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Dr Giovanna Zinzalla

Dr Giovanna Zinzalla

Visiting Researcher

(hosted by Professor Laura Itzhaki)

Principal Investigator

(Karolinska Institutet)

- Research areas of interest:

Transcription Factors

SWI/SNF (BAF) complexes

Protein-protein interactions

Cancer therapies

Metabolic diseases

Regenerative medicine

Tennison Court Road
Cambridge CB2 1PD
Office Phone: +44 (0) 1223 3 34026

Topics

  • Cancer and Infectious Diseases
  • Macromolecular Structure

Key Publications

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions. Allen MD, Bycroft M, Zinzalla G Protein Sci. 2020 Apr;29(4):1047-1053. 

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Sammak S, Hamdani N, Gorrec F, Allen MD, Freund SMV, Bycroft M, et al Biochemistry 2019 Jul 23;58(29):3144-3154.

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex. Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G FEBS J. 2018 11;285(22):4165-4180

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation. Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, et al Sci Rep 2018 Jul;8(1):10064

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex. Zinzalla G Chembiochem 2016 Apr;17(8):677-82

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs). Sammak S, Zinzalla G Prog. Biophys. Mol. Biol. 2015 Oct;119(1):41-6

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis. Allen MD, Freund SM, Zinzalla G, Bycroft M Structure 2015 Jul;23(7):1344-9

Tetracycline analogues with a selective inhibitory effect on HIF-1alpha Bendiabdellah Y, Rahman, KM, Uranchimeg B, Nahar KS, Antonow D, Shoemaker R.H., Melillo G, Zinzalla G, Thurston, DE Med. Chem. Commun., 2014,5, 923-926.

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, et al FEBS Lett. 2013 Apr;587(7):833-9

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry. Harvey SR, Porrini M, Stachl C, MacMillan D, Zinzalla G, Barran PE J. Am. Chem. Soc. 2012 Nov;134(47):19384-92

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold. Villanueva-Margalef I, Thurston DE, Zinzalla G Org. Biomol. Chem. 2010 Dec;8(23):5294-303

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5. Antonow D, Marrafa T, Dawood I, Ahmed T, Haque MR, Thurston DE, et al Chem. Commun. (Camb.) 2010 Apr;46(13):2289-91

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future. Zinzalla G, Thurston DE Future Med Chem 2009 Apr;1(1):65-93

Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia. Milroy LG, Zinzalla G, Loiseau F, Qian Z, Prencipe G, Pepper C, et al ChemMedChem 2008 Dec;3(12):1922-35

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, et al Angew. Chem. Int. Ed. Engl. 2007 ;46(14):2493-6

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives. Zinzalla G, Milroy LG, Ley SV Org. Biomol. Chem. 2006 May;4(10):1977-2002

All Publications 

See Giovanna Zinzalla's publications.