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Department of Pharmacology

Tuning ca2+ to control cell function


Key publications: 
  • Higazi, D.R., Fearnley, C.J., Drawnel, F.M., Talasila, A., Corps, E.M., Ritter, O., McDonald, F., Mikoshiba, K., Bootman, M.D. & Roderick, H.L. Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell 33, 472-82 (2009).
  • Harzheim, D., Movassagh, M., Foo, R.S., Ritter, O., Tashfeen, A., Conway, S.J., Bootman, M.D. & Roderick, H.L. Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci U S A 106, 11406-11 (2009).
Dr Llewelyn  Roderick
Not available for consultancy