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Department of Pharmacology

 

Mark did graduate work in molecular immunology at Oxford University Institute of Molecular Medicine and Southampton University Cancer Sciences. In his postdoctoral work at MIT he developed tools in chemical biology, advanced microscopy and nanotechnology to understand receptor trafficking. He became Professor of Protein Nanotechnology at Oxford University Department of Biochemistry, receiving the Royal Society of Chemistry Norman Heatley Prize for Chemical Biology. He is a founder of SpyBiotech, which is now running vaccine clinical trials, and several members of his group have founded their own start-up companies. Mark gives lectures and workshops on Entrepreneurship to undergraduates and graduate groups. Resources from his group have been distributed to more than a thousand academic groups and licensed to a range of companies. His work has been funded by ERC, BBSRC, EPSRC, MRC, Wellcome Trust and through collaborations with multiple pharma and biotech companies. He moved to Cambridge to take up the Sheild Chair of Pharmacology in 2022.

Publications

Key publications: 

NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.
Scheu AHA, Lim SYT, Metzner FJ, Mohammed S, Howarth M. Nature Communications 2021 Jan 29;12(1):717.

Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid.
Wicke N, Bedford MR, Howarth M. Communications Biology 2021 Aug 11;4(1):960.

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ. Science 2021 Feb 12;371(6530):735-741.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses. Tan TK, Rijal P, Rahikainen R, Keeble AH…Howarth M*, Townsend AR*. Nature Communications 2021 Jan 22;12(1):542. *Corresponding authors

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation.
Rahikainen R, Rijal P, Tan TK, Wu HJ, Andersson AC, Barrett JR, Bowden TA, Draper SJ, Townsend AR, Howarth M. Angewandte Chemie 2021 Jan 4;60(1):321-330.

Approaching infinite affinity through engineering of peptide-protein interaction. 
Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP*, Howarth M*. PNAS 2019 116:26523-26533.  *Corresponding authors

Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox. 
Khairil Anuar INA, Banerjee A, Keeble AH, Carella A, Nikov GI, Howarth M. Nature Communications 2019 10:1734.

Publication (Symplectic Elements)

Journal articles

2023 (Accepted for publication)

CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.

pub_doi: 
10.1126/sciimmunol.ade6364
Publisher: 
American Association for the Advancement of Science
Journal name: 
Science Immunology
pub_author_name: 
Gristick
Hartweger
Loewe
van Schooten
Ramos
Oliveira
Nishimura
Koranda
Wall
Yao
Poston
Gazumyan
Wiatr
Horning
Keeffe
Hoffmann
Yang
Abernathy
Dam
Gao
Gnanapragasam
Kakutani
Pavlovitch-Bedzyk
Seaman
Howarth
McGuire
Stamatatos
Martin
West
Nussenzweig
Bjorkman
Publication ID: 
1470460
pub_author_initials: 
HB
H
M
J
V
TY
Y
NS
A
K-H
D
A
M
M
JR
MAG
Z
ME
K-MA
H
PNP
LM
AJ
MS
M
AT
L
MA
AP
MC
PJ
Publication volume: 
8
Publication number: 
Edition: 
pub_date_day: 
20
pub_date_month: 
1
pub_date_year: 
2023 (Accepted for publication)
pub_title: 
CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.

2023

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology.

pub_doi: 
10.1101/2023.02.24.529520
Publisher: 
Journal name: 
bioRxiv
pub_author_name: 
Hills
Tan
Cohen
Keeffe
Keeble
Gnanapragasam
Storm
Hill
Liu
Gilbert-Jaramillo
Afzal
Napier
James
Bjorkman
Townsend
Howarth
Publication ID: 
1470723
pub_author_initials: 
RA
TK
AA
JR
AH
PNP
KN
ML
S
J
M
A
WS
PJ
AR
M
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
24
pub_date_month: 
2
pub_date_year: 
2023
pub_title: 
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology.

Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.

pub_doi: 
10.1038/s41467-023-35949-8
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Huang
Chen
Mohapatra
Nguyen
Schimanski
Tan
Rijal
Vester
Hills
Howarth
Keeffe
Cohen
Kakutani
Wu
Shahed-Al-Mahmud
Chou
Bjorkman
Townsend
Ma
Publication ID: 
1457438
pub_author_initials: 
K-YA
X
A
HTV
L
TK
P
SK
RA
M
JR
AA
LM
Y-M
M
Y-C
PJ
AR
C
Publication volume: 
14
Publication number: 
Edition: 
pub_date_day: 
19
pub_date_month: 
1
pub_date_year: 
2023
pub_title: 
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.

2022 (No publication date)

Simultaneous identification of viruses and viral variants with programmable DNA nanobait

pub_doi: 
Publisher: 
Nature Research
Journal name: 
Nature Nanotechnology
pub_author_name: 
Boskovic
Zhu
Tivony
Ohmann
Chen
Alawami
Đorđević
Ermann
Pereira Dias
Fairhead
Howarth
Baker
Keyser
Publication ID: 
1439112
pub_author_initials: 
F
J
R
A
K
M
M
N
J
M
M
S
UF
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
12
pub_date_month: 
11
pub_date_year: 
2022 (No publication date)
pub_title: 
Simultaneous identification of viruses and viral variants with programmable DNA nanobait

2022

Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2.

pub_doi: 
10.1016/j.ymthe.2022.08.002
Publisher: 
Journal name: 
Mol Ther
pub_author_name: 
Dicks
Rose
Russell
Bowman
Graham
Jimenez-Guardeño
Doores
Malim
Draper
Howarth
Biswas
Publication ID: 
1468700
pub_author_initials: 
MDJ
LM
RA
LAH
C
JM
KJ
MH
SJ
M
S
Publication volume: 
30
Publication number: 
Edition: 
pub_date_day: 
7
pub_date_month: 
12
pub_date_year: 
2022
pub_title: 
Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2.

DogCatcher allows loop-friendly protein-protein ligation.

pub_doi: 
10.1016/j.chembiol.2021.07.005
Publisher: 
Journal name: 
Cell Chem Biol
pub_author_name: 
Keeble
Yadav
Ferla
Bauer
Chuntharpursat-Bon
Huang
Bon
Howarth
Publication ID: 
1468701
pub_author_initials: 
AH
VK
MP
CC
E
J
RS
M
Publication volume: 
29
Publication number: 
Edition: 
pub_date_day: 
17
pub_date_month: 
2
pub_date_year: 
2022
pub_title: 
DogCatcher allows loop-friendly protein-protein ligation.

Virus-like particles against infectious disease and cancer: guidance for the nano-architect.

pub_doi: 
10.1016/j.copbio.2021.09.012
Publisher: 
Journal name: 
Curr Opin Biotechnol
pub_author_name: 
Hills
Howarth
Publication ID: 
1468692
pub_author_initials: 
RA
M
Publication volume: 
73
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2022
pub_title: 
Virus-like particles against infectious disease and cancer: guidance for the nano-architect.

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly.

pub_doi: 
10.1038/s41467-022-31193-8
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Vester
Rahikainen
Khairil Anuar
Hills
Tan
Howarth
Publication ID: 
1468693
pub_author_initials: 
SK
R
INA
RA
TK
M
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
28
pub_date_month: 
6
pub_date_year: 
2022
pub_title: 
SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly.

2021

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.

pub_doi: 
10.1038/s41467-020-20654-7
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Tan
Rijal
Rahikainen
Keeble
Schimanski
Hussain
Harvey
Hayes
Edwards
McLean
Martini
Pedrera
Thakur
Conceicao
Dietrich
Shelton
Ludi
Wilsden
Browning
Zagrajek
Bialy
Bhat
Stevenson-Leggett
Hollinghurst
Tully
Moffat
Chiu
Waters
Gray
Azhar
Mioulet
Newman
Asfor
Burman
Crossley
Hammond
Tchilian
Charleston
Bailey
Tuthill
Graham
Duyvesteyn
Malinauskas
Huo
Tree
Buttigieg
Owens
Carroll
Daniels
McCauley
Stuart
Huang
Howarth
Townsend
Publication ID: 
1380048
pub_author_initials: 
TK
P
R
AH
L
S
R
JWP
JC
RK
V
M
N
C
I
H
A
G
C
AK
D
S
P
P
M
K
C
R
A
M
V
J
AS
A
S
JA
E
B
D
TJ
SP
HME
T
J
JA
KR
RJ
MW
RS
JW
DI
K-YA
M
AR
Publication volume: 
12
Publication number: 
Edition: 
pub_date_day: 
22
pub_date_month: 
1
pub_date_year: 
2021
pub_title: 
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation

pub_doi: 
10.1002/ange.202009663
Publisher: 
Wiley
Journal name: 
Angewandte Chemie
pub_author_name: 
Rahikainen
Rijal
Tan
Wu
Andersson
Barrett
Bowden
Draper
Townsend
Howarth
Publication ID: 
1468683
pub_author_initials: 
R
P
TK
H
AC
JR
TA
SJ
AR
M
Publication volume: 
133
Publication number: 
Edition: 
pub_date_day: 
4
pub_date_month: 
1
pub_date_year: 
2021
pub_title: 
Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation

Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid.

pub_doi: 
10.1038/s42003-021-02487-2
Publisher: 
Journal name: 
Commun Biol
pub_author_name: 
Wicke
Bedford
Howarth
Publication ID: 
1468689
pub_author_initials: 
N
MR
M
Publication volume: 
4
Publication number: 
Edition: 
pub_date_day: 
11
pub_date_month: 
8
pub_date_year: 
2021
pub_title: 
Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid.

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.

pub_doi: 
10.1126/science.abf6840
Publisher: 
Journal name: 
Science
pub_author_name: 
Cohen
Gnanapragasam
Lee
Hoffman
Ou
Kakutani
Keeffe
Wu
Howarth
West
Barnes
Nussenzweig
Bjorkman
Publication ID: 
1468690
pub_author_initials: 
AA
PNP
YE
PR
S
LM
JR
H-J
M
AP
CO
MC
PJ
Publication volume: 
371
Publication number: 
Edition: 
pub_date_day: 
12
pub_date_month: 
2
pub_date_year: 
2021
pub_title: 
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.

NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.

pub_doi: 
10.1038/s41467-021-20963-5
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Scheu
Lim
Metzner
Mohammed
Howarth
Publication ID: 
1468691
pub_author_initials: 
AHA
SYT
FJ
S
M
Publication volume: 
12
Publication number: 
Edition: 
pub_date_day: 
29
pub_date_month: 
1
pub_date_year: 
2021
pub_title: 
NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation.

pub_doi: 
10.1002/anie.202009663
Publisher: 
Journal name: 
Angew Chem Int Ed Engl
pub_author_name: 
Rahikainen
Rijal
Tan
Wu
Andersson
Barrett
Bowden
Draper
Townsend
Howarth
Publication ID: 
1468698
pub_author_initials: 
R
P
TK
H-J
A-MC
JR
TA
SJ
AR
M
Publication volume: 
60
Publication number: 
Edition: 
pub_date_day: 
4
pub_date_month: 
1
pub_date_year: 
2021
pub_title: 
Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation.

2020

Power to the protein: enhancing and combining activities using the Spy toolbox.

pub_doi: 
10.1039/d0sc01878c
Publisher: 
Journal name: 
Chem Sci
pub_author_name: 
Keeble
Howarth
Publication ID: 
1468685
pub_author_initials: 
AH
M
Publication volume: 
11
Publication number: 
Edition: 
pub_date_day: 
28
pub_date_month: 
7
pub_date_year: 
2020
pub_title: 
Power to the protein: enhancing and combining activities using the Spy toolbox.

Transmembrane protein rotaxanes reveal kinetic traps in the refolding of translocated substrates.

pub_doi: 
10.1038/s42003-020-0840-5
Publisher: 
Journal name: 
Commun Biol
pub_author_name: 
Feng
Martin-Baniandres
Booth
Veggiani
Howarth
Bayley
Rodriguez-Larrea
Publication ID: 
1468695
pub_author_initials: 
J
P
MJ
G
M
H
D
Publication volume: 
3
Publication number: 
Edition: 
pub_date_day: 
3
pub_date_month: 
4
pub_date_year: 
2020
pub_title: 
Transmembrane protein rotaxanes reveal kinetic traps in the refolding of translocated substrates.

2019

SnoopLigase peptide-peptide conjugation enables modular vaccine assembly.

pub_doi: 
10.1038/s41598-019-40985-w
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Andersson
Buldun
Pattinson
Draper
Howarth
Publication ID: 
1468706
pub_author_initials: 
A-MC
CM
DJ
SJ
M
Publication volume: 
9
Publication number: 
Edition: 
pub_date_day: 
15
pub_date_month: 
3
pub_date_year: 
2019
pub_title: 
SnoopLigase peptide-peptide conjugation enables modular vaccine assembly.

Approaching infinite affinity through engineering of peptide-protein interaction.

pub_doi: 
10.1073/pnas.1909653116
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Keeble
Turkki
Stokes
Khairil Anuar
Rahikainen
Hytönen
Howarth
Publication ID: 
1468684
pub_author_initials: 
AH
P
S
INA
R
VP
M
Publication volume: 
116
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
12
pub_date_year: 
2019
pub_title: 
Approaching infinite affinity through engineering of peptide-protein interaction.

Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox.

pub_doi: 
10.1038/s41467-019-09678-w
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Khairil Anuar
Banerjee
Keeble
Carella
Nikov
Howarth
Publication ID: 
1468694
pub_author_initials: 
INA
A
AH
A
GI
M
Publication volume: 
10
Publication number: 
Edition: 
pub_date_day: 
15
pub_date_month: 
4
pub_date_year: 
2019
pub_title: 
Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox.

2018

Spy and Snoop protein superglues for nano-assembly and tickling the immune system

pub_doi: 
10.1016/j.nbt.2018.05.140
Publisher: 
Elsevier BV
Journal name: 
New Biotechnology
pub_author_name: 
Howarth
Publication ID: 
1468708
pub_author_initials: 
M
Publication volume: 
44
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
10
pub_date_year: 
2018
pub_title: 
Spy and Snoop protein superglues for nano-assembly and tickling the immune system

Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions.

pub_doi: 
10.1016/j.biomaterials.2018.07.020
Publisher: 
Journal name: 
Biomaterials
pub_author_name: 
Wieduwild
Howarth
Publication ID: 
1468709
pub_author_initials: 
R
M
Publication volume: 
180
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
10
pub_date_year: 
2018
pub_title: 
Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions.

New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue.

pub_doi: 
10.3389/fimmu.2018.01432
Publisher: 
Journal name: 
Front Immunol
pub_author_name: 
Brune
Howarth
Publication ID: 
1468710
pub_author_initials: 
KD
M
Publication volume: 
9
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2018
pub_title: 
New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue.

Editorial overview: Nanobiotechnology: Baby steps and giant strides towards molecular mastery.

pub_doi: 
10.1016/j.copbio.2018.05.001
Publisher: 
Journal name: 
Curr Opin Biotechnol
pub_author_name: 
Howarth
Jaramillo
Publication ID: 
1468711
pub_author_initials: 
M
A
Publication volume: 
51
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2018
pub_title: 
Editorial overview: Nanobiotechnology: Baby steps and giant strides towards molecular mastery.

SnoopLigase Catalyzes Peptide-Peptide Locking and Enables Solid-Phase Conjugate Isolation.

pub_doi: 
10.1021/jacs.7b13237
Publisher: 
Journal name: 
J Am Chem Soc
pub_author_name: 
Buldun
Jean
Bedford
Howarth
Publication ID: 
1468712
pub_author_initials: 
CM
JX
MR
M
Publication volume: 
140
Publication number: 
Edition: 
pub_date_day: 
28
pub_date_month: 
2
pub_date_year: 
2018
pub_title: 
SnoopLigase Catalyzes Peptide-Peptide Locking and Enables Solid-Phase Conjugate Isolation.

