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Subpopulation of hypothalamic POMC neurons

last modified Feb 02, 2016 10:07 AM
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons...

Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-opiomelanocortin (POMC) peptides, perturbations of which disrupt energy balance and promote severe obesity. However, POMC neurons are neurochemically diverse and the crucial source of POMC peptides that regulate energy homeostasis and body weight remains to be fully clarified...Read more:

http://www.molmetab.com/article/S2212-8778%2816%2900017-X/abstract?rss=yes

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