Publications

pub-cover

2026

  • Ascanelli C, Gilberto S, Batho CA, Tunali G, Ma M, Glover M, Seaton A, Taylor J, Richmond H, Butler R, Cuesta SM, Hess S, Khaled W, Minter R, Laman H, Itzhaki LS, Hunt J, Wilson CH. Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo. Preprint, bioRxiv. 2026 Jul 16. doi: 10.64898/2026.07.16.738859.
  • Spain F, Gimenez D, Acevedo-Jake AM, Mylemans B, Brooks NJ, Korona B, Huang DT, Edwards TA, Leney AC, Itzhaki L, Woolfson DN, Wilson AJ. De novo grafted coiled-coil peptides as p53/hDM2 inhibitors. RSC Chem Biol. 2026 Jun 11. doi: 10.1039/d6cb00063k. 
  • Naqvi MM, Zacharopoulou M, Saha S, Banerjee A, Yilmaz SZ, Sunderlikova V, Johnson CM, Kumita JR, Yang SH, Gordon R, Ohlmeyer M, Tans SJ, Gur M, Bahar I, Itzhaki LS. Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65. JACS Au. 2026 Apr 20;6(5):2753-2765. doi: 10.1021/jacsau.6c00003. 
  • Yilmaz SZ, Banerjee A, Saha S, Ohlmeyer M, Gordon R, Itzhaki LS, Bahar I, Gur M. Small Molecule Activator of Phosphatase PP2A Remodels Scaffold PR65 Structural Dynamics To Promote Holoenzyme Assembly. JACS Au. 2026 Jan 20;6(2):1102-1117. doi: 10.1021/jacsau.5c01514. 

2025

  • Korona B, Mylemans B., Acevedo-Jake AM, MacRae A,  Edwards TA,  Huang DT, Wilson AJ,  Woolfson DN, Itzhaki LS. Coiled-coil scaffolds for targeted protein degradation. bioRxiv (2025). 10.64898/2025.12.22.695764
  • Mylemans B, Korona B, Acevedo-Jake AM, Huang DT, Edwards TA,  Wilson AJ, Itzhaki LS, Woolfson DN. De novo designed bifunctional proteins for targeted protein degradation. bioRxiv (2025). 10.64898/2025.12.22.695915
  • Acevedo-Jake AM, Mylemans B, Kay DF, Zhang P, Korona B, Rhys GG, Leney AC, Huang DR, Edwards TA, Itzhaki LS, Woolfson DN, Wilson AJ. Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition. ACS Chem. Bio. 2025. DOI: 10.1021/acschembio.5c00137
  • Ng TLC, Hoare MP, Maristany MJ, Wilde EJ, Sneideris T, Huertas J, Agbetiameh BK, Furukawa M, Josep JA, Knowles TPJ, Collepardo-Guevara R, Itzhaki LS, Kumita JR. Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates. Chem. Sci. 2025. doi: 10.1039/D5SC00903K
  • Bismut, S., Schneider, M.M. Miyasaki, M., Feng, Y., Wilde, E.J. Gunawardena, M.D., Knowles, T.P.J., Kaminski Schierle, G.S., Itzhaki, L S., Kumita, J.R. Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils. Protein Science doiI: 10.1002/pro.70150
  • Waterhouse M, Lazarus K, Santolla MF, Pensa S, Williams E, Siu AJQ, Mohammed H, Mohorianu I, Maggiolini M, Carroll J, Itzhaki LS, Rahman T, Khaled WT. CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer. EMBO J. 2025. doi: 10.1038/s44318-025-00447-8
  • Yang-Schulz A, Zacharopoulou M, Yilmaz SZ, Banerjee A, Saha S, Nietlispach D, Ohlmeyer M, Gur M, Itzhaki LS, Bahar I, Gordon R. Direct observation of small molecule activator binding to single PR65 protein. NPJ Biosens. 2025. doi: 10.1038/s44328-024-00018-7
  • Baker AG, Ho APT, Itzhaki LS, Fruk L. Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology. Angew Chem Int Ed Engl. 2025. doi: 10.1002/anie.202503958
  • Acevedo-Jake AM, Mylemans B, Kay DF, Zhang P, Korona B, Rhys GG, Leney AC, Huang DT, Edwards TA, Itzhaki L, Woolfson DN, Wilson AJ. Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition. ACS Chem Biol. 2025 Jun 20;20(6):1309-1318. doi: 10.1021/acschembio.5c00137.
  • Eapen R, Okoye C, Stubbs C, Schimpl M, Tischer T, McCall E, Zacharopoulou M, Ferrer F, Barford D, Spring D, Lindon C, Phillips C, Itzhaki LS. Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome. eLife 2025. doi:10.7554/eLife.104238.2

2024

  • Korona B, Itzhaki LS. How to target membrane proteins for degradation: Bringing GPCRs into the TPD fold. J Biol Chem. 2024. doi: 10.1016/j.jbc.2024.107926
  • King HR, Bycroft M, Nguyen TB, Kelly G, Vinogradove AA, Rowling PJE, Stottf K, Ascher DB, Suga H, ItzhakiLS and Artavanis-Tsakonasa K. Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides. PNAS 2024 Vol. 121 No. 21 e2322923121 https://doi.org/10.1073/pnas.2322923121
  • Banerjee A, Mathew S, Naqvi MM, Yilmaz SZ, Zacharopoulou M, Doruker P, Kumita JR, Yang SH, Gur M, Itzhaki LS, Gordon R, Bahar I. Influence of point mutations on PR65 conformational adaptability: Insights from molecular simulations and nanoaperture optical tweezers.Sci Adv. 2024 May 31;10(22):eadn2208. doi: 10.1126/sciadv.adn2208.
  • Crawshaw S, Murphy AM, Rowling PJE, Nietlispach D, Itzhaki LS, Carr JP. Investigating the Interactions of the Cucumber Mosaic Virus 2b Protein with the Viral 1a Replicase Component and the Cellular RNA Silencing Factor Argonaute 1. Viruses. 2024 Apr 25;16(5):676. doi: 10.3390/v16050676.
  • Ventura C, Banerjee A, Zacharopoulou M, Itzhaki LS, Bahar I. Tandem-repeat proteins conformational mechanics are optimized to facilitate functional interactions and complexations. Curr Opin Struct Biol. 2024 Feb;84:102744. doi: 10.1016/j.sbi.2023.102744.

2023

  • Zhang H, Wu S, Itzhaki LS, Perrett S. Interaction between huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins. Protein Sci. 2023 Dec;32(12):e4810. doi: 10.1002/pro.4810.
  • Zenkevičiūtė G, Xu W, Iegre J, Seki H, Tan YS, Rowling PJE, Ferrer F, Verma C, Spring DR, Laman H, Itzhaki LS. Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase. bioRxiv preprint doi:https://doi.org/10.1101/2023.04.27.535981
  • Kaynak BT, Dahmani ZL, Doruker P, Banerjee A, Yang SH, Gordon R, Itzhaki LS, Bahar I. Cooperative mechanics of PR65 scaffold underlies the allosteric regulation of the phosphatase PP2A. Structure. 2023 May 4;31(5):607-618.e3. doi: 10.1016/j.str. Epub 2023 Mar 21.PMID: 36948205 

2022    

  • Synakewicz M., R. S. Eapen, A. Perez-Riba, P. J. E. Rowling, D. Bauer, A. Weißl, G. Fischer, M. Hyvönen, M. Rief, L. S. Itzhaki, and J. Stigler. Unraveling the mechanics of a repeat-protein nanospring: from folding of individual repeats to fluctuations of the superhelix. ACS Nano, 16(3): 3895-3905.
  • Okoye C., Rowling P., Itzhaki L.S, Lindon C. Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation. Front. Phys. 13, 913063.
  • Rowling P.J.E., Murton B.L., Du Z., Itzhaki L.S. Multivalent interaction of beta-catenin with its intrinsically disordered binding partner adenomatous polyposis coli. Front. Mol. Biosci. 9, 896493.
  • Chee Wezen X., Chandran A., Eapen R.S., Waters E., Bricio-Moreno L., Tosi T., Dolan S., Millership C., Kadioglu A., Gründling A., Itzhaki L.S., Welch M., Rahman T.  Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors.         J Chem Inf Model. 62 2586-2599. doi: 10.1021/acs.jcim.2c00300.
  • Hajisalem G., Babaei E., Dobinson M., Iwamoto S., Sharifi Z., Eby J., Synakewicz M., Itzhaki L.S., Gordon R. Accessible high-performance double nanohole tweezers. Opt Express. 30 3760-3769. doi: 10.1364/OE.446756.
  • Xu C.K., Castellana-Cruz M., Chen S.W., Du Z., Meisl G., Levin A., Mannini B., Itzhaki L.S., Knowles T.P.J., Dobson C.M., Cremades N., Kumita J.R.. The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity. Molecules. 27 1293. doi: 10.3390/molecules27041293.

2021

  • Madden SK, Itzhaki LS. Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1. Protein Eng Des Sel. Feb 15;34:gzab027. doi: 10.1093/protein/gzab027
  • Burbidge O., M. W. Pastok, S. L. Hodder, G. Zenkevičiūtė, M. E. M. Noble, J. A. Endicott, and L. S. Itzhaki. Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a.Pre-print.
  • Ripka J. F., A. Perez-Riba, P. K. Chaturbedy, and L. S. Itzhaki. Testing the length limit of loop grafting in a helical repeat protein. Curr. Res. Struct. Biol., 3(1): 30-40.  
  • Smith B. M., P. J. E. Rowling, C. M. Dobson, and L. S. Itzhaki. Parallel and sequential pathways of molecular recognition of a tandem-repeat protein and its intrinsically disordered binding partner. Biomolecules, 11(6):827.  
  • Diamante, A., P. Chaturbedy, P. Rowling, J. Kumita, R. S. Eapen, S. H. McLaughlin, M. de la Roche, A. Perez-Riba, and L. S. Itzhaki. Engineering mono- and multi-valent inhibitors on a modular scaffold. Chem. Sci., 12(3):880-895.  

2020

  • Du Z., S. Chakrabarti, Y. Kulaberoglu, E. S. J. Smith, C. M. Dobson, L. S. Itzhaki, and J. R. Kumita. Probing the unfolded protein response in long-lived naked mole-rats. Biochem. Biophys. Res. Commun., 529(4):1151-1157.  
  • Madden S. K., and L. S. Itzhaki. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery. Biochim. Biophys. Acta Proteins Proteom., 1868(7):140405.  
  • Sharma K., A. V. Strizhak, E. Fowler, W. Xu, B. Chappell, H. F. Sore, W. R. J. D. Galloway, M. N. Grayson, Y. H. Lau, L. S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ACS Omega., 5(2):1157-1169.  
  • Strizhak A. V., O. Babii, S. Afonin, I. Bakanovich, T. Pantelejevs, W. Xu, E. Fowler, R. Eapen, K. Sharma, M. O. Platonov, V. V. Hurmach, L. S. Itzhaki, M. Hyvönen, A. S. Ulrich, D. R. Spring, and I. V. Komarov. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Org. Biomol. Chem., 18(28):5359-5369.
  • Bergkvist, L., Z. Du, G. Elovsson, H. Appelqvist, L. S. Itzhaki, J. R. Kumita, K. Kågedal, and A. C. Brorsson. Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease. FEBS Open Bio., 10(3):338-350.

2019 

  • Lowe A. R., and L. S. Itzhaki. Editorial Overview: Biophysical and computational methods. Curr. Opin. Struct. Biol., 58(1):7-9.  
  • Sharma K., A. V. Strizhak, E. Fowler, X. Wang, W. Xu, C. H. Jensen, Y. Wu, H. F. Sore, Y. H. Lau, M. Hyvönen, L. S. Itzhaki, and D. R. Spring. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. Org. Biomol. Chem., 17(34):8014-8018.  
  • Perez-Riba, A., E. Komives, E. R. G. Main and L. S. Itzhaki. Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold. Sci. Rep., 9:15439.
  • Synakewicz, M., D. Bauer, M. Rief, and L. S. Itzhaki. Bioorthogonal protein-DNA conjugation methods for force spectroscopy. Sci. Rep., 9:13820. 
  • Wright, J. N., W. L. Wong, J. A. Harvey, J. A. Garnett, L. S. Itzhaki, and E. R. G. Main. Scalable geometrically designed protein cages assembled via genetically encoded split inteins. Structure, 27(5):776-784, 2019. 
  • Sivertsson, E. M., S. E. Jackson, and L. S. Itzhaki. The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein. Sci Rep., 9:2421. 
  • Madden, S. K., A. Perez-Riba, and L. S. Itzhaki. Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold. Protein Sci., 28(4):738-745. 
  • Perez-Riba, A., and L. S. Itzhaki. The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition. Curr Opin Struct Biol., 54(1):43-49. 
  • Wu, Y., A. Kaur, E. Fowler, M. M. Wiedmann, R. Young, W. R. J. D. Galloway, L. Olsen, H. F. Sore, A. Chattopadhyay, T. T. Kwan, W. Xu, S. J. Walsh, P. de Andrade, M. Janecek, S. Arumugam, L. S. Itzhaki, Y. H. Lau, and D. R. Spring. Toolbox of diverse linkers for navigating the cellular efficacy landscape of stapled peptides. ACS Chem. Biol., 14(3):526-533. 
  • Yadahalli, S., J. L. Neira, C. M. Johnson, Y. S. Tan, P. J. E. Rowling, A. Chattopadhyay, C. S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2. Sci. Rep., 9:693. 


2018 

  • Perez-Riba, A., A. R. Lowe, E. R. G. Main, and L. S. Itzhaki. Context-dependent energetics of loop extensions in a family of tandem-repeat proteins. Biophys. J., 114(11):2552-2562. 
  • Perez-Riba, A., M. Synakewicz, and L. S. Itzhaki. Opinion piece: Folding cooperativity and allosteric function in the tandem-repeat protein class. Phil. Trans. R. Soc. B, 373:20170188. 
  • Harvey, J. A., L. S. Itzhaki, and E. R. G. Main. Programmed protein self-assembly driven by genetically encoded intein-mediated native chemical ligation. ACS Synth. Biol., 7(4):1067-1074. 
  • Lowe A. R., A. Perez-Riba, L. S. Itzhaki, and E. R. G. Main. PyFolding: An open-source software package for graphing, analysis and simulation of thermodynamic and kinetic models of protein folding. Biophys. J., 114(3):511-521. 

2017 

  • Guttenplan, A. P. M., L. J. Young, D. Matak-Vinkovic, C. F. Kaminski, T. P. J. Knowles, and L. S. Itzhaki. Nanoscale click-reactive scaffolds from peptide self-assembly. J. Nanobiotechnol., 15(1):70. 
  • Perez-Riba, A., and L. S. Itzhaki. A method for rapid high-throughput biophysical analysis of proteins. Sci. Rep., 7:9071. 
  • Serrano, J. C., J. Sipthorp, W. Xu, L. S. Itzhaki, and S. V. Ley. A new methodology for incorporating chiral linkers into stapled peptides. ChemBioChem, 18(1):1066–1071. 
  • Xu, W., Y. Heng Lau, G. Fischer, Y. S. Tan, A. Chattopadhyay, M. de la Roche, M. Hyvönen, C. S. Verma, D. R. Spring, and L. S. Itzhaki. Macrocyclized extended peptide Inhibiting the substrate-recognition domain of tankyrase. J. Am. Chem. Soc., 139(1):2245-2256. 
  • Wiedmann, M. M., Y. S. Tan, Y. Wu, S. Aibara, W. Xu, H. F. Sore, C. S. Verma, L. S. Itzhaki, M. Stewart, J. D. Brenton, and D. R. Spring. Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer. Angew. Chem. Int. Edit., 56(1):524 –529. 


2016 

  • Chattopadhyay, A., C. J. O'Connor, F. Zhang, C. Galvagnion, W. R. J. D. Galloway, Y. S. Tan, J. E. Stokes, T. Rahman, C. Verma, D. R. Spring, and L. S. Itzhaki. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci. Rep., 6:23732. 


2015 

  • Hutton, R. D., J. Wilkinson, M. Faccin, E. Sivertsson, A. Pelizzola, A. R. Lowe, P. Bruscolini, and L. S. Itzhaki. Mapping the topography of a protein energy landscape. J. Am. Chem. Soc., 137(46):14610–14625. 
  • Gaboriau, D. C., P. J. Rowling, C. G. Morrison, and L. S. Itzhaki. Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity. Biochem. J., 466(3):613–624. 
  • Tsytlonok, M., S. M. Ibrahim, P. Rowling, W. Xu, M. J. Ruedas-Rama, A. Orte, D. Klenerman, and L. S. Itzhaki. Single-molecule FRET reveals hidden complexity in a protein energy landscape. Structure, 23(1):190–198. 
  • Rowling, P. J. E., E. M. Sivertsson, A. Perez-Riba, E. R. G. Main and L. S. Itzhaki. Dissecting and reprogramming the folding and assembly of tandem-repeat proteins. Biochem. Soc. T., 43(5):881-888. 


2014 

  • Kelly, S. E., G. Meisl, P. J. E. Rowling, S. H. McLaughlin, T. Knowles, and L. S. Itzhaki. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein. Phys. Chem. Chem. Phys., 16(1):6448–6459. 
  • Lau, Y. H., P. de Andrade, S.-T. Quah, M. Rossmann, L. Laraia, N. Skold, T. J. Sum, P. J. E. Rowling, T. L. Joseph, C. Verma, M. Hyvonen, L. S. Itzhaki, A. R. Venkitaraman, C. J. Brown, D. P. Lane, and D. R. Spring. Functionalised staple linkages for modulating the cellular activity of stapled peptides. Chem. Sci., 5(1):1804–1809. 
  • Sivertsson, E. and L. S. Itzhaki. Protein folding: when ribosomes pick the structure. Nat. Chem., 6:378–379. 
  • Sivertsson, E. and L. S. Itzhaki. A virus that can take the heat. Structure, 22(11):1549 – 1550. 


2013 

  • Javadi, Y., and L. S. Itzhaki. Tandem-repeat proteins: regularity plus modularity equals design-ability. Curr. Opin. Struct. Biol., 23(4):622 – 631. 
  • Settanni, G., D. Serquera, P. E. Marszalek, E. Paci, and L. S. Itzhaki. Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. PLoS Comput. Biol., 9(1):e1002864. 
  • Tsytlonok, M., P. O. Craig, E. Sivertsson, D. Serquera, S. Perrett, R. B. Best, P. G. Wolynes, and L. S. Itzhaki. Complex energy landscape of a giant repeat protein. Structure, 21(11):1954–1965. 
  • Tsytlonok, M. and L. S. Itzhaki. The how’s and why’s of protein folding intermediates. Arch. Biochem. Biophys., 531(12):14 – 23. Protein Folding and Stability. 
  • Tsytlonok, M., P. Sormanni, P. J. E. Rowling, M. Vendruscolo, and L. S. Itzhaki. Subdomain architecture and stability of a giant repeat protein. J. Phys. Chem., 117(42):13029–13037. 
  • Xu, L.-Q., S. Wu, A. K. Buell, S. I. A. Cohen, L.-J. Chen, W.-H. Hu, S. A. Cusack, L. S. Itzhaki, H. Zhang, T. P. J. Knowles, C. M. Dobson, M. E. Welland, G. W. Jones, and S. Perrett. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 368(1617). 


