skip to content

Department of Pharmacology

 
Author(s): 
Sureshan, KM, Trusselle, M, Tovey, SC, Taylor, CW, Potter, BVL
Abstract: 

Guanophostin A, the guanosine counterpart of the inositol 1,4,5-trisphosphate receptor agonist adenophostin A, has been synthesized and is the first synthetic adenophostin A-like analogue to be equipotent to its parent in stimulating intracellular Ca2+ release; its nucleotide moiety is proposed to interact with the receptor binding core by guanine base cation-pi stacking with Arg504 and hydrogen bonding with Glu505 and interaction of the ribosyl 2'-phosphate group with the helix-dipole of alpha6.

Publication ID: 
65651
Published date: 
21 May 2006
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Chem Commun (Camb)
Publication volume: 
Publisher: 
Parent title: 
Edition: 
Publication number: