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Department of Pharmacology

 
Author(s): 
Skupin, A, Kettenmann, H, Winkler, U, Wartenberg, M, Sauer, H, Tovey, SC, Taylor, CW, Falcke, M
Abstract: 

Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.

Publication ID: 
69706
Published date: 
15 March 2008
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Biophys J
Publication volume: 
94
Publisher: 
Parent title: 
Edition: 
Publication number: