Dr Matthew Harper – Group Leader
Fellow in Pharmacology Jesus College
E-Mail: mth29@cam.ac.uk
Tel: +44 1223 334032/334024
Fax: +44 1223 334100
Keywords
Thrombosis, Thrombocytopenia, Platelets, Cellular signalling, Cell death, Calcium, Apoptosis, Necrosis, Phosphatidylserine exposure, 3Rs, Microparticles
Investigator Biography
Lab members
Key publications
Millington-Burgess SL, Harper MT (2022). Maintaining flippase activity in procoagulant platelets is a novel approach to reduce thrombin generation. J Thromb Haemost, In Press
An "occlusive thrombosis-on-a-chip" microfluidic device for investigating the effect of anti-thrombotic drugs. Lab Chip, 21, 4104-4117.
Abbasian N, Millington-Burgess SL, Chabra S, Malcor JD, Harper MT (2020). Supramaximal calcium signaling triggers procoagulant platelet formation. Blood Adv, In Press
Millington-Burgess SL, Rahman T, Harper MT (2020). R5421 is not a selective inhibitor platelet scramblase activity. Br J Pharmacol, 117, 4007-4020.
Wei H, Malcor JM, Harper MT (2018). Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets. Sci Rep, 8, 9987.
Harper MT, Camacho Londono JE, Quick K, Camacho Londono J, Philipp SE, Birnbaumer L, Freichel M, Poole AW (2013). Transient receptor potential channels function as a coincidence signal detector mediated phosphatidylserine exposure. Science Signalling, 6, ra50.
If you are interested in our research, please contact Matthew. Prospective PhD students should consult the University's Postgraduate Admissions site, and in particular the postgraduate funding section. Post-doctoral research opportunities will be advertised by the Department and on the University Jobs page. Regretfully, the Harper lab is unable to provide any undergraduate summer placements in 2022.
Former lab members
Dr Nima Abbasian (now Charles River)
Dr Bonita Apta (now Lead Scientist, Lonza Biologics)
Dr Jessica Davies (now Cambridge Graduate Medicine)
Dr Ivelin Ivanov (now Department of Pathology, University of Cambridge)
Mr Luc Francis (now King's College London)
Dr Dora Lopresto (now Associate, Boston Consulting Group)
Dr Sarah Millington-Burgess (now Senior Teaching Associate, Department of Pharmacology)
Dr Alice Sowton (now Department of Physiology, Development & Neuroscience, University of Cambridge)
Dr Hao Wei (now Department of Immunology, Fudan University, Shanghai)
Undergraduate members
Grace Atkinson - Lottie Arnold - Jasmine Bawa - James Brice - Shirom Chabra - Lana Huang - Rebecca Gilchirst - Evonne Gaw - Celine Goh - Zhiyuan Lin - Wenxin Ma - Keiran Smith - Georgia Tooth