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Biomolecular imaging using atomic force microscopy (AFM)

 

Mike Edwardson

Professor J M Edwardson - Group leader

Head of the Department

Undergraduate Admissions for Christ's College
Graduate Studies Prospectus at Christ's College

E-Mail: jme1000@cam.ac.uk
Tel: +44 1223 334014/334042
Fax: +44 1223 334100

Keywords

Neurobiology, neurotransmitter receptors, atomic force microscopy, single-molecule imaging

Investigator biography

Mike has spent most of his career in Cambridge. He was an undergraduate and postgraduate student at Trinity College (BA, 1976; PhD 1979). He then worked for a short time as a post-doctoral research associate with Prof. Alan Cuthbert, FRS, before moving in 1980 to a Lectureship at the School of Pharmacy, University of London. He returned to Cambridge in 1984 to a Lectureship. He was subsequently promoted to Reader in 2000 and became Professor of Molecular Pharmacology in 2009. Mike has spent extended periods of research leave at Yale University and the University of Wisconsin, Madison. He has a wide network of collaborators, within Cambridge, elsewhere in the UK, and in the US, Japan, France, Brazil and Chile. He is a Fellow and Director of Pre-Clinical Studies at Christ’s College. His research interest is in the imaging of biomolecules using atomic force microscopy. He is currently Head of the Department of Pharmacology.

Key publications

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M. and Chapman, E.R. (2016) Exocytotic fusion pores are composed of both lipids and proteins. Nat. Struct. Mol. Biol. 23, 67-73

Balasuriya, D.,D’Sa, L., Talker, R., Dupuis, E., Maurin, F., Martin, P., Borgese, F., Soriani, O., and Edwardson, J.M. (2014) A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®). J. Biol. Chem. 289, 32353-32363

Suzuki, Y., Goetze, T.A., Stroebel, D., Balasuriya, D., Yoshimura, S.H., Henderson, R.M., Paoletti, P., Takeyasu, K. and Edwardson, J.M. (2013) Visualization of structural changes accompanying activation of NMDA receptors using fast-scan AFM imaging. J. Biol. Chem. 288, 778-784

Balasuriya, D., Stewart, A.P. and Edwardson, J.M. (2013) The sigma-1 receptor interacts directly with GluN1 but not GluN2A in the GluN1/GluN2A NMDA receptor. J. Neurosci. 33, 18219-18224

Lab members

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