Mark did graduate work in molecular immunology at Oxford University Institute of Molecular Medicine and Southampton University Cancer Sciences. In his postdoctoral work at MIT he developed tools in chemical biology, advanced microscopy and nanotechnology to understand receptor trafficking. He became Professor of Protein Nanotechnology at Oxford University Department of Biochemistry, receiving the Royal Society of Chemistry Norman Heatley Prize for Chemical Biology. He is a founder of SpyBiotech, which is now running vaccine clinical trials, and several members of his group have founded their own start-up companies. Mark gives lectures and workshops on Entrepreneurship to undergraduates and graduate groups. Resources from his group have been distributed to more than a thousand academic groups and licensed to a range of companies. His work has been funded by ERC, BBSRC, EPSRC, MRC, Wellcome Trust and through collaborations with multiple pharma and biotech companies. He moved to Cambridge to take up the Sheild Chair of Pharmacology in 2022.
Publications
NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.
Scheu AHA, Lim SYT, Metzner FJ, Mohammed S, Howarth M. Nature Communications 2021 Jan 29;12(1):717.
Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid.
Wicke N, Bedford MR, Howarth M. Communications Biology 2021 Aug 11;4(1):960.
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ. Science 2021 Feb 12;371(6530):735-741.
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses. Tan TK, Rijal P, Rahikainen R, Keeble AH…Howarth M*, Townsend AR*. Nature Communications 2021 Jan 22;12(1):542. *Corresponding authors
Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation.
Rahikainen R, Rijal P, Tan TK, Wu HJ, Andersson AC, Barrett JR, Bowden TA, Draper SJ, Townsend AR, Howarth M. Angewandte Chemie 2021 Jan 4;60(1):321-330.
Approaching infinite affinity through engineering of peptide-protein interaction.
Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP*, Howarth M*. PNAS 2019 116:26523-26533. *Corresponding authors
Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox.
Khairil Anuar INA, Banerjee A, Keeble AH, Carella A, Nikov GI, Howarth M. Nature Communications 2019 10:1734.
Publication (Symplectic Elements)
2023 (Accepted for publication)
Doi: 10.1021/jacs.3c07827
Doi: http://doi.org/10.1126/sciimmunol.ade6364
2023
Doi: http://doi.org/10.1101/2023.02.24.529520
Doi: http://doi.org/10.1038/s41467-023-35949-8
Doi: 10.1021/acs.bioconjchem.3c00122
2022 (No publication date)
2022
Doi: http://doi.org/10.1016/j.ymthe.2022.08.002
Doi: http://doi.org/10.1016/j.chembiol.2021.07.005
Doi: http://doi.org/10.1016/j.copbio.2021.09.012
Doi: http://doi.org/10.1038/s41467-022-31193-8
2021
Doi: http://doi.org/10.1002/anie.202009663
Doi: http://doi.org/10.1038/s41467-020-20654-7
Doi: 10.1002/ange.202009663
Doi: http://doi.org/10.1038/s42003-021-02487-2
Doi: http://doi.org/10.1126/science.abf6840
Doi: http://doi.org/10.1038/s41467-021-20963-5
2020
Doi: http://doi.org/10.1039/d0sc01878c
Doi: http://doi.org/10.1038/s42003-020-0840-5
2019
Doi: http://doi.org/10.1038/s41598-019-40985-w
Doi: http://doi.org/10.1073/pnas.1909653116
Doi: http://doi.org/10.1038/s41467-019-09678-w
2018
Doi: http://doi.org/10.1021/acsnano.8b02805
Doi: 10.1016/j.nbt.2018.05.140
Doi: http://doi.org/10.1016/j.biomaterials.2018.07.020
Doi: http://doi.org/10.3389/fimmu.2018.01432
Doi: http://doi.org/10.1016/j.copbio.2018.05.001
Doi: http://doi.org/10.1021/jacs.7b13237
Doi: http://doi.org/10.1016/j.copbio.2017.10.006
2017
Doi: http://doi.org/10.1002/anie.201707623
Doi: http://doi.org/10.1021/acssynbio.6b00292
Doi: 10.1002/ange.201707623
Doi: http://doi.org/10.1016/j.chembiol.2017.06.015
Doi: http://doi.org/10.1038/s41598-017-03798-3
Doi: http://doi.org/10.1074/jbc.H117.777466
Doi: http://doi.org/10.1021/acs.bioconjchem.7b00174
Doi: http://doi.org/10.1021/jacs.7b00540
2016
Doi: http://doi.org/10.1038/srep21151
Doi: http://doi.org/10.1038/srep19234
Doi: http://doi.org/10.1038/srep34176
Doi: http://doi.org/10.1073/pnas.1519214113
2015
Doi: http://doi.org/10.1038/nsmb.3011
Doi: http://doi.org/10.1016/j.cbpa.2015.10.002
2014
Doi: 10.1002/ange.201402519
Doi: http://doi.org/10.1016/j.jmb.2013.09.016
Doi: http://doi.org/10.1021/ja505584f
Doi: http://doi.org/10.1016/j.jmb.2013.10.021
Doi: http://doi.org/10.1016/j.bmc.2014.07.029
Doi: http://doi.org/10.1073/pnas.1315776111
Doi: http://doi.org/10.1016/j.tibtech.2014.08.001
Doi: http://doi.org/10.1002/anie.201402519
2013
Doi: http://doi.org/10.1021/nn3042122
Doi: http://doi.org/10.1158/0008-5472.CAN-12-2956
2012
Doi: 10.1016/j.bpj.2011.11.3897
Doi: http://doi.org/10.1073/pnas.1115485109
Doi: http://doi.org/10.1021/nn304793z
2011 (Published online)
Doi: http://doi.org/10.1096/fasebj.25.1_supplement.568.2
2011
Doi: http://doi.org/10.1016/j.bpj.2011.05.013
Doi: http://doi.org/10.1042/BJ20101593
Doi: http://doi.org/10.1371/journal.pcbi.1002144
2010
Doi: http://doi.org/10.1021/ja910795a
Doi: http://doi.org/10.1038/emboj.2010.29
Doi: http://doi.org/10.1038/nmeth.1450
Doi: 10.1096/fasebj.24.1_supplement.lb168
2009
Doi: http://doi.org/10.1074/jbc.M109.034322
2008
Doi: http://doi.org/10.1038/nprot.2008.20
Doi: http://doi.org/10.1021/ja076069p
Doi: http://doi.org/10.1038/nmeth.1206
Doi: http://doi.org/10.1002/eji.200737832
2006
Doi: http://doi.org/10.1038/nmeth861
Doi: http://doi.org/10.1038/nchembio0306-127
2005
Doi: http://doi.org/10.1073/pnas.0503125102
Doi: http://doi.org/10.1038/nmeth735
2004
Doi: http://doi.org/10.1073/pnas.0306294101
Doi: http://doi.org/10.1021/cc049945t
Doi: http://doi.org/10.1111/j.0105-2896.2004.00141.x
Doi: http://doi.org/10.1002/chem.200305232
2002
Doi: http://doi.org/10.1016/s1074-7613(01)00260-6
2001
Doi: http://doi.org/10.1034/j.1399-0039.2001.580604.x
2021
Doi: http://doi.org/10.1007/978-1-0716-0928-6_2
2019
Doi: http://doi.org/10.1016/bs.mie.2018.12.010
2016
Doi: http://doi.org/10.1016/bs.mie.2016.05.004
2015
Doi: http://doi.org/10.1007/978-1-4939-2272-7_12