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Publications

2020

Hockley JR, Barker KH, Taylor TS, Callejo G, Husson ZM, Bulmer DC, Smith ESJ. (2020) Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.Mol Pain.  epub

Taylor TS, Konda P, John SS, Bulmer DC, Hockley JRF, Smith ESJ. (2020) Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiol Rep. epub

 

2019

Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA, Sanger GJ, Knowles CH, Araujo EJA, Winchester WJ, Bulmer DC. (2019) Functional and anatomical deficits in visceral nociception with age: mechanism of silent appendicitis in the elderly? Pain epub

Chakrabarti S, Jadon DR, Bulmer DC, Smith ESJ. (2019) Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain. Rheumatology (Oxford). epub

Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. (2019) Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 10(1):1029. epub

Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ. (2019) Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut. 68(4):633-644.

 

2018

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N. (2018) 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D. Sci Signal. 11(561). epub

Aktar R, Peiris M, Fikree A, Cibert-Goton V, Walmsley M, Tough IR, Watanabe P, Araujo EJA, Mohammed SD, Delalande JM, Bulmer DC, Scott SM, Cox HM, Voermans NC, Aziz Q, Blackshaw LA. (2018) The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones. J Physiol. 596(17):4237-4251.

Hockley JRF, Smith ESJ, Bulmer DC. (2018) Human visceral nociception: findings from translational studies in human tissue. Am J Physiol Gastrointest Liver Physiol. 315(4):G464-G472.

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. (2018) Ex vivo study of human visceral nociceptors. Gut. 67(1):86-96.

 

2017

Balemans D, Mondelaers SU, Cibert-Goton V, Stakenborg N, Aguilera-Lizarraga J, Dooley J, Liston A, Bulmer DC, Vanden Berghe P, Boeckxstaens GE, Wouters MM. (2017) Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS. Sci Rep. 7(1):13606. 

Peiris M, Hockley JR, Reed DE, Smith ESJ, Bulmer DC, Blackshaw LA. (2017) Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Mol Pain.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC*, Cendán CM, McMurray G. (2017) Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. J Physiol. 595(8):2661-2679. * joint last author

Peiris M, Hockley JRF, Reed DE, St. John Smith E, Bulmer DC, Blackshaw LA. (2017) Peripheral KV7 channels regulate visceral sensory function in mouse and human colon. Molecular Pain epub.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC*, Cendán CM*, McMurray G*. (2017) Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. J Physiol. 595(8):2661-2679.

2016


McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. (2016) Ex vivo study of human visceral nociceptors. Gut EPUB

Hockley JRF, Tranter M, McGuire C, Boundouki G, Cibert-Goton V, Thaha M, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, and Bulmer DC. (2016) P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci 36(8):2364-76.

Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Van Brabant W, Van der Merwe S, Mols R, Ghesquire B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts S, Augustijns S, Hellings P, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens G. (2016) Histamine 1 receptor antagonism as treatment for irritable bowel syndrome: a randomized, double-blind, randomised placebo-controlled proof-of-concept clinical trial. Gastroenterology 150(4):875-87.

2015

Hockley JRF, Winchester WJ, Bulmer DC (2015) The voltage-gated sodium channel NaV1.9 in visceral pain. Neurogastroenterol Motil 28(3):316-26.

Bulmer DC, Botha CA, Wheeldon A, Grey K, Mein CA, Lee K, Knowles CH, Winchester WJ, Aziz Q. (2015) Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Neurogastroenterol Motil.27(5):656-62.

Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M, Bulmer DC, Young RL, Blackshaw LA. (2015) Mechanisms of activation of mouse and human enteroendocrine cells by nutrients. Gut. 64(4):618-26.

2014

Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. (2014) Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain. 155(10):1962-75.

2013

Javid FA*, Bulmer DC*, Broad J et al. (2013). Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors. Eur J Pharmacol 699, (1-3) 48-54. *Joint first author

2011


Bulmer DC and Grundy D. (2011) Achieving translation in models of visceral pain. Current Opinion in Pharmacology 11(6):575-81.


Peiris M*, Bulmer DC*, Baker M, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. (2011) Human visceral afferent recordings: Preliminary Report. Gut. 60(2), 204-8.

2010


Snoek SA, Verstege MI, van der Zanden EP, Deeks N, Bulmer DC, Skynner M, Lee K, te Velde AA, Boeckxstaens GE and de Jonge WJ (2010). Selective alpha7 nicotinic acetylcholine receptor agonists 1 worsen disease in experimental colitis. Br J Pharmacol 160(2):322-33.


o'Mahony SM, Bulmer DC, Coelho AM, Fitzgerald P, Bongiovanni C, Lee K, Winchester W, Dinan TG, Cryan JF (2010). 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterol Motil 22(5):573-8.

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*Joint first author