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Seminars & Events

Department of Pharmacology Tea Club

 

tea clubTea Club will be held as usual in the Departmental Lecture Theatre at 4 pm on Fridays in Full Term. After the talk there will be wine and nibbles and a chance to talk informally with the speaker. If anyone wishes to have some time with any speaker before the talk, or have dinner with them afterwards, please contact in advance.

 

 

 


Visualizing and controlling the cell cycle machinery in single cells

Dr Joerg Mansfeld

Monday 04 December 2017, 15:00-16:00

Cell cycle kinetics are crucial to cell fate decisions. Although live imaging has provided extensive insights into this relationship at the single-cell level, the limited number of fluorescent markers that can be used in a single experiment has hindered efforts to link the dynamics of individual proteins responsible for decision making directly to cell cycle progression. I will present an all-in-one cell cycle reporter that allows simultaneous analysis of cell cycle progression, including the transition into quiescence, and the dynamics of individual fate determinants. Focusing on cyclin D1 as a major cell cycle regulator, we present evidence that a crucial cell cycle function of cyclin D1 is to prevent the transition into quiescence and identify a unique cyclin D1 protein kinetics that are indicative of very short G1 phases. In addition, to allow manipulating the levels of endogenous proteins at will, we introduce a novel approach to render already existing GFP (trap) lines amenable to auxin-dependent degradation by simple ectopic expression of a degradation cassette using human cells and zebrafish as a proofs of principle.

If you have a question about this talk, please contact Dr. Cath Lindon.

Tea Club Michaelmas 2017 

 

6th October

David Bulmer

Translational studies in visceral pain

Department of Pharmacology, University of Cambridge

13th October

Grant Churchill

Academic drug repurposing reveals a lithium mimetic for bipolar disorder: from in vitro identification to clinical trials

Department of Pharmacology, University of Oxford

20th October

Jane Mitchell

COX-2, non steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular side effects: myths, legends and future direction

Institute of Cardiovascular Medicine & Science, Imperial College, London

27th October

Matthew Freeman

The cell biological control of signalling by rhomboid-like proteins

Sir William Dunn School of Pathology, University of Oxford

3rd November

Anne Bertolotti

Selective inhibition of a phosphatase to restore proteostasis defects and treat neurodegenerative diseases

LMB, University of Cambridge

10th November

Daniela Riccardi

The calcium-sensing receptor in physiology and disease

School of Biosciences, University of Cardiff

17th November

David Atwell

Regulation of blood flow in the brain and heart by capillary pericytes

Neuroscience, Physiology & Pharmacology, UCL, London

24th November

Ana Rossi

Mechanisms linking hypoxia, type 2 IP3 receptors and invasiveness in glioblastoma cells

Department of Pharmacology, University of Cambridge