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Department of Pharmacology




  • Dulloo, I, Atakpa-Adaji, P, Yeh, Y-C, Levet, C, Muliyil, S, Lu, F, Taylor, CW & Freeman, M (2022) iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat. Commun. 13, 1257. Commentary in Cell Calcium 104, 102593.
  • Chakraborty, P, Deb, BP, Taylor, CW & Hasan, G (2022) Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+.


  • Thillaiappan, NB, Smith HA, Atakpa-Adaji, P, & Taylor, CW (2021) KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals. Nat. Commun. 12, 4514. Commentary in Cell Calcium 100, 102470.
  • Shen, Y, Thillaiappan, NB & Taylor, CW (2021) The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel. Proc. Natl. Acad. Sci USA 118, e2010789118. Commentary in Cell Calcium 97, 102421. Faculty of 1000, ‘special significance’.
  • Rossi, AM, Riley, AM, Dupont, G, Rahman, T, Potter, BVL & Taylor, CW (2021) Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allow graded responses to IP3. Cell Rep. 37, 109932.
  • Tan, S-L, Barri, M, Atakpa-Adaji, P, Taylor, CW, Smith, ESJ & Murrell-Lagnado, RD (2021) P2X4 receptors mediate Ca2+ release from lysosomes in response to stimulation of P2X7 and H1 histamine receptors. Int. J. Mol. Sci. 22, 10492.
  • Bootman, M, Galione, A & Taylor C (2021) Professor Sir Michael Berridge FRS (1938-2020). Biochem. Biophys. Acta. 1868, 119014.


  • Shipton, ML, Riley, AM, Rossi, AM, Brearley, CA, Taylor CW & Potter, BVL (2020) Both D- and L-glucose polyphosphates mimic D-myo-inositol 1,4,5-trisphosphate: new synthetic agonists and partial agonists at the Ins(1,4,5)P3 receptor. J. Med. Chem. 63, 5442-5457.
  • Mills, SJ, Rossi, AM, Konieczny, V, Bakowski, D, Taylor, CW & Potter, BVL (2020) D-chiro-inositol ribophostin: a highly potent agonist of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and biological activities. J. Med. Chem. 63, 3238-3251.
  • Rossi, AM & Taylor, CW (2020) Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4. Cell Calcium. 87, 102188.
  • Sierla, M, Prole, DL, Saraiva, N, Carrara, G, Dinischiotu, N, Vaattovaara, A, Wrzaczek, M, Taylor, CW, Smith GA, Feys, B (2020) Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants. bioRxiv 859678.
  • Su, X, Dohle, W, Mills, SJ, Watt, JM, Rossi, AM, Taylor, CW & Potter, BVL (2020) Inositol adenophostin: convergent synthesis of a potent agonist of D-myo-inositol 1,4,5-trisphosphate receptors. ACS Omega. 5, 28793-28811.
  • Lagos-Cabre, R, Ivanova, A & Taylor CW (2020) Ca2+ release by IP3 receptors is required to orient the mitotic spindle. Cell Rep. 33, 108483.
  • Rossi, AM & Taylor CW (2020) Analyses of ligand binding to IP3 receptors by fluorescence polarization. Methods Mol. Biol. 2091, 107-120. Bootman, M, Galione, A & Taylor C (2020) Obituary: Professor Sir Michael Berridge FRS (1938-2020). Curr. Biol. 30, R374-R376.
  • Atakpa-Adaji, P, Thillaiappan, NB & Taylor, CW (2020) IP3 receptors and their intimate liaisons. Curr. Opin. Physiol. 17, 9-16.


  • Atakpa, P, van Marrewijk, L, Apta-Smith, M, Chakraborty, S & Taylor CW (2019) GPN does not release lysosomal Ca2+, but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C. J Cell Sci. 132, jcs223883 (Research Highlight: J. Cell Sci. 132, e0301; Featured in Cell Calcium 86, 102139).
  • Prole, DL & Taylor CW (2019) A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling. BMC Biol. 17, 41.
  • Dohle, W, Su, X, Mills, SJ, Rossi, AM, Taylor, CW & Potter BVL (2019) A synthetic cyclitol-ribose conjugate polyphosphate is a highly potent second messenger mimic. Chem. Sci. 10, 5382-5390.
  • Yu, F, Hubrack, SZ, Chakraborty, S, Sun, L, Adap, E, Kulkarni, R, Billing, AM, Graumann, J, Taylor, CW & Machaca, K (2019) Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis. Proc. Natl. Acad. Sci. USA. 116, 10392-10401.
  • Brailoiu, E, Chakraborty, S, Brailoiu, GC., Zhao, P, Ilies, M., Barr, JL, Unterwald, EM, Abood, ME & Taylor CW (2019) Choline is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors. Cell Rep. 26, 330-337.
  • Taylor, CW & Machaca, K (2019) IP3 receptors and store-operated Ca2+ entry: a license to fill. Curr. Opin. Cell. Biol. 57, 1-7.
  • Prole, DL & Taylor, CW (2019) Structure and function of IP3 receptors. Cold Spring Harb. Perspect. Biol. 11, a035063.


  • Dale, P, Head, V, Dowling, MR & Taylor, CW (2018) Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. Cell Calcium 71, 53-64.
  • Riley, AM, Unterlass, J, Konieczny, V, Taylor, CW, Helleday, T & Potter, BVL (2018) A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. MedChemComm. 9, 1105-1113 (cover image). Muller, MS, Fouyssac, M & Taylor CW (2018) Effective glucose uptake by human astrocytes requires its sequestration in the endoplasmic reticulum by glucose-6-phosphatase-β. Curr. Biol. 28, 3481-3486. (Featured in: Pellerin, L, Neurogenetics: astrocytes have a sweet spot for glucose. Curr. Biol. 28, R1258-R1260).
  • Atakpa, P, Thillaiappan, NB, Mataragka, S, Prole DL & Taylor, CW (2018) IP3 receptors preferentially associate with ER-lysosome contact sites and selectively deliver Ca2+ to lysosomes. Cell Rep. 25, 3180-3193. (Featured in: Cell Calcium 80, 194-196)
  • Mataragka, S & Taylor CW (2018) All three IP3 receptor subtypes generate Ca2+ puffs, the universal building blocks of IP3-evoked Ca2+ signals. J Cell Sci. 131, jcs220848.
  • Taylor, CW, Thillaiappan, NB & Prole, DL (2018) Immobile IP3 receptor clusters: building blocks for IP3-evoked Ca2+ signals. Messenger 6, 22-28.
  • Rossi, AM & Taylor, CW (2018) IP3 receptors – lessons from analyses ex cellula. J Cell Sci. 132, jcs222463.
  • Thillaiappan, NB, Chakraborty, P, Hasan, G & Taylor CW (2018) IP3 receptors and Ca2+ entry. Biochem. Biophys. Acta. 1866, 1092-1100.


  • Konieczny, V, Tovey, SC, Mataragka, S, Prole, DL & Taylor, CW (2017) Cyclic AMP recruits a discrete intracellular Ca2+ stores by unmasking hypersensitive IP3 receptors. Cell Rep. 18, 711-722.
  • Muller, M & Taylor CW (2017) ATP evokes Ca2+ signals in cultured foetal human cortical astrocytes entirely through G protein-coupled P2Y receptors. J. Neurochem. 142, 876-885.
  • Taylor, EJA, Pantazaka, E, Shelley, KL & Taylor CW. (2017) Prostaglandin E2 inhibits histamine-evoked Ca2+ release in human aortic smooth muscle cells through hyperactive cyclic AMP signaling junctions and protein kinase A. Mol. Pharm. 92, 533-545.
  • Keebler, MV & Taylor CW (2017) Endogenous signalling pathways and caged-IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites. J Cell Sci. 130, 3728-3739.
  • Thillaiappan, NB, Chavda, AP, Tovey, SC, Prole, DL & Taylor CW (2017) Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions where STIM evokes Ca2+ entry. Nat. Comm. 8, 1505. (F1000 Recommended by several faculty).
  • Taylor, CW (2017) Regulation of IP3 receptors by cyclic AMP. Cell Calcium 63, 48-52.


