Key Publications and online material
Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors.
Vikram B. Kasaragod, Martin Mortensen, Steven W. Hardwick, Ayla A. Wahid, Valentina Dorovykh, Dimitri Y. Chirgadze, Trevor G. Smart, Paul S. Miller. Nature, 2022. (COMING SOON!)
Heteromeric GABAA receptor structures in positively-modulated active states.
Miller. PS, Masiulis. S, Malinauskas T, Kotecha. A, Rao. S, Chavali. S, De Colibus. L, Pardon. E, Hannan. S, Scott. S, Sun. Z, Frenz. B, Klesse. G, Li. S, Diprose. DM, Siebert. AC, Esnouf. RM, DiMaio. F, Tucker. SJ, Smart. TG, Steyaert. J, Babu. MM, Sansom. MSP, Huiskonen. JT, Aricescu. AR. Biorxiv, 2018. https://www.biorxiv.org/content/early/2018/06/05/338343
Structural basis for GABAA receptor potentiation by neurosteroids.
Miller. PS, Scott. S, Masiulis. S, De Colibus. L, Pardon. E, Steyaert. J, Aricescu. AR. Nature Structure and Molecular Biology. 2017, 24(11), p. 986-992.
Structural basis of Smoothened regulation by its extracellular domains.
Byrne. EFX, Sircar. R, Miller. PS, Hedger. G, Luchetti. G, Nachtergaele. S, Tully. MD, Mydock-McGrane. L, Covey. DF, Rambo. RP, Sansom. MSP, Newstead. S, Rohatgi. R, Siebold. C. Nature. 2016, 535, p. 517-522.
Crystal structure of a human GABAAR.
Miller. PS, Aricescu. AR. Nature. 2014, 512, p. 270-275.
Cys-loop Receptors: Activation and Modulation.
Miller. PS, Smart TG. Trends in Pharmacological Sciences. 2010, 31, 4, p.161.