2012 

  • Itzhaki, L. S., and G. D. Rose. Folding and binding: lingering questions, emerging answers. Curr. Opin. Struct. Biol., 22(1):1–3. 
  • Itzhaki, L. S., and A. Lowe. From artificial antibodies to nanosprings. In Matthews, J., editor, Protein Dimerization and Oligomerization in Biology, volume 747 of Advances in Experimental Medicine and Biology, pages 153–166. Springer New York. 
  • Roark, R., L. S. Itzhaki, and A. Philpott. Complex regulation controls Neurogenin3 proteolysis. Biol. Open, 1(12):1264–1272. 
  • Rousseau, F., J. Schymkowitz, and L. Itzhaki. Implications of 3D domain swapping for protein folding, misfolding and function. In Matthews, J., editor, Protein Dimerization and Oligomerization in Biology, volume 747 of Advances in Experimental Medicine and Biology, pages 137–152. Springer New York. 
  • Tsytlonok, M., and L. S. Itzhaki. Using FlAsH to probe conformational changes in a large HEAT repeat protein. ChemBioChem, 13(8):1199–1205. 


2010 

  • Itzhaki, L. S., and P. Wolynes. Nature and nurture in protein folding and binding. Curr. Opin. Struct. Biol., 20(1):1–2. 
  • Murton, B. L., W. L. Chin, C. P. Ponting, and L. S. Itzhaki. Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase. J. Mol. Biol., 398(4):481–488. 
  • Rowling, P. J. E., R. Cook, and L. S. Itzhaki. Toward classification of BRCA1 missense variants using a biophysical approach. J. Biol. Chem., 285(26):20080–20087. 
  • Serquera, D., W. Lee, G. Settanni, P. E. Marszalek, E. Paci, and L. S. Itzhaki. Mechanical unfolding of an ankyrin repeat protein. Biophys. J., 98(7):1294–1301. 
  •  

2009 

  • Zhang, H., H. M. Loovers, L.-Q. Xu, M. Wang, P. J. E. Rowling, L. S. Itzhaki, W. Gong, J.-M. Zhou, G. W. Jones, and S. Perrett. Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase. Mol. Microbiol.,71(3):702–716. 

2008 

  • Itzhaki, L. S., and P. Wolynes. The quest to understand protein folding. Curr. Opin. Struct. Biol., 18(1):1–3, 2008. 
  • Werbeck, N. D., P. J. E. Rowling, V. R. Chellamuthu, and L. S. Itzhaki. Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc. Natl. Acad. Sci., 105(29):9982–9987. 


2007 

  • Lian, H.-Y., H. Zhang, Z.-R. Zhang, H. M. Loovers, G. W. Jones, P. J. E. Rowling, L. S. Itzhaki, J.-M. Zhou, and S. Perrett. Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J. Biol. Chem., 282(16):11931–11940. 
  • Lowe, A. R., and L. S. Itzhaki. Biophysical characterisation of the small ankyrin repeat protein myotrophin. J. Mol. Bio., 365(4):1245 – 1255.  
  • Lowe, A. R., and L. S. Itzhaki. Rational redesign of the folding pathway of a modular protein. Proc. Natl. Acad. Sci., 104(8):2679–2684. 
  • Moreau, M. J., A. T. McGeoch, A. R. Lowe, L. S. Itzhaki, and S. D. Bell. ATPase site architecture and helicase mechanism of an archaeal MCM. Mol. Cell, 28(2):304 – 314, 2007. 
  • Werbeck, N. D., and L. S. Itzhaki. Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc. Natl. Acad. Sci., 104(19):7863–7868, 2007.

A full list including publications older than 2007 can be found on PubMed.