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Department of Pharmacology

 
Author(s): 
Taylor, CW
Abstract: 

Store-operated Ca2+ entry (SOCE) mediates much of the Ca2+ entry evoked by receptors that stimulate phospholipase C. However, for 20 years, the plasma membrane Ca2+ channel and the signal linking its activation to loss of Ca2+ from the endoplasmic reticulum (ER) have eluded detection. But the search might now be over. Two proteins, STIM1 (the ER Ca2+ sensor) and Orai1 (the Ca2+ channel), have recently been identified as the missing links in SOCE.

Publication ID: 
66520
Published date: 
November 2006
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Trends Biochem Sci
Publication volume: 
31
Publisher: 
Parent title: 
Edition: 
Publication number: