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Department of Pharmacology

 

Department of Pharmacology - MRC Toxicology Unit - Newnham College 4-year PhD Studentship

Applications are invited from women for a 4-year PhD studentship Department of Pharmacology – MRC Toxicology Unit – Newnham College PhD Studentship as part of the School of the Biological Sciences Doctoral Training Program (SBS DTP) to conduct research in the Department of Pharmacology and MRC Toxicology Unit available from October 2022.  The Studentship will be awarded on a competitive basis and applicants will be expected to demonstrate a strong academic background and an aptitude for research.

The studentship is funded by the Department of Pharmacology via the David James Studentship scheme, the MRC Toxicology Unit, and Newnham College. The successful applicant will become a member of Newnham College, which offers a lively and welcoming women’s College, and will have the opportunity to take part in SBS DTP activities. Available projects are listed here.

This award will cover UK University fees and a maintenance allowance at the RCUK rate. Information about University fees and standard maintenance costs for 2022/2023 is available here

Applicants should have or be about to achieve a first or upper second-class degree from a UK university or an equivalent standard from an overseas university and meet the University of Cambridge entrance requirements.  Full details of the University’s entrance requirements are specified here

APPLICATION PROCEDURE

Step 1: Contact supervisors
The projects offered will be co-supervised by research groups in Pharmacology and MRC Toxicology. The Departments are situated adjacent to each other and are linked by shared communal spaces. A list of supervisors and projects can be found here. Make contact with potential supervisors by email to find out more information about projects. Include in your email your CV, detailing your academic record and contact details for 2 academic referees.

Step 2: University Application
If the supervisors wish to support you for the competition, they will ask you to apply formally to the University using the online application form (Applicant Portal). For more information, see https://www.phar.cam.ac.uk/postgraduate-admissions

Project-related questions may be addressed directly to the supervisor.  Requests for general information or enquiries about procedures, including advice if you have already submitted an application to the Department of Pharmacology or MRC Toxicology Unit, can be made via email to phar-postgradadmin@lists.cam.ac.uk

Online applications with ALL supporting documentation to be submitted by
12 midday on Monday 28 February 2022 at the latest.

Interview dates to be confirmed. 

The University values diversity and is committed to equality of opportunity.

 


David James - Wolfson College - School of Biological Sciences 4-year PhD studentship

Applications are invited for a 4-year David James – Wolfson College – SBS PhD Studentship as part of the School of the Biological Sciences Doctoral Training Program (SBS DTP) to conduct research in the Department of Pharmacology available from October 2022. The Studentship will be awarded on a competitive basis and applicants will be expected to demonstrate a strong academic background and an aptitude for research.

The studentship is funded by the Department of Pharmacology via the David James Studentship scheme, Wolfson College, and the School of Biological Sciences. The successful applicant will become a member of Wolfson College, which offers a lively and welcoming home to a diverse and cosmopolitan community of postgraduate and older (21+) undergraduate students, as well as having the opportunity to take part in SBS DTP activities.

This award will cover UK University fees and a maintenance allowance at the RCUK rate. Information about University fees and standard maintenance costs for 2022/2023 is available here.  You will also undertake a 3-month Professional Internship for PhD students (PIPS) at some stage during your study and will participate in training and cohort-building events. 

Applicants for this course should have or be about to achieve a first or upper second-class degree from a UK university or an equivalent standard from an overseas university and meet the University of Cambridge entrance requirements.  Full details of the University’s entrance requirements are specified here.

APPLICATION PROCEDURE

Step 1: Contact supervisor(s)

Make contact with potential supervisor(s) within the Department of Pharmacology by email to find out more information about projects. A list of supervisors and available projects is available at here. Include your CV, detailing your academic record and contact details for 2 academic referees.

Step 2: University Application

If the supervisor wishes to support you for the competition, he/she will ask you to apply formally to the University using the online application form (Applicant Portal). For more information, see https://www.phar.cam.ac.uk/postgraduate-admissions

Project related questions may be addressed directly to the supervisor. Requests for general information or enquiries about procedures including advice if you have already submitted an application to our Department via email to phar-postgradadmin@lists.cam.ac.uk

Online applications with ALL supporting documentation to be submitted by
12 midday on Tuesday 31 January 2022 at the latest.

Interview dates to be confirmed.

The University values diversity and is committed to equality of opportunity.

 


 

3 Year PhD studentship to study the molecular mechanisms of visceral pain

Department of Pharmacology, University of Cambridge, UK

Sensory neurones detect touch, temperature, itch and pain, all of which are key to our ability to sense our external, as well as internal environment. Of all chronic pain syndromes, bowel pain conditions, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), are some of the most difficult to treat. Consequently, there is great urgency to further understanding of the pain mechanisms in IBD and IBS to answer a significant unmet clinical need.

