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Dr Graham Ladds

Dr Graham Ladds

University Lecturer


Office Phone: +44 (0) 1223 3 34020 / Lab: 3 34028

Keywords

  • G proteins, GPCRs, Signal Bias, cell signalling, RAMPs, computational modelling, RGS proteins, mathematical simulations

Topics

  • Cell Signalling

Key Publications

1. Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S.J., Moarec, J-C, Woodlock, D.A., Reynolds, C.A., Poyner, D.R., Watkins, H.A. and Ladds, G. (2016) RAMP-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. J. Biol. Chem. pii: jbc.M116.751362.

2. Knight, A., Hemmings, J.L., Frenguelli, B.G., Dowell, S.J., Lochner, M. and Ladds, G. (2016) Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. J. Med Chem. 59: 947.

3. Shigeto, M., Ramracheya, R., Cha, C-Y., Chibalina, M., Tarasov, A., Philippaert, K., Reinbothe, T., Rorsman, N., Salehi. A., Sones, W., Vergari, E., Weston, C., Gorelik, J., Katsura, M., Nikolaev, O., Vennekens, R., Zaccolo, M., Gallione, A., Johnson, P.R.V., Kaku, K., Ladds, G. and Rorsman, P. (2015) Physiological concentrations of GLP-1 increases insulin secretion in mouse and human pancreatic b-cells by PKC-dependent activation of TRPM4 channels. J Clin Invest. 125: 4714.

4. Weston, C., Li, J., Li, N., Barkan, G., Richards, G.O., Roberts, D., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S., Willars, G. and LaddsG. (2015) Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290: 23009.

5.    Weston, C., Poyner, D., Patel, V., Dowell, S. and Ladds, G. (2014) Investigating G protein signaling bias at the glucagon-like peptide-1 receptor in yeast. Brit. J. Pharmacol. 171: 3651-65.

 

Investigator Biography

Graham studied Biochemistry at the University of Birmingham before completing a PhD in yeast pheromone signalling with John Davey at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest of GPCRs. He was appointed a lecturer at Warwick in 2006. In 2015 he was appointed to a lectureship in the Pharmacology Department, the University of Cambridge. He is a full member of the British Pharmacology Society and regularly attends meetings both in the UK and Australia. He has a long-standing collaboration with Dr Simon Dowell at GlaxoSmithKline. His group is interested in RAMP-mediated signalling bias of family B GPCRs.