Department of Pharmacology Tea Club

Tea Club will be held as usual in the Departmental Lecture Theatre at 4 pm on Fridays in Full Term. After the talk there will be wine and nibbles and a chance to talk informally with the speaker. If anyone wishes to have some time with any speaker before the talk, or have dinner with them afterwards, please contact Dr Matthew Harper in advance.

Lent 2017

Tea Club Seminars

20^th January
Andreas Bender From virtual screening to mode of action analysis: How computers can help chemical biology and drug discovery
Centre for Molecular Informatics, University of Cambridge

27^th January
Wenshu Xu  Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase
Department of Pharmacology, University of Cambridge

3^rd  February
David Poyner How does CGRP activate its receptor? An odyssey of a family B G-protein coupled receptor
Aston University

10^th February
Amrita Ahluwalia A reductionist approach to cardiovascular disease: Inorganic nitrate to nitrite to NO
William Harvey Research Institute, Queen Mary University of London

17^th February
Norman Davey Decoding the hidden regulatory landscape of the proteome
University College Dublin

24^th February
Margaret Ashcroft Exploring the molecular interface between mitochondria and the cellular oxygen-sensing machinery
University of Cambridge

3^rd March
Sussan Nourshargh Neutrophil transmigration in vivo: Modes, mechanisms and pathogenesis
William Harvey Research Institute, Queen Mary University of London

10^th March
Charlotte Summers  The role of neutrophil-endothelial interactions in modulating lung inflammation
Department of Anaesthesia, University of Cambridge

Previous Tea Club seminars:

Michaelmas 2016

Tea Club Seminars

7^th October
Aylin Hanyaloglu Multi-Dimensional Programming of G Protein-Coupled Receptor Signalling: Mechanisms and Applications
Imperial College London

14^th October
Martin Bushall How Do MicroRNAs Work?
MRC Toxicology Unit, Leicester

21^st October
Thora Karadottir Neuronal Regulation of Myelination and Remyelination
Cambridge Stem Cell Institute

28^th October
Ken Meissner Quantum Dots and Microspheres and Red Blood Cells, Oh My!
University of Swansea

4^th November
Sandip Patel Non-canonical Signalling Through Acidic Calcium Stores
University College London

11^th November
Graham Ladds Systems analysis of G protein-coupled receptor pharmacology
Department of Pharmacology, University of Cambridge

18^th November
Jules Griffin From mouse to man and back again, applications of metabolomics (and lipidomics) to type 2 diabetes
Department of Biochemistry, University of Cambridge

25^th November
Kyren Lazarus Understanding the Role of BCL11A in Triple Negative Breast Cancer
Department of Pharmacology, University of Cambridge

Lent 2016

Tea Club Seminars

22nd January
Meritxell Huch To be confirmed
Department of Physiology, Development & Neuroscience, University of Cambridge

29th January
Ian Prior Isoform and codon-specific Ras signalling
University of Liverpool

5th February
Alastair Poole Platelets: from biogenesis to function
University of Bristol

12th February
Victoria Chapman Pharmacological studies of peripheral versus central mechanisms of arthritis pain
University of Nottingham

19th February
Richard Gilbertson Mapping Cancer Origins
Cambridge Cancer Centre

26th February
Cath Lindon Ubiquitin-mediated pathways in proteostasis and cell division
Department of Pharmacology, University of Cambridge

4th March
Graham Ladds Signalling bias at G protein-coupled receptors
Department of Pharmacology, University of Cambridge

Michaelmas 2015

Tea Club Seminars

October 9^th Mathew Garnett (Wellcome Trust Sanger Institute, University of Cambridge
‘High-throughput approaches in cancer cell models to enable precision cancer medicine’

 Oct 16^th Darren Cross, Richard A Ward, Ray Finlay (AstraZeneca Oncology Innovative Medicines)
‘Inhibition of EGF receptor signalling: The Discovery of AZD9291’

Oct 23^rd Margaret Cunningham (University of Strathclyde)
‘Probing thrombin-mediated platelet function using novel cyclic pepducins that target discrete regions of proteinase-activated receptor-4 (PAR4)’

Oct 30^th David Beech (University of Leeds)
‘The magic of calcium ion entry: discovery, disease and drugs’

Nov 6^th Mike Murphy (MRC Mitochondrial Biology Unit, University of Cambridge)
‘How mitochondrial ROS contribute to pathologies: mechanisms and potential therapies'

Nov 13^th Irene Tracey (Nuffield Department of Clinical Neurosciences, University of Oxford)
‘TBC’

Nov 20^th Tim Warner (William Harvey Research Institute, London)
‘Platelets in time and space: understanding the actions of anti-platelet drugs within the body’

Nov 27^th Elizabeth Murchison (Department of Veterinary Medicine, University of Cambridge)
‘Genome diversity and evolution of transmissible cancers in dogs and Tasmanian devils’

Matthew Harper (Tea Club Organiser)

Lent 2015

Tea Club Seminars

Jan 16^th Ken Smith (CIMR and Dept of Medicine.Cambridge)

‘Genomics, immunity and the biology of clinical outcome.’