Nanoteamwork: covalent protein assembly beyond duets towards protein ensembles and orchestras.

pub_doi: 
10.1016/j.copbio.2017.10.006
Publisher: 
Journal name: 
Curr Opin Biotechnol
pub_author_name: 
Banerjee
Howarth
Publication ID: 
1468713
pub_author_initials: 
A
M
Publication volume: 
51
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2018
pub_title: 
Nanoteamwork: covalent protein assembly beyond duets towards protein ensembles and orchestras.

Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination.

pub_doi: 
10.1021/acsnano.8b02805
Publisher: 
Journal name: 
ACS Nano
pub_author_name: 
Bruun
Andersson
Draper
Howarth
Publication ID: 
1468699
pub_author_initials: 
TUJ
A-MC
SJ
M
Publication volume: 
12
Publication number: 
Edition: 
pub_date_day: 
25
pub_date_month: 
9
pub_date_year: 
2018
pub_title: 
Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination.

2017

Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction.

pub_doi: 
10.1016/j.chembiol.2017.06.015
Publisher: 
Journal name: 
Cell Chem Biol
pub_author_name: 
Jacobsen
Fairhead
Fogelstrand
Howarth
Publication ID: 
1468714
pub_author_initials: 
MT
M
P
M
Publication volume: 
24
Publication number: 
Edition: 
pub_date_day: 
17
pub_date_month: 
8
pub_date_year: 
2017
pub_title: 
Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction.

Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines.

pub_doi: 
10.1038/s41598-017-03798-3
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Leneghan
Miura
Taylor
Li
Jin
Brune
Bachmann
Howarth
Long
Biswas
Publication ID: 
1468715
pub_author_initials: 
DB
K
IJ
Y
J
KD
MF
M
CA
S
Publication volume: 
7
Publication number: 
Edition: 
pub_date_day: 
19
pub_date_month: 
6
pub_date_year: 
2017
pub_title: 
Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines.

Smart superglue in streptococci? The proof is in the pulling.

pub_doi: 
10.1074/jbc.H117.777466
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Howarth
Publication ID: 
1468716
pub_author_initials: 
M
Publication volume: 
292
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
5
pub_date_year: 
2017
pub_title: 
Smart superglue in streptococci? The proof is in the pulling.

Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization.

pub_doi: 
10.1021/acs.bioconjchem.7b00174
Publisher: 
Journal name: 
Bioconjug Chem
pub_author_name: 
Brune
Buldun
Li
Taylor
Brod
Biswas
Howarth
Publication ID: 
1468717
pub_author_initials: 
KD
CM
Y
IJ
F
S
M
Publication volume: 
28
Publication number: 
Edition: 
pub_date_day: 
17
pub_date_month: 
5
pub_date_year: 
2017
pub_title: 
Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization.

Controlling Multivalent Binding through Surface Chemistry: Model Study on Streptavidin.

pub_doi: 
10.1021/jacs.7b00540
Publisher: 
Journal name: 
J Am Chem Soc
pub_author_name: 
Dubacheva
Araya-Callis
Geert Volbeda
Fairhead
Codée
Howarth
Richter
Publication ID: 
1468718
pub_author_initials: 
GV
C
A
M
J
M
RP
Publication volume: 
139
Publication number: 
Edition: 
pub_date_day: 
22
pub_date_month: 
3
pub_date_year: 
2017
pub_title: 
Controlling Multivalent Binding through Surface Chemistry: Model Study on Streptavidin.

Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics.

pub_doi: 
10.1002/anie.201707623
Publisher: 
Journal name: 
Angew Chem Int Ed Engl
pub_author_name: 
Keeble
Banerjee
Ferla
Reddington
Anuar
Howarth
Publication ID: 
1468696
pub_author_initials: 
AH
A
MP
SC
INAK
M
Publication volume: 
56
Publication number: 
Edition: 
pub_date_day: 
22
pub_date_month: 
12
pub_date_year: 
2017
pub_title: 
Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics.

Extracellular Self-Assembly of Functional and Tunable Protein Conjugates from Bacillus subtilis.

pub_doi: 
10.1021/acssynbio.6b00292
Publisher: 
Journal name: 
ACS Synth Biol
pub_author_name: 
Gilbert
Howarth
Harwood
Ellis
Publication ID: 
1468719
pub_author_initials: 
C
M
CR
T
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
16
pub_date_month: 
6
pub_date_year: 
2017
pub_title: 
Extracellular Self-Assembly of Functional and Tunable Protein Conjugates from Bacillus subtilis.

Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics

pub_doi: 
10.1002/ange.201707623
Publisher: 
Wiley
Journal name: 
Angewandte Chemie
pub_author_name: 
Keeble
Banerjee
Ferla
Reddington
Anuar
Howarth
Publication ID: 
1468697
pub_author_initials: 
AH
A
MP
SC
INAK
M
Publication volume: 
129
Publication number: 
Edition: 
pub_date_day: 
22
pub_date_month: 
12
pub_date_year: 
2017
pub_title: 
Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics

2016

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization.

pub_doi: 
10.1038/srep19234
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Brune
Leneghan
Brian
Ishizuka
Bachmann
Draper
Biswas
Howarth
Publication ID: 
1468727
pub_author_initials: 
KD
DB
IJ
AS
MF
SJ
S
M
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
19
pub_date_month: 
1
pub_date_year: 
2016
pub_title: 
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization.

