Abstract:
Herein, we describe the development of a novel staple with an
electrophilic warhead to enable the generation of stapled peptide
covalent inhibitors of the p53-MDM2 protein-protein interaction
(PPI). The peptide developed showed complete and selective
covalent binding resulting in potent inhibition of p53-MDM2 PPI.
Publication ID:
1101108
DOI link:
Published date:
14 June 2019 (Accepted for publication)
Publication source:
manual
Publication type:
Journal articles
Journal name:
Chemical Communications
Publication volume:
Publisher:
Royal Society of Chemistry
Parent title:
Edition:
Publication number: