skip to primary navigationskip to content
 

A brain highway for glucose

last modified Nov 27, 2018 09:15 AM
Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes...

Astrocytes, the most abundant cells in the brain, support the activity of neurones by providing them with essential nutrients. Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes. The authors propose, in a recent paper in Current Biology, that the ER provides an intracellular highway in astrocytes that allows glucose to be transported, protected from further metabolism, within the ER lumen from perivascular endfeet to the perisynaptic processes that feed neurons.

 

Müller, MS, Fouyssac, M & Taylor, CW (2018) Effective glucose uptake by human astrocytes requires its sequestration in the endoplasmic reticulum by glucose-6-phosphatase-β. Current Biology 28, 3481-3486.

« March 2020 »
March
MoTuWeThFrSaSu
1
2345678
9101112131415
16171819202122
23242526272829
3031

RSS Feed Latest news

University Closure Due to Covid-19 Outbreak

Mar 19, 2020

The Department of Pharmacology will be closed from 5pm on Friday 20th March and until further notice.

PolyProx Therapeutics

Mar 03, 2020

PolyProx Therapeutics raises an additional £1 million seed financing from new investor, LifeArc, to validate polyproxin® drug leads in oncology...

Ahmed Mostafa Part II Pharmacology student

Dec 17, 2019

Congratulations to Ahmed Mostafa, who was awarded the British Pharmacological Clinical Undergraduate Prize...

Dr. Himansha Singh

Nov 12, 2019

Dr. Himansha Singh wins Gordon Research Seminars best speaker prize/Nominated as Chair for Gordon Research Seminar 2021...

Platelet Society

Nov 09, 2019

Research charity Platelet Society focuses on pharmacology...

View all news