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Department of Pharmacology

Cyclic AMP


Key publications: 

AKAP79 and PKC, PKA and PDE4, participate in a Gq-linked muscarinic receptor and adenylyl cyclase 2 cAMP signalling complex. JX Shen and DMF Cooper. Biochem. J. 455, 47-56 (2013)

Direct binding of AC8 and Orai1 underlies dynamic Ca2+-regulated cAMP signalling.  D Willoughby, KL Everett, ML Halls, J Pacheco, P Skroblin, L Vaca, E Klussmann and DMF Cooper Science Signaling (2012) 5, ra29

Sub-picomolar relaxin signaling by a pre-assembled RXFP1, AKAP-79, AC2, β-arrestin 2, PDE4D3 complex. ML Halls and DMF Cooper EMBO Journal 29, 2772-2787 (2010)

Investigator biography:

I have worked on cyclic AMP since my Ph.D. on cAMP and lipolysis in Biochemistry in Bangor, North Wales. I then did a postdoc in Sussex (Biochemistry group, School of Biological Sciences) on ACTH – effects on adrenal steroidogenesis and control of its secretion by CRH. I went to the US – NIH (Bethesda, MD) in 1977 to join the lab of the later Nobel Laureate, Martin Rodbell, to work on G-proteins. My efforts were largely focused on proving that Gi was an entity that differed from Gs. I took a faculty position in the Pharmacology department of the University of Colorado School of Medicine (1982; becoming full Professor in 1991), where I initiated work on the impact of Calcium signaling on adenylyl cyclases. I spent a sabbatical year (1989) at the University of Geneva learning the issues surrounding Calcium imaging and ion channels, and a sabbatical (1995/96) in the Pharmacology department in Cambridge, with Robin Irvine, pursuing questions on inositol phosphates, susceptibilities of ACs to membrane potential, as well as Calcium imaging with aequorin-tagged ACs in Padua with Sarino Rizzuto. In 2002 I moved my lab to Pharmacology in Cambridge, where we continue to focus on the organizational properties of ACs and their association with Calcium channels.   

Signalling Pharmacology
Professor Dermot  Cooper
Not available for consultancy


Person keywords: 
Cellular signalling, cancer, adenylyl cyclase, protein kinase, cyclic AMP, AKAP, Akinase anchoring proteins