skip to primary navigationskip to content
 

A new messenger

last modified Jan 09, 2019 09:11 AM
A collaboration between the labs of Colin Taylor and Eugene Brailoiu (Temple University, Philadelphia) has identified a new messenger linking receptors in the plasma membrane to release of calcium from intracellular stores...

All cells talk to each other, detecting extracellular signals through receptors expressed in the plasma membrane. It is often the membrane itself that is metabolized to produce the intracellular signals that relay information from receptors to intracellular targets. IP3 is one product of this metabolism, and it causes release of calcium from intracellular stores. Work published in Cell Reports shows that receptors that stimulate IP3 formation also stimulate breakdown of another lipid, phosphatidylcholine. The choline produced by this reaction has hitherto been thought to be a by-product, but the new results show that choline works alongside IP3 to promote calcium release. Choline binds to a much studied protein, the sigma 1 receptor, which then enhances the calcium release evoked by IP3.

Brailoiu, E, Chakraborty, S....... Taylor, CW (2019) Choline is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors. Cell Reports 26, 330-337.

« February 2021 »
February
MoTuWeThFrSaSu
1234567
891011121314
15161718192021
22232425262728

Proud holders of Athena SWAN Bronze

Athenaswan

RSS Feed Latest news

LGBTQ+ STEM Spotlight Webinar

Feb 05, 2021

In celebration of UK LGBT History month, the Pharmacology Equality and Diversity Committee & partners to host an LGBTQ+ STEM Spotlight Webinar...

Experience Postgrad Life Sciences

Jan 11, 2021

New research internship opportunities...

British Pharmacological Society Fellowships

Nov 30, 2020

Congratulations to Robert Henderson and Graham Ladds who have both been awarded Fellowships of the British Pharmacological Society. Robert and Graham join Mike Edwardson as Fellows of this prestigious Society

Spotlight on Black Female Scientists in Cambridge

Oct 13, 2020

The department graduate and postdoc committee is pleased to be collaborating with Africans in STEM on another program to celebrate Black history month...

Department of Pharmacology Virtual Tea Club 2020-2021 Today

Oct 09, 2020

To be held online 4 pm Friday – 9th October Dr Ewan Smith Driving and Controlling Nociception Department of Pharmacology, University of Cambridge

View all news