Publications
Journigan VB, Feng Z, Rahman S...Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T. Structure-based design of novel biphenyl amide antagonists of human Transient Receptor Potential Cation Channel Subfamily M Member 8 channels (TRPM8) with potential implications in the treatment of sensory neuropathies. ACS Chemical Neuroscience 2020. 11(3):268-290. doi: 10.1021/acschemneuro.9b00404
Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ESJ, Rahman T. In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochemical Pharmacology. 2020 Feb 3:113834. doi: 10.1016/j.bcp.2020.113834
Chandran A., Chee X, Prole DL., Rahman T. Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation. Scientific Reports, 9:2454 | https://doi.org/10.1038/s41598-019-39301-3
Rahman S, Rahman T. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Scientific Reports, (2017). doi:10.1038/s41598-017-13343-x.
Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Science Signalling 2014; 7(352):ra109.
Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB (2013) CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proc Natl Acad Sci U S A 110: 8507-8512
Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009) Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+. Nature 458: 655-659
Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW (2009) Synthetic partial agonists reveal key steps in IP3 receptor activation. Nat Chem Biol 5: 631-639
Investigator Biography
Taufiq's early academic training was in pharmaceutical sciences with a B.Pharm and M.Pharm degrees from University of Dhaka, Bangladesh. His earlier research interest included ethnopharmacology and chemistry of natural products. After spending a year in Dhaka as a lecturer of pharmacy, he pursued an MSc in Molecular Pharmacology in the University of Manchester under the Commonwealth Scholarship and Fellowship program in 2003. During the MSc, he worked with Dr. Gillian Edwards in the Smooth Muscle Research Group and developed interest in ion channels and associated signalling pathways. In 2005, he started a PhD in the laboratory of Prof. Colin Taylor. During this time, he studied properties and some regulatory aspects of inositol-1,4,5 trisphosphate receptors (IP3Rs) at the single channel level. After the completion of his PhD in 2008, he continued research in the same lab as a post doc and then from October 2009, he started his first independent position as a Drapers’ Research Fellow at Pembroke College. In the last five years, he has continued research in calcium signalling and developed a strong parallel interest in rational designing and development of chemical probes and modulators of ion channels and other signalling proteins. In 2011, he received the Early Career Research Award in Signal Transduction from the Biochemical Society. Since October 2012 till September 2017, he worked as a Royal Society University Research Fellow in the Department. Alongside this, he started a new position as a University Lecturer from April 2016.
