Tandem-repeat proteins: Folding, function, role in disease and therapeutic intervention
Publications
Key publications:
Tsytlonok, M., Craig, P.O., Sivertsson, E., Serquera, D., Perrett, S., Best, R.B., Wolynes, P., Itzhaki, L.S. Complex energy landscape of a giant repeat protein. Structure 21: 1954-65 (2013).
Rowling, P.J.E., Cook, R., Itzhaki, L.S. Towards classification of BRCA1 missense variants using a biophysical approach. J. Biol. Chem. 285: 20080-7 (2010).
Werbeck, N.D., Rowling, P.J., Chellamuthu, V.R., Itzhaki, L.S. Shifting transition state in the unfolding of a large ankyrin repeat protein. Proc. Natl. Acad. Sci. USA 105: 9982-7 (2008).
Investigator biography:
Laura did her Ph.D. with Dr. Phil Evans, Department of Biochemistry, Cambridge, and then moved to a postdoc in the Department of Chemistry with Prof. Sir Alan Fersht. She subsequently held a Beit Memorial Fellowship in Medical Research and then an MRC Career Development Award, with which she started her own group. In 2003 she moved to the MRC Cancer Cell Unit, Cambridge and briefly returned to the the Department of Chemistry before taking up a Lectureship in the Department of Pharmacology in 2013.
Publication (Symplectic Elements)
Journal articles
2022 (Published online)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
pub_doi:
10.3390/molecules27041293
Publisher:
MDPI AG
Journal name:
Molecules
pub_author_name:
Xu
Castellana-Cruz
Chen
Du
Meisl
Levin
Mannini
Itzhaki
Knowles
Dobson
Cremades
Kumita
Publication ID:
1367019
pub_author_initials:
C
M
S
Z
G
A
B
L
T
C
N
J
Publication volume:
27
Publication number:
Edition:
DOI link:
pub_date_day:
15
pub_date_month:
2
pub_date_year:
2022 (Published online)
pub_title:
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
2022 (Accepted for publication)
The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
pub_doi:
Publisher:
MDPI AG
Journal name:
Molecules
pub_author_name:
Kumita
Xu
Castellana-Cruz
Chen
Du
Meisl
Levin
Mannini
Itzhaki
Knowles
Dobson
Cremades
Publication ID:
1365449
pub_author_initials:
J
C
M
S
Z
G
A
B
L
T
C
N
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
10
pub_date_month:
2
pub_date_year:
2022 (Accepted for publication)
pub_title:
The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
Unraveling the Mechanics of a Repeat-Protein Nanospring — From Folding of Individual Repeats to Fluctuations of the Superhelix
pub_doi:
Publisher:
American Chemical Society
Journal name:
ACS Nano
pub_author_name:
Itzhaki
Stigler
Perez-Riba
Bauer
Weißl
Hyvönen
Fischer
Rowling
Rief
Eapen
Publication ID:
1366791
pub_author_initials:
L
J
A
D
A
M
G
P
M
R
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
27
pub_date_month:
1
pub_date_year:
2022 (Accepted for publication)
pub_title:
Unraveling the Mechanics of a Repeat-Protein Nanospring — From Folding of Individual Repeats to Fluctuations of the Superhelix
Structure-based discovery of lipoteichoic acid synthase inhibitors
pub_doi:
10.1021/acs.jcim.2c00300
Publisher:
American Chemical Society
Journal name:
Journal of Chemical Information and Modeling
pub_author_name:
Wezen
Chandran
Sakariah Eapen
Waters
Bricio Mareno
Tomasso
Dolan
Millership
Kadioglu
Grundling
Itzhaki
Welch
Rahman
Publication ID:
1380083
pub_author_initials:
XC
A
R
E
L
T
SK
C
A
A
LS
M
T
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
22
pub_date_month:
4
pub_date_year:
2022 (Accepted for publication)
pub_title:
Structure-based discovery of lipoteichoic acid synthase inhibitors
2022
Accessible high-performance double nanohole tweezers.
pub_doi:
10.1364/OE.446756
Publisher:
Journal name:
Opt Express
pub_author_name:
Hajisalem
Babaei
Dobinson
Iwamoto
Sharifi
Eby
Synakewicz
Itzhaki
Gordon
Publication ID:
1366313
pub_author_initials:
G
E
M
S
Z
J
M
LS
R
Publication volume:
30
Publication number:
Edition:
DOI link:
pub_date_day:
31
pub_date_month:
1
pub_date_year:
2022
pub_title:
Accessible high-performance double nanohole tweezers.
2021 (Accepted for publication)
Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1
pub_doi:
Publisher:
Oxford University Press (OUP)
Journal name:
Protein Engineering Design and Selection
pub_author_name:
Itzhaki
Madden
Publication ID:
1334066
pub_author_initials:
L
S
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
4
pub_date_month:
10
pub_date_year:
2021 (Accepted for publication)
pub_title:
Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1
2021
Testing the length limit of loop grafting in a helical repeat protein
pub_doi:
10.1016/j.crstbi.2020.12.002
Publisher:
Elsevier BV
Journal name:
Current Research in Structural Biology
pub_author_name:
Ripka
Perez-Riba
Chaturbedy
Itzhaki
Publication ID:
1256751
pub_author_initials:
J
A
PK
L
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
1
pub_date_year:
2021
pub_title:
Testing the length limit of loop grafting in a helical repeat protein
Parallel and sequential pathways of molecular recognition of a tandem-repeat protein and its intrinsically disordered binding partner
pub_doi:
10.1101/2021.04.15.439979
Publisher:
Journal name:
pub_author_name:
Smith
Rowling
Dobson
Itzhaki
Publication ID:
1287106
pub_author_initials:
B
P
C
L
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2021
pub_title:
Parallel and sequential pathways of molecular recognition of a tandem-repeat protein and its intrinsically disordered binding partner
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
pub_doi:
10.1101/2021.07.01.450670
Publisher:
Journal name:
pub_author_name:
Burbidge
Pastok
Hodder
Zenkeviciute
Noble
Endicott
Itzhaki
Publication ID:
1305690
pub_author_initials:
O
M
S
G
MEM
J
L
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2021
pub_title:
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner.
pub_doi:
10.3390/biom11060827
Publisher:
Journal name:
Biomolecules
pub_author_name:
Smith
Rowling
Dobson
Itzhaki
Publication ID:
1298127
pub_author_initials:
BM
PJE
CM
LS
Publication volume:
11
Publication number:
Edition:
DOI link:
pub_date_day:
1
pub_date_month:
6
pub_date_year:
2021
pub_title:
Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner.
Consensus tetratricopeptide repeat proteins are complex superhelical nanosprings
pub_doi:
10.1101/2021.03.27.437344
Publisher:
Journal name:
pub_author_name:
Synakewicz
Eapen
Perez-Riba
Bauer
Weißl
Fischer
Hyvönen
Rief
Itzhaki
Stigler
Publication ID:
1317689
pub_author_initials:
M
RS
A
D
A
G
M
M
LS
J
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
28
pub_date_month:
3
pub_date_year:
2021
pub_title:
Consensus tetratricopeptide repeat proteins are complex superhelical nanosprings
2020 (Accepted for publication)
Engineering mono- and multi-valent inhibitors on a modular scaffold
pub_doi:
10.1039/D0SC03175E
Publisher:
Royal Society of Chemistry
Journal name:
Chemical Science
pub_author_name:
Itzhaki
Diamante
Chaturbedy
Rowling
Kumita
Eapen
Mclaughlin
de la Roche
perez-riba
Publication ID:
1250341
pub_author_initials:
L
A
P
P
J
R
S
M
A
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
19
pub_date_month:
11
pub_date_year:
2020 (Accepted for publication)
pub_title:
Engineering mono- and multi-valent inhibitors on a modular scaffold
Probing the unfolded protein response in long-lived naked mole-rats
pub_doi:
Publisher:
Elsevier
Journal name:
Biochemical and Biophysical Research Communications
pub_author_name:
Kumita
Du
Chakrabarti
Kulaberoglu
Smith
Dobson
Itzhaki
Publication ID:
1206832
pub_author_initials:
J
Z
S
Y
E
C
L
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
24
pub_date_month:
6
pub_date_year:
2020 (Accepted for publication)
pub_title:
Probing the unfolded protein response in long-lived naked mole-rats
2020
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
pub_doi:
10.1021/acsomega.9b03459
Publisher:
Journal name:
ACS Omega
pub_author_name:
Sharma
Strizhak
Fowler
Xu
Chappell
Sore
Galloway
Grayson
Lau
Itzhaki
Spring
Publication ID:
1166031
pub_author_initials:
K
AV
E
W
B
HF
WRJD
MN
YH
LS
DR
Publication volume:
5
Publication number:
Edition:
DOI link:
pub_date_day:
21
pub_date_month:
1
pub_date_year:
2020
pub_title:
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery.
pub_doi:
10.1016/j.bbapap.2020.140405
Publisher:
Journal name:
Biochim Biophys Acta Proteins Proteom
pub_author_name:
Madden
Itzhaki
Publication ID:
1183274
pub_author_initials:
SK
LS
Publication volume:
1868
Publication number:
Edition:
pub_date_day:
pub_date_month:
7
pub_date_year:
2020
pub_title:
Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery.
Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease.
pub_doi:
10.1002/2211-5463.12773
Publisher:
Journal name:
FEBS Open Bio
pub_author_name:
Bergkvist
Du
Elovsson
Appelqvist
Itzhaki
Kumita
Kågedal
Brorsson
Publication ID:
1163243
pub_author_initials:
L
Z
G
H
LS
JR
K
A-C
Publication volume:
10
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
3
pub_date_year:
2020
pub_title:
Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease.
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
pub_doi:
10.1039/d0ob00831a
Publisher:
Journal name:
Org Biomol Chem
pub_author_name:
Strizhak
Babii
Afonin
Bakanovich
Pantelejevs
Xu
Fowler
Eapen
Sharma
Platonov
Hurmach
Itzhaki
Hyvönen
Ulrich
Spring
Komarov
Publication ID:
1197090
pub_author_initials:
AV
O
S
I
T
W
E
R
K
MO
VV
L
M
AS
DR
IV
Publication volume:
18
Publication number:
Edition:
DOI link:
pub_date_day:
22
pub_date_month:
7
pub_date_year:
2020
pub_title:
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
2019 (Accepted for publication)
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
pub_doi:
10.1039/C9CC04022F
Publisher:
Royal Society of Chemistry
Journal name:
Chemical Communications
pub_author_name:
Charoenpattarapreeda
Tan
Iegre
Walsh
Fowler
Eapen
Wu
Sore
Verma
Itzhaki
Spring
Publication ID:
1101108
pub_author_initials:
J
YS
J
SJ
E
R
Y
H
CS
L
D
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
14
pub_date_month:
6
pub_date_year:
2019 (Accepted for publication)
pub_title:
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
2019
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
pub_doi:
10.1021/acschembio.9b00063
Publisher:
Journal name:
ACS Chem Biol
pub_author_name:
Wu
Kaur
Fowler
Wiedmann
Young
Galloway
Olsen
Sore
Chattopadhyay
Kwan
Xu
Walsh
de Andrade
Janecek
Arumugam
Itzhaki
Lau
Spring
Publication ID:
1063483
pub_author_initials:
Y
A
E
MM
R
WRJD
L
HF
A
TT-L
W
SJ
P
M
S
LS
YH
DR
Publication volume:
14
Publication number:
Edition:
pub_date_day:
15
pub_date_month:
3
pub_date_year:
2019
pub_title:
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition.
pub_doi:
10.1016/j.sbi.2018.12.004
Publisher:
Journal name:
Curr Opin Struct Biol
pub_author_name:
Perez-Riba
Itzhaki
Publication ID:
1064355
pub_author_initials:
A
LS
Publication volume:
54
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
2
pub_date_year:
2019
pub_title:
The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition.
Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold.
pub_doi:
10.1002/pro.3586
Publisher:
Journal name:
Protein Sci
pub_author_name:
Madden
Perez-Riba
Itzhaki
Publication ID:
1064356
pub_author_initials:
SK
A
LS
Publication volume:
28
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
4
pub_date_year:
2019
pub_title:
Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold.
The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein.
pub_doi:
10.1038/s41598-018-38173-3
Publisher:
Journal name:
Sci Rep
pub_author_name:
Sivertsson
Jackson
Itzhaki
Publication ID:
1065804
pub_author_initials:
EM
SE
LS
Publication volume:
9
Publication number:
Edition:
pub_date_day:
20
pub_date_month:
2
pub_date_year:
2019
pub_title:
The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein.
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
pub_doi:
10.1039/c9ob01745c
Publisher:
Journal name:
Org Biomol Chem
pub_author_name:
Sharma
Strizhak
Fowler
Wang
Xu
Hatt Jensen
Wu
Sore
Lau
Hyvönen
Itzhaki
Spring
Publication ID:
1110109
pub_author_initials:
K
AV
E
X
W
C
Y
HF
YH
M
LS
DR
Publication volume:
17
Publication number:
Edition:
DOI link:
pub_date_day:
28
pub_date_month:
8
pub_date_year:
2019
pub_title:
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
Editorial Overview: Biophysical and computational methods.
pub_doi:
10.1016/j.sbi.2019.08.005
Publisher:
Journal name:
Curr Opin Struct Biol
pub_author_name:
Lowe
Itzhaki
Publication ID:
1126804
pub_author_initials:
AR
LS
Publication volume:
58
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
10
pub_date_year:
2019
pub_title:
Editorial Overview: Biophysical and computational methods.
Bioorthogonal protein-DNA conjugation methods for force spectroscopy.
pub_doi:
10.1038/s41598-019-49843-1
Publisher:
Journal name:
Sci Rep
pub_author_name:
Synakewicz
Bauer
Rief
Itzhaki
Publication ID:
1126805
pub_author_initials:
M
D
M
LS
Publication volume:
9
Publication number:
Edition:
pub_date_day:
25
pub_date_month:
9
pub_date_year:
2019
pub_title:
Bioorthogonal protein-DNA conjugation methods for force spectroscopy.
Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold.
pub_doi:
10.1038/s41598-019-49905-4
Publisher:
Journal name:
Sci Rep
pub_author_name:
Perez-Riba
Komives
Main
Itzhaki
Publication ID:
1135682
pub_author_initials:
A
E
ERG
LS
Publication volume:
9
Publication number:
Edition:
pub_date_day:
28
pub_date_month:
10
pub_date_year:
2019
pub_title:
Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold.
Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins.
pub_doi:
10.1016/j.str.2019.02.005
Publisher:
Journal name:
Structure
pub_author_name:
Wright
Wong
Harvey
Garnett
Itzhaki
Main
Publication ID:
1078143
pub_author_initials:
JN
WL
JA
JA
LS
ERG
Publication volume:
27
Publication number:
Edition:
DOI link:
pub_date_day:
7
pub_date_month:
5
pub_date_year:
2019
pub_title:
Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins.
2018 (Accepted for publication)
Folding cooperativity and allosteric function in the tandem-repeat protein class
pub_doi:
Publisher:
Royal Society Publishing
Journal name:
Philosophical Transactions of the Royal Society B: Biological Sciences
pub_author_name:
Itzhaki
Perez-Riba
Synakewicz
Publication ID:
965874
pub_author_initials:
LSR
A
M
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
17
pub_date_month:
1
pub_date_year:
2018 (Accepted for publication)
pub_title:
Folding cooperativity and allosteric function in the tandem-repeat protein class
Context-dependent energetics of loop extensions in a family of tandem-repeat proteins
pub_doi:
Publisher:
Biophysical Society
Journal name:
Biophysical Journal
pub_author_name:
Itzhaki
Main
Perez-Riba
Lowe
Publication ID:
990067
pub_author_initials:
LSR
E
A
A
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
29
pub_date_month:
3
pub_date_year:
2018 (Accepted for publication)
pub_title:
Context-dependent energetics of loop extensions in a family of tandem-repeat proteins
Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2
pub_doi:
Publisher:
Nature Publishing Group
Journal name:
Scientific Reports
pub_author_name:
Itzhaki
Yadahalli
Neira
Johnson
Tan
Rowling
Chattopadhyay
Verma
Publication ID:
1041793
pub_author_initials:
LSR
S
J
C
YS
P
A
C
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
15
pub_date_month:
11
pub_date_year:
2018 (Accepted for publication)
pub_title:
Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2
2018
PyFolding: An open-source software package for graphing, simulation and analysis of the biophysical properties of proteins
pub_doi:
10.1016/j.bpj.2017.11.3779
Publisher:
Biophysical Society
Journal name:
Biophysical Journal
pub_author_name:
Itzhaki
Lowe
Perez-Riba
Main
Publication ID:
957777
pub_author_initials:
LS
A
A
E
Publication volume:
114
Publication number:
Edition:
pub_date_day:
6
pub_date_month:
2
pub_date_year:
2018
pub_title:
PyFolding: An open-source software package for graphing, simulation and analysis of the biophysical properties of proteins
Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.
pub_doi:
10.1021/acssynbio.7b00447
Publisher:
Journal name:
ACS Synth Biol
pub_author_name:
Harvey
Itzhaki
Main
Publication ID:
970420
pub_author_initials:
JA
LS
ERG
Publication volume:
7
Publication number:
Edition:
DOI link:
pub_date_day:
20
pub_date_month:
4
pub_date_year:
2018
pub_title:
Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.
2017 (Accepted for publication)
A method for rapid high-throughput biophysical analysis of proteins
pub_doi:
10.1038/s41598-017-08664-w
Publisher:
Nature Publishing Group
Journal name:
Scientific Reports
pub_author_name:
Itzhaki
Perez-Riba
Publication ID:
921936
pub_author_initials:
LSR
A
Publication volume:
7
Publication number:
9071
Edition:
pub_date_day:
14
pub_date_month:
7
pub_date_year:
2017 (Accepted for publication)
pub_title:
A method for rapid high-throughput biophysical analysis of proteins
Nanoscale Click-Reactive Scaffolds from Peptide Self-Assembly
pub_doi:
Publisher:
BioMed Central
Journal name:
Journal of Nanobiotechnology
pub_author_name:
Itzhaki
Guttenplan
knowles
kaminski
young
Matak-Vinkovic
Publication ID:
933233
pub_author_initials:
LSR
A
T
C
L
D
Publication volume:
Publication number:
Edition:
DOI link:
pub_date_day:
22
pub_date_month:
9
pub_date_year:
2017 (Accepted for publication)
pub_title:
Nanoscale Click-Reactive Scaffolds from Peptide Self-Assembly
2017
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
pub_doi:
10.1002/anie.201609427
Publisher:
Journal name:
Angew Chem Int Ed Engl
pub_author_name:
Wiedmann
Tan
Wu
Aibara
Xu
Sore
Verma
Itzhaki
Stewart
Brenton
Spring
Publication ID:
871216
pub_author_initials:
MM
YS
Y
S
W
HF
CS
L
M
JD
DR
Publication volume:
56
Publication number:
Edition:
DOI link:
pub_date_day:
9
pub_date_month:
1
pub_date_year:
2017
pub_title:
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase
pub_doi:
10.1021/jacs.6b10234
Publisher:
American Chemical Society
Journal name:
Journal of the American Chemical Society
pub_author_name:
Xu
Lau
Fischer
Tan
Chattopadhyay
de la Roche
Hyvönen
Verma
Spring
Itzhaki
Publication ID:
877821
pub_author_initials:
W
YH
G
YS
A
M
M
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DR
LS
Publication volume:
139
Publication number:
Edition:
DOI link:
pub_date_day:
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pub_date_month:
2
pub_date_year:
2017
pub_title:
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
pub_doi:
10.1002/ange.201609427
Publisher:
Wiley
Journal name:
Angewandte Chemie
pub_author_name:
Wiedmann
Tan
Wu
Aibara
Xu
Sore
Verma
Itzhaki
Stewart
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Spring
Publication ID:
879951
pub_author_initials:
MM
YS
Y
S
W
HF
CS
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JD
DR
Publication volume:
129
Publication number:
Edition:
DOI link:
pub_date_day:
9
pub_date_month:
1
pub_date_year:
2017
pub_title:
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
A Novel Methodology for the Incorporation of Chiral Linkers in Stapled Peptides
pub_doi:
10.1002/cbic.201700075
Publisher:
John Wiley & Sons Ltd.
Journal name:
Chembiochem : a European journal of chemical biology
pub_author_name:
Serrano
Sipthorp
Xu
Itzhaki
Ley
Publication ID:
889001
pub_author_initials:
JC
J
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LS
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Publication volume:
18
Publication number:
Edition:
DOI link:
pub_date_day:
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pub_date_month:
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pub_date_year:
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pub_title:
A Novel Methodology for the Incorporation of Chiral Linkers in Stapled Peptides
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Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
pub_doi:
10.1038/srep23732
Publisher:
Nature Publishing Group
Journal name:
Scientific Reports
pub_author_name:
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Zhang
Galvagnion
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Verma
Spring
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Publication ID:
760259
pub_author_initials:
A
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JE
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DR
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Publication volume:
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Publication number:
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pub_date_year:
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pub_title:
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
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Single-molecule FRET reveals hidden complexity in a protein energy landscape.
pub_doi:
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Journal name:
Structure
pub_author_name:
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Rowling
Xu
Ruedas-Rama
Orte
Klenerman
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Publication ID:
665900
pub_author_initials:
M
SM
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Publication volume:
23
Publication number:
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pub_title:
Single-molecule FRET reveals hidden complexity in a protein energy landscape.
Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity.
pub_doi:
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Biochem J
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Rowling
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Publication ID:
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DCA
PJE
CG
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Publication volume:
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Edition:
DOI link:
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15
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pub_date_year:
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pub_title:
Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity.
Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.
pub_doi:
10.1042/BST20150099
Publisher:
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Biochem Soc Trans
pub_author_name:
Rowling
Sivertsson
Perez-Riba
Main
Itzhaki
Publication ID:
718413
pub_author_initials:
PJE
EM
A
ERG
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Publication volume:
43
Publication number:
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DOI link:
pub_date_day:
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10
pub_date_year:
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pub_title:
Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.
Mapping the Topography of a Protein Energy Landscape.
pub_doi:
10.1021/jacs.5b07370
Publisher:
Journal name:
J Am Chem Soc
pub_author_name:
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Pelizzola
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Bruscolini
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Publication ID:
720909
pub_author_initials:
RD
J
M
EM
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AR
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Publication volume:
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DOI link:
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11
pub_date_year:
2015
pub_title:
Mapping the Topography of a Protein Energy Landscape.
Folding of nascent chains of knotted proteins
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Publisher:
Journal name:
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
pub_author_name:
Jackson
Lim
Mallam
Hsu
Itzhaki
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Publication ID:
779949
pub_author_initials:
SE
NC
AL
DS
LS
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Publication volume:
44
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2015
pub_title:
Folding of nascent chains of knotted proteins
2014
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.
pub_doi:
10.1039/c3cp54818j
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Phys Chem Chem Phys
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SH
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16
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pub_title:
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.
Protein folding: When ribosomes pick the structure.
pub_doi:
10.1038/nchem.1926
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Journal name:
Nat Chem
pub_author_name:
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Publication ID:
632760
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EM
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Publication volume:
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pub_title:
Protein folding: When ribosomes pick the structure.
Functionalised staple linkages for modulating the cellular activity of stapled peptides
pub_doi:
10.1039/c4sc00045e
Publisher:
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Chemical Science
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Quah
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Laraia
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Rowling
Joseph
Verma
Hyvönen
Itzhaki
Venkitaraman
Brown
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pub_author_initials:
YH
P
ST
M
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TJ
PJE
TL
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pub_date_month:
5
pub_date_year:
2014
pub_title:
Functionalised staple linkages for modulating the cellular activity of stapled peptides
Protein folding: When ribosomes pick the structure.
pub_doi:
10.1038/nchem.1926
Publisher:
Journal name:
Nature chemistry
pub_author_name:
Sivertsson
Itzhaki
Publication ID:
654660
pub_author_initials:
EM
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Publication volume:
6
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1
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1
pub_date_year:
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pub_title:
Protein folding: When ribosomes pick the structure.
A virus that can take the heat.
pub_doi:
10.1016/j.str.2014.10.003
Publisher:
Journal name:
Structure
pub_author_name:
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Itzhaki
Publication ID:
660696
pub_author_initials:
EM
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Publication volume:
22
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pub_date_month:
11
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2014
pub_title:
A virus that can take the heat.
2013
The how's and why's of protein folding intermediates.
pub_doi:
10.1016/j.abb.2012.10.006
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Journal name:
Arch Biochem Biophys
pub_author_name:
Tsytlonok
Itzhaki
Publication ID:
477197
pub_author_initials:
M
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Publication volume:
531
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DOI link:
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pub_title:
The how's and why's of protein folding intermediates.
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
pub_doi:
10.1371/journal.pcbi.1002864
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PLoS Comput Biol
pub_author_name:
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Serquera
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Paci
Itzhaki
Publication ID:
507371
pub_author_initials:
G
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Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2
pub_doi:
10.1098/rstb.2011.0410
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Journal name:
Philosophical Transactions of the Royal Society B: Biological Sciences
pub_author_name:
Xu
Wu
Buell
Cohen
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Hu
Cusack
Itzhaki
Zhang
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Dobson
Welland
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534593
pub_author_initials:
LQ
S
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SIA
LJ
WH
SA
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Publication volume:
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5
pub_date_year:
2013
pub_title:
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2
The how's and why's of protein folding intermediates
pub_doi:
10.1016/j.abb.2012.10.006
Publisher:
Journal name:
Archives of Biochemistry and Biophysics
pub_author_name:
Tsytlonok
Itzhaki
Publication ID:
571865
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M
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Publication volume:
531
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pub_title:
The how's and why's of protein folding intermediates
Tandem-repeat proteins: Regularity plus modularity equals design-ability
pub_doi:
10.1016/j.sbi.2013.06.011
Publisher:
Journal name:
Current Opinion in Structural Biology
pub_author_name:
Javadi
Itzhaki
Publication ID:
590685
pub_author_initials:
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Publication volume:
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DOI link:
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pub_date_year:
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pub_title:
Tandem-repeat proteins: Regularity plus modularity equals design-ability
Subdomain architecture and stability of a giant repeat protein.
pub_doi:
10.1021/jp402360x
Publisher:
Journal name:
J Phys Chem B
pub_author_name:
Tsytlonok
Sormanni
Rowling
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Publication ID:
597333
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M
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PJE
M
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Publication volume:
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2013
pub_title:
Subdomain architecture and stability of a giant repeat protein.
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
pub_doi:
10.1098/rstb.2011.0410
Publisher:
Journal name:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
pub_author_name:
Xu
Wu
Buell
Cohen
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Hu
Cusack
Itzhaki
Zhang
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Dobson
Welland
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598221
pub_author_initials:
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CM
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GW
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Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Complex energy landscape of a giant repeat protein.
pub_doi:
10.1016/j.str.2013.08.028
Publisher:
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Tsytlonok
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Serquera
Perrett
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Itzhaki
Publication ID:
599930
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M
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RB
PG
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21
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5
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11
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2013
pub_title:
Complex energy landscape of a giant repeat protein.
2012
Using FlAsH to probe conformational changes in a large HEAT repeat protein.
pub_doi:
10.1002/cbic.201200012
Publisher:
Journal name:
Chembiochem
pub_author_name:
Tsytlonok
Itzhaki
Publication ID:
438181
pub_author_initials:
M
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Publication volume:
13
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Edition:
DOI link:
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2012
pub_title:
Using FlAsH to probe conformational changes in a large HEAT repeat protein.
From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.
pub_doi:
10.1007/978-1-4614-3229-6_10
Publisher:
Journal name:
Adv Exp Med Biol
pub_author_name:
Itzhaki
Lowe
Publication ID:
458539
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LS
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Publication volume:
747
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Edition:
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2012
pub_title:
From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.
Implications of 3D domain swapping for protein folding, misfolding and function.
pub_doi:
10.1007/978-1-4614-3229-6_9
Publisher:
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Adv Exp Med Biol
pub_author_name:
Rousseau
Schymkowitz
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Publication ID:
458540
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J
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Publication volume:
747
Publication number:
Edition:
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2012
pub_title:
Implications of 3D domain swapping for protein folding, misfolding and function.
From artificial antibodies to nanosprings: The biophysical properties of repeat proteins
pub_doi:
10.1007/978-1-4614-3229-6-10
Publisher:
Journal name:
Advances in Experimental Medicine and Biology
pub_author_name:
Itzhaki
Lowe
Publication ID:
495554
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747
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2012
pub_title:
From artificial antibodies to nanosprings: The biophysical properties of repeat proteins
Implications of 3D domain swapping for protein folding, misfolding and function
pub_doi:
10.1007/978-1-4614-3229-6-9
Publisher:
Journal name:
Advances in Experimental Medicine and Biology
pub_author_name:
Rousseau
Schymkowitz
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Publication ID:
495555
pub_author_initials:
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J
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Publication volume:
747
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2012
pub_title:
Implications of 3D domain swapping for protein folding, misfolding and function
Folding and binding: lingering questions, emerging answers.
pub_doi:
10.1016/j.sbi.2012.01.001
Publisher:
Journal name:
Curr Opin Struct Biol
pub_author_name:
Itzhaki
Rose
Publication ID:
422392
pub_author_initials:
LS
GD
Publication volume:
22
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Edition:
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2
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2012
pub_title:
Folding and binding: lingering questions, emerging answers.
2010
Nature and nurture in protein folding and binding.
pub_doi:
10.1016/j.sbi.2010.01.007
Publisher:
Journal name:
Curr Opin Struct Biol
pub_author_name:
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Wolynes
Publication ID:
422619
pub_author_initials:
L
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Publication volume:
20
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Edition:
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2
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2010
pub_title:
Nature and nurture in protein folding and binding.
Nature and nurture in protein folding and binding (vol 20, pg 1, 2010)
pub_doi:
10.1016/j.sbi.2010.03.003
Publisher:
Journal name:
CURR OPIN STRUC BIOL
pub_author_name:
Itzhaki
Wolynes
Publication ID:
422622
pub_author_initials:
L
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Publication volume:
20
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pub_date_year:
2010
pub_title:
Nature and nurture in protein folding and binding (vol 20, pg 1, 2010)
Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach
pub_doi:
10.1074/jbc.M109.088922
Publisher:
Journal name:
J BIOL CHEM
pub_author_name:
Rowling
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Itzhaki
Publication ID:
280993
pub_author_initials:
PJE
R
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Publication volume:
285
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Edition:
DOI link:
pub_date_day:
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pub_date_month:
6
pub_date_year:
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pub_title:
Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach
Erratum to 'Nature and nurture in protein folding and binding' [Curr Opin Struct Biol 2010, 20:1-2]
pub_doi:
10.1016/j.sbi.2010.03.003
Publisher:
Journal name:
Current Opinion in Structural Biology
pub_author_name:
Itzhaki
Wolynes
Publication ID:
422625
pub_author_initials:
L
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Publication volume:
20
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DOI link:
pub_date_day:
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6
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pub_title:
Erratum to 'Nature and nurture in protein folding and binding' [Curr Opin Struct Biol 2010, 20:1-2]
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
pub_doi:
10.1016/j.jmb.2010.03.036
Publisher:
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J Mol Biol
pub_author_name:
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Chin
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Publication ID:
76867
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BL
WL
CP
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Publication volume:
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Publication number:
Edition:
DOI link:
pub_date_day:
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2010
pub_title:
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
Mechanical unfolding of an ankyrin repeat protein.
pub_doi:
10.1016/j.bpj.2009.12.4287
Publisher:
Journal name:
Biophys J
pub_author_name:
Serquera
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Settanni
Marszalek
Paci
Itzhaki
Publication ID:
422391
pub_author_initials:
D
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Publication volume:
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4
pub_date_year:
2010
pub_title:
Mechanical unfolding of an ankyrin repeat protein.
2009
Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase
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Publisher:
Journal name:
MOL MICROBIOL
pub_author_name:
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Loovers
Xu
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Rowling
Itzhaki
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Publication ID:
280922
pub_author_initials:
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pub_title:
Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase
2008
Shifting transition states in the unfolding of a large ankyrin repeat protein
pub_doi:
10.1073/pnas.0705300105
Publisher:
Journal name:
P NATL ACAD SCI USA
pub_author_name:
Werbeck
Rowling
Chellamuthu
Itzhaki
Publication ID:
280926
pub_author_initials:
ND
PJE
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105
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Edition:
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pub_title:
Shifting transition states in the unfolding of a large ankyrin repeat protein
Shifting transition states in the unfolding of a large ankyrin repeat protein (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (9982-9987) DOI: 10.1073/pnas.0705300105)
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Publisher:
Journal name:
Proceedings of the National Academy of Sciences of the United States of America
pub_author_name:
Werbeck
Rowling
Chellamuthu
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Publication ID:
283898
pub_author_initials:
ND
PJE
VR
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Publication volume:
105
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DOI link:
pub_date_day:
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pub_date_month:
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pub_date_year:
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pub_title:
Shifting transition states in the unfolding of a large ankyrin repeat protein (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (9982-9987) DOI: 10.1073/pnas.0705300105)
The quest to understand protein folding
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Publisher:
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pub_author_name:
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422617
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pub_title:
The quest to understand protein folding
2007
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils
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Publication volume:
282
Publication number:
Edition:
DOI link:
pub_date_day:
20
pub_date_month:
4
pub_date_year:
2007
pub_title:
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils
Biophysical characterisation of the small ankyrin repeat protein myotrophin.
pub_doi:
10.1016/j.jmb.2006.10.060
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Lowe
Itzhaki
Publication ID:
422387
pub_author_initials:
AR
LS
Publication volume:
365
Publication number:
Edition:
DOI link:
pub_date_day:
26
pub_date_month:
1
pub_date_year:
2007
pub_title:
Biophysical characterisation of the small ankyrin repeat protein myotrophin.
Rational redesign of the folding pathway of a modular protein.
pub_doi:
10.1073/pnas.0604653104
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Lowe
Itzhaki
Publication ID:
422388
pub_author_initials:
AR
LS
Publication volume:
104
Publication number:
Edition:
DOI link:
pub_date_day:
20
pub_date_month:
2
pub_date_year:
2007
pub_title:
Rational redesign of the folding pathway of a modular protein.
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.
pub_doi:
10.1073/pnas.0610315104
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Werbeck
Itzhaki
Publication ID:
422389
pub_author_initials:
ND
LS
Publication volume:
104
Publication number:
Edition:
DOI link:
pub_date_day:
8
pub_date_month:
5
pub_date_year:
2007
pub_title:
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.
ATPase site architecture and helicase mechanism of an archaeal MCM.
pub_doi:
10.1016/j.molcel.2007.08.013
Publisher:
Journal name:
Mol Cell
pub_author_name:
Moreau
McGeoch
Lowe
Itzhaki
Bell
Publication ID:
422390
pub_author_initials:
MJ
AT
AR
LS
SD
Publication volume:
28
Publication number:
Edition:
pub_date_day:
26
pub_date_month:
10
pub_date_year:
2007
pub_title:
ATPase site architecture and helicase mechanism of an archaeal MCM.
2006
Folding and fibril formation of the cell cycle protein Cks1
pub_doi:
10.1074/jbc.M603628200
Publisher:
Journal name:
J BIOL CHEM
pub_author_name:
Bader
Seeliger
Kelly
Ilag
Meersman
Limones
Luisi
Dobson
Itzhaki
Publication ID:
45187
pub_author_initials:
R
MA
SE
LL
F
A
BF
CM
LS
Publication volume:
281
Publication number:
Edition:
DOI link:
pub_date_day:
7
pub_date_month:
7
pub_date_year:
2006
pub_title:
Folding and fibril formation of the cell cycle protein Cks1
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.
pub_doi:
10.1016/j.jmb.2006.08.032
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Yao
Zhou
Kelly
Seeliger
Robinson
Itzhaki
Publication ID:
168670
pub_author_initials:
Z-P
M
SE
MA
CV
LS
Publication volume:
363
Publication number:
Edition:
DOI link:
pub_date_day:
27
pub_date_month:
10
pub_date_year:
2006
pub_title:
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.
Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.
pub_doi:
10.1016/j.jmb.2006.07.061
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Rousseau
Wilkinson
Villanueva
Serrano
Schymkowitz
Itzhaki
Publication ID:
422386
pub_author_initials:
F
H
J
L
JWH
LS
Publication volume:
363
Publication number:
Edition:
DOI link:
pub_date_day:
20
pub_date_month:
10
pub_date_year:
2006
pub_title:
Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.
2005
Crystal structure of the ENT domain of human EMSY.
pub_doi:
10.1016/j.jmb.2005.05.047
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Chavali
Ekblad
Basu
Brissett
Veprintsev
Hughes-Davies
Kouzarides
Itzhaki
Doherty
Publication ID:
63184
pub_author_initials:
GB
CMS
BP
NC
D
L
T
LS
AJ
Publication volume:
350
Publication number:
Edition:
DOI link:
pub_date_day:
29
pub_date_month:
7
pub_date_year:
2005
pub_title:
Crystal structure of the ENT domain of human EMSY.
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
pub_doi:
10.1038/sj.embor.7400415
Publisher:
Journal name:
EMBO Rep
pub_author_name:
Ekblad
Chavali
Basu
Freund
Veprintsev
Hughes-Davies
Kouzarides
Doherty
Itzhaki
Publication ID:
63108
pub_author_initials:
CMS
GB
BP
SMV
D
L
T
AJ
LS
Publication volume:
6
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
7
pub_date_year:
2005
pub_title:
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.
pub_doi:
10.1074/jbc.M501450200
Publisher:
Journal name:
J Biol Chem
pub_author_name:
Seeliger
Spichty
Kelly
Bycroft
Freund
Karplus
Itzhaki
Publication ID:
422385
pub_author_initials:
MA
M
SE
M
SMV
M
LS
Publication volume:
280
Publication number:
Edition:
DOI link:
pub_date_day:
26
pub_date_month:
8
pub_date_year:
2005
pub_title:
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.
2004
Erratum: Cooperative organization in a macromolecular complex (Nature Structural and Molecular Biology (2003) 10 (718-724))
pub_doi:
10.1038/nsmb0704-678b
Publisher:
Journal name:
Nature Structural and Molecular Biology
pub_author_name:
Seeliger
Breward
Friedler
Schon
Itzhaki
Publication ID:
422396
pub_author_initials:
MA
SE
A
O
LS
Publication volume:
11
Publication number:
Edition:
DOI link:
pub_date_day:
1
pub_date_month:
1
pub_date_year:
2004
pub_title:
Erratum: Cooperative organization in a macromolecular complex (Nature Structural and Molecular Biology (2003) 10 (718-724))
Intermediates control domain swapping during folding of p13suc1.
pub_doi:
10.1074/jbc.M310640200
Publisher:
Journal name:
J Biol Chem
pub_author_name:
Rousseau
Schymkowitz
Wilkinson
Itzhaki
Publication ID:
422383
pub_author_initials:
F
JWH
HR
LS
Publication volume:
279
Publication number:
Edition:
DOI link:
pub_date_day:
27
pub_date_month:
2
pub_date_year:
2004
pub_title:
Intermediates control domain swapping during folding of p13suc1.
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
pub_doi:
10.1110/ps.03461404
Publisher:
Journal name:
Protein Sci
pub_author_name:
Ekblad
Friedler
Veprintsev
Weinberg
Itzhaki
Publication ID:
422384
pub_author_initials:
CMS
A
D
RL
LS
Publication volume:
13
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
3
pub_date_year:
2004
pub_title:
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
2003
Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family.
pub_doi:
10.1016/s0022-2836(02)01202-0
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Seeliger
Breward
Itzhaki
Publication ID:
422380
pub_author_initials:
MA
SE
LS
Publication volume:
325
Publication number:
Edition:
pub_date_day:
3
pub_date_month:
1
pub_date_year:
2003
pub_title:
Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family.
The unfolding story of three-dimensional domain swapping.
pub_doi:
10.1016/s0969-2126(03)00029-7
Publisher:
Journal name:
Structure
pub_author_name:
Rousseau
Schymkowitz
Itzhaki
Publication ID:
422381
pub_author_initials:
F
JWH
LS
Publication volume:
11
Publication number:
Edition:
pub_date_day:
pub_date_month:
3
pub_date_year:
2003
pub_title:
The unfolding story of three-dimensional domain swapping.
Sequential unfolding of ankyrin repeats in tumor suppressor p16.
pub_doi:
10.1016/s0969-2126(02)00929-2
Publisher:
Journal name:
Structure
pub_author_name:
Tang
Fersht
Itzhaki
Publication ID:
166161
pub_author_initials:
KS
AR
LS
Publication volume:
11
Publication number:
Edition:
pub_date_day:
pub_date_month:
1
pub_date_year:
2003
pub_title:
Sequential unfolding of ankyrin repeats in tumor suppressor p16.
Cooperative organization in a macromolecular complex.
pub_doi:
10.1038/nsb962
Publisher:
Journal name:
Nat Struct Biol
pub_author_name:
Seeliger
Breward
Friedler
Schon
Itzhaki
Publication ID:
422382
pub_author_initials:
MA
SE
A
O
LS
Publication volume:
10
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
9
pub_date_year:
2003
pub_title:
Cooperative organization in a macromolecular complex.
2002
Three different binding sites of Cks1 are required for p27-ubiquitin ligation
pub_doi:
10.1074/jbc.M205254200
Publisher:
Journal name:
J BIOL CHEM
pub_author_name:
Sitry
Seeliger
Ko
Ganoth
Breward
Itzhaki
Pagano
Hershko
Publication ID:
179773
pub_author_initials:
D
MA
TK
D
SE
LS
M
A
Publication volume:
277
Publication number:
Edition:
DOI link:
pub_date_day:
1
pub_date_month:
11
pub_date_year:
2002
pub_title:
Three different binding sites of Cks1 are required for p27-ubiquitin ligation
Folding and association of the human cell cycle regulatory proteins ckshs1 and ckshs2.
pub_doi:
10.1021/bi0113465
Publisher:
Journal name:
Biochemistry
pub_author_name:
Seeliger
Schymkowitz
Rousseau
Wilkinson
Itzhaki
Publication ID:
422377
pub_author_initials:
MA
JWH
F
HR
LS
Publication volume:
41
Publication number:
Edition:
DOI link:
pub_date_day:
29
pub_date_month:
1
pub_date_year:
2002
pub_title:
Folding and association of the human cell cycle regulatory proteins ckshs1 and ckshs2.
The structure of the transition state for folding of domain-swapped dimeric p13suc1.
pub_doi:
10.1016/s0969-2126(02)00762-1
Publisher:
Journal name:
Structure
pub_author_name:
Rousseau
Schymkowitz
Wilkinson
Itzhaki
Publication ID:
422378
pub_author_initials:
F
JWH
HR
LS
Publication volume:
10
Publication number:
Edition:
pub_date_day:
pub_date_month:
5
pub_date_year:
2002
pub_title:
The structure of the transition state for folding of domain-swapped dimeric p13suc1.
Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.
pub_doi:
10.1016/s0022-2836(02)00478-3
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Ekblad
Wilkinson
Schymkowitz
Rousseau
Freund
Itzhaki
Publication ID:
422379
pub_author_initials:
CMS
HR
JWH
F
SMV
LS
Publication volume:
320
Publication number:
Edition:
pub_date_day:
12
pub_date_month:
7
pub_date_year:
2002
pub_title:
Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.
2001
Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.
pub_doi:
10.1073/pnas.101542098
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Rousseau
Schymkowitz
Wilkinson
Itzhaki
Publication ID:
422375
pub_author_initials:
F
JW
HR
LS
Publication volume:
98
Publication number:
Edition:
DOI link:
pub_date_day:
8
pub_date_month:
5
pub_date_year:
2001
pub_title:
Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.
Observation of signal transduction in three-dimensional domain swapping.
pub_doi:
10.1038/nsb1001-888
Publisher:
Journal name:
Nat Struct Biol
pub_author_name:
Schymkowitz
Rousseau
Wilkinson
Friedler
Itzhaki
Publication ID:
422376
pub_author_initials:
JW
F
HR
A
LS
Publication volume:
8
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
10
pub_date_year:
2001
pub_title:
Observation of signal transduction in three-dimensional domain swapping.
2000
The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping.
pub_doi:
10.1016/s0969-2126(00)00084-8
Publisher:
Journal name:
Structure
pub_author_name:
Schymkowitz
Rousseau
Irvine
Itzhaki
Publication ID:
422373
pub_author_initials:
JW
F
LR
LS
Publication volume:
8
Publication number:
Edition:
pub_date_day:
15
pub_date_month:
1
pub_date_year:
2000
pub_title:
The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping.
Sequence conservation provides the best prediction of the role of proline residues in p13suc1.
pub_doi:
10.1006/jmbi.2000.3958
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Schymkowitz
Rousseau
Itzhaki
Publication ID:
422374
pub_author_initials:
JW
F
LS
Publication volume:
301
Publication number:
Edition:
DOI link:
pub_date_day:
4
pub_date_month:
8
pub_date_year:
2000
pub_title:
Sequence conservation provides the best prediction of the role of proline residues in p13suc1.
1999
Stability and folding of the tumour suppressor protein p16.
pub_doi:
10.1006/jmbi.1998.2420
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Tang
Guralnick
Wang
Fersht
Itzhaki
Publication ID:
168161
pub_author_initials:
KS
BJ
WK
AR
LS
Publication volume:
285
Publication number:
Edition:
DOI link:
pub_date_day:
29
pub_date_month:
1
pub_date_year:
1999
pub_title:
Stability and folding of the tumour suppressor protein p16.
1998
Stability and folding of the cell cycle regulatory protein, p13(suc1).
pub_doi:
10.1006/jmbi.1998.2173
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Rousseau
Schymkowitz
Sánchez del Pino
Itzhaki
Publication ID:
422394
pub_author_initials:
F
JW
M
LS
Publication volume:
284
Publication number:
Edition:
DOI link:
pub_date_day:
27
pub_date_month:
11
pub_date_year:
1998
pub_title:
Stability and folding of the cell cycle regulatory protein, p13(suc1).
Hydrogen exchange and protein folding.
pub_doi:
10.1016/s0959-440x(98)80018-3
Publisher:
Journal name:
Curr Opin Struct Biol
pub_author_name:
Clarke
Itzhaki
Publication ID:
89331
pub_author_initials:
J
LS
Publication volume:
8
Publication number:
Edition:
pub_date_day:
pub_date_month:
2
pub_date_year:
1998
pub_title:
Hydrogen exchange and protein folding.
A reply to Englander and Woodward
pub_doi:
Publisher:
Journal name:
TRENDS BIOCHEM SCI
pub_author_name:
Clarke
Itzhaki
Fersht
Publication ID:
92639
pub_author_initials:
J
LS
AR
Publication volume:
23
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
10
pub_date_year:
1998
pub_title:
A reply to Englander and Woodward
Synergy between simulation and experiment in describing the energy landscape of protein folding.
pub_doi:
10.1073/pnas.95.15.8473
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Ladurner
Itzhaki
Daggett
Fersht
Publication ID:
169887
pub_author_initials:
AG
LS
V
AR
Publication volume:
95
Publication number:
Edition:
DOI link:
pub_date_day:
21
pub_date_month:
7
pub_date_year:
1998
pub_title:
Synergy between simulation and experiment in describing the energy landscape of protein folding.
1997
Strain in the transition state of folding and in the native state of proteins
pub_doi:
Publisher:
Journal name:
PROTEIN ENG
pub_author_name:
Ladurner
Itzhaki
Fersht
Publication ID:
422624
pub_author_initials:
A
L
A
Publication volume:
10
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
1997
pub_title:
Strain in the transition state of folding and in the native state of proteins
Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways?
pub_doi:
10.1016/s0968-0004(97)01087-6
Publisher:
Journal name:
Trends Biochem Sci
pub_author_name:
Clarke
Itzhaki
Fersht
Publication ID:
422398
pub_author_initials:
J
LS
AR
Publication volume:
22
Publication number:
Edition:
pub_date_day:
pub_date_month:
8
pub_date_year:
1997
pub_title:
Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways?
Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2.
pub_doi:
10.1006/jmbi.1997.1303
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Ladurner
Itzhaki
de Prat Gay
Fersht
Publication ID:
161894
pub_author_initials:
AG
LS
G
AR
Publication volume:
273
Publication number:
Edition:
DOI link:
pub_date_day:
17
pub_date_month:
10
pub_date_year:
1997
pub_title:
Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2.
Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis.
pub_doi:
10.1006/jmbi.1997.1088
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Neira
Itzhaki
Otzen
Davis
Fersht
Publication ID:
167208
pub_author_initials:
JL
LS
DE
B
AR
Publication volume:
270
Publication number:
Edition:
DOI link:
pub_date_day:
4
pub_date_month:
7
pub_date_year:
1997
pub_title:
Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis.
Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature.
pub_doi:
10.1006/jmbi.1997.1049
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Itzhaki
Neira
Fersht
Publication ID:
162573
pub_author_initials:
LS
JL
AR
Publication volume:
270
Publication number:
Edition:
DOI link:
pub_date_day:
4
pub_date_month:
7
pub_date_year:
1997
pub_title:
Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature.
Following co-operative formation of secondary and tertiary structure in a single protein module.
pub_doi:
10.1006/jmbi.1997.0932
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Neira
Itzhaki
Ladurner
Davis
de Prat Gay
Fersht
Publication ID:
162681
pub_author_initials:
JL
LS
AG
B
G
AR
Publication volume:
268
Publication number:
Edition:
DOI link:
pub_date_day:
25
pub_date_month:
4
pub_date_year:
1997
pub_title:
Following co-operative formation of secondary and tertiary structure in a single protein module.
Strain in the folding nucleus of chymotrypsin inhibitor 2.
pub_doi:
10.1016/S1359-0278(97)00050-3
Publisher:
Journal name:
Fold Des
pub_author_name:
Ladurner
Itzhaki
Fersht
Publication ID:
168199
pub_author_initials:
AG
LS
AR
Publication volume:
2
Publication number:
Edition:
pub_date_day:
pub_date_month:
pub_date_year:
1997
pub_title:
Strain in the folding nucleus of chymotrypsin inhibitor 2.
1996
Structure of the transition state for folding of a protein derived from experiment and simulation.
pub_doi:
10.1006/jmbi.1996.0173
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Daggett
Li
Itzhaki
Otzen
Fersht
Publication ID:
165856
pub_author_initials:
V
A
LS
DE
AR
Publication volume:
257
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Edition:
DOI link:
pub_date_day:
29
pub_date_month:
3
pub_date_year:
1996
pub_title:
Structure of the transition state for folding of a protein derived from experiment and simulation.
Solvent isotope effects on the refolding kinetics of hen egg-white lysozyme.
pub_doi:
10.1002/pro.5560050117
Publisher:
Journal name:
Protein Sci
pub_author_name:
Itzhaki
Evans
Publication ID:
422393
pub_author_initials:
LS
PA
Publication volume:
5
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
1
pub_date_year:
1996
pub_title:
Solvent isotope effects on the refolding kinetics of hen egg-white lysozyme.
1995
Movement of the position of the transition state in protein folding.
pub_doi:
10.1021/bi00041a047
Publisher:
Journal name:
Biochemistry
pub_author_name:
Matouschek
Otzen
Itzhaki
Jackson
Fersht
Publication ID:
178565
pub_author_initials:
A
DE
LS
SE
AR
Publication volume:
34
Publication number:
Edition:
DOI link:
pub_date_day:
17
pub_date_month:
10
pub_date_year:
1995
pub_title:
Movement of the position of the transition state in protein folding.
Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2.
pub_doi:
10.1006/jmbi.1995.0617
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Itzhaki
Neira
Ruiz-Sanz
de Prat Gay
Fersht
Publication ID:
168140
pub_author_initials:
LS
JL
J
G
AR
Publication volume:
254
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Edition:
DOI link:
pub_date_day:
24
pub_date_month:
11
pub_date_year:
1995
pub_title:
Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2.
The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding.
pub_doi:
10.1006/jmbi.1995.0616
Publisher:
Journal name:
J Mol Biol
pub_author_name:
Itzhaki
Otzen
Fersht
Publication ID:
168636
pub_author_initials:
LS
DE
AR
Publication volume:
254
Publication number:
Edition:
DOI link:
pub_date_day:
24
pub_date_month:
11
pub_date_year:
1995
pub_title:
The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding.
Nature and consequences of GroEL-protein interactions.
pub_doi:
10.1021/bi00044a037
Publisher:
Journal name:
Biochemistry
pub_author_name:
Itzhaki
Otzen
Fersht
Publication ID:
165070
pub_author_initials:
LS
DE
AR
Publication volume:
34
Publication number:
Edition:
DOI link:
pub_date_day:
7
pub_date_month:
11
pub_date_year:
1995
pub_title:
Nature and consequences of GroEL-protein interactions.
Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.
pub_doi:
10.1073/pnas.92.9.3683
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
De Prat Gay
Ruiz-Sanz
Neira
Itzhaki
Fersht
Publication ID:
161967
pub_author_initials:
G
J
JL
LS
AR
Publication volume:
92
Publication number:
Edition:
DOI link:
pub_date_day:
25
pub_date_month:
4
pub_date_year:
1995
pub_title:
Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.
1994
Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.
pub_doi:
10.1073/pnas.91.22.10426
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Fersht
Itzhaki
elMasry
Matthews
Otzen
Publication ID:
169215
pub_author_initials:
AR
LS
NF
JM
DE
Publication volume:
91
Publication number:
Edition:
DOI link:
pub_date_day:
25
pub_date_month:
10
pub_date_year:
1994
pub_title:
Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.
Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.
pub_doi:
10.1073/pnas.91.22.10422
Publisher:
Journal name:
Proc Natl Acad Sci U S A
pub_author_name:
Otzen
Itzhaki
elMasry
Jackson
Fersht
Publication ID:
178205
pub_author_initials:
DE
LS
NF
SE
AR
Publication volume:
91
Publication number:
Edition:
DOI link:
pub_date_day:
25
pub_date_month:
10
pub_date_year:
1994
pub_title:
Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.
Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.
pub_doi:
10.1021/bi00183a026
Publisher:
Journal name:
Biochemistry
pub_author_name:
Itzhaki
Evans
Dobson
Radford
Publication ID:
86058
pub_author_initials:
LS
PA
CM
SE
Publication volume:
33
Publication number:
Edition:
DOI link:
pub_date_day:
3
pub_date_month:
5
pub_date_year:
1994
pub_title:
Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.
1990
A unique binding cavity for divalent cations in the DNA-metal-chromomycin A3 complex.
pub_doi:
10.1002/bip.360290303
Publisher:
Journal name:
Biopolymers
pub_author_name:
Itzhaki
Weinberger
Livnah
Berman
Publication ID:
422620
pub_author_initials:
L
S
N
E
Publication volume:
29
Publication number:
Edition:
DOI link:
pub_date_day:
15
pub_date_month:
2
pub_date_year:
1990
pub_title:
A unique binding cavity for divalent cations in the DNA-metal-chromomycin A3 complex.
Theses / dissertations
2021 (No publication date)
Probing the protein homeostasis mechanisms in long-lived naked mole-rats
pub_doi:
Publisher:
University of Cambridge
Journal name:
pub_author_name:
Du
Publication ID:
1310254
pub_author_initials:
Z
Publication volume:
Publication number:
Edition:
pub_editor_name:
Itzhaki
Kumita
pub_editor_initials:
L
J
DOI link:
pub_date_day:
2
pub_date_month:
8
pub_date_year:
2021 (No publication date)
pub_title:
Probing the protein homeostasis mechanisms in long-lived naked mole-rats
Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
pub_doi:
Publisher:
University of Cambridge
Journal name:
pub_author_name:
Diamante
Publication ID:
1286275
pub_author_initials:
A
Publication volume:
Publication number:
Edition:
pub_editor_name:
Itzhaki
pub_editor_initials:
L
DOI link:
pub_date_day:
14
pub_date_month:
4
pub_date_year:
2021 (No publication date)
pub_title:
Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
2020 (No publication date)
Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
pub_doi:
Publisher:
University of Cambridge
Journal name:
pub_author_name:
Eapen
Publication ID:
1240873
pub_author_initials:
R
Publication volume:
Publication number:
Edition:
pub_editor_name:
Itzhaki
Phillips
pub_editor_initials:
L
C
DOI link:
pub_date_day:
26
pub_date_month:
10
pub_date_year:
2020 (No publication date)
pub_title:
Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
pub_doi:
Publisher:
University of Cambridge
Journal name:
pub_author_name:
Zenkeviciute
Publication ID:
1197154
pub_author_initials:
G
Publication volume:
Publication number:
Edition:
pub_editor_name:
Itzhaki
pub_editor_initials:
L
DOI link:
pub_date_day:
13
pub_date_month:
5
pub_date_year:
2020 (No publication date)
pub_title:
Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
Conference proceedings
2018
Engineered Mono- and Multi-Valent Repeat-Protein Arrays to Inhibit Oncogenic Tankyrases
pub_doi:
Publisher:
Journal name:
PROTEIN SCIENCE
pub_author_name:
Diamante
Perez-Riba
de la Roche
Itzhaki
Publication ID:
1038901
pub_author_initials:
A
A
M
L
Publication volume:
27
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2018
pub_title:
Engineered Mono- and Multi-Valent Repeat-Protein Arrays to Inhibit Oncogenic Tankyrases
Peptide Grafting into a Repeat Protein Imparts Low Nanomolar Affinity for Keap1
pub_doi:
Publisher:
Journal name:
PROTEIN SCIENCE
pub_author_name:
Madden
Perez-Riba
Itzhaki
Publication ID:
1039424
pub_author_initials:
S
A
L
Publication volume:
27
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2018
pub_title:
Peptide Grafting into a Repeat Protein Imparts Low Nanomolar Affinity for Keap1
2017
Capturing a biological nanospring in action
pub_doi:
Publisher:
Journal name:
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
pub_author_name:
Synakewicz
Settanni
Rief
Itzhaki
Publication ID:
960210
pub_author_initials:
M
G
M
L
Publication volume:
46
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2017
pub_title:
Capturing a biological nanospring in action
Entropically-Challenged Tandem-repeat Proteins: Breakdown of Nearest-Neighbour Cooperativity
pub_doi:
Publisher:
Journal name:
PROTEIN SCIENCE
pub_author_name:
Perez-Riba
Lowe
Main
Komives
Itzhaki
Publication ID:
962828
pub_author_initials:
A
A
E
E
L
Publication volume:
26
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
pub_date_year:
2017
pub_title:
Entropically-Challenged Tandem-repeat Proteins: Breakdown of Nearest-Neighbour Cooperativity
2016
The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins
pub_doi:
10.1016/j.bpj.2015.11.1008
Publisher:
Journal name:
BIOPHYSICAL JOURNAL
pub_author_name:
Perez-Riba
Main
Itzhaki
Publication ID:
780621
pub_author_initials:
A
ER
LS
Publication volume:
110
Publication number:
Edition:
pub_date_day:
pub_date_month:
pub_date_year:
2016
pub_title:
The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins
2004
Investigation of protein interations between Cks1 and Skp2 using hydrogen exchange nano-electrospray mass spectrometry
pub_doi:
Publisher:
Journal name:
PROTEIN SCIENCE
pub_author_name:
Yao
Seeliger
Itzhaki
Robinson
Publication ID:
181340
pub_author_initials:
Z
MA
LS
CV
Publication volume:
13
Publication number:
Edition:
DOI link:
pub_date_day:
pub_date_month:
8
pub_date_year:
2004
pub_title:
Investigation of protein interations between Cks1 and Skp2 using hydrogen exchange nano-electrospray mass spectrometry
