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Department of Pharmacology

 

2024

Alexander J. Boys, Amparo Güemes, Rohit A. Gupta, Friederike H. Uhlig, Niall P. Hyland, David C. Bulmer, George G. Malliaras, Róisín M. Owens. Implantable Bioelectronics for Real-time in vivo Recordings of Enteric Neural Activity. bioRxiv 2024.03.22.586292; doi: https://doi.org/10.1101/2024.03.22.586292

Michelle Y Meng, Luke W Paine, David Sagnat, Ivana Bello, Sophie Oldroyd, Farideh Javid, Matthew T Harper, James RF Hockley, Ewan St. J Smith, Róisín M Owens, Laurent Alric, Etienne Buscail, Fraser Welsh, NathalieVergnolle, David C Bulmer TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. bioRxiv 2024.04.12.589184; doi: https://doi.org/10.1101/2024.04.12.589184

Rohit A Gupta, James P Higham, Paulina Urriola-Muñoz, Katie H Barker, Luke Paine, Joshua Ghooraroo, James RF Hockley, Taufiq Rahman, Ewan St John Smith, Alistair JH Brown, Rie Suzuki, David C Bulmer. GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release. bioRxiv 2023.09.12.557415; doi: https://doi.org/10.1101/2023.09.12.557415

Conley TE, Slater R, Moss S, Bulmer DC, Negro JR, Ijaz UZ, Pritchard DM, Parkes M, Probert C. Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome. EBioMedicine. 2024 Aug 21;107:105282. doi: 10.1016/j.ebiom.2024.105282. Online ahead of print.PMID: 39173527 Free article.

Engelmann-Kewitz M, Khwaja I, Takahashi K, Parkes M, Norton C, Hart A, Bulmer D, Aziz Q. Factors associated with chronic abdominal pain in patients with inflammatory bowel disease in remission: A pilot cross-sectional study. Neurogastroenterol Motil. 2024 Jul 30:e14881. doi: 10.1111/nmo.14881. Online ahead of print.PMID: 39078931

Aguilera-Lizarraga J, Ritoux A, Bulmer DC, Smith ESJ. Intestinal barrier function in the naked mole-rat: an emergent model for gastrointestinal insights. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 1;327(2):G188-G201. doi: 10.1152/ajpgi.00080.2024. Epub 2024 Jun 25.PMID: 38915279 Free article.

Pattison LA, Cloake A, Chakrabarti S, Hilton H, Rickman RH, Higham JP, Meng MY, Paine LW, Dannawi M, Qiu L, Ritoux A, Bulmer DC, Callejo G, Smith ESJ. Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience. Pain. 2024 Aug 1;165(8):1761-1773. doi: 10.1097/j.pain.0000000000003190. Epub 2024 Mar 5.PMID: 38452214 Free PMC article.

Higham JP, Smith ESJ, Bulmer DC. A note on estimating absolute cytosolic Ca2+ concentration in sensory neurons using a single wavelength Ca2+ indicator. Mol Pain. 2024 Jan-Dec;20:17448069241230420. doi: 10.1177/17448069241230420.PMID: 38379503 Free PMC article.

Higham JP, Bhebhe CN, Gupta RA, Tranter MM, Barakat FM, Dogra H, Bab N, Wozniak E, Barker KH, Wilson CH, Mein CA, Raine T, Cox JJ, Wood JN, Croft NM, Wright PD, Bulmer DC. Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease. Pain. 2024 Jul 1;165(7):1592-1604. doi: 10.1097/j.pain.0000000000003159. Epub 2024 Jan 29.PMID: 38293826 Free PMC article.

Oldroyd P, Oldroyd S, Meng M, Makwana R, Sanger G, Bulmer D, Malliaras GG, Owens RM. Stretchable Device for Simultaneous Measurements of Contractility and Electrophysiology of Neuromuscular Tissue in the Gastrointestinal Tract. Adv Mater. 2024 May;36(19):e2312735. doi: 10.1002/adma.202312735. Epub 2024 Feb 12.PMID: 38290128

McCoy R, Oldroyd S, Yang W, Wang K, Hoven D, Bulmer D, Zilbauer M, Owens RM. In Vitro Models for Investigating Intestinal Host-Pathogen Interactions. Adv Sci (Weinh). 2024 Feb;11(8):e2306727. doi: 10.1002/advs.202306727. Epub 2023 Dec 28.PMID: 38155358 Free PMC article. Review.

Barron SL, Oldroyd SV, Saez J, Chernaik A, Guo W, McCaughan F, Bulmer D, Owens RM. A Conformable Organic Electronic Device for Monitoring Epithelial Integrity at the Air Liquid Interface. Adv Mater. 2024 Feb;36(8):e2306679. doi: 10.1002/adma.202306679. Epub 2023 Dec 12.PMID: 38061027

2023

Bhebhe CN, Higham JP, Gupta RA, Raine T, Bulmer DC. KV7 but not dual small and intermediate KCa channel openers inhibit the activation of colonic afferents by noxious stimuli. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G436-G445. doi: 10.1152/ajpgi.00141.2023. Epub 2023 Sep 5.PMID: 37667839 Free PMC article.

Collins JM, Hyland NP, Clarke G, Fitzgerald P, Julio-Pieper M, Bulmer DC, Dinan TG, Cryan JF, O'Mahony SM. Beta 3-adrenoceptor agonism ameliorates early-life stress-induced visceral hypersensitivity in male rats. J Neurochem. 2023 Mar 12. doi: 10.1111/jnc.15804. Online ahead of print.PMID: 36906887 Free article.

Barker KH, Higham JP, Pattison LA, Chessell IP, Welsh F, Smith ESJ, Bulmer DC. Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity. Am J Physiol Gastrointest Liver Physiol. 2023 Apr 1;324(4):G250-G261. doi: 10.1152/ajpgi.00280.2022. Epub 2023 Feb 7.PMID: 36749569 Free PMC article.

Bulmer D. Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle. Gut. 2023 Sep;72(9):1636-1637. doi: 10.1136/gutjnl-2022-329184. Epub 2023 Feb 3.PMID: 36737232 No abstract available.

2022

Barker KH, Higham JP, Pattison LA, Taylor TS, Chessell IP, Welsh F, Smith ESJ, Bulmer DC Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity. J Physiol. 2022 Aug;600(16):3819-3836. doi: 10.1113/JP283170. Epub 2022 Jul 21.PMID: 35775903 Free PMC article.

2021

Takahashi K, Khwaja IG, Schreyer JR, Bulmer D, Peiris M, Terai S, Aziz Q. Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review. Crohns Colitis 360. 2021 Nov 8;3(4):otab073. doi: 10.1093/crocol/otab073. eCollection 2021 Oct.PMID: 36777266 Free PMC article. Review.

Cibert-Goton V, Lam C, Lingaya M, Falcone Y, Wood JN, Bulmer DC, Spiller R.  Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D. Clin Transl Gastroenterol. 2021 Feb 22;12(2):e00313. doi: 10.14309/ctg.0000000000000313.PMID: 33617189 Free PMC article.

2020

Chakrabarti S, Hore Z, Pattison LA, Lalnunhlimi S, Bhebhe CN, Callejo G, Bulmer DC, Taams LS, Denk F, Smith ESJ. Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain. Pain. 2020 Sep 1;161(9):2129-2141. doi: 10.1097/j.pain.0000000000001890.PMID: 32332252 Free PMC article.

Hockley JR, Barker KH, Taylor TS, Callejo G, Husson ZM, Bulmer DC, Smith ESJ. (2020) Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.Mol Pain.  epub

Taylor TS, Konda P, John SS, Bulmer DC, Hockley JRF, Smith ESJ. (2020) Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiol Rep. epub

 

2019

Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA, Sanger GJ, Knowles CH, Araujo EJA, Winchester WJ, Bulmer DC. (2019) Functional and anatomical deficits in visceral nociception with age: mechanism of silent appendicitis in the elderly? Pain epub

Chakrabarti S, Jadon DR, Bulmer DC, Smith ESJ. (2019) Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain. Rheumatology (Oxford). epub

Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. (2019) Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 10(1):1029. epub

Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ. (2019) Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut. 68(4):633-644.

