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Department of Pharmacology




  • RITTER M, SCHMIDT S, JAKAB M, PAULMICHL M, & HENDERSON R (2013). Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains. Cell Physiol Biochem 32, 46-52.
  • SUZUKI Y, GOETZE TA, STROEBEL D, BALASURIYA D, YOSHIMURA SH, HENDERSON RM, PAOLETTI P, TAKEYASU K, & EDWARDSON JM (2013). Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging. J Biol Chem 288, 778-784.


  • MELA I, KRANASTER R, HENDERSON RM, BALASUBRAMANIAN S, & EDWARDSON JM (2012). Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy. Biochemistry 51, 578-585.


  • SUZUKI Y, GILMORE JL, YOSHIMURA SH, HENDERSON RM, LYUBCHENKO YL, & TAKEYASU K (2011). Visual analysis of concerted cleavage by type IIF restriction enzyme SfiI in subsecond time region. Biophys J 101, 2992-2998.
  • DRYDEN DT, EDWARDSON JM, & HENDERSON RM (2011). DNA translocation by type III restriction enzymes: a comparison of current models of their operation derived from ensemble and single-molecule measurements. Nucleic Acids Res 39, 4525-4531.
  • BRASCH J, HARRISON OJ, AHLSEN G, CARNALLY SM, HENDERSON RM, HONIG B, & SHAPIRO L (2011). Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. J Mol Biol 408, 57-73.


  • TAKAHASHI H, SHAHIN V, HENDERSON RM, TAKEYASU K, & EDWARDSON JM (2010). Interaction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy. Biophys J 99, 2550-2558.
  • YOKOKAWA M, CARNALLY SM, HENDERSON RM, TAKEYASU K, & EDWARDSON JM (2010). Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification. FEBS Lett 584, 3107-3110.
  • CARNALLY SM, JOHANNESSEN M, HENDERSON RM, JACKSON MB, & EDWARDSON JM (2010). Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels. Biophys J 98, 1182-1191.


  • NEAVES KJ, HUPPERT JL, HENDERSON RM, & EDWARDSON JM (2009). Direct visualization of G-quadruplexes in DNA using atomic force microscopy. Nucleic Acids Res 37, 6269-6275.
  • NEAVES K.J., COOPER L.P., WHITE J.H., CARNALLY S.M., DRYDEN D.T.F., EDWARDSON J.M., & HENDERSON R.M. (2009). Atomic force microscopy of the EcoKI Type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping. Nucleic Acids Res 37, 2053-2063.


  • BARRERA N.P., BETTS J, YOU H., HENDERSON R.M., MARTIN I.L., DUNN S.M., & EDWARDSON J.M. (2008). Atomic force microscopy reveals the stoichiometry and subunit arrangement of the α4ß3δGABA(A) receptor. Mol Pharmacol 73, 960-967.
  • BARRERA N.P., HENDERSON R.M., & EDWARDSON J.M. (2008). Determination of the architecture of ionotropic receptors using AFM imaging. Pflügers Arch 456, 199-209.
  • CARNALLY S.M., DEV H.S., STEWART A.P., BARRERA N.P., VAN BEMMELEN M.X., SCHILD L., HENDERSON R.M., & EDWARDSON J.M. (2008). Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging. Biochem Biophys Res Commun 372, 752-755.
  • SHAHIN V., DATTA D., HUI E., HENDERSON R.M., CHAPMAN E.R., & EDWARDSON J.M. (2008). Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry 47, 2143-2152.


  • BARRERA NP, SHAIFTA Y, MCFADZEAN I, WARD JP, HENDERSON RM, & EDWARDSON JM (2007). AFM imaging reveals the tetrameric structure of the TRPC1 channel. Biochem Biophys Res Commun 358, 1086-1090.
  • BARRERA NP, HENDERSON RM, MURRELL-LAGNADO RD, & EDWARDSON JM (2007). The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Biophys J 93, 505-512.
  • CRAMPTON N, YOKOKAWA M, DRYDEN DT, EDWARDSON JM, RAO DN, TAKEYASU K, YOSHIMURA SH, & HENDERSON RM (2007). Fast-scan atomic force microscopy reveals that the type III restriction enzyme EcoP15I is capable of DNA translocation and looping. Proc Natl Acad Sci U S A 104, 12755-12760.
  • CRAMPTON N, ROES S, DRYDEN DT, RAO DN, EDWARDSON JM, & HENDERSON RM (2007). DNA looping and translocation provide an optimal cleavage mechanism for the type III restriction enzymes. EMBO J. 26, 3815-3825.
  • BENNETT AE, LIU J, VAN RD, BLISS D, ARTHOS J, HENDERSON RM, & SUBRAMANIAM S (2007). Cryo electron tomographic analysis of an HIV neutralizing protein and its complex with native viral gp120. J Biol Chem. 282, 27754-27759.


  • ORMOND SJ, BARRERA NP, QURESHI OS, HENDERSON RM, EDWARDSON JM, & MURRELL-LAGNADO RD (2006). An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum. Mol Pharmacol 69, 1692-1700.


  • TSENG YD, GE H, WANG X, EDWARDSON JM, WARING MJ, FITZGERALD WJ, & HENDERSON RM (2005). Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA. Journal of Molecular Biology 345, 745-758.=
  • BARRERA NP, ORMOND SJ, HENDERSON RM, MURRELL-LAGNADO RD, & EDWARDSON JM (2005). AFM imaging demonstrates that P2X2 receptors are trimers, but that P2X6 receptor subunits do not oligomerize. Journal of Biological Chemistry 280, 10759-10765


  • EDWARDSON, J. M. & HENDERSON, R. M. (2004). Atomic force microscopy and drug discovery. Drug Discovery Today 9, 64-71.
  • HENDERSON, R. M., EDWARDSON, J. M., GEISSE, N. A., & SASLOWSKY, D. E. (2004) Lipid rafts: Feeling is believing. News in Physiological Sciences 19, 39-43.
  • GEISSE, N. A., COVER, T. L. HENDERSON, R. M. & EDWARDSON, J. M. (2004) Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy. Biochemical Journal 381, 911-917.
  • GARAVAGLIA M, DOPINTO S, RITTER M, FURST J, SAINO S, GUIZZARDI F, JAKAB M, BAZZINI C, VEZZOLI V, DOSSENA S, RODIGHIERO S, SIRONI C, BOTTA G, MEYER G, HENDERSON R.M., & PAULMICHL M (2004). Membrane thickness changes ion-selectivity of channel-proteins. Cellular Physiology and Biochemistry 14, 231-240.
  • VIRSTEDT J, BERGE T, HENDERSON RM, WARING MJ, & TRAVERS AA (2004). The influence of DNA stiffness upon nucleosome formation.Journal of Structural Biology 148, 66-85.


  • LAWRENCE, J. C., SASLOWSKY, D. E., EDWARDSON, J. M., & HENDERSON, R. M. (2003) Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. Biophysical Journal 84, 1827-1832
  • BERGE, T., HAKEN, E. L., WARING, M. J., & HENDERSON, R. M. (2003) The binding mode of the DNA bis-intercalator luzopeptin investigated using atomic force microscopy. Journal of Structural Biology 142, 241-246
  • NEISH, C. S., MARTIN, I. L., DAVIES, M., HENDERSON, R. M. & EDWARDSON, J. M. (2003) Atomic force microscopy of ionotropic receptors bearing subunit-specific tags provides a method for determining receptor architecture. Nanotechnology 14, 864-872.
  • HENDERSON, R. M. (2003). Atomic force microscopy in renal physiology. Methods in Molecular Medicine 86, 139-153.
  • SASLOWSKY, D. E., LAWRENCE, J. C., HENDERSON, R. M., & EDWARDSON, J. M. (2003). Syntaxin is efficiently excluded from sphingomyelin-enriched domains in supported lipid bilayers containing cholesterol. Journal of Membrane Biology 194, 153-164.


  • WALKINSHAW, M. D., TAYLOR, P., STURROCK, S. S., ATANASIU, C., BERGE, T., HENDERSON, R. M., EDWARDSON, J. M., & DRYDEN, D. T. F. (2002). Structure of ocr from bacteriophage T7, a protein that mimics B-form DNA. Molecular Cell 9, 187-194.
  • NEISH, C. S., MARTIN, I. L., HENDERSON, R. M., & EDWARDSON, J. M. (2002). Direct visualization of ligand-protein interactions using atomic force microscopy. British Journal of Pharmacology 135, 1943-1950.
  • BERGE, T., JENKINS, N. S., HOPKIRK, R. B., WARING, M. J., EDWARDSON, J. M., & HENDERSON, R. M. (2002). Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy. Nucleic Acids Research 30, 2980-2986.
  • SASLOWSKY, D. E., LAWRENCE, J., REN, X., BROWN, D. A., HENDERSON, R. M., & EDWARDSON, J. M. (2002) Placental alkaline phosphatase is efficiently targeted to rafts in supported lipid bilayers. Journal of Biological Chemistry 277, 26966-26970
  • ELLIS, D. J., SHADAN, S., JAMES, P. S., HENDERSON, R. M., EDWARDSON, J. M., HUTCHINGS, A., & JONES, R. (2002) Post-testicular development of a novel membrane substructure within the equatorial segment of ram, bull, boar and goat spermatozoa as viewed by atomic force microscopy (AFM). Journal of Structural Biology 138, 187-198.
  • GEISSE, N. A., WASLE, B., SASLOWSKY, D. E., HENDERSON, R. M., & EDWARDSON, J. M. (2002) Syncollin homo-oligomers associate with lipid bilayers in the form of doughnut-shaped structures. Journal of Membrane Biology 189, 83-92


