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Biomolecular imaging using atomic force microscopy (AFM)

 

Mike Edwardson

Professor J M Edwardson - Group leader

Sheild Professor of Pharmacology

Head of the Department

E-Mail: jme1000@cam.ac.uk
Tel: +44 1223 334014/334042
Fax: +44 1223 334100

Keywords

Neurotransmitter receptors, atomic force microscopy, single-molecule imaging, syncollin

Investigator biography

Mike has spent most of his career in Cambridge. He was an undergraduate and postgraduate student at Trinity College (BA, 1976; Ph.D. 1979). He then worked for a short time as a post-doctoral research associate with Prof. Alan Cuthbert, FRS, before moving in 1980 to a Lectureship at the School of Pharmacy, University of London. He returned to Cambridge in 1984 to a Lectureship. He was subsequently promoted to Reader in 2000 and Professor of Molecular Pharmacology in 2009. He became Sheild Professor of Pharmacology in 2017. Mike has spent extended periods of research leave at Yale University and the University of Wisconsin, Madison. He has a wide network of collaborators within Cambridge, elsewhere in the UK, and in the US, Japan, Brazil, and Chile. He is a Fellow of Christ’s College. His research interest is in the imaging of biomolecules using atomic force microscopy. He is currently Head of the Department of Pharmacology.

Key publications

Dawe, G.B., Kadir, M.F., Venskutonytė, R., Perozzo, A.M., Yan, Y., Alexander, R.P.D., Navarrete, C., Santander, E.A., Arsenault, M., Fuentes, C., Aurousseau, M.R.P., Frydenvang, K., Barrera, N.P., Kastrup, J.S., Edwardson, J.M., and Bowie, D. (2019) Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively-spliced AMPA receptors. Neuron 102, 976-992

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M. and Chapman, E.R. (2016) Exocytotic fusion pores are composed of both lipids and proteins. Nat. Struct. Mol. Biol. 23, 67-73

Liu, H., Bai, H., Xue, R., Takahashi, H., Edwardson, J.M. and Chapman, E.R. (2014) Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling. Nat. Neurosci. 17, 670-677

Balasuriya, D., D’Sa, L., Talker, R., Dupuis, E., Maurin, F., Martin, P., Borgese, F., Soriani, O. and Edwardson, J.M. (2014) A direct interaction between the Sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®). J. Biol. Chem. 289, 32353-32363

Suzuki, Y., Goetze, T.A., Stroebel, D., Balasuriya, D., Yoshimura, S.H., Henderson, R.M., Paoletti, P., Takeyasu, K. and Edwardson, J.M. (2013) Visualization of structural changes accompanying activation of NMDA receptors using fast-scan AFM imaging. J. Biol. Chem. 288, 778-784

Lab members