skip to primary navigationskip to content
 

A new messenger

last modified Jan 09, 2019 09:11 AM
A collaboration between the labs of Colin Taylor and Eugene Brailoiu (Temple University, Philadelphia) has identified a new messenger linking receptors in the plasma membrane to release of calcium from intracellular stores...

All cells talk to each other, detecting extracellular signals through receptors expressed in the plasma membrane. It is often the membrane itself that is metabolized to produce the intracellular signals that relay information from receptors to intracellular targets. IP3 is one product of this metabolism, and it causes release of calcium from intracellular stores. Work published in Cell Reports shows that receptors that stimulate IP3 formation also stimulate breakdown of another lipid, phosphatidylcholine. The choline produced by this reaction has hitherto been thought to be a by-product, but the new results show that choline works alongside IP3 to promote calcium release. Choline binds to a much studied protein, the sigma 1 receptor, which then enhances the calcium release evoked by IP3.

Brailoiu, E, Chakraborty, S....... Taylor, CW (2019) Choline is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors. Cell Reports 26, 330-337.

« July 2019 »
July
MoTuWeThFrSaSu
1234567
891011121314
15161718192021
22232425262728
293031

RSS Feed Latest news

Professor Laura Itzhaki

Jul 12, 2019

Congratulations Laura on just being awarded a BBSRC grant.

Ewan and Matthew

Jun 26, 2019

Ewan has been promoted to Reader and Matthew to Senior Lecturer...

Dr Hendrik van Veen

Jun 24, 2019

Dr Hendrik van Veen from the Department of Pharmacology in Cambridge receives the “Edmond de Rothschild Chair” Prize by the Edmond de Rothschild Foundation…

Dr Kerry Barkan

May 23, 2019

Dr Kerry Barkan now holds a UK Athletics Coach Licence after completing the Leadership in Running Fitness (LiRF) course...

View all news