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Department of Pharmacology

 
Author(s): 
Mura, M, Hopkins, TG, Michael, T, Abd-Latip, N, Weir, J, Aboagye, E, Mauri, F, Jameson, C, Sturge, J, Gabra, H, Bushell, M, Willis, AE, Curry, E, Blagden, SP
Abstract: 

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5'-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression.

Publication ID: 
1009284
Published date: 
24 September 2015
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Oncogene
Publication volume: 
34
Publisher: 
Parent title: 
Edition: 
Publication number: