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Department of Pharmacology



Selected publications

Waters, R.A., Robinson, J. and Edwardson, J.M. (2021) Syncollin is an antibacterial polypeptide. Cell. Microbiol. e13372. doi: 10.1111/cmi.13372021;23:e13372

Zabolotnaya, E., Mela, I., Williamson, M.J., Bray, S.M., Yau, S.K., Papatziamou, D., Edwardson, J.M., Robinson, N.P. and Henderson, R.M. (2020) Novel modes of action of the archaeal Mre11-Rad50 DNA-repair complex revealed by Fast-scan atomic force microscopy. Proc. Natl. Acad. Sci. USA 117, 14936-14947

Sim M.F.M., Persiani, E., Talukder, M.M.U., Mcilroy, G.D., Roumane, A., Edwardson, J.M. and Rochford, J.J. (2020) Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation. Sci. Rep. 10, 3259.  DOI:

Jiao, Y., Ahmed, U., Sim, M.F.M., Bejar, A., Zhang, X, Talukder, M.M.U., Rice, R., Flannick, J., Podgornaia, A.I., Reilly, D.F., Engreitz, J.M., Kost-Alimova, M., Hartland, K., Mercader, J.-M., Georges, S., Wagh, V., Tadin-Strapps, M., Doench, J.G., Edwardson, J.M., Rochford, J.J., Rosen, E.D. and Majithia, A.R. (2019) Discovering metabolic disease gene interactions by correlated effects on cellular morphology. Mol. Metab. 24, 108-119

Rubio Lara, J.A., Bergler, F., Attwood, S.J., Edwardson, J.M. and Welland, M.E. (2019) Ultra-flat gold QCM electrodes fabricated with pressure forming template stripping for protein studies at the nanoscale. Langmuir doi: 10.1021/acs.langmuir.8b03782

Dawe, G.B., Kadir, M.F., Venskutonytė, R., Perozzo, A.M., Yan, Y., Alexander, R.P.D., Navarrete, C., Santander, E.A., Arsenault, M., Fuentes, C., Aurousseau, M.R.P., Frydenvang, K., Barrera, N.P., Kastrup, J.S., Edwardson, J.M., and Bowie, D. (2019) Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively-spliced AMPA receptors. Neuron 102, 976-992

Amadeu de Oliveira, F., MacVinish, L.J., Amin, S., Herath, D., Jeggle, P., Mela, I., Pieri, M., Sharma, C., Jarvis, G.E., Levy, F.M., Santesso, M.R., Khan, Z.N.,Leite, A.L., Oliveira, R.C., Buzalaf, M.A.R. and  Edwardson, J.M. (2018) The effect of fluoride on the structure, function, and proteome of intestinal epithelia. Env. Toxicol. 33, 63-71

Santiago, A.C., Miguel, M.C., Khan, Z.N., Schneider, V.K., Soares-Costa, A., Pelá, V.T., Gironda, C.C., Leite, A.L., Edwardson, J.M., Buzalaf, M.A.R. and Henrique-Silva, F. (2017) A new sugarcane cystatin strongly binds to dental enamel and reduces erosion. J. Dent. Res. 96, 1051-1057

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M. and Chapman, E.R. (2016) Exocytotic fusion pores are composed of both lipids and proteins. Nat. Struct. Mol. Biol. 23, 67-73

Hanna, M.G. IV, Mela, I., Wang, L., Henderson, R.M., Chapman, E.R., Edwardson, J.M. and Audhya, A. (2016) Sar1 GTPase activity is regulated by membrane curvature. J. Biol. Chem. 291, 1014-1027

Stewart, A.P., Sandford, R.N., Karet Frankl, F.E. and Edwardson, J.M. (2015) Pathogenic uromodulin mutations result in premature intracellular polymerization. FEBS Lett. 589, 89-93

Takahashi, H., Mayers, J.R., Wang, L., Edwardson, J.M. and Audhya, A. (2015) Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro. Biophys. J. 108, 76-84

Balasuriya, D., D’Sa, L., Talker, R., Dupuis, E., Maurin, F., Martin, P., Borgese, F., Soriani, O., and Edwardson, J.M. (2014) A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®). J. Biol. Chem. 289, 32353-32363

Liu, H., Bai, H., Xue, R., Takahashi, H., Edwardson, J.M. and Chapman, E.R. (2014) Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling. Nat. Neurosci. 17, 670-677

Suzuki, Y., Goetze, T.A., Stroebel, D., Balasuriya, D., Yoshimura, S.H., Henderson, R.M., Paoletti, P., Takeyasu, K. and Edwardson, J.M. (2013) Visualization of structural changes accompanying activation of NMDA receptors using fast-scan AFM imaging. J. Biol. Chem. 288, 778-784

Balasuriya, D., Stewart, A.P. and Edwardson, J.M. (2013) The sigma-1 receptor interacts directly with GluN1 but not GluN2A in the GluN1/GluN2A NMDA receptor. J. Neurosci. 33, 18219-18224

PubMed link to all Mike Edwardson’s publications