  • Srivats, S, Balasuriya, D, Pasche, M, Vistal, G, Edwardson, JM, Taylor, CW, & Murrell-Lagnado, R. (2016) Sigma 1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1. J. Cell Biol. 213, 65-79.
  • Konieczny, V, Stefanakis, JG, Sitsanidis, EX, Ioannidou, N-AT. Papadopoulos, NV, Fylaktakidou, KC, Taylor CW* & Koumbis, AE* (2016) Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors. Org. Biomol. Chem. 14, 2504-2514.
  • Chakraborty, S, Kumar, DB, Chorna, T, Konieczny, V, Taylor CW* & Hasan G* (2016) Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons. J. Cell Sci. 129, 3903-3910.
  • Kennedy, AJ, Yang, P, Read, C, Kuc, RE, Yang, L, Taylor, EJA, Taylor CW, Maguire, JJ & Davenport, AP (2016) Human chemerin receptors (CMKLR1) show biased agonism and cause vasoconstriction by inhibiting cAMP accumulation. J. Am. Heart Assoc. 5, e004421.
  • Vibhute, AM, Pushpanandan, P, Varghese, M, Konieczny, V, Taylor, CW & Sureshan, KM (2016) Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+ release through IP3 receptors. RSC Advances 6, 86346.
  • Konieczny, V, Tovey, SC, Mataragka, S, Prole, DL & Taylor, CW (2016) Cyclic AMP recruits a discrete intracellular Ca2+ store by unmasking hypersensitive IP3 receptors. In press.
  • Prole, DL & Taylor, CW (2016) Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs. J. Physiol. 594, 2849-2866.
  • Taylor, CW & Konieczny, V (2016) IP3 receptors: Take four to open. Sci. Signal. 9, pe1.
  • Taylor, CW (2017) Regulation of IP3 receptors by cyclic AMP. Cell Calcium In press.


  • Meena, A, Tovey, SC & Taylor, CW (2015) Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors via cAMP junctions. J. Cell Sci. 128, 408-420.
  • Carrara, G, Saraiva, N, Parsons, M, Byrne, B, Prole, DL*, Taylor, CW* & Smith GL* (2015) Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration. J. Biol. Chem. 290, 11785-11801.
  • Vibhute, AM, Konieczny, V, Taylor, CW & Sureshan, KM (2015). Triazolophostins: a library of novel and potent agonists of IP3 receptors. Org. Biomol. Chem. 13, 6657-6880.
  • Geyer, M, Huang, F, Sun, Y, Vogel, SM, Malik, AB, Taylor, CW & Komarova, YA. (2015) Microtubule-associated protein EB3 regulates IP3 receptor clustering and Ca2+ signaling in endothelial cells. Cell Rep. 12, 79-89.
  • Prole, DL, López-Sanjurjo, CI, Tovey, SC & Taylor CW (2015) Fluorescence methods for analysis of interactions between Ca2+ signalling, lysosomes and endoplasmic reticulum. Meth. Cell Biol. 126, 237-259.


  • Thurley, K, Tovey, SC, Moenke, G, Prince, VL, Meena, A, Thomas, AP, Skupin, A, Taylor, CW* & Falcke, M* (2014) Reliable encoding of extracellular stimuli within random sequences of Ca2+ spikes. Sci Signal. 7, ra59.
  • Saleem, H, Tovey, SC, Molinski, TF & Taylor, CW (2014) Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor. Br. J. Pharmacol. 171, 3298-3312
  • Wu, J, Prole, DL, Shen, Y, Lin, Z, Gnanasekaran, A, Liu, Y, Chen, L, Zhou, H, Wayne Chen, SR, Usachev, YM, Taylor, CW & Campbell, RE (2014) Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Biochem. J. 464, 13-22..
  • López Sanjurjo, CI, Tovey, SC & Taylor CW (2014) Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. PLoS One 9, e111275.
  • Taylor, CW, Tovey, SC, Rossi, AM, Lopez Sanjurjo, CI, Prole, DL & Rahman, T (2014) Structural organization of signalling to and from IP3 receptors. Biochem. Soc. Trans. 42, 63-70.


  • Sun, Y, Rossi, AM, Rahman, T & Taylor, CW (2013) Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif. Biochem. J. 449, 39-49.
  • Lopez Sanjurjo, CI, Tovey, SC, Prole, DL & Taylor CW (2013) Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum. J. Cell Sci. 126, 289-300.
  • Saraiva, N, Prole, DL, Carrara, G, Maluquer de Motes, C, Johnson, BF, Byrne, B, Taylor, CW & Smith, GL (2013) Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium. J. Biol. Chem. 288, 13057-13-67.
  • Tovey, SC & Taylor CW (2013) Cyclic AMP directs IP3-evoked Ca2+ signalling to different intracellular Ca2+ stores. J. Cell Sci. 126, 2305-2313.
  • Saleem, H, Tovey, SC, Rahman, T, Riley, AM, Potter, BVL & Taylor CW (2013) Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3. PLoS One 8, e54877.
  • Li, C, Enomoto, M, Rossi, AM, Seo, M-D, Rahman, T, Stathopulos, P, Taylor, CW*, Ikura, M* & Ames, JB* (2013) CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proc. Natl. Acad. Sci. USA. 110, 8507-8512.
  • Khan, SA, Rossi, AM, Riley, AM, Potter, BVL, & Taylor, CW (2013) Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain. Biochem. J. 451, 177-184.
  • Saleem, H, Tovey, SC, Riley, AM, Potter, BVL & Taylor CW (2013) Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues. PLoS One 8, e58027.
  • Chavda, AP, Prole, DL & Taylor CW (2013) A bead aggregation assay for detection of low-affinity protein-protein interactions reveals interactions between N-terminal domains of inositol 1,4,5-trisphosphate receptors. PLoS One 8, e60609.
  • Saraiva, N., Prole, DL, Carrara, G, Johnson, BF, Taylor, CW, Parsons, M & Smith, GL (2013) hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2. J.
  • Pantazaka, E, Taylor, EJA, Bernard, WG & Taylor CW (2013) Ca2+ signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 receptors in human aortic smooth muscle. Br. J. Pharmacol. 169, 1624-1634.
  • Prole, DL & Taylor, CW (2013) Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa. PLoS One 8, e66068.
  • Taylor, CW, Tovey, SC & Rossi, AM (2013) High-throughput analyses of IP3 receptor behavior. Cold Spring Harbor Protocols. Calcium Techniques. A Laboratory Manual (eds Parys, JB, Bootman, MD, Yule, DI & Bultynck, G), CSH laboratory Press, pp 914-917.
  • Rossi, AM & Taylor, CW (2013) High-throughput fluorescence polarization assay of ligand binding to IP3 receptors. Cold Spring Harbor Protocols. Calcium Techniques. A Laboratory Manual (eds Parys, JB, Bootman, MD, Yule, DI & Bultynck, G), CSH laboratory Press, pp 938-946.
  • Tovey, SC & Taylor, CW (2013) High-throughput functional assays of IP3-evoked Ca2+ release. Cold Spring Harbor Protocols. Calcium Techniques. A Laboratory Manual (eds Parys, JB, Bootman, MD, Yule, DI & Bultynck, G), CSH laboratory Press, pp 930-937.
  • Taylor, CW (2013) Inositol trisphosphate (IP3) receptors. Encyclopedia of Signaling Molecules (ed. S Choi). 10, 972-979.


