Publications

Molecular arrangement and modulation of extrasynaptic αβδ GABAA receptors.

Nestorow, S. A., Chen, W.-N., Bertrand, D., Wahid, A. A., Wyatt, C. E., Mortensen, M., Clairfeuille, T., Reutlinger, M., Friz, G., Pardon, E., Steyaert, J., Ladds, G., Cecere, G., Smart, T. G., Hernandez, M.-C., Joedicke, L. & Miller, P. S.

Nature communications, 2026.

https://doi.org/10.1038/s41467-026-76879-5

Determining the molecular and physiological actions of subtype-selective nanobodies of GABA-A receptors.

Gonzalez-Prada, J. E., Liu, S., Shang, C., Chernoff, C. S., Bright, D. P., Mortensen, M., Jones, C. J., Nestorow, S. E., Kasaragod, V. B., Chen, W.-N., Hannan, S., Zhou, J., Dunn, A. W. E., Soltani, A., Turner, R. J., Duggan, N. M., Yuan, Y., Wahid, A. A., Hardwick, S. W., Scott, S., Chirgadze, D. Y., Pardon, E., Steyaert, J., Aricescu, A. R., Paulsen, O., Belin, D., Smart, T. G. & Miller, P. S.

Science Advances, 2026, Jul, 12(31). PMID: 42525743.

https://doi.org/10.1126/sciadv.aeg3548

Molecular mechanism of action of a blood brain barrier shuttle antibody.

Liu, S., King, O. E., Wahid, A. A., Shang, C., Pattison, L. A., Malinauskas, T., Santander, E. A., Nestorow, S. E., Chen, W.-N., Mavridou, V., Browne, J. I., Smith, E. S. J., Linley, J. E., Webster, C. & Miller, P. S. Preprint on Biorxiv (2026), https://doi.org/10.64898/2026.06.30.735565.

A robust platform for recombinant production of animal venom toxin modulators of ion channels.

Gonzalez-Prada, J.E., Haworth, A., Browne, J., Salvage, S.C., Secomandi, N., Rush, A., Ritoux, A., Dannawi, M., Lee, L., Mavridou, V., Dong, Y.Y., Smith, E.S., Jackson, A., Stevens, E. and Miller P.S.

Pre-print on bioRxiv (2025), doi 10.1101/2025.06.11.659050

https://www.biorxiv.org/content/10.1101/2025.06.11.659050v1.full

The molecular basis of drug selectivity for alpha5 subunit-containing GABAA receptors.

Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen W-N, Lucas X, Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez M-C, Miller PS.

Nature Structure and Molecular Biology, 2023, Dec, 30(12), p. 1936-1946. PMID: 37903907.

https://www.nature.com/articles/s41594-023-01133-1

HIGHLIGHTS:

1) Engineered GABA-A a5 receptor for drug design

2) Basis of a5 selectivity for b-carbolines, benzodiazepines and isoxazoles revealed

3) Ligands displacements oberved between isoxazole negative vs positive modulators

Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors.

Vikram B. Kasaragod, Martin Mortensen, Steven W. Hardwick, Ayla A. Wahid, Valentina Dorovykh, Dimitri Y. Chirgadze, Trevor G. Smart, Paul S. Miller.

Nature, 2022, Feb, 602(7897), p. 529-533. PMID: 35140402. https://www.nature.com/articles/s41586-022-04402-z

HIGHLIGHTS:

1) GABA-A receptor bound by alpha-Cobratoxin

2) Molecular mechanism of inhibition by zinc

3) Observation of a low efficacy GABA-bound conformation for an extrasynaptic receptor

Heteromeric GABAA receptor structures in positively-modulated active states.

Miller. PS, Masiulis. S, Malinauskas T, Kotecha. A, Rao. S, Chavali. S, De Colibus. L, Pardon. E, Hannan. S, Scott. S, Sun. Z, Frenz. B, Klesse. G, Li. S, Diprose. DM, Siebert. AC, Esnouf. RM, DiMaio. F, Tucker. SJ, Smart. TG, Steyaert. J, Babu. MM, Sansom. MSP, Huiskonen. JT, Aricescu. AR. Biorxiv, 2018. https://www.biorxiv.org/content/early/2018/06/05/338343

Structural basis for GABAA receptor potentiation by neurosteroids.

Miller. PS, Scott. S, Masiulis. S, De Colibus. L, Pardon. E, Steyaert. J, Aricescu. AR.

Nature Structure and Molecular Biology. 2017, 24(11), p. 986-992.

Structural basis of Smoothened regulation by its extracellular domains.

Byrne. EFX, Sircar. R, Miller. PS, Hedger. G, Luchetti. G, Nachtergaele. S, Tully. MD, Mydock-McGrane. L, Covey. DF, Rambo. RP, Sansom. MSP, Newstead. S, Rohatgi. R, Siebold. C.

Nature. 2016, 535, p. 517-522.

Crystal structure of a human GABAAR.

Miller. PS, Aricescu. AR.

Nature. 2014, 512, p. 270-275.

Cys-loop Receptors: Activation and Modulation.

Miller. PS, Smart TG.

Trends in Pharmacological Sciences. 2010, 31, 4, p.161.