A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force.

pub_doi: 
10.1038/srep34176
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Bano
Banerji
Howarth
Jackson
Richter
Publication ID: 
1468731
pub_author_initials: 
F
S
M
DG
RP
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
29
pub_date_month: 
9
pub_date_year: 
2016
pub_title: 
A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force.

Programmable polyproteams built using twin peptide superglues.

pub_doi: 
10.1073/pnas.1519214113
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Veggiani
Nakamura
Brenner
Gayet
Yan
Robinson
Howarth
Publication ID: 
1468733
pub_author_initials: 
G
T
MD
RV
J
CV
M
Publication volume: 
113
Publication number: 
Edition: 
pub_date_day: 
2
pub_date_month: 
2
pub_date_year: 
2016
pub_title: 
Programmable polyproteams built using twin peptide superglues.

SpyRing interrogation: analyzing how enzyme resilience can be achieved with phytase and distinct cyclization chemistries.

pub_doi: 
10.1038/srep21151
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Schoene
Bennett
Howarth
Publication ID: 
1468724
pub_author_initials: 
C
SP
M
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
2
pub_date_year: 
2016
pub_title: 
SpyRing interrogation: analyzing how enzyme resilience can be achieved with phytase and distinct cyclization chemistries.

2015

Say it with proteins: an alphabet of crystal structures.

pub_doi: 
10.1038/nsmb.3011
Publisher: 
Journal name: 
Nat Struct Mol Biol
pub_author_name: 
Howarth
Publication ID: 
1468738
pub_author_initials: 
M
Publication volume: 
22
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
5
pub_date_year: 
2015
pub_title: 
Say it with proteins: an alphabet of crystal structures.

Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher.

pub_doi: 
10.1016/j.cbpa.2015.10.002
Publisher: 
Journal name: 
Curr Opin Chem Biol
pub_author_name: 
Reddington
Howarth
Publication ID: 
1468740
pub_author_initials: 
SC
M
Publication volume: 
29
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2015
pub_title: 
Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher.

2014

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.

pub_doi: 
10.1021/ja505584f
Publisher: 
Journal name: 
J Am Chem Soc
pub_author_name: 
Fairhead
Veggiani
Lever
Yan
Mesner
Robinson
Dushek
van der Merwe
Howarth
Publication ID: 
1468728
pub_author_initials: 
M
G
M
J
D
CV
O
PA
M
Publication volume: 
136
Publication number: 
Edition: 
pub_date_day: 
3
pub_date_month: 
9
pub_date_year: 
2014
pub_title: 
SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.

Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag.

pub_doi: 
10.1016/j.jmb.2013.10.021
Publisher: 
Journal name: 
J Mol Biol
pub_author_name: 
Li
Fierer
Rapoport
Howarth
Publication ID: 
1468729
pub_author_initials: 
L
JO
TA
M
Publication volume: 
426
Publication number: 
Edition: 
pub_date_day: 
23
pub_date_month: 
1
pub_date_year: 
2014
pub_title: 
Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag.

Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction.

pub_doi: 
10.1016/j.bmc.2014.07.029
Publisher: 
Journal name: 
Bioorg Med Chem
pub_author_name: 
Fairhead
Shen
Chan
Lowe
Donohoe
Howarth
Publication ID: 
788391
pub_author_initials: 
M
D
LKM
ED
TJ
M
Publication volume: 
22
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
10
pub_date_year: 
2014
pub_title: 
Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction.

SpyLigase peptide-peptide ligation polymerizes affibodies to enhance magnetic cancer cell capture.

pub_doi: 
10.1073/pnas.1315776111
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Fierer
Veggiani
Howarth
Publication ID: 
1468732
pub_author_initials: 
JO
G
M
Publication volume: 
111
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
4
pub_date_year: 
2014
pub_title: 
SpyLigase peptide-peptide ligation polymerizes affibodies to enhance magnetic cancer cell capture.

Superglue from bacteria: unbreakable bridges for protein nanotechnology.

pub_doi: 
10.1016/j.tibtech.2014.08.001
Publisher: 
Journal name: 
Trends Biotechnol
pub_author_name: 
Veggiani
Zakeri
Howarth
Publication ID: 
1423438
pub_author_initials: 
G
B
M
Publication volume: 
32
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
10
pub_date_year: 
2014
pub_title: 
Superglue from bacteria: unbreakable bridges for protein nanotechnology.

SpyTag/SpyCatcher cyclization confers resilience to boiling on a mesophilic enzyme.

pub_doi: 
10.1002/anie.201402519
Publisher: 
Journal name: 
Angew Chem Int Ed Engl
pub_author_name: 
Schoene
Fierer
Bennett
Howarth
Publication ID: 
1468741
pub_author_initials: 
C
JO
SP
M
Publication volume: 
53
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
6
pub_date_year: 
2014
pub_title: 
SpyTag/SpyCatcher cyclization confers resilience to boiling on a mesophilic enzyme.

SpyTag/SpyCatcher Cyclization Confers Resilience to Boiling on a Mesophilic Enzyme

pub_doi: 
10.1002/ange.201402519
Publisher: 
Wiley
Journal name: 
Angewandte Chemie
pub_author_name: 
Schoene
Fierer
Bennett
Howarth
Publication ID: 
1468721
pub_author_initials: 
C
JO
SP
M
Publication volume: 
126
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
6
pub_date_year: 
2014
pub_title: 
SpyTag/SpyCatcher Cyclization Confers Resilience to Boiling on a Mesophilic Enzyme

Plug-and-play pairing via defined divalent streptavidins.

pub_doi: 
10.1016/j.jmb.2013.09.016
Publisher: 
Journal name: 
J Mol Biol
pub_author_name: 
Fairhead
Krndija
Lowe
Howarth
Publication ID: 
1468722
pub_author_initials: 
M
D
ED
M
Publication volume: 
426
Publication number: 
Edition: 
pub_date_day: 
9
pub_date_month: 
1
pub_date_year: 
2014
pub_title: 
Plug-and-play pairing via defined divalent streptavidins.