  • Seo, M-D, Velamakanni, S, Ishiyama, N, Stathopulos, PB, Rossi, AM, Khan, SA, Dale, P, Li, C, Ames, JB, Ikura, M & Taylor, CW (2012) Structural and functional conservation of key domains in InsP3 and ryanodine receptors. Nature 483, 108-112. PMCID 22286060. Commentary in Science Signaling (2012) 5, pe24.
  • Govindan, S & Taylor, CW (2012) P2Y receptors subtypes evoke different Ca2+ signals in cultured aortic smooth muscle cells. Purinergic Signal. 8, 763-777. PMCID 22767215
  • Sureshan, KA, Riley, AM, Tovey, SC, Taylor, CW & Potter, BVL (2012) Contribution of phosphates  and adenine to the potency of adenophostins at the IP3 receptor: synthesis of all possible bisphosphates of adenophostin A. J. Med. Chem. 55, 1706-1720. PMCID 22248345.
  • Prole, DL & Taylor CW (2012) Identification and analysis of cation channel homologues in human pathogenic fungi. PLoS One 7, e42404. PMCID 22767215.
  • Taylor, CW & Tovey, SC (2012) From parathyroid hormone to cytosolic Ca2+ signals. Biochem. Soc. Trans. 40, 147-152. PMCID 22260681.
  • Konieczny, V, Keebler, MV & Taylor, CW (2012) Spatial organization of intracellular Ca2+ signals. Semin. Cell Dev. Biol. 23, 172-180. PMCID 21925615.
  • Taylor, CW and Prole DL (2012) Ca2+ signalling by IP3 receptors. Subcell. Biochem. 59, 1-34. PMCID 22260681.
  • Taylor, CW & Dale, P (2012) Intracellular Ca2+ channels - a growing community. Mol. Cell Endocrinol. 353, 21-28. PMCID 21889573.
  • Rossi, AM, Tovey, SC, Rahman, T, Prole, DL & Taylor CW (2012) Analysis of IP3 receptors in and out of cells. Biochim. Biophys. Acta. 1820, 1214-1227. PMCID 22033379.


  • Hooper, R, Churamani, D, Brailoiu, E, Taylor, CW & Patel, S (2011) Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J. Biol. Chem. 286, 9141-9149. PMCID 21173144
  • Rossi, AM & Taylor, CW (2011) Analysis of protein-ligand interactions by fluorescence polarization. Nature Protocols. 6, 365-387. PMCID 21372817
  • Pantazaka, E and Taylor, CW (2011) Differential distribution, clustering and lateral diffusion of subtypes of inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 286, 23378-23387. PMCID 21550988
  • Prole, DP & Taylor, CW (2011) Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites. PLoS One. 6, e26218. PMCID 22022573
  • Rahman, T-U, Skupin, A, Falcke, M & Taylor CW (2011) InsP3R channel gating altered by clustering? Rahman et al. Reply. Nature 478, E2-E3.
  • Thurley, K, Smith, I, Tovey, SC, Taylor, CW, Parker, I & Falcke, M (2011) Timescales of IP3-evoked Ca2+ spikes emerge from Ca2+ puffs only at the cellular level. Biophys. J. 101, 2638-2644. PMCID 22261051.
  • Patel, S, Ramakrishnan, L, Rahman, T, Hamdoun, A, Marchant, JS, Taylor, CW & Brailoiu, E (2011) The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: role of the two-pore channels. Cell Calcium 50, 157-167. PMCID 3160778.


  • Pantazaka, E & Taylor, CW (2010) Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain. Biochem. J. 425, 61-69. PMCID 19845505.
  • Rossi, AM. Sureshan, KM, Riley, AM, Potter, BVL & Taylor CW (2010) Selective determinants of IP3 and adenophostin A interactions with IP3 receptors. Br. J. Pharmacol. 161, 1070-1085. PMCID 20977457.
  • Tovey, SC, Dedos, SG, Rahman, T, Taylor, EJA, Pantazaka, E & Taylor CW (2010) Regulation of inositol 1,4,5-trisphosphate receptors by cyclic AMP independent of cyclic AMP-dependent protein kinase. J. Biol. Chem. 285, 12979-12989. PMCID 20189985.
  • Govindan, S, Taylor EJA & Taylor CW (2010) Ca2+ signalling by P2Y receptors in cultured rat aortic smooth muscle cells. Br. J. Pharmacol. 160, 1953-1962. PMCID 20649593.
  • Ding, Z, Rossi, AM, Riley, AM, Rahman, T, Potter, BVL & Taylor CW (2010) Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand. Mol. Pharmacol. 77, 995-1004. PMCID 20215561.
  • Brailoiu, E, Rahman, T, Churamani, D, Prole, DL, Brailoiu, GC, Hooper, R, Taylor, CW & Patel, S (2010) An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. J. Biol. Chem. 285, 38511-38516. PMCID 20880839.
  • Wolfram, F, Morris, E & Taylor, CW (2010) Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor. Biochem. J. 428, 483-489. PMCID 20377523.
  • Rossi, AM, Riley, AM, Potter, BVL & Taylor, CW (2010) Adenophostins: high-affinity agonists of IP3 receptors. Curr. Top. Membr. 66, 209-233. PMCID 22353482.
  • Taylor, CW & Tovey, SC (2010) IP3 receptors: towards understanding their activation. Cold Spring Harb. Perspect. Biol. 2, 004010. PMCID 20980441.
  • Rahman, T & Taylor, CW (2010) Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors. pp199-224 in Methods in Cell Biology (Ed. M Whittaker).


  • Sureshan, KA, Riley, AM, Rossi, AM, Tovey, SC, Dedos, SG, Taylor, CW & Potter BVL (2009) Activation of IP3 receptors by synthetic bisphosphate ligands. Chem. Commun. 1204-1206. PMCID 19240874.
  • Rosker, C, Meur, GM, Taylor, EJA & Taylor, CW (2009) Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic β-cells. J. Biol. Chem. 284, 5186-5194. PMCID 19115207. Extended commentary in Islets, 1, 82-84.
  • Rossi, AM, Riley, AM, Tovey, SC, Rahman, T, Dellis, O, Taylor, EJA, Veresov, VG, Potter, BVL & Taylor CW (2009) Synthetic partial agonists reveal keys steps in IP3 receptor activation. Nat. Chem. Biol. 5, 631-639. PMCID 10668195.
  • Rahman, T-U, Skupin, A, Falcke, M & Taylor CW (2009) Clustering of IP3 receptors by IP3 retunes their regulation by IP3 and Ca2+. Nature. 458, 655-659. PMCID 19348050. Featured article in Nature Signaling Gateway (March 2009); research highlight in Nature Reviews: Molecular Cell Biology 10, 238; BBSRC press release, Scientists eavesdrop on the exciting conversations within cells (
  • Rahman, T & Taylor, CW (2009) Dynamic regulation of IP3 receptor clustering and activity by IP3. Channels 3, 1-7. PMCID 19617706.
  • Taylor CW & Ding Z (2009) IP3 receptors. Handbook of Cellular Signalling (Eds R Bradshaw & E Dennis), pp919-923.
  • Taylor, CW, Rahman, T-U & Pantazaka, E (2009) Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals. Chaos. 19, 037102-1-10. PMCID 19798811.
  • Taylor, CW, Rahman T-U, Tovey, S.C., Dedos, S.G., Taylor, E.J.A. & Velamakanni, S. (2009) IP3 receptors: some lessons from DT40 cells. Immunol. Rev. 231, 23-44. PMCID 19754888.
  • Taylor, CW, Prole, DP & Rahman, T (2009) Ca2+ channels on the move. Biochemistry. 48, 12062-12080. PMCID 19928968.


