Pre-print
Rickman, R., Pattison, L.A., Qiu, L., Dannawi, M., Welsh, F., and Smith, E.S.† The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice. Pre-print on bioRxiv, doi
Aguilera-Lizarraga, J.†, LIm, T.K., Pattison, L.A., Paine, L.W., Bulmer, D.C. and Smith, E.S.† Pro-inflammatory mediators sensitise transient receptor potential melastatin 3 cation channel (TRPM3) signalling in mouse sensory neurons. bioRxiv doi
Lim, T.K.†, Ritoux, A., Paine, L.W., Fergusson, L., Abdul, T.
Smith, E.S.† ioRxiv, doi 1Sokolowski, D., Miclǎus, M., Nater, A., Faykoo-Martinez, M, Hoekzema, K., Zuzarte, P., Monis, S., Akhtar Alvi, S., Erdmann, J., Erdmann, A.L., Kumaragurubaran, R., Bayerl, J., Yoo, D.A., Karimpour, N., Ungerleider, K., Hou, H., Fergal, M., Hourlier, T., Clarke, Z.A., Lischer, H.E., Leordean, D.V., Jiang, Y., Pugh, T.J., Smith, E.S., Haggerty, L., Laird, D.J., Lilue, J., Holmes, M.M., Eichler, E.E., Bruggmann, R., Simpson, J.T., Balmus, G., and Wilson, M.D. An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology. Pre-print on bioRxiv, doi 10.1101/2024.11.26.625329
Drugachenok, P., Urriola-Munoz, P., Qiu, L., Han, Z., Smith, E.S., and Rahman, T.† Functional characterization of the store-operated calcium entry pathway in naked mole-rat cells. Pre-print on bioRxiv, doi 10.1101/2024.12.15.628530
2024
Pattison, L.A.†, Rickman, R.H., Hilton, H., Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain. PNAS, 121, e24106531
Smith, E.S.† (2024)Pattison, L.A.†, Cloake, A., Chakrabarti, S., Hilton, H., Rickman, R.H., Higham, J.P., Meng, M.Y., Paine, L.W., Qiu, L., Ritoux, A., Bulmer, D.C. and Smith, E.S. (2024) Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience. PAIN, 165, 1761-1773.
Aguilera-Lizarraga, J.†, Ritoux, A., Bulmer, D.C. and Smith, E.S.† (2024) Intestinal barrier function in the naked mole-rat: an emergent model for gastrointestinal insights. Am J Physiol, 327, G188-201.
Meng, M., Paine, L.W., Sagnat, D., Bello, I., Oldroyd, S., Javid, F., Harper, M.T., Hockley, J.R.F., Smith, E.S., Owens, R.M., Alric, L., Buscail, E., Welsh, F., Vergnolle, N and Bulmer, D.C. (2024) TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Brit J Pharmacol, in press, doi 10.1111/bph.17408
Gupta, R.A, Higham, J.P., Urriola-Muñoz, P., Barker, K.H., Paine, L., Ghooraroo, J., Hockley, J.R.F., Rahman, T., Smith, E.S., Brown, A.J.H., Suzuki, R. and Bulmer, D.C. GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of Substance P release. PAIN, in press doi 10.1097/j.pain.0000000000003399
Higham, J.P.†, Smith, E.S. and Bulmer, D.C. (2024) A note on estimating absolute cytosolic [Ca2+] in sensory neurons using a single wavelength Ca2+ indicator. Mol Pain, 20, 1-6.
2023
Sanchez, J.P., Middleton, S.J., Pattison, L.A., Hilton, H., Awadeelkareem, M.A., Zuberi, S.R, Renke, M.B., Hu, H., Yang, X., Clarke, A.J., Smith, E.S. and Bennett, D.L.† (2023) Inhibition of sensory neuron driven acute, inflammatory and neuropathic pain using a humanised chemogenetic system. Sci Trans Med, 15, eadh3839.
Bohic, M., Pattison, L.A., Jhumka, Z.A., Rossi, H., Thackray, J.K., Ricci, M., Mossazghi, N., Foster, W., Ogundare, S., Twomey, C.R., Hilton, H., Arnold, J., Tischfield, M.A., Yttri, E.A., Smith, E.S., Abdus-Saboor, I.† and Abraira, V.E.† (2023) Mapping the neuroethological signatures of pain, analgesia, and recovery in mice. Neuron, 111, 2811-2830.
Ai, M., Hotham, W.E., Pattison, L.A., Ma, Q., Henson, F.M.D† and Smith, E.S.† (2023) Human mesenchymal stem cells and derived extracellular vesicles reduce sensory neuron hyperexcitability and pain-related behaviors in a mouse model of osteoarthritis. Arth Rheum, 75, 352-363
Smith, E.S.† (2023) A new art to treating osteoarthritis pain? Osteo Cart, 31, 1275-77
Barker, K.H., Higham, J.P., Pattison, L.A., Chessell, I.P., Welsh, F., Smith, E.S., and Bulmer, D.C.† (2023) Sensitisation of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity. Am J Physiol Gastrointest Liver Physiol, 324, 250-261
Parey, E., Frost, S., Uribarren, A., Park, T.J., Zoettl, M., Smith, E.S., Berthelot, C. and Villar, D. Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits. Genome Biol in press, doi 10.1101/gr.277715.123
Urriola-Muñoz, P., Pattison, L.A., and Smith, E.S.† (2023) Dysregulation of ADAM10 shedding activity as a mechanism of cancer resistance in the naked mole-rat. J Cell Physiol, 238, 761-775
Walters, E.T., Crook, R.J., Neely, G.G., Price, T. J. and Smith, E.S. (2023) Persistent nociceptor hyperactivity as a painful evolutionary adaptation. TiNS, 46, 211-27
2022
Goyens, J., Baeckens, S., Smith, E.S., Pozzi, J., and Mason, M.J. (2022) Parallel evolution of semicircular canal form and sensitivity in subterranean mammals. J Comp Physiol A, 208, 627-40
Fatima, I., Chen, G., Botchkareva, N.V., Sharov, A.A., Thornton, D., Wilkinson, H.N., Hardman, M.J., Grutzkau, A., de Magalhaes, J.P., Seluanov, A., Smith, E.S., Gorbunova, V., Mardaryev, A.N.†, Faulkes, C.G.†, and Botchkarev, V.A.† (2022) Skin aging in long-lived naked mole-rats is accompanied by increased expression of longevity-associated and tumor suppressor genes. J Inv Derm, 142, 2853-63
Cagan, A., Baez-Ortega, A., Brzozowska, N., Abascal, F., Coorens, T.H., Sanders, M.A., Lawson, A.R., Harvey, L.M., Bhosle, S.G., Jones, D., Alcantara, R.E., Butler, T.M., Hooks, Y., Roberts, K., Anderson, E., Flach, E., Spiro, S., Januszczak, I., Wrigglesworth, E., Perkins, M.W., Deaville, R., Druce, M., Bogeska, R., Milsom, M.D., Neumann, B., Gorman, F., Constantino-Casas, F., Peachey, L., Bochynska, D., Smith, E.S., Gerstung, M., Campbell, P.J., Murchison, E.P., Stratton, M.R., and Martincorena, I.† (2022) Somatic mutation rates scale with lifespan across mammals. Nature, 604, 517-24
Miessner, H., Siedel, J. and Smith, E.S. (2022) In vitro models for investigating itch. Front Mol Neurosci, 15, 084126
Barker, K.H., Higham, J.P., Pattison, L.A., Taylor, T.S., Chessell, I.P., Welsh, F., Smith, E.S., and Bulmer, D.C.† Sensitisation of colonic nociceptors by TNF is dependent on TNFR1 expression and p38 MAPK activity. J Physiol, 600, 3819-3836
Buffenstein, R.†, Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J....Smith, E.S.†. (2022). The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole-rat biology. Biol Rev, 97, 115-140
Gomes, D.M., Loth, A., Hockley, J.R.F. and Smith, E.S.† Gut Reaction: The Impact of a Film on Public Understanding of Gastrointestinal Conditions. Front Comms, 7, 769052
Latragna,A., Sabaté, A., Tsimpos, P., Vermeiren, S., Gualdani, R., Chakrabarti, S., Callejo, G., Shomroni, O., Sitte, M., Kricha, S., Luypaert, M., Vanhollebeke, B., Laumet, G., Salinas-Riester, G., Smith, E. S., Ris, L. and Bellefroid, E.J.† (2022) Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors. PAIN, in press doi 10.1097/j.pain.0000000000002536
2021
Chakrabarti, S., Ai, M., Wongn, W.Y.K., Newell, K., Henson, F.M.D.† and Smith, E.S.† (2021) Functional characterization of ovine dorsal root ganglion neurons reveals peripheral sensitization after osteochondral defect. eNeuro, 8, ENEURO.0237-21.2021
Tan, S.L., Barri, M., Atakpa-Adaji, P., Taylor, C.W., Smith, E.S., Murrell-Lagnado, R.D.† (2021). P2X4 receptors mediate Ca2+ release from lysosomes in response to stimulation of P2X7 and H1 histamine receptors. Int J Mol Sci, 22, 10492
Smith, E.S., Park, T.J., Holmes, M.M. and Buffenstein, R.† (2021). Some Exciting Future Directions for Work on Naked Mole-Rats. Adv Exp Med Biol, 1319, 409-420.
