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Department of Pharmacology

 

 

Key Publications and online material

Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors.

Vikram B. Kasaragod, Martin Mortensen, Steven W. Hardwick, Ayla A. Wahid, Valentina Dorovykh, Dimitri Y. Chirgadze, Trevor G. Smart, Paul S. Miller. Nature, 2022. (COMING SOON!)

Heteromeric GABAA receptor structures in positively-modulated active states.

Miller. PS, Masiulis. S, Malinauskas T, Kotecha. A, Rao. S, Chavali. S, De Colibus. L, Pardon. E, Hannan. S, Scott. S, Sun. Z, Frenz. B, Klesse. G, Li. S, Diprose. DM, Siebert. AC, Esnouf. RM, DiMaio. F, Tucker. SJ, Smart. TG, Steyaert. J, Babu. MM, Sansom. MSP, Huiskonen. JT, Aricescu. AR. Biorxiv, 2018. https://www.biorxiv.org/content/early/2018/06/05/338343

Structural basis for GABAA receptor potentiation by neurosteroids.

Miller. PS, Scott. S, Masiulis. S, De Colibus. L, Pardon. E, Steyaert. J, Aricescu. AR. Nature Structure and Molecular Biology. 2017, 24(11), p. 986-992.

Structural basis of Smoothened regulation by its extracellular domains.

Byrne. EFX, Sircar. R, Miller. PS, Hedger. G, Luchetti. G, Nachtergaele. S, Tully. MD, Mydock-McGrane. L, Covey. DF, Rambo. RP, Sansom. MSP, Newstead. S, Rohatgi. R, Siebold. C. Nature. 2016, 535, p. 517-522.

Crystal structure of a human GABAAR.

Miller. PS, Aricescu. AR. Nature. 2014, 512, p. 270-275.

Cys-loop Receptors: Activation and Modulation.

Miller. PS, Smart TG. Trends in Pharmacological Sciences. 2010, 31, 4, p.161.