  • Skupin, A, Kettenmann, H, Winkler, U, Wartenberg, M, Sauer, H, Tovey, SC, Taylor, CW & Falcke, M (2008) How does intracellular Ca2+ oscillate: by chance or by the clock? Biophys. J. 94, 2404-2411. PMCID 18065468.
  • Dellis, O, Rossi, AM, Dedos, SG & Taylor CW (2008) Counting inositol trisphosphate receptors into the plasma membrane. J. Biol. Chem. 283, 751-755. PMCID 17999955.
  • Tovey, SC, Dedos, SG, Taylor, EJA, Church, JE & Taylor CW (2008) Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. J. Cell Biol. 183, 297-311. PMCID 18936250. Commentary in Science Signaling 1, ec368 (2008), and Editors' Choice in Science 322, 1026.
  • Sureshan, KA, Trusselle, M, Tovey, SC, Taylor, CW & Potter BVL (2008) 2-Position base-modified analogs of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling. J. Org. Chem. 73, 1682-1692. PMCID 18247493.
  • Sun, Y & Taylor, CW (2008) A calmodulin antagonist reveals a calmodulin-independent inter-domain interaction essential for activation of inositol 1,4,5-trisphosphate receptors. Biochem. J. 416, 243-253. PMCID18637794.
  • Taylor, CW & Rossi, AM (2008) IP3 receptors. Encyclopedia of Molecular Pharmacology, 2nd edition (Eds. S Offermanns & W Rosenthal) Springer. pp661-664


  • Meur, G, Parker, AKT, Gergely, F & Taylor, CW (2007) Targeting and retention of type 1 ryanodine receptors to the endoplasmic reticulum. J. Biol. Chem. 282, 23096-23103. PMCID 17526491.


  • Mochizuki, T, Kondo, Y, Abe, H, Taylor, CW, Potter, BVL, Matsuda, A & Shuto, S (2006) Design and synthesis of 5′-deoxy-5′-phenyladenophostin A, a highly potent IP3 receptor ligand. Org. Lett. 8, 1455-1458. PMCID 16562915.
  • Terauchi, M, Abe, H, Tovey, SC, Dedos, SG, Taylor, CW, Paul, M, Trusselle, M, Potter, BVL, Matsuda, A & Shuto, S (2006) A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of β-C-glucoside trisphosphates based on the conformational restriction strategy. J. Med. Chem. 49, 1900-1909. PMCID 16539376.
  • Suresham, KM, Trusselle, M, Tovey, SC, Taylor, CW & Potter, BVL (2006) Guanophostin: synthesis and evaluation of a high affinity agonist of the inositol trisphosphate receptor. Chem. Comm. 19, 2015-2017. Front cover. PMCID 16767260.
  • Woodcock, NA, Taylor, CW & Thornton, S (2006) Prostaglandin F increases the sensitivity of the contractile apparatus to Ca2+ in human myometrium. Am. J. Obs. Gyn. 195, 1404-1406. PMCID 16769023.
  • Dellis, O, Dedos, SG, Tovey, SC, Rahman, U-T, Dubel, SJ & Taylor CW (2006) Ca2+ entry through plasma membrane IP3 receptors. Science 313, 229-233. PMCID 16840702. Commentary in Science 313, 183-184.
  • Tovey, SC, Sun, Y & Taylor, CW (2006) Rapid functional assays of intracellular Ca2+ channels. Nat. Protoc.1, 259-263. PMCID 17406242.
  • Mochizuki, T, Kondo, Y, Abe, H, Tovey, SC, Dedos, SD, Taylor, CW, Paul, M, Potter, BVL, Matsuda, A & Shuto, S (2006) Synthesis of adenophostin A analogues conjugating an aromatic group at the 5′-position as potent IP3 receptor ligands. J. Med. Chem. 49, 5750-5758. PMCID 16970399.
  • Liu, Y & Taylor, CW (2006) Stimulation of arachidonic acid release by vasopressin in A7r5 vascular smooth muscle cells mediated by Ca2+-stimulated phospholipase A2. FEBS Lett. 580, 4114-4120. PMCID 16828086.
  • Dedos, SG, Tovey, SC & Taylor, CW (2006) Signalling from parathyroid hormone. Biochem. Soc. Trans. 34, 515-517. PMCID 16856848.
  • Taylor, CW (2006) Store-operated Ca2+ entry: a STIMulating stOrai. Trends Biochem. Sci. 31, 598-601. PMCID 17029812.
  • Taylor, CW & Dellis, O (2006) Plasma membrane IP3 receptors. Biochem. Soc. Trans. 34, 910-912. PMCID 17052225.


  • Terauchi, M, Yahiro,Y, Abe, H, Ichikawa, S., Tovey, SC, Dedos, SG, Taylor, CW, Potter, BVL, Matsuda, A & Shuto, S. (2005) Synthesis of 4,8-anhydro-D-glycero-D-ido-nonanitol 1,6,7-trisphosphate as a novel IP3 receptor ligand using a stereoselective radical cyclization reaction based on a conformational restriction strategy. Tetrahedron. 61, 3697-3707.
  • Laude, AJ, Tovey, SC, Dedos, SG, Potter, BVL, Lummis, SCR & Taylor, CW (2005) Rapid functional assays of recombinant IP3 receptors. Cell Calcium 38, 45-51. PMCID 15963563.
  • Borissow, CN, Black, SJ, Paul, M, Tovey, SC, Dedos, SG, Taylor, CW & Potter, BVL (2005) Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity. Org. Biomol. Chem. 3, 245-252. PMCID 15632966.
  • Dyer, JL, Liu, Y, Pino de la Huerga, I & Taylor, CW (2005) Long-lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release. J. Biol. Chem. 280, 8035-8044. PMCID 15632122.
  • Moneer, Z, Pino de la Huega, I, Taylor, EC, Broad, LM, Liu, Y, Tovey, SC, Staali, L & Taylor, CW (2005) Different phospholipase C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells. Biochem. J. 389, 821-829. PMCID 15918794.
  • Taylor, CW & Tovey, SC (2005) What’s in store for Ca2+ oscillations? J. Physiol. 562, 645. PMCID 15539392.


  • Woodcock, N, Taylor, CW & Thornton, S (2004) Effect of an oxytocin receptor antagonist and rho kinase inhibitor on the [Ca2+]i sensitivity of human myometrium. Am. J. Obs. Gynecol. 190, 222-228. PMCID 14749664.
  • Riley, AM, Laude, AJ, Taylor, CW & Potter, BVL. (2004) Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors. Bioconj. Chem. 15, 278-289. PMCID 15025523.
  • Parker, AKT, Gergely, F & Taylor CW (2004) Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains. J. Biol. Chem. 279, 23797-23805. PMCID 15033979.
  • Taylor, CW, da Fonseca, PCA & Morris EP (2004) IP3 receptors: the search for structure. Trends Biochem. Sci. 29, 210-219. PMCID 15082315.
  • Taylor, CW, Morris, E & da Fonseca, P (2004) IP3 receptors. In Encyclopedia of Biological Chemistry Vol. 2 (Ed. W Lennarz & M D Lane), pp478-481.
  • Taylor, CW & Moneer, Z (2004) Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells. Biol. Rev. 37, 6411-645. PMCID 15709692.
  • Rossi, AM & Taylor, CW (2004) Ca2+ regulation of inositol 1,4,5-trisphosphate receptors: can Ca2+ function without calmodulin? Mol. Pharmacol. 66, 199-203. PMCID 15266009.