Hadi, F., Smith, E.S.†, and Khaled, W.T.† (2021). Naked Mole-Rats: Resistant to Developing Cancer or Good at Avoiding It? Adv Exp Med Biol, 1319, 341-352.
Park, T.J.†, Smith, E.S.., Reznick, J., Bennett, N.C., Applegate, D.T., Larson, J., Lewin, G.R. (2021). African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia. Adv Exp Med Biol, 1319, 255-269.
Lewin, G.R.†, Smith, E.S., Reznick, J., Debus, K., Barker, A.J. and Park, T.J. (2021). The Somatosensory World of the African Naked Mole-Rat. Adv Exp Med Biol, 1319, 197-220.
Vice, E.N., Lagestee, S., Browe, B.M., Deb, D., Smith, E.S. and Park, T.J.† (2021). Sensory Systems of the African Naked Mole-Rat. Adv Exp Med Biol, 1319, 137-156.
Pattison, L.A., Krock, E., Svensson, C.I. and Smith, E.S.Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis. Pain, 15, 714-717.
(2021).Dulai, J.S., Smith, E.S.Acid-sensing ion channel 3: Analgesic target. Channels, 15, 94-127.
and Rahman, T.R. (2021).2020
Lee, M., Nahorski, M., Hockley, J.R.F., Lu, V., Ison, G., Pattison, L.A., Callejo, G., Stouffer, K., Fletcher, E., Brown, C., Drissi, I., Wheeler, D., Ernfors, P., Menon, D., Reimann, F., Smith, E.S., Woods, C.G. Human labour pain is influenced by the voltage-gated potassium channel KV6.4 subunit. Cell Reports, 32, 107941
Hadi, F., Kulaberoglu, Y., Lazarus, K., Bach, K., Ugur, R., Beattie, P., Smith, E.S. and Khaled, W.T. (2020). Transformation of naked mole-rat cells. Nature, 583, E1-E13
Chakrabarti, S., Pattison, L.A., Doleschall, B., Rickman, R.H., Blake, H., Callejo, G., Heppenstall, P.A. & Smith, E.S. Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice. Arth Rheum, 72, 1749-58
Chakrabarti, S., Hore, Z., Pattison, L.A., Lalnunhlimi, S., Bhebhe, C.N., Callejo, G., Bulmer, D.C., Taams, L.S., Denk, F. & Smith, E.S. Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain. Pain, 161, 2129-2141
Browe, B.M., Olsen, A.R., Ramirez, C., Rickman, R.H., Smith, E.S. and Park, T.J. The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway. Neurobiol Pain, 8, 100051
Du, Z., Chakrabarti, S., Kulaberoglu, Y., Smith, E.S., Dobson, C.M., Itzhaki, L. and Kumita, J. (2020). Probing the unfolded protein response in long-lived naked mole-rats. Biochem Biophys Res Comm, 529, 1151-1157
Hacker, L., Brunker, J., Smith, E.S., Gozales, I.Q. and Bohndiek, S.E. (2020). Photoacoustics resolves species-specific differences in haemoglobin concentration and oxygenation. J Biomed Opt,
Smith, E.S. and Park, T.J. (2020). Neurobiology: Crowdsourcing CO2 to conserve brain energy. Curr Biol, 30, R649-651
Smith, E.S., Park, T.J. and Lewin, G.R. (2020) Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms. J Comp Physiol A, 206, 313-325
Callejo, G., Pattison, L.A., Greenhalgh, J.C., Chakrabarti, S., Andreopoulou, E., Hockley, J.R.F., Smith, E.S. and Rahman, T. (2020) In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochem Pharmacol, 174, 113834