Jan 23^rdWendy Bickmore (MRC Human Genetics Unit, Edinburgh)

‘Spatial Genome Organisation and gene regulation.’

Jan 30^th Maria Fitzgerald (Dept of Neuroscience, Physiology & Pharmacology, UCL)

'The developing pain system: a lifelong story.'

Feb 6^thPhill Hawkins (Babraham Institute, Cambridge)

‘PI3Ks; the rules of engagement.’

Feb 13^th Pooneh Bagher (Dept of Pharmacology, Oxford)

‘Illuminating the lumen: endothelial calcium in both vasoconstriction and vasodilation.’

Feb 20^th Kim Nasmyth (Dept of Biochemistry, Oxford)

‘How are chromosomes held together?’

Feb 27^th Ann Ferguson-Smith (Dept of Genetics, Cambridge)

‘Parental-origin effects and the epigenetic control of genome function.’

Mar 6^th Tony Kouzarides (Gurdon Institute and Dept of Pathology, Cambridge)

‘Epigenetic pathways in transcription and cancer.’

Robin Irvine (Tea Club Organiser)

Michaelmas 2014

Tea Club Seminars

Oct 17^th Stephen O’Rahilly (Metabolic Research Laboratories, Cambridge)
‘Human obesity and insulin resistance: lessons from genetics’

Oct 24^th Momo Bentires-Alj (Friedrich Miescher Institute, Basel)
‘Targeted cancer therapy: act locally, think globally’

Oct 31^st Sue Jones (PDN, Cambridge)
‘Regulation of NMDA receptor activity in substantia nigra dopamine neurons’

Nov 7^th Steve Royle (Medical Cell Biology, Warwick)
‘How and why cells switch off clathrin-mediated endocytosis during mitosis’

Nov 14^th Tony Jackson (Biochemistry Dept, Cambridge)
‘A proteomic method for characterising local protein clusters on the plasma membrane'

Nov 21^nd Wolf Reik (Babraham Institute, Cambridge)
‘Epigenetic reprogramming in mammalian development’

Nov 28^th Dermot Cooper (Dept of Pharmacology, Cambridge)
‘Adenylyl cyclases – an evolving story’

Robin Irvine (Tea Club Organiser)

Lent 2014

Tea Club Seminars

Jan 17^th Julian Downward (CRUK, London Research Laboratories)
“Mechanisms of transformation by RAS oncogenes: searching for novel therapeutic
approaches.”

Jan 24^th Alex Gourine (Neuroscience, Physiology and Pharmacology, UCL)
“Astroglial control of vital neural networks.”

Jan 31^st Giles Hardingham (Centre for Intergrative Physiology Edinburgh)
“Ca²⁺ signaling and the control of survival and death in neurons.”

Feb 7^th Klaus Okkenhaug (Babraham Institute, Cambridge)
“PI3Ks in immunity, infection and cancer.”

Feb 14^th David Belin (Pharmacology, Cambridge)
“Probing the effectiveness of new drugs to treat addictions: what is it you want to
measure, and how do you achieve it?”

Feb 21^st Frances Platt (Pharmacology, Oxford)
“Lysosomal storage disorders: unanticipated links to more common diseases.”

Feb 28^th Jenny Pell (Pharmacology, Cambridge)
“Epigenetic regulation of muscle stem cell fate: generation of an ageing paradigm.”

March 7^th Laura Itzhaki (Pharmacology, Cambridge)
“Tandem repeat proteins: function, malfunction and therapeutic intervention.”

Robin Irvine (Tea Club Organiser)

Michaelmas 2013

Tea Club Seminars

Oct 11^th Robin May (School of Biosciences, Birmingham)

‘Host-pathogen interactions during fatal fungal infections.’

Oct 18^th Rafael Carozo Salas (Gurdon Institute, Cambridge)

‘Discovering genes and reconstructing pathways using microscopy-based functional genomics’.

Oct 25^th Akhilesh Reddy (Clinical Neurosciences, Cambridge)

‘Redox and metabolic oscillations in the clockwork’.

Nov 1^st Steve Tovey & Jon Clarke (Pharmacology, Cambridge)

‘cAMP directs IP₃-evoked Ca²⁺ signalling to different intracellular Ca²⁺ stores,’ and ‘Regulation and function of PI5P 4-kinases’.

Nov 8^th David Komander (LMB, Cambridge)

‘Mechanisms, functions and uses of OTU domain deubiquitinases.’

Nov 15^th Dan Davis (Centre for Inflammation Research, Manchester)

'Using super-resolution microscopy to watch immune cells kill.'

Nov 22^nd Azim Surani (Gurdon Institute, Cambridge)

‘Specification and programming of the germline for mammalian development.’

Nov 29^th Anant Parekh (Physiology, Anatomy and Genetics, Oxford)

‘Decoding local calcium signals: excitation-transcription coupling.’

Robin Irvine (Tea Club Organiser)