2013

Hydroxy-terminated conjugated polymer nanoparticles have near-unity bright fraction and reveal cholesterol-dependence of IGF1R nanodomains.

pub_doi: 
10.1021/nn3042122
Publisher: 
Journal name: 
ACS Nano
pub_author_name: 
Koner
Krndija
Hou
Sherratt
Howarth
Publication ID: 
1468725
pub_author_initials: 
AL
D
Q
DJ
M
Publication volume: 
7
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
2
pub_date_year: 
2013
pub_title: 
Hydroxy-terminated conjugated polymer nanoparticles have near-unity bright fraction and reveal cholesterol-dependence of IGF1R nanodomains.

Cholesterol loading and ultrastable protein interactions determine the level of tumor marker required for optimal isolation of cancer cells.

pub_doi: 
10.1158/0008-5472.CAN-12-2956
Publisher: 
Journal name: 
Cancer Res
pub_author_name: 
Jain
Veggiani
Howarth
Publication ID: 
1468742
pub_author_initials: 
J
G
M
Publication volume: 
73
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
4
pub_date_year: 
2013
pub_title: 
Cholesterol loading and ultrastable protein interactions determine the level of tumor marker required for optimal isolation of cancer cells.

2012

An Irreversible Lock to Proteins for Dynamic Force Spectroscopy at the Mammalian Cell Surface

pub_doi: 
10.1016/j.bpj.2011.11.3897
Publisher: 
Elsevier BV
Journal name: 
Biophysical Journal
pub_author_name: 
Celik
Zakeri
Howarth
Moy
Publication ID: 
1468726
pub_author_initials: 
E
B
M
VT
Publication volume: 
102
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
1
pub_date_year: 
2012
pub_title: 
An Irreversible Lock to Proteins for Dynamic Force Spectroscopy at the Mammalian Cell Surface

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin.

pub_doi: 
10.1073/pnas.1115485109
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Zakeri
Fierer
Celik
Chittock
Schwarz-Linek
Moy
Howarth
Publication ID: 
1468730
pub_author_initials: 
B
JO
E
EC
U
VT
M
Publication volume: 
109
Publication number: 
Edition: 
pub_date_day: 
20
pub_date_month: 
3
pub_date_year: 
2012
pub_title: 
Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin.

Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells.

pub_doi: 
10.1021/nn304793z
Publisher: 
Journal name: 
ACS Nano
pub_author_name: 
Liu
Phipps
Loh
Howarth
Ting
Publication ID: 
1423439
pub_author_initials: 
DS
WS
KH
M
AY
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
21
pub_date_month: 
12
pub_date_year: 
2012
pub_title: 
Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells.

2011 (Published online)

How streptavidin's utility in bionanotechnology was increased: pushing the limits of a non‐covalent interaction

pub_doi: 
10.1096/fasebj.25.1_supplement.568.2
Publisher: 
Journal name: 
The FASEB Journal
pub_author_name: 
Chivers
Lowe
Howarth
Publication ID: 
1468704
pub_author_initials: 
CE
E
M
Publication volume: 
25
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
4
pub_date_year: 
2011 (Published online)
pub_title: 
How streptavidin's utility in bionanotechnology was increased: pushing the limits of a non‐covalent interaction

2011

Mechanisms for size-dependent protein segregation at immune synapses assessed with molecular rulers.

pub_doi: 
10.1016/j.bpj.2011.05.013
Publisher: 
Journal name: 
Biophys J
pub_author_name: 
Alakoskela
Koner
Rudnicka
Köhler
Howarth
Davis
Publication ID: 
1155413
pub_author_initials: 
J-M
AL
D
K
M
DM
Publication volume: 
100
Publication number: 
Edition: 
pub_date_day: 
22
pub_date_month: 
6
pub_date_year: 
2011
pub_title: 
Mechanisms for size-dependent protein segregation at immune synapses assessed with molecular rulers.

How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer.

pub_doi: 
10.1042/BJ20101593
Publisher: 
Journal name: 
Biochem J
pub_author_name: 
Chivers
Koner
Lowe
Howarth
Publication ID: 
1468734
pub_author_initials: 
CE
AL
ED
M
Publication volume: 
435
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
4
pub_date_year: 
2011
pub_title: 
How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer.

A peptide filtering relation quantifies MHC class I peptide optimization.

pub_doi: 
10.1371/journal.pcbi.1002144
Publisher: 
Journal name: 
PLoS Comput Biol
pub_author_name: 
Dalchau
Phillips
Goldstein
Howarth
Cardelli
Emmott
Elliott
Werner
Publication ID: 
380779
pub_author_initials: 
N
A
LD
M
L
S
T
JM
Publication volume: 
7
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
10
pub_date_year: 
2011
pub_title: 
A peptide filtering relation quantifies MHC class I peptide optimization.

