Multi-analyte microelectronic biosensors

This paper describes the use of monolithic silicon technology for the fabrication of multi-analyte miniature biosensors for clinical applications. Electrochemically generated conducting polymers were used to entrap enzyme at the sensing microelectrode surfaces. This enzyme immobilisation procedure allows precise control of the spatial distribution of the enzyme and can, therefore, be applied to the fabrication of multi-electrode multi-analyte biosensors. The operation of two dual-enzyme microelectronic biosensors is described for the detection of glucose/galactose and glucose/urea respectively. © 1990.