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Hockley, J.R.F., Taylor, T.S., Callejo, G., Wilbrey, A.L., Gutterridge, A., Bach, K., Winchester, W.J., Bulmer, D.C., McMurray, G. Smith, E.S. Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut, in press 10.1136/gutjnl-2017-315631

Wright, A. J., Husson, Z. M. A., Hu, D. E., Callejo, G., Brindle, K. M. and Smith, E. S. Increased hyperpolarized [1-13C]lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13C-labeled bicarbonate. NMR Biomed in press 10.1002/nbm.3892

Schuhmacher, L. N., Callejo, G., Srivats, S. and Smith, E. S. (2018). Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers.  J Biol Chem, 293, 1756-1766.     

Smith, E.S. (2018). Advances in understanding nociception and neuropathic pain. J Neurol, 265, 231-238.



Prato, V., Taberner, F.J., Hockley, J.R.F., Callejo, G., Arcourt, A., Tazir, B., Hammer, L., Schad, P., Heppenstall, P.A., Smith, E.S. and Lechner, S.G. (2017). Functional and molecular characterization of mechanoinsensitive "silent" nociceptors. Cell Reports, 21, 3012.

Kulaberoglu, Y., Lin, K., Holder, M., Gai, Z., Gomez, M., Assefa Shifa, B., Mavis, M., Hoa, L., Sharif, A.A.D., Lujan, C., Smith, E.S., Bjedov, I., Tapon, N., Wu, G. and Hergovich, A. (2017). Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nature Comm., 8, 695.

Park, T. J., Reznick, J., Peterson, B. L., Blass, G., Omerbasic, D., Bennett, N.C. Kuich, P.H.J.L, Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V.G., Govind, V., Minshall, R.D., Smith, E.S., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R. (2017) Fructose-driven glycolysis supports anoxia resistance in the naked mole-ratScience356, 307-311.

Wetzel, C., Pifferi, S., Picci, P., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E. S., Bégy, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kreis, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R. (2017). Small molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neurosci, 20, 209-218

Peiris, M., Hockley, J. R., Reed, D. E., Smith, E. S., Bulmer, D. C., Blackshaw, L. A. (2017). Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Mol. Pain 13, 1744806917709371


Schuhmacher, L. N. and Smith, E. S. (2016). Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat. Mol. Brain997.

Mason, M. J., Cornwall, H. L. and Smith, E. S. (2016). Ear Structures of the Naked Mole-Rat, Heterocephalus glaber, and Its Relatives (Rodentia: Bathyergidae). PLoS One, 11, e0167079.

da Silva Serra, I., Husson, Z., Bartlett, J. D. and Smith E. S. (2016). Characterization of cutaneous and articular sensory neurons. Mol. Pain.12, 1-14
Omerbasic, D.*, Smith, E. S.*, Moroni, M, Eigenbrod, O., Homfeld, J., Reznick, J., Bennett, N. C. Faulkes, C., Selbach, M, and Lewin, G. R. (2016).  Hypofunctional TrkA accounts for the absence of pain sensitization in the African naked mole-ratCell Rep.17, 748-758 (* = equal contribution).



Schuhmacher, L. N., Husson, Z. and Smith, E. S. (2015). The naked mole-rat as an animal model in biomedical research: current perspectives. Open Acc Animal Phys, 7, 137-148


Jeggle, P., Smith, E. S., Stewart, A. P., Haerteis, S., Korbmacher ,C., Edwardson, J. M. (2015). Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels. Biochem Biophys Res Comm, 464, 38
Omerbašić, D., Schuhmacher, L. N., Bernal Sierra, Y. A., Smith, E. S. and Lewin, G. R (2015). ASICs and mammalian mechanoreceptor function. Neuropharmacol., 94, 80-86

Schuhmacher, L. N., Srivats, S. and Smith, E. St. J (2015). Structural domains underlying the activation of acid-sensing ion channel 2a. Mol. Pharmacol., 87, 561-71



Rahman, T. and Smith, E. St. J. (2014)In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing channel 3. Biochem. Biophys. Res. Commun., 450, 384-9
Lewin, G. R., Lechner, S. G. and Smith, E. St. J. (2014). Nerve growth factor and nociception: from experimental embryology to new analgesic therapy. Handb Exp Pharmacol, 220, 251-82.

Kozlenkov, A., Lapatsina, L., Lewin, G. R. and Smith, E. St. J. (2014). Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. J. Physiol., 592, 557-69.


Smith, E. St. J., Martinez-Valazquez, L. and Ringstad, N. (2013). A chemoreceptor that detects molecular carbon dioxide. J Biol Chem, 288, 37071-81.


Brand, J., Smith, E. St. J., Schwefel, D., Lapatsina, L., Poole, K., Omerbasic, D., Kozlenkov, A., Behlke, J., Lewin, G. R. and Daumke, O. (2012). A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J., 31, 3635 – 3646.

Lapatsina, L., Jira, J., Smith, E. St. J., Poole, K., Kozlenkov, A., Bilbao, D., Lewin, G. R. and Heppenstall, P. A. (2012). A complex of Stomatin and STOML3 defines a highly mobile vesicle pool in sensory neurons. Open Biology, 2, 120096.

Smith, E. St. J., Purfürst, E., Grigoryan, T., Park, T. J., Bennett, N. C. and Lewin, G. R. (2012). A specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: A comparative analysis using six species of Bathyergidae. J. Comp. Neurol., 520, 2785 – 2803.


Smith, E. St. J., Omerbasic, D., Lechner, S. G., Anirudhan, G., Lapatsina, L. and Lewin, G. R. (2011). The physiological basis of acid insensitivity in the African naked mole rat. Science, 334, 1557 – 1560.


Smith, E. St. J., Blass, G. R. C., Lewin, G.R. and Park, T.J. (2010). Lack of histamine-induced itch in the African naked mole-rat and “rescue” by substance P administration. Mol. Pain, 6, 29.


Smith, E. St. J. and Lewin, G. R. (2009). Nociceptors: a phylogenetic view. J. Comp. Physiol. A 195, 1089 – 1106.


Park, T. J., Lu, Y.*, Juttner, R.*, Smith, E. St. J.*, Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P. A., Laurito, C. E., Wilson, S. P. and Lewin, G. R. (2008). Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). PLoS Biol. 6, e13. (* equal contribution)


Cadiou, H., Studer, M., Jones, N. G., Smith, E. S., Ballard, A., McMahon, S.B. and McNaughton, P.A. (2007) Modulation of acid-sensing ion channel activity by nitric oxide. J. Neurosci., 27, 13251-13260.

Smith, E. S., Zhang, X., Cadiou, H. and McNaughton, P. A. (2007) Proton binding sites involved in the activation of acid sensing ion channel ASIC2a. Neurosci.Lett., 426, 12-17.

Smith, E. S., Cadiou, H. and McNaughton, P. A. (2007) Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience, 145, 686-698.

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