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Department of Pharmacology

 
Author(s): 
Wagner, GK, Riley, AM, Rosenberg, HJ, Taylor, CW, Guse, AH, Potter, BVL
Abstract: 

Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.

Publication ID: 
1062801
Published date: 
December 2003
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Nucleic Acids Res Suppl
Publication volume: 
Publisher: 
Parent title: 
Edition: 
Publication number: