Submitted by D.P. Juan on Tue, 21/02/2023 - 09:55
We are proud to announce that Abigail Pearce, a member of the Ladds Group, has successfully defended her Viva.
Her thesis she defended is entitled "Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G protein-Coupled Receptors", which looks at the endogenous mechanisms by which Class B1 GPCRs are regulated, focusing on allosteric modulators such as β-arrestins and Receptor Activity modifying Proteins. The focus of the thesis was on the Glucagon-Like Peptide-1 Receptor, and how changes in agonist bias lead to differences in insulin secretion, but other receptors were also studied.
Her panel consisted of:
- Dr Taufiq Rahman
- Dr Peter McCormick (External examiner, Queen Mary University of London)
We wish her all the best for her future career!