2010

Separating speed and ability to displace roadblocks during DNA translocation by FtsK.

pub_doi: 
10.1038/emboj.2010.29
Publisher: 
Journal name: 
EMBO J
pub_author_name: 
Crozat
Meglio
Allemand
Chivers
Howarth
Vénien-Bryan
Grainge
Sherratt
Publication ID: 
1468735
pub_author_initials: 
E
A
J-F
CE
M
C
I
DJ
Publication volume: 
29
Publication number: 
Edition: 
pub_date_day: 
21
pub_date_month: 
4
pub_date_year: 
2010
pub_title: 
Separating speed and ability to displace roadblocks during DNA translocation by FtsK.

A streptavidin variant with slower biotin dissociation and increased mechanostability.

pub_doi: 
10.1038/nmeth.1450
Publisher: 
Journal name: 
Nat Methods
pub_author_name: 
Chivers
Crozat
Chu
Moy
Sherratt
Howarth
Publication ID: 
1468736
pub_author_initials: 
CE
E
C
VT
DJ
M
Publication volume: 
7
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
5
pub_date_year: 
2010
pub_title: 
A streptavidin variant with slower biotin dissociation and increased mechanostability.

A molecular car‐crash: a speeding motor hits a new ultra‐stable non‐covalent interaction

pub_doi: 
10.1096/fasebj.24.1_supplement.lb168
Publisher: 
Wiley
Journal name: 
The FASEB Journal
pub_author_name: 
Chivers
Crozat
Chu
Moy
Sherratt
Howarth
Publication ID: 
1468705
pub_author_initials: 
CE
E
C
V
D
M
Publication volume: 
24
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
2010
pub_title: 
A molecular car‐crash: a speeding motor hits a new ultra‐stable non‐covalent interaction

Spontaneous intermolecular amide bond formation between side chains for irreversible peptide targeting.

pub_doi: 
10.1021/ja910795a
Publisher: 
Journal name: 
J Am Chem Soc
pub_author_name: 
Zakeri
Howarth
Publication ID: 
1468720
pub_author_initials: 
B
M
Publication volume: 
132
Publication number: 
Edition: 
pub_date_day: 
7
pub_date_month: 
4
pub_date_year: 
2010
pub_title: 
Spontaneous intermolecular amide bond formation between side chains for irreversible peptide targeting.

2009

Electrophilic affibodies forming covalent bonds to protein targets.

pub_doi: 
10.1074/jbc.M109.034322
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Holm
Moody
Howarth
Publication ID: 
1468739
pub_author_initials: 
L
P
M
Publication volume: 
284
Publication number: 
Edition: 
pub_date_day: 
20
pub_date_month: 
11
pub_date_year: 
2009
pub_title: 
Electrophilic affibodies forming covalent bonds to protein targets.

2008

Monovalent, reduced-size quantum dots for imaging receptors on living cells.

pub_doi: 
10.1038/nmeth.1206
Publisher: 
Journal name: 
Nat Methods
pub_author_name: 
Howarth
Liu
Puthenveetil
Zheng
Marshall
Schmidt
Wittrup
Bawendi
Ting
Publication ID: 
507695
pub_author_initials: 
M
W
S
Y
LF
MM
KD
MG
AY
Publication volume: 
5
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
5
pub_date_year: 
2008
pub_title: 
Monovalent, reduced-size quantum dots for imaging receptors on living cells.

Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

pub_doi: 
10.1002/eji.200737832
Publisher: 
Journal name: 
Eur J Immunol
pub_author_name: 
Thirdborough
Roddick
Radcliffe
Howarth
Stevenson
Elliott
Publication ID: 
1472658
pub_author_initials: 
SM
JS
JN
M
FK
T
Publication volume: 
38
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2008
pub_title: 
Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin.

pub_doi: 
10.1038/nprot.2008.20
Publisher: 
Journal name: 
Nat Protoc
pub_author_name: 
Howarth
Ting
Publication ID: 
1423440
pub_author_initials: 
M
AY
Publication volume: 
3
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2008
pub_title: 
Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin.

Compact biocompatible quantum dots functionalized for cellular imaging.

pub_doi: 
10.1021/ja076069p
Publisher: 
Journal name: 
J Am Chem Soc
pub_author_name: 
Liu
Howarth
Greytak
Zheng
Nocera
Ting
Bawendi
Publication ID: 
507696
pub_author_initials: 
W
M
AB
Y
DG
AY
MG
Publication volume: 
130
Publication number: 
Edition: 
pub_date_day: 
30
pub_date_month: 
1
pub_date_year: 
2008
pub_title: 
Compact biocompatible quantum dots functionalized for cellular imaging.

2006

A monovalent streptavidin with a single femtomolar biotin binding site.

pub_doi: 
10.1038/nmeth861
Publisher: 
Journal name: 
Nat Methods
pub_author_name: 
Howarth
Chinnapen
Gerrow
Dorrestein
Grandy
Kelleher
El-Husseini
Ting
Publication ID: 
1424763
pub_author_initials: 
M
DJ-F
K
PC
MR
NL
A
AY
Publication volume: 
3
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
2006
pub_title: 
A monovalent streptavidin with a single femtomolar biotin binding site.

Giving cells a new sugar-coating.

pub_doi: 
10.1038/nchembio0306-127
Publisher: 
Journal name: 
Nat Chem Biol
pub_author_name: 
Howarth
Ting
Publication ID: 
1468743
pub_author_initials: 
M
AY
Publication volume: 
2
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
3
pub_date_year: 
2006
pub_title: 
Giving cells a new sugar-coating.

