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Department of Pharmacology

Structure, function and chemico-biological regulation of ion channels and membrane receptors


Key publications: 

Journigan VB, Feng Z, Rahman S...Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T. Structure-based design of novel biphenyl amide antagonists of human Transient Receptor Potential Cation Channel Subfamily M Member 8 channels (TRPM8) with potential implications in the treatment of sensory neuropathies. ACS Chemical Neuroscience 2020. 11(3):268-290. doi: 10.1021/acschemneuro.9b00404

Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ESJ, Rahman T. In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochemical Pharmacology. 2020 Feb 3:113834. doi: 10.1016/j.bcp.2020.113834

Chandran A., Chee X, Prole DL., Rahman T. Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation. Scientific Reports, 9:2454 |

Rahman S, Rahman TUnveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Scientific Reports, (2017). doi:10.1038/s41598-017-13343-x.

Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Science Signalling 2014; 7(352):ra109.

Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB (2013) CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proc Natl Acad Sci U S A 110: 8507-8512

Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009) Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+Nature 458: 655-659

Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW (2009) Synthetic partial agonists reveal key steps in IP3 receptor activation. Nat Chem Biol 5: 631-639

Investigator Biography

Associate Professor
Dr Taufiq   Rahman

Contact Details

Not available for consultancy


Person keywords: 
Calcium signalling, single channel recordings, structural bioinformatics, rational drug design, membrane biology, molecular modelling, electrophysiology, drug repositioning