Chakrabarti, S., Jadon, D.R., Bulmer D.C. and Smith, E.S. (2020) Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain. Rheumatology, 59, 662-667
Hockley, J.R.F., Taylor, T.S., Callejo, G., Husson, Z.M. and Smith, E.S. (2020) Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves. Mol Pain, 16, 1-11
Taylor, T.S., Konda, P, John, S.S., Bulmer, D.C., Hockley, J.R.F & Smith, E.S. (2020) Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Phys Rep, 8, e14326
2019
Pattison, L.A., Callejo, G. and Smith, E.S. (2019). Evolution of acid nociception: ion channels and receptors for detecting acid. Phil Trans R Soc B, 374, 20190291
Kulaberoglu, Y., Bhushan, B., Hadi, F., Chakrabarti, S., Khaled, W.T., Rankin, K., Smith, E.S. and Frankel, D. (2019) The material properties of naked mole-rat hyaluronan. Sci Reports, 9, 6632 († co-corresponding authors)
Hockley, J.R.F., Taylor, T.S., Callejo, G., Wilbrey, A.L., Gutterridge, A., Bach, K., Winchester, W.J., Bulmer, D.C., McMurray, G. and Smith, E.S. (2019) Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut, 68, 633-644
2018
Bautzova, T., Hockley, J.R., Perez-Berezo, T., Pujo, J., Tranter, M.M., Desormeaux, C., Barbaro, M.R., Basso, L. Le Faouder, P-. Rolland, C., Malapert, P., Moqrich, A., Eutamene, H., Denadi-Souza, A., Vergnolle, N., Smith, E.S., Hughes, D.I., Barabara, G., Dietrich, G., Bulmer, D.C. and Cenac, N. (2018) 5-oxoETE triggers nociception in constipation predominant irritable bowel syndrome through MAS-related G protein coupled receptor D. Sci Sig, 11, eaal2171
Chakrabarti, S., Pattison, L.A., Singhal, K., Hockley, J.R.F., Callejo, G.and Smith, E.S. (2018) Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharm, 143, 49-62
Hockley, J.R.F., Smith, E.S. and Bulmer, D.C. (2018) Human visceral nociception: findings from translational studies in human tissue. Am J Physiol Gastro Liv Physiol, 315, G464-G472
Husson, Z. and Smith, E. S. (2018) Naked mole-rat cortical neurons are resistant to acid-induced cell death. Mol Brain, 11, 26
Wright, A. J., Husson, Z. M. A., Hu, D. E., Callejo, G., Brindle, K. M. and Smith, E. S. (2018) Increased hyperpolarized [1-13C]lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13C-labeled bicarbonate. NMR Biomed e3892
Schuhmacher, L. N., Callejo, G., Srivats, S. and Smith, E. S. (2018) Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers. J Biol Chem, 293, 1756-1766.
Smith, E.S. (2018). Advances in understanding nociception and neuropathic pain. J Neurol, 265, 231-238.
2017
Prato, V., Taberner, F.J., Hockley, J.R.F., Callejo, G., Arcourt, A., Tazir, B., Hammer, L., Schad, P., Heppenstall, P.A., Smith, E.S. and Lechner, S.G. (2017). Functional and molecular characterization of mechanoinsensitive "silent" nociceptors. Cell Reports, 21, 3012.
Kulaberoglu, Y., Lin, K., Holder, M., Gai, Z., Gomez, M., Assefa Shifa, B., Mavis, M., Hoa, L., Sharif, A.A.D., Lujan, C., Smith, E.S., Bjedov, I., Tapon, N., Wu, G. and Hergovich, A. (2017). Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nature Com., 8, 695.
Park, T. J., Reznick, J., Peterson, B. L., Blass, G., Omerbasic, D., Bennett, N.C. Kuich, P.H.J.L, Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V.G., Govind, V., Minshall, R.D., Smith, E.S., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R. (2017) Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science, 356, 307-311.
Wetzel, C., Pifferi, S., Picci, P., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E. S., Bégy, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kreis, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R. (2017). Small molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neurosci, 20, 209-218
Peiris, M., Hockley, J. R., Reed, D. E., Smith, E. S., Bulmer, D. C., Blackshaw, L. A. (2017). Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Mol Pain 13, 1744806917709371
2016
Schuhmacher, L. N. and Smith, E. S. (2016). Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat. Mol Brain, 9, 97.
Mason, M. J., Cornwall, H. L. and Smith, E. S. (2016). Ear Structures of the Naked Mole-Rat, Heterocephalus glaber, and Its Relatives (Rodentia: Bathyergidae). PLoS One, 11, e0167079.
2015
Schuhmacher, L. N., Srivats, S. and Smith, E. St. J (2015). Structural domains underlying the activation of acid-sensing ion channel 2a. Mol Pharmacol, 87, 561-71
2014
Rahman, T. and Smith, E. St. J. (2014)In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing channel 3. Biochem. Biophys. Res. Commun., 450, 384-9
Lewin, G. R., Lechner, S. G. and Smith, E. St. J. (2014). Nerve growth factor and nociception: from experimental embryology to new analgesic therapy. Handb Exp Pharmacol, 220, 251-82.
Kozlenkov, A., Lapatsina, L., Lewin, G. R. and Smith, E. St. J. (2014). Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. J Physiol, 592, 557-69.
2013
Smith, E. St. J., Martinez-Valazquez, L. and Ringstad, N. (2013). A chemoreceptor that detects molecular carbon dioxide. J Biol Chem, 288, 37071-81.
2012
Brand, J., Smith, E. St. J., Schwefel, D., Lapatsina, L., Poole, K., Omerbasic, D., Kozlenkov, A., Behlke, J., Lewin, G. R. and Daumke, O. (2012). A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J., 31, 3635 – 3646.
Lapatsina, L., Jira, J., Smith, E. St. J., Poole, K., Kozlenkov, A., Bilbao, D., Lewin, G. R. and Heppenstall, P. A. (2012). A complex of Stomatin and STOML3 defines a highly mobile vesicle pool in sensory neurons. Open Biology, 2, 120096.
Smith, E. St. J., Purfürst, E., Grigoryan, T., Park, T. J., Bennett, N. C. and Lewin, G. R. (2012). A specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: A comparative analysis using six species of Bathyergidae. J. Comp. Neurol., 520, 2785 – 2803.
2011
Smith, E. St. J., Omerbasic, D., Lechner, S. G., Anirudhan, G., Lapatsina, L. and Lewin, G. R. (2011). The physiological basis of acid insensitivity in the African naked mole rat. Science, 334, 1557 – 1560.
2010
Smith, E. St. J., Blass, G. R. C., Lewin, G.R. and Park, T.J. (2010). Lack of histamine-induced itch in the African naked mole-rat and “rescue” by substance P administration. Mol. Pain, 6, 29.
2009
Smith, E. St. J. and Lewin, G. R. (2009). Nociceptors: a phylogenetic view. J. Comp. Physiol. A 195, 1089 – 1106.
2008
Park, T. J., Lu, Y.*, Juttner, R.*, Smith, E. St. J., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P. A., Laurito, C. E., Wilson, S. P. and Lewin, G. R. (2008). Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). PLoS Biol. 6, e13. (* equal contribution)
2007
Cadiou, H., Studer, M., Jones, N. G., Smith, E. S., Ballard, A., McMahon, S.B. and McNaughton, P.A. (2007) Modulation of acid-sensing ion channel activity by nitric oxide. J. Neurosci., 27, 13251-13260.
Smith, E. S., Zhang, X., Cadiou, H. and McNaughton, P. A. (2007) Proton binding sites involved in the activation of acid sensing ion channel ASIC2a. Neurosci.Lett., 426, 12-17.
Smith, E. S., Cadiou, H. and McNaughton, P. A. (2007) Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience, 145, 686-698.
For a full list of publications go to Google Scholar.