skip to primary navigationskip to content
 

Shooting calcium at lysosomes

last modified Dec 12, 2018 08:43 AM
Peace Atakpa, working with Babu Thillaiappan, David Prole and Stefania Mataragka in Colin Taylor’s lab, has shown, using a variety of approaches including a novel genetically encoded Ca2+ sensor, that a specific intracellular channel selectively delivers Ca2+ to lysosomes...

Lysosomes recycle materials imported from outside the cell and obsolete materials from within. Ca2+ within lysosomes is important for these and other lysosomal functions, but it is not known how lysosomes acquire Ca2+. The authors used a low-affinity Ca2+ sensor targeted to the surface of lysosomes to demonstrate that inositol 1,4,5-trisphosphate receptors (IP3Rs), which are intracellular Ca2+ channels expressed in the endoplasmic reticulum (ER), selectively deliver Ca2+ to lysosomes. Optical imaging of cells expressing endogenously tagged IP3Rs further revealed that lysosomes hop between regions of the ER enriched in IP3Rs. Disrupting the contacts between lysosomes and ER prevents lysosomes from accumulating Ca2+. In their paper in Cell Reports, the authors conclude that the ER, by accumulating Ca2+ from the cytosol and then squirting it directly at lysosomes through IP3Rs, allows lysosomes to sequester Ca2+.

Atakpa P, Thillaiappan NB, Mataragka S, Prole DL & Taylor, CW (2018) IP3 receptors preferentially associate with ER-lysosome contact sites and selectively deliver Ca2+ to lysosomes. Cell Reports 25, 3180-3193

« July 2020 »
July
MoTuWeThFrSaSu
12345
6789101112
13141516171819
20212223242526
2728293031

RSS Feed Latest news

CONGRATULATIONS!

Jul 07, 2020

Ana Rossi and Janet Kumita

Transformation of naked mole-rat cells

Jul 01, 2020

Dr. Walid Khaled & Dr. Ewan Smith had a paper accepted in Nature that has been featured by the University and the Guardian...

Dr Graham Ladds

Jun 25, 2020

The Department is delighted to announce that Graham Ladds has been promoted to Reader...

Key cancer gene

Apr 14, 2020

Switching on a key cancer gene could provide first curative treatment for heart disease...

University Closure Due to Covid-19 Outbreak

Mar 19, 2020

The Department of Pharmacology will be closed from 5pm on Friday 20th March and until further notice.

View all news