skip to primary navigationskip to content
 

A brain highway for glucose

last modified Nov 27, 2018 09:15 AM
Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes...

Astrocytes, the most abundant cells in the brain, support the activity of neurones by providing them with essential nutrients. Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes. The authors propose, in a recent paper in Current Biology, that the ER provides an intracellular highway in astrocytes that allows glucose to be transported, protected from further metabolism, within the ER lumen from perivascular endfeet to the perisynaptic processes that feed neurons.

 

Müller, MS, Fouyssac, M & Taylor, CW (2018) Effective glucose uptake by human astrocytes requires its sequestration in the endoplasmic reticulum by glucose-6-phosphatase-β. Current Biology 28, 3481-3486.

« April 2019 »
April
MoTuWeThFrSaSu
1234567
891011121314
15161718192021
22232425262728
2930

RSS Feed Latest news

Young Pharmas

Mar 26, 2019

Over the past three months, sixteen bright sixth formers from Netherhall, Long Road, Hills Road and Comberton have been busy carrying out scientific experiments and investigating key concepts in pharmacology...

Guts at the Science Festival!

Mar 25, 2019

How gut function goes wrong, the impact it has on peoples’ lives and how scientists and clinicians are working to better treat those affected...

Nst1b Subject fair.

Mar 14, 2019

Cambridge Neuroscience Seminar at Robinson College on Thursday 14th March 2019

Jan 18, 2019

Cambridge Neuroscience is delighted to announce the 31st Cambridge Neuroscience Seminar, 'Signalling, Sensation & Sentience' hosted by the Department of Pharmacology on Thursday 14th March 2019, at Robinson College. Dr Ewan St John Smith is the chair of the Scientific Programme committee...

Global Young Scientists Summit - 2019

Jan 18, 2019

Karsten Bach is going to Singapore to participate in the GYSS 2019 which is taking place between 20-25 January...

View all news