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Publications

 

2017


Peiris M, Hockley JRF, Reed DE, St. John Smith E, Bulmer DC, Blackshaw LA. (2017) Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Molecular Pain epub.


Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC*, Cendán CM*, McMurray G*. (2017) Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. J Physiol. 595(8):2661-2679.

2016


McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. (2016) Ex vivo study of human visceral nociceptors. Gut EPUB


Hockley JRF, Tranter M, McGuire C, Boundouki G, Cibert-Goton V, Thaha M, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, and Bulmer DC. (2016) P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci 36(8):2364-76.


Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Van Brabant W, Van der Merwe S, Mols R, Ghesquire B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts S, Augustijns S, Hellings P, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens G. (2016) Histamine 1 receptor antagonism as treatment for irritable bowel syndrome: a randomized, double-blind, randomised placebo-controlled proof-of-concept clinical trial. Gastroenterology 150(4):875-87.

2015


Hockley JRF, Winchester WJ, Bulmer DC (2015) The voltage-gated sodium channel NaV1.9 in visceral pain. Neurogastroenterol Motil 28(3):316-26.


Bulmer DC, Botha CA, Wheeldon A, Grey K, Mein CA, Lee K, Knowles CH, Winchester WJ, Aziz Q. (2015) Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Neurogastroenterol Motil.27(5):656-62.


Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M, Bulmer DC, Young RL, Blackshaw LA. (2015) Mechanisms of activation of mouse and human enteroendocrine cells by nutrients. Gut. 64(4):618-26.

2014


Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. (2014) Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain. 155(10):1962-75.

2013


Javid FA*, Bulmer DC*, Broad J et al. (2013). Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors. Eur J Pharmacol 699, (1-3) 48-54. *Joint first author

2011


Bulmer DC and Grundy D. (2011) Achieving translation in models of visceral pain. Current Opinion in Pharmacology 11(6):575-81.


Peiris M*, Bulmer DC*, Baker M, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. (2011) Human visceral afferent recordings: Preliminary Report. Gut. 60(2), 204-8.

2010


Snoek SA, Verstege MI, van der Zanden EP, Deeks N, Bulmer DC, Skynner M, Lee K, te Velde AA, Boeckxstaens GE and de Jonge WJ (2010). Selective alpha7 nicotinic acetylcholine receptor agonists 1 worsen disease in experimental colitis. Br J Pharmacol 160(2):322-33.


o'Mahony SM, Bulmer DC, Coelho AM, Fitzgerald P, Bongiovanni C, Lee K, Winchester W, Dinan TG, Cryan JF (2010). 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterol Motil 22(5):573-8.

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*Joint first author