2005

Targeting quantum dots to surface proteins in living cells with biotin ligase.

pub_doi: 
10.1073/pnas.0503125102
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Howarth
Takao
Hayashi
Ting
Publication ID: 
1424762
pub_author_initials: 
M
K
Y
AY
Publication volume: 
102
Publication number: 
Edition: 
pub_date_day: 
24
pub_date_month: 
5
pub_date_year: 
2005
pub_title: 
Targeting quantum dots to surface proteins in living cells with biotin ligase.

Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase.

pub_doi: 
10.1038/nmeth735
Publisher: 
Journal name: 
Nat Methods
pub_author_name: 
Chen
Howarth
Lin
Ting
Publication ID: 
663061
pub_author_initials: 
I
M
W
AY
Publication volume: 
2
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2005
pub_title: 
Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase.

2004

Tapasin enhances MHC class I peptide presentation according to peptide half-life.

pub_doi: 
10.1073/pnas.0306294101
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Howarth
Williams
Tolstrup
Elliott
Publication ID: 
271792
pub_author_initials: 
M
A
AB
T
Publication volume: 
101
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
8
pub_date_year: 
2004
pub_title: 
Tapasin enhances MHC class I peptide presentation according to peptide half-life.

DNA transfection screening from single beads.

pub_doi: 
10.1021/cc049945t
Publisher: 
Journal name: 
J Comb Chem
pub_author_name: 
Yingyongnarongkul
Howarth
Elliott
Bradley
Publication ID: 
1472657
pub_author_initials: 
B-E
M
T
M
Publication volume: 
6
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2004
pub_title: 
DNA transfection screening from single beads.

The processing of antigens delivered as DNA vaccines.

pub_doi: 
10.1111/j.0105-2896.2004.00141.x
Publisher: 
Journal name: 
Immunol Rev
pub_author_name: 
Howarth
Elliott
Publication ID: 
1472660
pub_author_initials: 
M
T
Publication volume: 
199
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2004
pub_title: 
The processing of antigens delivered as DNA vaccines.

Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

pub_doi: 
10.1002/chem.200305232
Publisher: 
Journal name: 
Chemistry
pub_author_name: 
Yingyongnarongkul
Howarth
Elliott
Bradley
Publication ID: 
1472661
pub_author_initials: 
B-E
M
T
M
Publication volume: 
10
Publication number: 
Edition: 
pub_date_day: 
23
pub_date_month: 
1
pub_date_year: 
2004
pub_title: 
Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

2002

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin.

pub_doi: 
10.1016/s1074-7613(01)00260-6
Publisher: 
Journal name: 
Immunity
pub_author_name: 
Gao
Adhikari
Howarth
Nakamura
Gold
Hill
Knee
Michalak
Elliott
Publication ID: 
890817
pub_author_initials: 
B
R
M
K
MC
AB
R
M
T
Publication volume: 
16
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
1
pub_date_year: 
2002
pub_title: 
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin.

2001

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin.

pub_doi: 
10.1034/j.1399-0039.2001.580604.x
Publisher: 
Journal name: 
Tissue Antigens
pub_author_name: 
Barber
Howarth
Bowness
Elliott
Publication ID: 
1472659
pub_author_initials: 
LD
M
P
T
Publication volume: 
58
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2001
pub_title: 
The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin.
Book chapters

2021

SnoopLigase-Mediated Peptide-Peptide Conjugation and Purification.

pub_doi: 
10.1007/978-1-0716-0928-6_2
Publisher: 
Journal name: 
pub_author_name: 
Buldun
Khairil Anuar
Howarth
Publication ID: 
1468703
pub_author_initials: 
CM
INA
M
Publication volume: 
2208
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
SnoopLigase-Mediated Peptide-Peptide Conjugation and Purification.

2019

Insider information on successful covalent protein coupling with help from SpyBank.

pub_doi: 
10.1016/bs.mie.2018.12.010
Publisher: 
Journal name: 
pub_author_name: 
Keeble
Howarth
Publication ID: 
1468707
pub_author_initials: 
AH
M
Publication volume: 
617
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2019
pub_title: 
Insider information on successful covalent protein coupling with help from SpyBank.

2016

SpyRings Declassified: A Blueprint for Using Isopeptide-Mediated Cyclization to Enhance Enzyme Thermal Resilience.

pub_doi: 
10.1016/bs.mie.2016.05.004
Publisher: 
Journal name: 
pub_author_name: 
Schoene
Bennett
Howarth
Publication ID: 
1468737
pub_author_initials: 
C
SP
M
Publication volume: 
580
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2016
pub_title: 
SpyRings Declassified: A Blueprint for Using Isopeptide-Mediated Cyclization to Enhance Enzyme Thermal Resilience.

2015

Site-specific biotinylation of purified proteins using BirA.

pub_doi: 
10.1007/978-1-4939-2272-7_12
Publisher: 
Journal name: 
pub_author_name: 
Fairhead
Howarth
Publication ID: 
1468723
pub_author_initials: 
M
M
Publication volume: 
1266
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2015
pub_title: 
Site-specific biotinylation of purified proteins using BirA.
Sheild Professor of Pharmacology

Contact Details

+44 (0) 1223 3 34021 / Lab 3 34177
Not available for consultancy

Affiliations

Classifications: 
Person keywords: 
Protein engineering, synthetic biology, cancer signalling, antibodies, vaccines, protein design, protein-protein interactions, immunology, bioconjugation, gastroenterology, directed evolution.