Professor J M Edwardson - Group leader
Sheild Professor of Pharmacology
E-Mail: jme1000@cam.ac.uk
Tel: +44 1223 334014/334042
Fax: +44 1223 334100
Keywords
Neurotransmitter receptors, atomic force microscopy, single-molecule imaging
Investigator biography
Mike has spent most of his career in Cambridge. He was an undergraduate and postgraduate student at Trinity College (BA, 1976; Ph.D. 1979). He then worked for a short time as a post-doctoral research associate with Prof. Alan Cuthbert, FRS, before moving in 1980 to a Lectureship at the School of Pharmacy, University of London. He returned to Cambridge in 1984 to a Lectureship. He was subsequently promoted to Reader in 2000 and Professor of Molecular Pharmacology in 2009. He became Sheild Professor of Pharmacology in 2017. Mike has spent extended periods of research leave at Yale University and the University of Wisconsin, Madison. He has a wide network of collaborators within Cambridge, elsewhere in the UK, and in the US, Japan, Brazil, and Chile. He is a Fellow of Christ’s College. His research interest is in the imaging of biomolecules using atomic force microscopy.
Key publications
Waters, R.A., Robinson, J. and Edwardson, J.M. (2021) Syncollin is an antibacterial polypeptide. Cell. Microbiol. e13372. doi: 10.1111/cmi.13372021;23:e13372.
Dawe, G.B., Kadir, M.F., Venskutonytė, R., Perozzo, A.M., Yan, Y., Alexander, R.P.D., Navarrete, C., Santander, E.A., Arsenault, M., Fuentes, C., Aurousseau, M.R.P., Frydenvang, K., Barrera, N.P., Kastrup, J.S., Edwardson, J.M., and Bowie, D. (2019) Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively-spliced AMPA receptors. Neuron 102, 976-992
Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M. and Chapman, E.R. (2016) Exocytotic fusion pores are composed of both lipids and proteins. Nat. Struct. Mol. Biol. 23, 67-73
Liu, H., Bai, H., Xue, R., Takahashi, H., Edwardson, J.M. and Chapman, E.R. (2014) Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling. Nat. Neurosci. 17, 670-677
Balasuriya, D., D’Sa, L., Talker, R., Dupuis, E., Maurin, F., Martin, P., Borgese, F., Soriani, O. and Edwardson, J.M. (2014) A direct interaction between the Sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®). J. Biol. Chem. 289, 32353-32363
Suzuki, Y., Goetze, T.A., Stroebel, D., Balasuriya, D., Yoshimura, S.H., Henderson, R.M., Paoletti, P., Takeyasu, K. and Edwardson, J.M. (2013) Visualization of structural changes accompanying activation of NMDA receptors using fast-scan AFM imaging. J. Biol. Chem. 288, 778-784