  • Moneer, Z, Dyer, JA & Taylor, CW (2003) Nitric oxide coordinates the activities of the  capacitative and non-capacitative Ca2+ entry pathways by vasopressin. Biochem. J. 370, 439-448. PMCID 12459038.
  • Turvey, MR, Laude, AJ, Ives, OH, Seager, WH, Taylor, CW & Thorn, P (2003) Modulation of IP3-sensitive Ca2+ release by 2,3-butanedione monoxime. Pflüg. Archiv. 445, 614-621. PMCID 12634934.
  • daFonseca, PC, Morris, SA, Nerou, EP, Taylor, CW & Morris, EP (2003) Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single particle analysis. Proc. Natl. Acad. USA. 100, 3936-3941. PMCID 12651956.
  • Wagner, GK, Riley, AM, Rosenberg, HJ, Taylor, CW, Guse, AH and Potter, BVL (2003) Analogues of cyclic adenosine 5′-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction. Nucl. Acid. Res. Suppl. 3, 1-2. PMCID 14510350.
  • Rosenberg, HJ, Riley, AM, Laude, AJ, Taylor, CW & Potter BVL (2003) Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for adenophostin A-Ins(1,4,5)P3 receptor interaction. J. Med. Chem. 46, 4860-4871. PMCID 14584937.
  • Taylor, CW & Laude, AJ (2003) IP3 receptors and their regulation by calmodulin and Ca2+. Cell Calcium.35, 321-334. PMCID 12526803
  • Taylor, CW  (2003) IP3 receptors. In Handbook of Cellular Signalling. Volume 2 (Eds. R Bradshaw & E Dennis), Elsevier Science (USA) pp41-43.
  • Taylor, CW & Swatton, JE  (2003) Regulation of IP3 receptors by IP3 and Ca2+. In Understanding Calcium Dynamics. Experiments and Theory (Eds. M Falke & D Malchow), Springer-Verlag, Berlin, pp1-15.


  • Wissing, F, Nerou, EP & Taylor, CW (2002) A novel Ca2+-induced Ca2+ release mechanism mediated by neither inositol trisphosphate nor ryanodine receptors. Biochem. J. 361, 605-611. PMCID 11802790.
  • Moneer, Z & Taylor, CW (2002) Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation. Biochem. J. 362, 13-21. PMCID 11829735.
  • Kidd, JF, Pilkington, MF, Schell, MJ, Fogarty, KE, Skepper, JN, Taylor, CW & Thorn, P (2002) Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore. J. Biol. Chem. 277, 6504-6510. PMCID 11724773.
  • Swatton,  JE & Taylor, CW (2002) Fast biphasic regulation of type 3 inositol trisphosphate receptors by cytosolic calcium. J. Biol. Chem. 277, 17571-17579. PMCID 11875073.
  • Riley, AM, Morris, SA, Nerou, P, Correa, V, Potter, BVL & Taylor, CW (2002) Interactions of inositol 1,4,5-trisphosphate (IP3) receptors with synthetic poly(ethylene glycol)-linked dimers of IP3 suggest close spacing of the IP3-binding sites. J. Biol. Chem. 277, 40290-40295. PMCID 121834623.
  • Morris, SA, Nerou, EP, Riley, AM, Potter, BVL & Taylor, CW (2002) Determinants of adenophostin A binding to inositol trisphosphate receptors. Biochem. J. 367, 113-120. PMCID 12088506.
  • Tovey, SC, Goraya, TA & Taylor, CW (2003) Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP. Br. J. Pharmacol. 138, 81-90. PMCID 12522076.
  • Taylor CW (2002) Inositol trisphosphate (IP3) receptors. In Encyclopedia of Molecular Medicine (Ed. TE Creighton), John Wiley and Sons, New York. pp1758-1761.
  • Taylor, CW  (2002) Regulation of Ca2+ entry pathways by both limbs of the phosphoinositide pathway. (2002) In, Role of the Sarcoplasmic Reticulum in Smooth Muscle. Novartis Foundation Symposium 246, John Wiley and Sons, Chichester. pp91-107. PMCID 12164319.
  • Taylor, CW (2002) Controlling calcium entry. Cell 111, 767-769. PMCID 12526803.


  • Wang, Y, Chen, J, Wang, Y, Taylor, CW, Hirata, Y, Hagiwara, H, Mikoshiba, K, Toyo-oka, T, Omata, M & Sakaki, Y (2001) Crucial role of type 1, but not type 3, inositol 1,4,5-trisphosphate (IP3) receptors in IP3-induced Ca2+ release, capacitative Ca2+ entry, and proliferation of A7r5 vascular smooth muscle cells. Circ. Res. 88, 202-209. PMCID 11157673.
  • Nerou, EP, Riley, AM, Potter, BVL & Taylor, CW (2001) Selective recognition of inositol phosphates by subtypes of inositol trisphosphate receptor. Biochem. J. 355, 59-69. PMCID 11256949.
  • Correa, V, Riley, AM, Shuto, S, Horne, G, Nerou, P, Marwood, RD, Potter, BVL & Taylor, CW (2001) Structural determinants of adenophostin A activity at inositol trisphosphate receptors. Mol. Pharmacol. 59, 1206-1215. PMCID 11306705.
  • Riley, AM, Correa, V, Mahon, MF, Taylor, CW & Potter, BVL (2001) Bicyclic analogs of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity. J. Med. Chem. 44, 2108-2117. PMCID 11405648.
  • Rosenberg, HJ, Riley, AM, Marwood, R, Correa, V, Taylor, CW & Potter, BVL (2001) Xylopyranoside-based mimics of D-myo-inositol-trisphosphate: synthesis and effect of stereochemistry on biological activity. Carbohydr. Res. 332, 53-66. PMCID 1140388.
  • Swatton, JE, Morris, SA & Taylor, CW (2001) Functional properties of Drosophila IP3 receptors. Biochem. J. 359, 435-441. PMCID 11583592.
  • Taylor, CW (2001) Calcium. In The Oxford Companion to the Body (Ed. C Blakemore) Oxford University Press. pp123-124.
  • Taylor, CW (2001) Cell Signalling. In The Oxford Companion to the Body (Ed. C Blakemore) Oxford University Press. pp135-136.
  • Taylor, CW (2001) InsP3/ryanodine receptors In The Sigma-RBI Handbook of Receptor Classification and Signal Transduction, Fourth Edition. (Ed.  K Watling). pp 166-167.
  • Taylor, CW & Thorn, P (2001) Calcium signalling: IP3 rises again…and again. Curr. Biol. 11, R352-R355. PMCID 11369246.
  • Taylor, CW (2001) Review: A new generation of Ca2+ indicators with greatly improved fluorescence properties. The Biochemist. June 2001, p68.


  • Marwood, RD, Correa, V, Taylor, CW & Potter, BVL (2000) Synthesis of adenophostin A. Tetrahed. Asym. 11, 397-403.
  • Short, AD & Taylor, CW (2000) Parathyroid hormone controls the size of the intracellular Ca2+ stores available to receptors linked to inositol trisphosphate formation. J. Biol. Chem. 275, 1807-1813. PMCID 10636879.
  • Adkins, CE, Morris, SA, De Smedt, H, Sienaert, I, Török, K, & Taylor, CW (2000) Ca2+-calmodulin inhibits Ca2+ release mediated by types 1, 2 and 3 inositol trisphosphate receptors. Biochem. J. 345, 357-363. PMCID 10620513.
  • Rosenberg, HJ, Riley, AM, Correa, V, Taylor, CW & Potter, BVL (2000) C-Glycoside based mimics of D-myo-inositol-1,4,5-trisphosphate. Carbohydr. Res. 329, 7-16. PMCID 11086681.
  • De Kort, M, Correa, V, Valentijn, ARPM, Potter, BVL, Taylor, CW & van Boom, JH (2000) Synthesis of potent agonists of the D-myo-inositol 1,4,5-trisphosphate receptor based on clustered disaccharide polyphosphate analogs of adenophostin A. J. Med. Chem. 43, 3295-3303. PMCID 10966748.
  • Short, AD, Winston, GP & Taylor, CW (2000) Different receptors use inositol trisphosphate to mobilize Ca2+ from different intracellular pools. Biochem. J. 351, 683-686. PMCID 1221408.
  • Adkins, CE, Wissing, F, Potter, BVL & Taylor, CW (2000) Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A. Biochem. J. 352, 929-933. PMCID 11104705.
  • Tasker, PN, Taylor, CW & Nixon, GF (2000) Changes in expression and distribution of inositol 1,4,5-trisphosphate receptor subtypes following primary culture of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 273, 907-912. PMCID 10891346.
  • Marwood, RD, Jenkins, DJ, Correa, V, Taylor, CW & Potter, BVL (2000) Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy. J. Med. Chem. 43, 4278-4287. PMCID 11063623.


