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Department of Pharmacology

 
Author(s): 
Rossi, AM, Taylor, CW
Abstract: 

All Ca(2+) channels are regulated by Ca(2+), a feature that allows them to respond to their own activity and to the activities of neighboring Ca(2+) channels. Inhibition by Ca(2+) protects cells from potentially hazardous increases in cytosolic [Ca(2+)], and stimulation can mediate facilitation and regenerative propagation of Ca(2+) signals. Calmodulin is emerging as a key player in regulation of Ca(2+) channels by Ca(2+), but its role is more complex and more beautiful than might have been imagined.

Publication ID: 
61081
Published date: 
August 2004
Publication source: 
pubmed
Publication type: 
Journal articles
Journal name: 
Mol Pharmacol
Publication volume: 
66
Publisher: 
Parent title: 
Edition: 
Publication number: