Dr Matthew Harper – Group Leader
Fellow in Pharmacology Jesus College
E-Mail: mth29 [at] cam.ac.uk
Tel: +44 1223 34032
Keywords
Thrombosis, Platelets, Cellular signalling, Cell death, Calcium, Necrosis, Phosphatidylserine exposure, 3Rs, Microparticles
Investigator Biography
Lab members
Key publications
Riddle RB, Jennbacken K, Hansson KM, Harper MT. Multicellular vessel-on-a-chip reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis. Blood Vessels Thromb Haemost (in press)
Millington-Burgess SL, Harper MT (2022). Maintaining flippase activity in procoagulant platelets is a novel approach to reduce thrombin generation. J Thromb Haemost, In Press
An "occlusive thrombosis-on-a-chip" microfluidic device for investigating the effect of anti-thrombotic drugs. Lab Chip, 21, 4104-4117.
Abbasian N, Millington-Burgess SL, Chabra S, Malcor JD, Harper MT (2020). Supramaximal calcium signaling triggers procoagulant platelet formation. Blood Adv, 4, 154-164.
Millington-Burgess SL, Rahman T, Harper MT (2020). R5421 is not a selective inhibitor platelet scramblase activity. Br J Pharmacol, 117, 4007-4020.
Wei H, Malcor JM, Harper MT (2018). Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets. Sci Rep, 8, 9987.
If you are interested in our research, please contact Matthew. Prospective PhD students should consult the University's Postgraduate Admissions site, and in particular the postgraduate funding section. Post-doctoral research opportunities will be advertised by the Department and on the University Jobs page. Regretfully, the Harper lab is unable to provide any undergraduate summer placements in 2025.
Former lab members
Ms Clara Andiazabal (now PhD student, University of Cambridge)
Dr Jessica Berry
Dr Nima Abbasian (now Senior Scientist, Domainex)
Dr Bonita Apta (now Associate Principal Scientist, Lonza Biologics)
Ms Zoe Colucci (now PhD student, University of Cambridge)
Dr Jessica Davies (now Cambridge Graduate Medicine)
Mr Luc Francis (now King's College London)
Dr Roxanna Hajbabaie
Dr Ivelin Ivanov (now Department of Pathology, University of Cambridge)
Dr Dora Lopresto (now Director of Corporate Strategy and M&A, Grunenthal)
Dr Sarah Millington-Burgess (now Senior Teaching Associate, Department of Pharmacology)
Dr Rebecca Riddle (now Mestag Therapeutics)
Dr Alice Sowton (now MRC Mitochondrial Biology Unit, University of Cambridge)
Dr Hao Wei (now Associate Editor, Wiley)
Ms Leila Uddin
Undergraduate members
Grace Atkinson - Lottie Arnold - Jasmine Bawa - James Brice - Shirom Chabra - Navjot Flora - Lana Huang - Rebecca Gilchirst - Evonne Gaw - Celine Goh - Zhiyuan Lin - Wenxin Ma - Keiran Smith - Georgia Tooth - Raina Xing