  • Beecroft, MD, Marchant, JS, Riley, AM, Van Straten, NCR, Van der Marel, GA, Van Boom, JH, Potter, BVL & Taylor, CW (1999) Acyclophostin: A ribose-modified analog of adenophostin A with high affinity for inositol 1,4,5-trisphosphate receptors and pH-dependent efficacy. Mol. Pharmacol. 55, 109-117. PMCID 9882704.
  • McKillen, K, Thornton, S & Taylor, CW (1999) Oxytocin selectively increases the [Ca2+]i sensitivity of myometrium during the falling phase of phasic contractions. Am. J. Physiol. 276, E345-E351. PMCID 9950795.
  • Broad, LM, Cannon, TR & Taylor, CW (1999) A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin. J. Physiol. 517, 121-134. PMCID 10226154. Commentary by SR Bolsover, R Ashworth & F Archer, Activator of calcium influx proves a slippery customer J. Physiol. 517, 2.
  • McNulty, TJ & Taylor, CW (1999) A plasma membrane receptor for heavy metal ions stimulates Ca2+ mobilization in hepatocytes. Biochem. J. 339, 555-561. PMCID 10215593.
  • Morris, SA, Correa, V, Cardy, TJA, O’Beirne, G & Taylor CW (1999) Interactions between inositol trisphosphate receptors and fluorescent Ca2+ indicators. Cell Calcium 25, 137-142. PMCID 10326680.
  • Marwood, RD, Riley, AM, Correa, V, Taylor, CW & Potter, BVL (1999) Simplification of adenophostin A defines a minimal s structure for potent glucopyraonoside-based mimics of D-myo-inositol 1,4,5-trisphosphate. Bioorg. Med. Chem. Lett. 9, 453-458. PMCID 10091701.
  • Snitsarev, VA & Taylor, CW (1999) Overshooting cytosolic Ca2+ signals evoked by capacitative Ca2+ entry result from delayed stimulation of a plasma membrane Ca2+ pump. Cell Calcium. 25, 409-417. PMCID 10579052.
  • Broad, LM, Cannon, TR, Short, AD & Taylor, CW (1999) Receptors linked to polyphosphoinositide hydrolysis stimulate Ca2+ extrusion by a phospholipase C-independent mechanism. Biochem. J. 342, 199-206. PMCID 10432317.
  • Felemez, M, Schlewer, G, Jenkins, DJ, Correa, V, Taylor, CW, Potter, BVL & Spiess, B. (1999) Inframolecular studies of the protonation of 1D-1,2,3/3,5-cyclopentanepentaol 1,3,4-trisphosphate, a ring contacted analogue of 1D-myo-inositol 1,4,5-trisphosphate. Carbohydr. Res. 322, 95-101.
  • Swatton, JE, Morris, SA, Cardy, TJA & Taylor, CW (1999) Type 3 inositol trisphosphate receptors in RINm5F cells are biphasically regulated by cytosolic Ca2+ and mediate quantal Ca2+ mobilization. Biochem. J. 344, 55-60. PMCID 10548533.
  • Adkins, CE & Taylor, CW (1999) Lateral inhibition of inositol trisphophate receptors by cytosolic calcium. Curr. Biol. 9, 1115-1118. PMCID 10531009. Commentary by Bootman, MD & Lipp, P, Calcium Signalling: Ringing changes to the 'bell-shaped curve' Curr. Biol. 9, R876-R878.
  • Taylor, CW & Marchant, JS (1999) Measuring inositol 1,4,5-trisphosphate-evoked 45Ca2+ release from intracellular stores. In Signal Transduction: A Practical Approach. IRL Press, Oxford. pp361-384.
  • Taylor CW (1999) Measuring Ca2+ fluxes in permeabilized cells. In Calcium Signaling (Ed. J W Putney), CRC Press, Boca Raton, USA. pp111-130.
  • Taylor, CW, Genazzani, AA & Morris, SA (1999) Expression of inositol trisphosphate receptors. Cell Calcium. 26, 237-251.


  • Ukhanov, K, Ukhanova, M, Taylor, CW & Payne, R (1998) Putative inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in Limulus photoreceptors. Neuroscience 86, 23-28. PMCID 9692740.
  • Marchant, JS & Taylor, CW (1998) Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate. Biochemistry 37, 11524-11533. PMCID 9708988.
  • Cardy, TJA & Taylor, CW (1998) A novel role for calmodulin: Ca2+-independent inhibition of type 1 inositol trisphosphate receptors. Biochem. J. 334, 447-455. PMCID 9716504.
  • Beecroft, MD & Taylor, CW (1998) Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes. Biochem. J. 334, 431-435. PMCID 9716502.
  • Taylor CW & Broad, L (1998) Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls. Trends Pharmacol. Sci. 19, 370-375. PMCID 9786025.
  • Taylor CW (1998) Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+ channels. Biochem. Biophys. Acta. 1426, 19-33. PMCID 9838027.
  • Taylor, CW (1998) Intracellular Ca2+ channels. In The RBI Handbook of Receptor Classification and Signal Transduction. Third edition, edited by K Watling. pp142-143.


  • Madge, L, Marshall, ICB & Taylor, CW (1997) Delayed autoregulation of the Ca2+ signals resulting from Ca2+ entry in bovine pulmonary artery endothelial cells. J. Physiol. 498, 351-369. PMCID 9032684.
  • Marchant, JS, Chang, Y-T, Chung, S-K, Irvine, RF & Taylor, CW (1997) Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors. Biochem. J. 321, 573-576. PMCID 9032438.
  • Beecroft, MD & Taylor, CW (1997) Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to depend on their desensitization or regulation by luminal or cytosolic Ca2+. Biochem. J. 326, 215-220. PMCID 9337871.
  • Marchant, JS & Taylor, CW (1997) Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity. Curr. Biol. 7, 510-518. PMCID 9210378. Commentary by AP Dawson, How do IP3 receptors work? Curr. Biol. 7, R544-R547.
  • Patel, S, Morris, SA, Adkins, CE, O’Beirne, G & Taylor, CW (1997) Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: redistribution of calmodulin as a possible means of regulating Ca2+ mobilization. Proc. Natl. Acad. Sci. USA 94, 11627-11632. PMCID 0326661.
  • Marchant, JS, Beecroft, MD, Riley, AM, Jenkins, JJ, Marwood, RD, Taylor, CW & Potter, BVL (1997) Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors. Biochemistry 36, 12780-12790. PMCID 9335535.
  • Cardy, TJA, Traynor, D & Taylor, CW (1997) Differential regulation of types 1 and 3 inositol trisphosphate receptors by cytosolic Ca2+. Biochem. J. 328, 785-793. PMCID 9396721.
  • Taylor, CW (1997) Inositol 1,4,5-trisphosphate receptors. In Principles of Medical Biology, volume 8A (Eds FE Bittar & N Bittar), JAI Press Inc., Greenwich, CT, pp161-172.