Based in the labs of Dr Ewan St. John Smith and Prof. Geoff Woods at the University of Cambridge, this project will use a combination of in vitro and in vivo techniques to further characterise the properties of sensory neurones innervating the bowel and the roles of key receptors they express.

This project funded by AstraZeneca is part of the MRC/Versus Arthritis “Advanced Pain Discovery Platform” ADVANTAGE consortium https://mrc.ukri.org/research/initiatives/advanced-pain-discovery-platform-apdp/. ADVANTAGE is a multi-centre consortium which brings together patients, clinicians and basic scientists, to focus on mechanisms of visceral pain and improving therapeutic outcomes for visceral pain sufferers.

The successful candidate will be provided with comprehensive training in molecular neuroscience, including:

-              In vivo models, retrograde tracing and behavioural experiments

-              Ca2+-imaging, ex vivo and patch-clamp electrophysiology

-              Cell culture of primary neurones

-              Molecular biology techniques, such as qPCR

-              Research placement at the AstraZeneca Discovery Centre (DISC) – Cambridge

Environment

The student will join a vibrant and engaging research group focused on understanding the molecular basis of pain in conditions such as arthritis and colitis within the Department of Pharmacology, University of Cambridge. A key component of the studentship are two placements: with industrial collaborator AstraZeneca who will provide a research placement, allowing access to cutting edge equipment and techniques to support the project; and in Prof. Woods's laboratory that focuses on discovering Mendelian effects controlling human pain sensing

Skills/Attributes

-              A willingness to learn new techniques and leverage those skills to solve research challenges.

-              Demonstrable self-motivation and independent initiative.

-              Excellent team working and communication skills (oral and written).

-              Obtained or expect to obtain a minimum 2.1 degree (or equivalent) in Biomedical Sciences, Pharmacology, Neuroscience, Cellular or Molecular Biology and Biochemistry or an equivalent course.

We welcome applications from all qualified candidates, especially those from under-represented minorities in neuroscience. The expected start date is October 1st 2022, although an earlier start date might be possible. Funding covers tuition fees at the UK rate and a student stipend for 3-years.

All applications for this project should be made through the University’s online Postgraduate Applicant Portal. In the application form, please state in the Prospective Supervisor section, “Professor Ewan St John Smith (ADVANTAGE PhD Studentship)” and also mention “ADVANTAGE PhD Studentship” in the funding section. The deadline for applications is 16:00 on Monday 28th of February.

For further information about the project, please feel free to contact Ewan: es336@cam.ac.uk.

 


Dr David James Studentship

davidjamesBW

During his life, Dr James was a well-respected Departmental Administrator. His legacy provides scholarships for the most gifted postgraduates to pursue focused and original research. The David James Studentship has provided full financial support for a number of PhD students within the Department since October 2011.

Via PhD studentships, the David James Fund is supporting the next generation of Cambridge pharmacologists, whose work will be crucial to developing better treatments for diseases such as cancer, cardiovascular disease, arthritis, diabetes and Crohn's disease.

Dr James' legacy also supports the David James Annual Lecture Series.

 


Awardee Biographies

Roberta Cacioppo

David James PhD Studentship, 2019-2023

I obtained a Bachelor’s degree in Biotechnologies from the University of Palermo in Italy, during which I studied the role for a long non-coding RNA in regulating TBPH subcellular localization.

I carried out my MSc research in the group of Dr. Rousseau at the MRC PPU in Dundee, where I identified a novel regulator of the selective translation of proteasome assembly chaperones during cellular stress.

I joined the Lindon Lab in 2019 as a David James PhD Student, and I’m currently studying the post-transcriptional regulation of the cell cycle regulator Aurora Kinase A. I am greatly enjoying the scientific and cultural diversity that our Department offers, which has allowed me to widen my technical skillset and work in a stimulating environment.

I like to spend my free time outside the lab socializing, cooking, and travelling.

 

Rosie Waters

AstraZeneca-David James PhD Studentship, 2017-2021

My PhD, co-funded by David James Studentship and AstraZeneca, was focused on understanding the structure and function of the protein syncollin, and it covered both protein structural studies and physiological assays, including work with bacteria and neutrophils.

What I enjoyed most about my PhD was the variety of experimental techniques, which allowed many opportunities for collaboration and a broader skillset to be acquired.

I am now putting these skills to good use in the in vitro pharmacology group of a neuroscience biotech company.