  • OBERLEITHNER, H., SCHILLERS, H., SCHNEIDER, S. W., & HENDERSON, R. M. (2001). Nanoarchitecture of plasma membrane visualized with atomic force microscopy. In Ion Channel Localization Methods and Protocols , eds. Lopatin, A. N. & Nichols, C. G., The Humana Press, Inc, Totowa, NJ.


  • AVERY, J., ELLIS, D. J., LANG, T., HOLROYD, P., RIEDEL, D., HENDERSON, R. M., EDWARDSON, J. M., & JAHN, R. (2000). A cell-free system for regulated exocytosis in PC12 cells. Journal of Cell Biology 48, 317-324.
  • HENDERSON, R. M. & OBERLEITHNER, H.(2000) Pushing, pulling, dragging and vibrating renal epithelia using atomic force microscopy. Am.J.Physiol. Renal Physiol. 278, F689-F701
  • BERGE, T., ELLIS, D.J., DRYDEN, D.T.F., EDWARDSON, J.M. & HENDERSON, R.M. (2000). Translocation-independent dimerization of the EcoKI endonuclease visualized by atomic force microscopy. Biophys.J. 79, 479-484.


  • ELLIS, D. J., BERGE, T., EDWARDSON, J. M. & HENDERSON, R. M. (1999). Investigation of protein partnerships using atomic force microscopy. Microscopy Research and Technique 44, 368-377.
  • ELLIS, D. J., DRYDEN, D. T. F., BERGE, T., EDWARDSON, J. M. & HENDERSON, R. M. (1999). Direct observation of DNA translocation and cleavage by the EcoKI endonuclease using atomic force microscopy. Nature Structural Biology 6, 15-17.
  • DRYDEN, D. T. F., DAVIES, G. D., POWELL, L. M., MURRAY, N. E., ELLIS, D. J., BERGE, T., EDWARDSON, J. M., & HENDERSON, R. M. (1999). The assembly of the EcoKI Type I DNA restriction/modification enzyme and its interaction with DNA. Biochemical Society Transactions 27, 691-696.


  • SCHNEIDER, S. W., LfRMER, J., HENDERSON, R. M. & OBERLEITHNER, H. (1998). Molecular weights of individual proteins correlate with molecular volumes measured by atomic force microscopy. Pfl?gers Archiv, European Journal of Physiology 435, 362-367.


  • HENDERSON, R. M. (1997). High resolution imaging of biological macromolecules using the atomic force microscope. Experimental Nephrology 5, 453-456.
  • OBERLEITHNER, H., GEIBEL, J., GUGGINO, W., HENDERSON, R. M., HUNTER, M., SCHNEIDER, S. W., SCHWAB, A. & WANG, W. (1997). Life on biomembranes viewed with the atomic force microscope. Wiener Klinische Wochenschrift 109, 419-423.
  • OBERLEITHNER, H., SCHNEIDER, S. W. & HENDERSON, R. M. (1997). Structural activity of a cloned potassium channel (ROMK1) monitored with the atomic force microscope: The "molecular-sandwich" technique. Proceedings of the National Academy of Sciences of the United States of America 94, 14144-14149.


  • HENDERSON, R. M., SCHNEIDER, S., LI, Q., HORNBY, D., WHITE, S. J. & OBERLEITHNER, H. (1996). Imaging ROMK1 inwardly-rectifying ATP-sensitive K+ channel using atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America 93, 8756-8760.
  • OBERLEITHNER, H., SCHNEIDER, S., LfRMER, J. & HENDERSON, R. M. (1996). Viewing the renal epithelium with the atomic force microscope. Kidney and Blood Pressure Research 19, 142-147.