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Publications

 

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2019

  • Wright, J. N., W. L. Wong, J. A. Harvey, J. A. Garnett, L. S. Itzhaki LS and E. R. G. Main. Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins. Structure  27(5):776-784.e4, 2019.
  • Sivertsson, E. M., S. E. Jackson and L. S. Itzhaki. The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein. Sci Rep. 9(1):2421, 2019.
  • Madden, S. K., A. Perez-Riba and L. S. Itzhaki. Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold. Protein Sci. 28(4):738-745, 2019.
  • Perez-Riba, A., and L. S. Itzhaki. The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition. Curr Opin Struct Biol. 54:43-49, 2019.
  • Wu, Y., A. Kaur, E. Fowler, M. M. Wiedmann, R. Young, W. R. J. D. Galloway, L. Olsen, H. F. Sore, A. Chattopadhyay, T. T. Kwan, W. Xu, S. J. Walsh, P. de Andrade, M. Janecek, S. Arumugam, L. S. Itzhaki, Y. H. Lau and D. R. Spring. Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides. ACS Chem Biol.14(3):526-533, 2019.
  • Yadahalli, S., J. L. Neira, C. M. Johnson, Y. S. Tan, P. J. E. Rowling, A. Chattopadhyay, C. S. Verma and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2. Sci Rep. 9(1):693, 2019.

2018

  • Perez-Riba, A., A. R. Lowe, E. R. G. Main and L. S. Itzhaki. Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins. Biophys. J. 114(11):2552-2562, 2018.
  • Perez-Riba, A., M. Synakewicz and L. S. Itzhaki. Opinion piece: Folding cooperativity and allosteric function in the tandem-repeat protein class.

2017

  • Guttenplan, A. P. M.,  L. J. Young, D. Matak-Vinkovic, C. F. Kaminski, T. P. J. Knowles and L. S. Itzhaki. Nanoscale click-reactive scaffolds from peptide self-assembly. J. Nanobiotechnol. 15:70, 2017.
  • Perez-Riba, A., and L. S. Itzhaki. A method for rapid high-throughput biophysical analysis of proteins. Scientific Reports 7, 9071, 2017
  • Serrano, J. C., J. Sipthorp, W. Xu, L. S. Itzhaki and S. V. Ley. A New Methodology for Incorporating Chiral Linkers into Stapled Peptides. ChemBioChem 18:1066–1071, 2017.
  • Xu, W., Y. Heng Lau, G. Fischer, Y. S. Tan, A. Chattopadhyay, M. de la Roche, M. Hyvönen, C. S. Verma, D. R. Spring, and L. S. Itzhaki. Macrocyclized extended peptide Inhibiting the substrate-recognition domain of tankyrase. J. Am. Chem Soc., 139:2245-2256 139, 2017.
  • Wiedmann, M. M., Y. S. Tan, Y. Wu, S. Aibara, W. Xu, H. F. Sore, C. S. Verma, L. S. Itzhaki, M. Stewart, J. D. Brenton, and D. R. Spring. Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer. Angew. Chem. Int. Edit., 56:524 –529, 2017.

2016

  • Chattopadhyay, A., C. J. O'Connor, F. Zhang, C. Galvagnion, W. R. J. D. Galloway, Y. S. Tan, J. E. Stokes, T. Rahman, C. Verma, D. R. Spring, and L. S. Itzhaki. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci. Rep., 6:23732, 2016.

2015

  • Hutton, R. D., J. Wilkinson, M. Faccin, E. Sivertsson, A. Pelizzola, A. R. Lowe, P. Bruscolini, and L. S. Itzhaki. Mapping the topography of a protein energy landscape. J. Am. Chem. Soc. 137(46):14610–14625, 2015.
  • Gaboriau, D. C., P. J. Rowling, C. G. Morrison, and L. S. Itzhaki. Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity. Biochemical Journal, 466(3):613–624, 2015.
  • Tsytlonok, M., S. M. Ibrahim, P. Rowling, W. Xu, M. J. Ruedas-Rama, A. Orte, D. Klenerman, and L. Itzhaki. Single-molecule FRET reveals hidden complexity in a protein energy landscape. Structure, 23(1):190–198, 2015.
  • Rowling, P. J. E., E. M. Sivertsson, A. Perez-Riba, E. R. G. Main and L. S. Itzhaki. Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.

2014

  • Kelly, S. E., G. Meisl, P. J. E. Rowling, S. H. McLaughlin, T. Knowles, and L. S. Itzhaki. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein. Phys. Chem. Chem. Phys., 16:6448–6459, 2014.
  • Lau, Y. H., P. de Andrade, S.-T. Quah, M. Rossmann, L. Laraia, N. Skold, T. J. Sum, P. J. E. Rowling, T. L. Joseph, C. Verma, M. Hyvonen, L. S. Itzhaki, A. R. Venkitaraman, C. J. Brown, D. P. Lane, and D. R. Spring. Functionalised staple linkages for modulating the cellular activity of stapled peptides. Chem. Sci., 5:1804–1809, 2014.
  • Sivertsson, E. and L. S. Itzhaki. Protein folding: when ribosomes pick the structure. Nature Chemistry, 6:378–379, 2014.
  • Sivertsson, E. and L. Itzhaki. A virus that can take the heat. Structure, 22(11):1549 – 1550, 2014.

