skip to primary navigationskip to content
 

A new messenger

last modified Jan 09, 2019 09:11 AM
A collaboration between the labs of Colin Taylor and Eugene Brailoiu (Temple University, Philadelphia) has identified a new messenger linking receptors in the plasma membrane to release of calcium from intracellular stores...

All cells talk to each other, detecting extracellular signals through receptors expressed in the plasma membrane. It is often the membrane itself that is metabolized to produce the intracellular signals that relay information from receptors to intracellular targets. IP3 is one product of this metabolism, and it causes release of calcium from intracellular stores. Work published in Cell Reports shows that receptors that stimulate IP3 formation also stimulate breakdown of another lipid, phosphatidylcholine. The choline produced by this reaction has hitherto been thought to be a by-product, but the new results show that choline works alongside IP3 to promote calcium release. Choline binds to a much studied protein, the sigma 1 receptor, which then enhances the calcium release evoked by IP3.

Brailoiu, E, Chakraborty, S....... Taylor, CW (2019) Choline is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors. Cell Reports 26, 330-337.

« March 2019 »
March
MoTuWeThFrSaSu
123
45678910
11121314151617
18192021222324
25262728293031

RSS Feed Latest news

Nst1b Subject fair.

Mar 14, 2019

Cambridge Neuroscience Seminar at Robinson College on Thursday 14th March 2019

Jan 18, 2019

Cambridge Neuroscience is delighted to announce the 31st Cambridge Neuroscience Seminar, 'Signalling, Sensation & Sentience' hosted by the Department of Pharmacology on Thursday 14th March 2019, at Robinson College. Dr Ewan St John Smith is the chair of the Scientific Programme committee...

Global Young Scientists Summit - 2019

Jan 18, 2019

Karsten Bach is going to Singapore to participate in the GYSS 2019 which is taking place between 20-25 January...

A new messenger

Jan 09, 2019

A collaboration between the labs of Colin Taylor and Eugene Brailoiu (Temple University, Philadelphia) has identified a new messenger linking receptors in the plasma membrane to release of calcium from intracellular stores...

A new approach to measuring pain

Dec 30, 2018

Recent work from the Smith lab, led by Gates Scholar Sampurna Chakrabarti, identified that mice with inflammation in 1 knee spent less time digging than healthy mice...

View all news