Publications

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Key Publications

1. Mazzaferro, S., Chen, H.J., Cahn, O., Yang, A., Shepilov, D., Chen, J., Alcaino, C., Macarelli, V., Mali, I., Gribble, F., Reimann, F., Marioni J, and Merkle FT^§. GLP1R Agonists Activate Human POMC Neurons. BioRxiv, April 2024, doi: 10.1101/2024.04.02.587825.
2. Chen H-J C, Yang A, Mazzaferro S, Mali I, Cahn O, Kentistou K, Rowley C, Stewart  N, Seah JWE,  Pisupati V, Kirwan P, Aggarwal S, Toyohara T, Mary H.C. Florido MHC, Cowan C, Quambusch L, Hyvönen  M,. Livesey MR, Perry JRB, Marioni JC, Merkle FT^§. Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss. BioRxiv. July 2023. doi:10.1101/2023.07.18.549357.
3. Harding EC, Chen H-J C , Schwiening A, Aggarwal S, Rowley C, Swinden D, Mallucci G, Merkle FT^§. Metformin may reduce dementia risk through neuroprotection not mitigation of diabetes. BioRxiv. July 2023. doi:10.1101/2023.07.18.549549.
4. Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, … Skarnes WC^§, Cookson MR^§, Ward ME^§, Merkle FT^§. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 Dec 1;29(12):1685-1702.e22. doi: 10.1016/j.stem.2022.11.004. PMID: 36459969; PMCID: PMC9782786.
5. Merkle FT^§, Ghosh S et al., Whole genome analysis of human embryonic stem cells enables rational line selection based on genetic variation. Cell Stem Cell 2022 Mar 3;29(3):472-486.e7. doi: 10.1016/j.stem.2022.01.011. Epub 2022 Feb 16. PMID: 35176222; PMCID: PMC8900618.
6. Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT^§. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Molecular Metabolism, 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. PMID: 30201275
7. Merkle FT, Ghosh S, Kamataki N, Mitchell J, Avior Y, Mello C, Kashin S, Mekhoubad S, Ilic D, Charlton M, Saphier G, Handsaker RE, Genovese G, Bar S, Benvenisty N, McCarroll S, Eggan K. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature, E-pub. 26 April 2017. DOI 10.1038/nature22312. PMC5427175.
8. Merkle FT, Mirzadeh Z, Alvarez-Buylla A. Mosaic organization of neural stem cells in the adult brain. Science. 2007 Jul 20;317(5836):381-4. PMID: 17615304. doi: 10.1126/science.1144914.

Lead and/or corresponding authorship is indicated with the symbol^§. Summary statistics from Google Scholar (September 2025): Citations: >10500, h-index 31, i10-index 36.

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