2013

  • Javadi, Y. and L. S. Itzhaki. Tandem-repeat proteins: regularity plus modularity equals design-ability. Current Opinion in Structural Biology, 23(4):622 – 631, 2013.
  • Settanni, G., D. Serquera, P. E. Marszalek, E. Paci, and L. S. Itzhaki. Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. PLoS Comput Biol, 9(1):e1002864, 2013.
  • Tsytlonok, M., P. O. Craig, E. Sivertsson, D. Serquera, S. Perrett, R. B. Best, P. G. Wolynes, and L. S. Itzhaki. Complex energy landscape of a giant repeat protein. Structure, 21(11):1954–1965, 2013.
  • Tsytlonok, M. and L. S. Itzhaki. The how’s and why’s of protein folding intermediates. Archives of Biochemistry and Biophysics, 531(12):14 – 23, 2013. Protein Folding and Stability.
  • Tsytlonok, M., P. Sormanni, P. J. E. Rowling, M. Vendruscolo, and L. S. Itzhaki. Subdomain architecture and stability of a giant repeat protein. The Journal of Physical Chemistry B, 117(42):13029–13037, 2013.
  • Xu, L.-Q., S. Wu, A. K. Buell, S. I. A. Cohen, L.-J. Chen, W.-H. Hu, S. A. Cusack, L. S. Itzhaki, H. Zhang, T. P. J. Knowles, C. M. Dobson, M. E. Welland, G. W. Jones, and S. Perrett. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 368(1617), 2013.

2012

  • Itzhaki, L. S. and G. D. Rose. Folding and binding: lingering questions, emerging answers. Current Opinion in Structural Biology, 22(1):1 – 3, 2012.
  • Itzhaki, L. and A. Lowe. From artificial antibodies to nanosprings. In Matthews, J., editor, Protein Dimerization and Oligomerization in Biology, volume 747 of Advances in Experimental Medicine and Biology, pages 153–166. Springer New York, 2012.
  • Roark, R., L. Itzhaki, and A. Philpott. Complex regulation controls Neurogenin3 proteolysis. Biology Open, 1(12):1264–1272, 2012.
  • Rousseau, F., J. Schymkowitz, and L. Itzhaki. Implications of 3D domain swapping for protein folding, misfolding and function. In Matthews, J., editor, Protein Dimerization and Oligomerization in Biology, volume 747 of Advances in Experimental Medicine and Biology, pages 137–152. Springer New York, 2012.
  • Tsytlonok, M. and L. S. Itzhaki. Using FlAsH to probe conformational changes in a large HEAT repeat protein. ChemBioChem, 13(8):1199–1205, 2012.

2010

  • Itzhaki, L. and P. Wolynes. Nature and nurture in protein folding and binding. Current Opinion in Structural Biology, 20(1):1 – 2, 2010.
  • Murton, B. L., W. L. Chin, C. P. Ponting, and L. S. Itzhaki. Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase. Journal of Molecular Biology, 398(4):481 – 488, 2010.
  • Rowling, P. J. E., R. Cook, and L. S. Itzhaki. Toward classification of BRCA1 missense variants using a biophysical approach. Journal of Biological Chemistry, 285(26):20080–20087, 2010.
  • Serquera, D., W. Lee, G. Settanni, P. E. Marszalek, E. Paci, and L. S. Itzhaki. Mechanical unfolding of an ankyrin repeat protein. Biophysical Journal, 98(7):1294–1301, 2010.

2009

  • Zhang, H., H. M. Loovers, L.-Q. Xu, M. Wang, P. J. E. Rowling, L. S. Itzhaki, W. Gong, J.-M. Zhou, G. W. Jones, and S. Perrett. Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase. Molecular Microbiology,
    71(3):702–716, 2009.

2008

  • Itzhaki, L. and P. Wolynes. The quest to understand protein folding. Current Opinion in Structural Biology, 18(1):1 – 3, 2008.
  • Werbeck, N. D., P. J. E. Rowling, V. R. Chellamuthu, and L. S. Itzhaki. Shifting transition states in the unfolding of a large ankyrin repeat protein. Proceedings of the National Academy of Sciences, 105(29):9982–9987, 2008.

2007

  • Lian, H.-Y., H. Zhang, Z.-R. Zhang, H. M. Loovers, G. W. Jones, P. J. E. Rowling, L. S. Itzhaki, J.-M. Zhou, and S. Perrett. Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. Journal of Biological Chemistry, 282(16):11931–11940, 2007.
  • Lowe, A. R. and L. S. Itzhaki. Biophysical characterisation of the small ankyrin repeat protein myotrophin. Journal of Molecular Biology, 365(4):1245 – 1255, 2007. Lowe, A. R. and L. S. Itzhaki. Rational redesign of the folding pathway of a modular protein. Proceedings of the National Academy of Sciences, 104(8):2679–2684, 2007.
  • Moreau, M. J., A. T. McGeoch, A. R. Lowe, L. S. Itzhaki, and S. D. Bell. ATPase site architecture and helicase mechanism of an archaeal MCM. Molecular Cell, 28(2):304 – 314, 2007.
  • Werbeck, N. D. and L. S. Itzhaki. Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proceedings of the National Academy of Sciences, 104(19):7863–7868, 2007.

 

A full list including publications older than 2007 can be found on PubMed.