  • Combettes, L, Cheek, TR & Taylor, CW (1996) Regulation of inositol trisphosphate receptors by luminal Ca2+ contributes to quantal Ca2+ mobilisation. EMBO. J. 15, 2086-2093. PMCID 8641274.
  • Broad, L, Powis, DA & Taylor, CW (1996) Differentiation of BC3H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway. Biochem. J. 316, 759-764. PMCID 8670149.
  • Patel, S, Harris, A, O’Beirne, G, Cook, ND & Taylor, CW (1996) Kinetic analysis of inositol trisphosphate binding to pure inositol trisphosphate receptors using scintillation proximity assay. Biochem. Biophys. Res. Commun. 221, 821-825. PMCID 8630045.
  • Snitsarev, VA, McNulty, TJ & Taylor, CW (1996) Endogenous heavy metal ions perturb fura 2 measurements of both basal and hormone-evoked Ca2+ signals. Biophys. J. 71, 1048-1056. PMCID 8842241.
  • Hargreaves, AC, Gunthorpe, MJ, Taylor, CW & Lummis, SCR (1996) Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels. Mol. Pharmacol. 50, 1284-1294. PMCID 8913360.


  • Byron, KL & Taylor, CW (1995) Vasopressin stimulation of Ca2+ mobilization, two bivalent cation entry pathways and Ca2+ efflux in A7r5 rat smooth muscle cells. J. Physiol. 485, 455-468. PMCID 7666368.
  • Patel, S & Taylor, CW (1995) Quantal responses to inositol 1,4,5-trisphosphate are not a consequence of Ca2+ regulation of inositol 1,4,5-trisphosphate receptors. Biochem. J. 312, 789-794. PMCID 8554521.
  • Taylor, CW (1995) Intracellular Ca2+ channels. In The RBI Handbook of Receptor Classification, edited by JW Kebabian, JL Neumeyer and K Watling, pp 28-29.
  • Taylor, CW & Traynor, D (1995) Calcium and inositol trisphosphate receptors. J. Membr. Biol. 145, 109-118. PMCID 7563013.
  • Taylor, CW (1995) Why do hormones stimulate Ca2+ mobilization? Biochem. Soc. Trans. 23, 637-642. PMCID 8566433.


  • Dasso, LLT & Taylor, CW (1994) Interactions between Ca2+-mobilizing receptors and their G proteins in hepatocytes. J. Biol. Chem. 269, 8647-8652. PMCID 8132593.
  • Marshall, ICB & Taylor CW (1994) Two calcium-binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformational states. Biochem. J. 301, 591-598. PMCID 8043006.
  • Hargreaves, AC, Lummis, SCR & Taylor, CW (1994) Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors. Mol. Pharmacol. 46, 1120-1128. PMCID 7808432.
  • Taylor, CW (1994) Intracellular calcium signals in hepatocytes. In The Liver: Biology and Pathobiology, third edition. (Eds. IM Arias, WB Jacoby, J Boyer, N Fausto, D Shafritz, & D Schacter). Raven Press. Chapter 49, pp 943-950.
  • Taylor, C.W. (1994) Calcium sparks a wave of excitement. Trends Pharmacol. Sci. 15, 271-274. PMCID 7940992.


  • McNulty, TJ & Taylor, CW (1993) Caffeine-stimulated Ca2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors. Biochem. J. 291, 799-801. PMCID 7583876.
  • Byron, KL & Taylor, CW (1993) Spontaneous Ca2+ spiking in a vascular smooth muscle cell line is independent of intracellular Ca2+ stores. J. Biol. Chem. 268, 6945-6952. PMCID 8463226.
  • Richardson, A & Taylor, CW (1993) Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization. J. Biol. Chem. 268, 11528-11533. PMCID 8389355.
  • Marshall, ICB & Taylor, CW (1993) Biphasic effects of cytosolic Ca2+ on Ins(1,4,5)P3-stimulated Ca2+ mobilization in hepatocytes. J. Biol. Chem. 268, 13214-13220. PMCID 8514760.
  • Oldershaw, KA & Taylor, CW (1993) Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor. Biochem. J. 292, 631-633. PMCID 8391254.
  • Jenkins, AL, Bootman, MD, Taylor, CW, Mackie, EJ & Stone, SR (1993) Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells. J. Biol. Chem. 268, 21433-21437. PMCID 8407986.
  • Taylor CW & Lummis, SCR (1993) An Introduction to Receptors. In Receptor Autoradiography: Principles and Practice. (Eds. J Wharton & JM Polak), Oxford University Press, pp 1-12.
  • Taylor, CW & Richardson, A (1993) Structure and function of inositol 1,4,5-trisphosphate receptors. In The International Encyclopedia of Pharmacology and Therapeutics. Intracellular Messengers (Ed. CW Taylor) Pergamon Press Inc., Oxford. pp199-254.
  • Marshall, ICB & Taylor, CW (1993) Regulation of inositol 1,4,5-trisphosphate receptors. J. exp. Biol. 184, 161-182. PMCID 8270854.
  • Taylor, CW (editor) (1993) The International Encyclopedia of Pharmacology and Therapeutics. Intracellular Messengers. Pergamon Press Inc., Oxford. pp491.


  • Bootman, MD, Berridge MJ & Taylor CW (1992) All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells. J. Physiol. 450, 163-178. PMCID 1432707.
  • Nunn, DL & Taylor, CW (1992) Luminal Ca2+ increases the sensitivity of Ca2+ stores to inositol 1,4,5-trisphosphate. Mol. Pharmacol. 41, 115-119. PMCID 1310137.
  • Missiaen, L, Taylor, CW & Berridge, MJ (1992) Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate-sensitive stores in rat hepatocytes. J. Physiol. 455, 623-640. PMCID 1484365.
  • Missiaen, L, Taylor, CW & Berridge, MJ (1992) Pyrophosphatase-induced Ca2+ release is unrelated to the spontaneous release from inositol 1,4,5-trisphosphate sensitive Ca2+ stores. Biochem. J. 282, 306-308. PMCID 1311558.
  • Oldershaw, KA, Richardson, A & Taylor, CW (1992) Prolonged exposure to inositol 1,4,5-trisphosphate does not cause intrinsic desensitization of the intracellular Ca2+-mobilizing receptor. J. Biol. Chem. 267, 16312-16316. PMCID 1322898.
  • Dasso, LLT & Taylor, CW (1992) Different Ca2+-mobilizing receptors share the same G protein pool in hepatocytes. Mol. Pharmacol. 42, 453-457. PMCID 1357543.
  • Bootman, MD, Taylor, CW & Berridge, MJ (1992) The thiol reagent, thimerosal, evokes Ca2+-spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 267, 25113-25119. PMCID 1334081.
  • Taylor, CW (1992) Kinetics of inositol 1,4,5-trisphosphate-stimulated Ca2+ mobilization. Adv. Second Messenger Phosphoprotein Res. 26, 109-142. PMCID 1419356
  • Taylor, CW, Bond, J, Oldershaw, KA & Nunn DL (1992) Inositol trisphosphate receptors and intracellular calcium: experimental approaches. In Neuromethods. Intracellular Messengers (Eds. AR Boulton, GB Baker & CW Taylor). Humana Press Inc., Totawa, NJ. pp79-128.
  • Taylor, CW & Marshall, ICB (1992) Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. Trends Biochem. Sci. 17, 403-407. PMCID 1333657.
  • Boulton, AR, Baker, GB & Taylor CW (editors) (1992) Neuromethods, volume 20. Intracellular Messengers. Humana Press Inc., Totawa NJ. pp580


  • Oldershaw, KA, Nunn, DL & Taylor, CW  (1991) Quantal Ca2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes. Biochem. J. 278, 705-708. PMCID 1898359.
  • Missiaen, L, Taylor, CW & Berridge, MJ (1991) Spontaneous calcium release from inositol 1,4,5-trisphosphate-sensitive calcium stores. Nature 352, 241-244. PMCID 1857419.
  • Bond, JM & Taylor, CW (1991) Solubilization of rat liver inositol 1,4,5-trisphosphate receptor. Cell. Signall. 3, 607-612. PMCID 1664740.
  • Dasso, LTL & Taylor CW (1991) Heparin and other polyanions uncouple α1-adrenoceptors from their G proteins. Biochem. J. 280, 791-795. PMCID 1662487.
  • Taylor, CW (1991) Formation, actions, and metabolism of  inositol 1,4,5-trisphosphate.  In Neuroendocrine Research Methods (Ed B Greenstein) Harwood Academic Publishers, London. pp921-935.
  • Taylor, CW & Richardson, A (1991) Structure and function of inositol 1,4,5-trisphosphate receptors. Pharmac. Ther. 51, 97-137. PMCID 1663251.


