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Department of Pharmacology

 
Author(s): 
Hill, C, Goddard, A, Davey, J, Ladds, G
Abstract: 

Regulator of G protein signalling (RGS) proteins are vital in the adaptation of cells to stimulation via G protein-coupled receptors. Yeast have been integral in elucidating the important role that RGS proteins play within cellular processes. In addition to extensive characterisation of the endogenous RGS proteins, these organisms have enabled the identification and analysis of numerous mammalian homologues. The simplicity and plasticity of the yeast pheromone-response pathway has facilitated studies which would have been impossible in mammalian systems and it is certain that yeast will continue to have a great impact on this field of research in the future.

Publication ID: 
707529
Published date: 
June 2006
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Semin Cell Dev Biol
Publication volume: 
17
Publisher: 
Parent title: 
Edition: 
Publication number: