roderick, H.L., Berridge, M.J. and Peppiatt, C.M. (2002c) 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated ca2+ entry but an inconsistent inhibitor of InsP3-induced ca2+ release. Faseb J, 16, 1145-1150.
  • Gu, S., Roderick, H.L., Camacho, P. and Jiang, J.X. (2001) Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. J Biol Chem, 276, 24137-24144.
  • Gu, S., Roderick, H.L., Camacho, P. and Jiang, J.X. (2000) Identification and characterization of an amino acid transporter expressed differentially in liver. Proc Natl Acad Sci U S A, 97, 3230-3235.
  • Roderick, H.L., Lechleiter, J.D. and Camacho, P. (2000) Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b. J Cell Biol, 149, 1235-1248.
  • Oliver, J.D., Roderick, H.L., Llewellyn, D.H. and High, S. (1999) ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin. Mol Biol Cell, 10, 2573-2582.
  • Llewellyn, D.H. and Roderick, H.L. (1998) Overexpression of calreticulin fails to abolish its induction by perturbation of normal ER function. Biochem Cell Biol, 76, 875-880.
  • Roderick, H.L., Llewellyn, D.H., Campbell, A.K. and Kendall, J.M. (1998) Role of calreticulin in regulating intracellular ca2+ storage and capacitative ca2+ entry in HeLa cells. Cell Calcium, 24, 253-262.
  • Llewellyn, D.H., Roderick, H.L. and Rose, S. (1997) KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells. Biochem Biophys Res Commun, 240, 36-40.
  • Roderick, H.L., Campbell, A.K. and Llewellyn, D.H. (1997) Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors. FEBS Lett, 405, 181-185.