 

2018

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N. (2018) 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D. Sci Signal. 11(561). epub

Aktar R, Peiris M, Fikree A, Cibert-Goton V, Walmsley M, Tough IR, Watanabe P, Araujo EJA, Mohammed SD, Delalande JM, Bulmer DC, Scott SM, Cox HM, Voermans NC, Aziz Q, Blackshaw LA. (2018) The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones. J Physiol. 596(17):4237-4251.

Hockley JRF, Smith ESJ, Bulmer DC. (2018) Human visceral nociception: findings from translational studies in human tissue. Am J Physiol Gastrointest Liver Physiol. 315(4):G464-G472.

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. (2018) Ex vivo study of human visceral nociceptors. Gut. 67(1):86-96.

 

2017

Balemans D, Mondelaers SU, Cibert-Goton V, Stakenborg N, Aguilera-Lizarraga J, Dooley J, Liston A, Bulmer DC, Vanden Berghe P, Boeckxstaens GE, Wouters MM. (2017) Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS. Sci Rep. 7(1):13606. 

Peiris M, Hockley JR, Reed DE, Smith ESJ, Bulmer DC, Blackshaw LA. (2017) Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Mol Pain.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC*, Cendán CM, McMurray G. (2017) Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. J Physiol. 595(8):2661-2679. * joint last author

Peiris M, Hockley JRF, Reed DE, St. John Smith E, Bulmer DC, Blackshaw LA. (2017) Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Molecular Pain epub.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC*, Cendán CM*, McMurray G*. (2017) Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. J Physiol. 595(8):2661-2679.

2016

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. (2016) Ex vivo study of human visceral nociceptors. Gut EPUB

Hockley JRF, Tranter M, McGuire C, Boundouki G, Cibert-Goton V, Thaha M, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, and Bulmer DC. (2016) P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci 36(8):2364-76.

Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Van Brabant W, Van der Merwe S, Mols R, Ghesquire B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts S, Augustijns S, Hellings P, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens G. (2016) Histamine 1 receptor antagonism as treatment for irritable bowel syndrome: a randomized, double-blind, randomised placebo-controlled proof-of-concept clinical trial. Gastroenterology 150(4):875-87.

2015

Hockley JRF, Winchester WJ, Bulmer DC (2015) The voltage-gated sodium channel NaV1.9 in visceral pain. Neurogastroenterol Motil 28(3):316-26.

Bulmer DC, Botha CA, Wheeldon A, Grey K, Mein CA, Lee K, Knowles CH, Winchester WJ, Aziz Q. (2015) Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Neurogastroenterol Motil.27(5):656-62.

Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M, Bulmer DC, Young RL, Blackshaw LA. (2015) Mechanisms of activation of mouse and human enteroendocrine cells by nutrients. Gut. 64(4):618-26.

2014

Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. (2014) Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain. 155(10):1962-75.

2013

Javid FA*, Bulmer DC*, Broad J et al. (2013). Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors. Eur J Pharmacol 699, (1-3) 48-54. *Joint first author

2011

Bulmer DC and Grundy D. (2011) Achieving translation in models of visceral pain. Current Opinion in Pharmacology 11(6):575-81.

Peiris M*, Bulmer DC*, Baker M, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. (2011) Human visceral afferent recordings: Preliminary Report. Gut. 60(2), 204-8.

2010

Snoek SA, Verstege MI, van der Zanden EP, Deeks N, Bulmer DC, Skynner M, Lee K, te Velde AA, Boeckxstaens GE and de Jonge WJ (2010). Selective alpha7 nicotinic acetylcholine receptor agonists 1 worsen disease in experimental colitis. Br J Pharmacol 160(2):322-33.

o'Mahony SM, Bulmer DC, Coelho AM, Fitzgerald P, Bongiovanni C, Lee K, Winchester W, Dinan TG, Cryan JF (2010). 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterol Motil 22(5):573-8.
 

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*Joint first author