  • Nunn, DL, Potter, BVL & Taylor, CW (1990) Molecular target size of inositol trisphosphate receptors in cerebellum and liver. Biochem. J. 265, 393-398. PMCID 2154187.
  • Taylor, CW & Potter, BVL (1990) The size of the inositol 1,4,5-trisphosphate-sensitive Ca2+ store depends on inositol trisphosphate concentration. Biochem. J. 266, 189-194. PMCID 2310372.
  • Nunn, DL & Taylor CW (1990) Liver inositol 1,4,5-trisphosphate-binding sites are the calcium-mobilizing receptors. Biochem. J. 270, 227-232. PMCID 2168702.
  • Oldershaw, KA & Taylor CW (1990) 2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores. FEBS Lett. 274, 214-216. PMCID 2253774.
  • Taylor, CW (1990) Growth factors and polyphosphoinositide metabolism. In Growth Factors, Differentiation Factors and Cytokines (Ed. A Habenicht). Springer-Verlag. pp384-394.
  • Lummis, SCR, Galione, A & Taylor, CW (1990) Transmembrane signalling in insects. Annu. Rev. Entomol. 35, 345-377.
  • Taylor, CW (1990) Receptor-regulated Ca2+ entry: secret pathway or secret messenger? Trends Pharmacol. Sci. 11, 269-271. PMCID 2167542
  • Taylor, CW (1990) The role of G proteins in transmembrane signalling. Biochem. J. 272, 1-13. Reprinted in Biochemical Journal: Reviews 1990 (Ed. PJ England & WH Evans), Portland Press Ltd., London. pp185-197. PMCID 2176077.


  • Taylor, CW, Berridge, MJ, Cooke, AM & Potter BVL (1989) Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium. Biochem. J. 259, 645-650. PMCID 2786414.
  • Taylor, CW & Potter, BVL (1989) Actions and metabolism of synthetic inositol phosphates. In Biochemical Approaches to Cellular Calcium (Eds. E Reid, GMW Cook, and JP Luzio). Royal Society of Chemistry, London. pp199-210.


  • Taylor, CW, Berridge, MJ, Brown, KD, Cooke, AM & Potter, BVL (1988) DL‑myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes. Biochem. Biophys. Res. Commun. 150, 626-632. PMCID 3342041.
  • Taylor, CW, Blakeley, DM, Corps, AN, Berridge, MJ & Brown, KD (1988) Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells. Biochem. J. 249, 917-920.PMCID 2833233.
  • Taylor, CW, Blakeley, DM & Brown, KD (1988) Guanine nucleotides stimulate hydrolysis of phosphatidylinositol and polyphosphoinositides in permeabilized Swiss 3T3 cells. FEBS Lett. 237, 163-167. PMCID 2844585.
  • Taylor, CW (1988) Phosphoinositide metabolism and control of cell proliferation. In Advanced Research in Animal Cell Technology (Ed. AOA Miller). NATO ASI Series, Springer-Verlag. pp187-200.
  • Taylor, CW (1988) Time and space - novel aspects of hormone action. Trends Pharmacol. Sci. 9, 43-45. PMCID 3245077
  • Berridge, MJ & Taylor, CW (1988) Inositol trisphosphate and calcium signaling. Cold Spring Harbor Symp. Quant. Biol. 53, 927-933. PMCID 326711.


  • Wilson, HA, Greenblatt, D, Taylor, CW, Putney, JW, Tsien, RY, Finkelman, FD & Chused, TM (1987) The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fcγ receptor. J. Immunol. 138, 1712-1718. PMCID 2950170
  • Taylor, CW (1987) Cell responses to phosphoinositide-hydrolysing receptors: some potential sites of modulation. In Cellular Processes underlying Desensitization and Adaptation to Signal Molecules (Eds. TM Konijn, PJM Van Haastert, H Van der Starre, H Van der Wel, MD Houslay) Springer-Verlag. pp177-195.
  • Taylor, CW & Putney, JW Jr. (1987) Phosphoinositides and calcium signalling. In Calcium and Cell Function Vol. 7 (Ed. WY Cheung)  Academic Press. pp1-38.
  • Taylor, CW (1987) Receptor regulation of calcium entry. Trends Pharmacol. Sci. 8, 79-80.


  • Merritt, JE, Taylor, CW, Rubin, RP & Putney, JW Jr. (1986) Evidence suggesting that a novel guanine nucleotide-dependent regulatory protein couples receptors to phospholipase C in exocrine pancreas. Biochem. J. 236, 337-343. PMCID 3019312.
  • Taylor, CW, Merritt, JE, Putney, JW Jr. & Rubin, RB (1986) Effects of calcium on phosphoinositide turnover in exocrine pancreas. Biochem. J. 238, 765-772. PMCID 3026361
  • Merritt, JE, Taylor, CW, Rubin, RP & Putney, JW Jr. (1986) Isomers of inositol trisphosphate in exocrine pancreas. Biochem. J. 238, 825-829. PMCID 3492200
  • Taylor, CW, Merritt, JE, Rubin, RP & Putney, JW Jr. (1986) A guanine nucleotide- regulatory protein couples substance P receptors to phospholipase C in rat parotid gland. Biochem. Biophys. Res. Commun. 136, 825-829. PMCID 3010971.
  • Taylor, CW (1986) Calcium regulation in insects. Adv. Insect Physiol. 19, 155‑186.
  • Taylor, CW & Merritt, JE (1986) Receptor coupling to polyphosphoinositide turnover: a parallel with the adenylate cyclase system. Trends Pharmacol. Sci. 7, 238-242.
  • Putney, JW Jr., Aub, DL, Taylor, CW & Merritt, JE (1986) Formation and biological action of inositol 1,4,5-trisphosphate. Fed. Proc. 45, 2634-2638. PMCID 3019783.
  • Taylor, CW & Putney, JW Jr. (1986) Receptor regulation of phosphoinositide and calcium metabolism. Proc. Western Pharmacol. Soc. 29, 307-309. PMCID 3020572
  • Taylor, CW (1986) Growth factors control a network of interacting messengers. Trends Pharmacol. Sci. 7, 467-471.


  • Taylor, CW (1985) Calcium absorption by the midgut of the blowfly, Calliphora vicina. J. exp. Biol. 114, 551-561.
  • Taylor, CW (1985) Calcium regulation by blowflies: absence of a role for midgut. Am. J. Physiol. 249, R204-R213. PMCID 4025578.
  • Taylor, CW & Putney, JW Jr. (1985) Size of the inositol trisphosphate-sensitive calcium pool in guinea-pig hepatocytes. Biochem. J. 232, 435-438. PMCID 3879172
  • Taylor, CW (1985) Calcium regulation in vertebrates: an overview. Comp. Biochem. Physiol. 82A, 249-255.


  • Taylor, CW (1984) Transcellular calcium transport by the midgut of the blowfly, Calliphora vicina. Cell Calcium 5, 377-390. PMCID 6435879
  • Taylor, CW (1984) Calcium distribution during egg development in Calliphora vicina. J. Insect Physiol. 30, 905-910.