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Recent Part II BBS dissertation

Recent pharmacology dissertation titles offered in Part II BBS

The department offers a wide range of dissertation titles for students taking Part II BBS. Below are some examples of titles offered in 2016/17. The subheadings are somewhat arbitrary, but hopefully convey the wide scope of themes on offer and the huge importance of pharmacology to biomedical science.

New therapeutic strategies

  • Therapeutic potential of intrabodies
  • Targeting protein-protein interactions as a therapeutic strategy
  • The use of pluripotent stem cells in regenerative medicine
  • Quantitative systems pharmacology – is this the future of drug discovery?
  • Is germline CRISPR editing ready for the clinic?
  • Impact of big data on drug R&D and healthcare
  • Targeting virulence as a potential strategy for combating pathogenic bacteria
  • Pharmacological chaperones and their application in treating diseases

Challenging the dogma

  • Is aspirin a useful anti-thrombotic?
  • Are SSRIs really competitive inhibitors of SERT?
  • What are the mechanisms of drug entry in cells and tissues?
  • The relative significance of drugs and diet in influencing plasma lipid levels?

Understanding disease to guide therapy

  • The amyloid hypothesis and potential treatments for neurodegenerative diseases
  • Cystic fibrosis-related diabetes
  • The role of neutrophils in arterial thrombosis
  • What are the links between hypoxia and neurodegenerative diseases (e.g. Alzheimer’s disease)?
  • Is chronic visceral pain a manifestation of central or peripheral processes?
  • Bacterial host interactions in the development of chronic visceral pain: does early life exposure to pathogen influence pain sensitivity in adulthood?
  • Bacterial host interactions in cystic fibrosis

From molecular mechanism to drug target

  • Targeted degradation of CFTR: prospects for therapeutic interventions in CF
  • Duel glucagon and glucagon-like peptide 1 agonists as new treatments for type II diabetes
  • The structure of the exocytotic fusion pore
  • How do SNAREs mediate membrane fusion?
  • Trapping pain with TRPs: are TRP channels good targets for alleviating pain?
    • Pharmacological intervention in the cell cycle.
    • Lipid transporters in health and disease
    • Store-operated calcium entry pathway as a potential therapeutic target