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Dr Giovanna Zinzalla

Dr Giovanna Zinzalla

Visiting Researcher

(hosted by Professor Laura Itzhaki)

Principal Investigator

(Karolinska Institutet)

- Research areas of interest:

Transcription Factors

SWI/SNF (BAF) complexes

Protein-Protein Interactions

Cancer therapies

Metabolic diseases

Regenerative medicine

Tennison Court Road
Cambridge CB2 1PD
Office Phone: +44 (0) 1223 3 34026


  • Cancer and Infectious Diseases
  • Macromolecular Structure

Key Publications

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions. Allen MD, Bycroft M, Zinzalla G Protein Sci. 2020 Jan;():

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Sammak S, Hamdani N, Gorrec F, Allen MD, Freund SMV, Bycroft M, et al Biochemistry 2019 Jul;():

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex. Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G FEBS J. 2018 11;285(22):4165-4180

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation. Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, et al Sci Rep 2018 Jul;8(1):10064

Targeting MYC: is it getting any easier? Zinzalla G Future Med Chem 2016 Oct;8(16):1899-1902 A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex. Zinzalla G Chembiochem 2016 Apr;17(8):677-82

Paving the way to targeting HECT ubiquitin ligases. Zinzalla G Future Med Chem 2015 ;7(16):2107-11

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs). Sammak S, Zinzalla G Prog. Biophys. Mol. Biol. 2015 Oct;119(1):41-6

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis. Allen MD, Freund SM, Zinzalla G, Bycroft M Structure 2015 Jul;23(7):1344-9

Tetracycline analogues with a selective inhibitory effect on HIF-1alpha Bendiabdellah Y, Rahman, KM, Uranchimeg B, Nahar KS, Antonow D, Shoemaker R.H., Melillo G, Zinzalla G, Thurston, DE Med. Chem. Commun., 2014,5, 923-926.

Understanding and Exploiting ProteinProtein Interactions as Drug Targets Zinzalla, Giovanna October 2013, Future Medicine book series, Publisher: Future Science Group

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. Heidelberger S, Zinzalla G, Antonow D, Essex S, Basu BP, Palmer J, et al Bioorg. Med. Chem. Lett. 2013 Aug;23(16):4719-22

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, et al FEBS Lett. 2013 Apr;587(7):833-9

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry. Harvey SR, Porrini M, Stachl C, MacMillan D, Zinzalla G, Barran PE J. Am. Chem. Soc. 2012 Nov;134(47):19384-92

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition. Husby J, Todd AK, Haider SM, Zinzalla G, Thurston DE, Neidle S J Chem Inf Model 2012 May;52(5):1179-92

A novel small-molecule inhibitor of IL-6 signalling. Zinzalla G, Haque MR, Basu BP, Anderson J, Kaye SL, Haider S, et al Bioorg. Med. Chem. Lett. 2010 Dec;20(23):7029-32

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold. Villanueva-Margalef I, Thurston DE, Zinzalla G Org. Biomol. Chem. 2010 Dec;8(23):5294-303

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5. Antonow D, Marrafa T, Dawood I, Ahmed T, Haque MR, Thurston DE, et al Chem. Commun. (Camb.) 2010 Apr;46(13):2289-91

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future. Zinzalla G, Thurston DE Future Med Chem 2009 Apr;1(1):65-93

Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia. Milroy LG, Zinzalla G, Loiseau F, Qian Z, Prencipe G, Pepper C, et al ChemMedChem 2008 Dec;3(12):1922-35

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, et al Angew. Chem. Int. Ed. Engl. 2007 ;46(14):2493-6

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives. Zinzalla G, Milroy LG, Ley SV Org. Biomol. Chem. 2006 May;4(10):1977-2002

Polymer-supported haloarene chromium dicarbonyl isonitrile complexes: a study of their synthesis and reactivity. Baldoli C, Maiorana S, Licandro E, Casiraghi L, Zinzalla G, Seneci P, et al J Comb Chem ;5(6):809-13

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction. Baldoli C, Maiorana S, Licandro E, Zinzalla G, Perdicchia D Org. Lett. 2002 Nov;4(24):4341-4

Bendiabdellah, Y.; Margalef-Villanueva, I.; Misale, A.; Nahar, K.; Haque, M.R.; Thurston, D.E.; Zinzalla, G. One-pot synthesis of fused tetracyclic scaffolds via a Lewis acid promoted domino reaction of naphthoquinones Synthesis 2011, 14, 2321 View the Abstract Online

Baldoli, C.; Giannini, C.; Licandro, E.; Maiorana, S.; Zinzalla, G., A Thymine-PNA monomer as new isocyanide component in the Ugi reaction: a direct entry to PNA dimers Synlett, 2004, 6, 1044 View the Abstract Online