skip to primary navigationskip to content
 

A brain highway for glucose

last modified Nov 27, 2018 09:15 AM
Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes...

Astrocytes, the most abundant cells in the brain, support the activity of neurones by providing them with essential nutrients. Margit Muller (in Colin Taylor’s lab) has shown, using optical sensors that report glucose concentrations within the endoplasmic reticulum (ER), that a hitherto enigmatic enzyme, glucose-6-phosphatase-β, is required for effective glucose uptake by astrocytes. The authors propose, in a recent paper in Current Biology, that the ER provides an intracellular highway in astrocytes that allows glucose to be transported, protected from further metabolism, within the ER lumen from perivascular endfeet to the perisynaptic processes that feed neurons.

 

Müller, MS, Fouyssac, M & Taylor, CW (2018) Effective glucose uptake by human astrocytes requires its sequestration in the endoplasmic reticulum by glucose-6-phosphatase-β. Current Biology 28, 3481-3486.

« January 2020 »
January
MoTuWeThFrSaSu
12345
6789101112
13141516171819
20212223242526
2728293031

RSS Feed Latest news

Ahmed Mostafa Part II Pharmacology student

Dec 17, 2019

Congratulations to Ahmed Mostafa, who was awarded the British Pharmacological Clinical Undergraduate Prize...

Dr. Himansha Singh

Nov 12, 2019

Dr. Himansha Singh wins Gordon Research Seminars best speaker prize/Nominated as Chair for Gordon Research Seminar 2021...

Platelet Society

Nov 09, 2019

Research charity Platelet Society focuses on pharmacology...

Professor Laura Itzhaki

Nov 06, 2019

Prof Laura Itzhaki named by BioBeat 19 as one of 50 trailblazers shaping UK bioscience...

Dr Cathy Wilson

Oct 28, 2019

Dr Cathy Wilson joined the Department of Pharmacology

View all news