Please click here for a complete list of publications.
2023
Heydenreich FM, Marti-Solano M, Sandhu M, Kobilka BK, Bouvier M, Babu MM. Molecular determinants of ligand efficacy and potency in GPCR signaling. Science 382(6677):eadh1859 (2023).
Marti-Solano M. A multi-dimensional view of context-dependent G protein-coupled receptor function. Biochem Soc Trans 51(1):13-20 (2023).
2021
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, et al. Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation. Cell Rep 34(12):108862 (2021).
2020
Marti-Solano M*, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, et al. Combinatorial GPCR isoform expression impacts signalling and drug responses. Nature 587(7835):650-656 (2020). *co-corresponding author.
Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, et al. Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable. Neuron 108(6):1146-1162.e10 (2020).
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, Filipek S, Filizola M, Gómez-Tamayo JC, Gonzalez A, Gutiérrez-de-Terán H, Jiménez-Rosés M, Jespers W, Kapla J, Khelashvili G, Kolb P, Latek D, Marti-Solano M, Matricon P, Matsoukas MT, Miszta P, Olivella M, Perez-Benito L, Provasi D, Ríos S, Torrecillas IR, Sallander J, Sztyler A, Vasile S, Weinstein H, Zachariae U, Hildebrand PW, de Fabritiis G, Sanz F, Gloriam, DE, Cordomi A, Guixà-González R, Selent J. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nat Methods 17(8):777-787 (2020).
2019
Queiroz RML, Smith T, Villanueva E, Marti-Solano M, Monti M, Pizzinga M, et al. Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS). Nat Biotechnol 37(2): 169-178 (2019).
Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Slodkowicz G, Marti-Solano M, et al. A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Nat Commun 10(1):667 (2019).
2018
Wootten D, Christopoulos A, Marti-Solano M, Babu MM, Sexton PM. Mechanisms of signalling and biased agonism in G protein-coupled receptors. Nat Rev Mol Cell Biol 19(10): 638-653 (2018).
Hoppe A, Marti-Solano M, Drabek M, Bünemann M, Kolb P, Rinne A. The allosteric site regulates the voltage sensitivity of muscarinic receptors. Cell Signal 42:114-126 (2018).
2017
Guixà-González R, Albasanz JL, Rodriguez-Espigares I, Pastor M, Sanz F, Martí-Solano M, et al. Membrane cholesterol access into a G protein-coupled receptor. Nat Commun 8: 14505 (2017).
2016
Villanueva E, Martí-Solano M, Fillat C. Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness. Sci Rep 6: 27546 (2016).
Martí-Solano M, Schmidt D, Kolb P, Selent J. Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry. Drug Discov Today 21(4): 625-31 (2016).
Pegueroles C, Ferrés-Coy A, Martí-Solano M, Aquadro CF, Pascual M, Mestres F. Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura. Sci Rep 6: 23754 (2016).
2015
Martí-Solano M, Iglesias A, de Fabritiis G, Sanz F, Brea J, Loza MI, et al. Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation. Mol Pharmacol 87(4): 740-6 (2015).
2014
Martí-Solano M, Sanz F, Pastor M, Selent J. A dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivity. PLoS One 9(10):e109312 (2014).
Kufareva I, Katrich V, Participants of GPCR Dock 2013 (including Martí-Solano M, Pastor M and Selent J), Stevens RC, Abagyan R. Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure 22(8): 1120-39 (2014).
Martí-Solano M, Birney E, Bril A, Della Pasqua O, Kitano H, Mons B, et al. Integrative knowledge management to enhance pharmaceutical R&D. Nat Rev Drug Discov 13(4): 239-40 (2014).
Selent J*, Martí-Solano M*, Rodríguez J, Atanes P, Brea J, Castro M, et al. Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles. Eur J Med Chem 77, 91-5 (2014).*shared first authorship.
2013
Martí-Solano M, Guixà-González R, Sanz F, Pastor M, Selent J. Novel insights into biased agonism at G protein-coupled receptors and their potential for drug design. Curr Pharm Des 19(28), 5156-66 (2013).
2012
Karmouty-Quintana H, Siddiqui S, Hassan M, Tsuchiya K, Risse P-A, Xicota-Vila L, Marti-Solano M, Martin JG. Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. Am J Physiol Lung Cell Mol Physiol 302(8), L736–45 (2012).