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Dr Paul Miller

Dr Paul Miller

University Lecturer


Office Phone: +44 1233 361267 / Lab 334177

Keywords

  • Protein engineering, protein-protein interactions, GABAA receptors, Cys-loop receptors, pLGICs, nanobodies, X-ray crystallography, cryo-EM, electrophysiology

Key Publications

Heteromeric GABAA receptor structures in positively-modulated active states. Miller. PS, Masiulis. S, Malinauskas T, Kotecha. A, Rao. S, Chavali. S, De Colibus. L, Pardon. E, Hannan. S, Scott. S, Sun. Z, Frenz. B, Klesse. G, Li. S, Diprose. DM, Siebert. AC, Esnouf. RM, DiMaio. F, Tucker. SJ, Smart. TG, Steyaert. J, Babu. MM, Sansom. MSP, Huiskonen. JT, Aricescu. AR. https://www.biorxiv.org/content/early/2018/06/05/338343

Structural basis for GABAA receptor potentiation by neurosteroids. Miller. PS, Scott. S, Masiulis. S, De Colibus. L, Pardon. E, Steyaert. J, Aricescu. AR. Nature Structure and Molecular Biology. 2017, 24(11), p. 986-992.

Structural basis of Smoothened regulation by its extracellular domains. Byrne. EFX, Sircar. R, Miller. PS, Hedger. G, Luchetti. G, Nachtergaele. S, Tully. MD, Mydock-McGrane. L, Covey. DF, Rambo. RP, Sansom. MSP, Newstead. S, Rohatgi. R, Siebold. C. Nature. 2016, 535, p. 517-522.

Crystal structure of a human GABAAR. Miller. PS, Aricescu. AR. Nature. 2014, 512, p. 270-275.

Cys-loop Receptors: Activation and Modulation. Miller. PS, Smart TG. Trends in Pharmacological Sciences. 2010, 31, 4, p.161.

Investigator Biography

Paul did his PhD and a postdoc with Professor Trevor G Smart at University College London, where he applied electrophysiological and pharmacological approaches to link structure and function for, principally, glycine receptors. Subsequently, from 2010, Paul attained a Wellcome Trust OXION postdoctoral fellowship, in the Division of Structural Biology at University of Oxford, where he played an important role in establishing methodologies for structural studies of membrane proteins within the department. Paul used these techniques to solve structures of GABAARs and, through collaboration, was involved in raising immunological modulators against GABAARs with novel pharmacology and high selectivity. He joined the Department of Pharmacology, University of Cambridge as a lecturer in 2018.