Graham studied Biochemistry at the University of Birmingham before completing a PhD in yeast pheromone signalling at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest of GPCRs. He progressed through the ranks at Warwick become an Associate Professor before leaving in 2015 to join the Department of Pharmacology at Cambridge, where he is also a Fellow of St John’s College. In 2020, he was promoted to a Readership in Receptor Pharmacology and was elected a Fellow of the British Pharmacological Society. His research group use a combination of pharmacological investigations and mathematical modelling to study factors that control agonist bias at GPCRs. These investigations have enabled him to foster strong collaborations with the pharmaceutical industry (GSK, Takeda and Firmenich) which have recently been enhanced though him being awarded a Royal Society Industry Fellowship to collaborate with AstraZeneca.
Publications
1. Shaw, W.M., Yamauchi, H., Mead, J., Gowers, G.F., Oling, D., Larsson, N., Wigglesworth, M.*, Ladds, G.* and Ellis, T.* (2019) Engineering a model cell for rational tuning of GPCR signalling Cell pii: S0092-8674(19)30205-3. doi: 10.1016/j.cell.2019.02.023.
2. Bridge, L., Mead, J., Frattini, E., Winfield, I., and Ladds, G.(2018) Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. J. Theoretical. Biol.7: 44-65.
3. Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S.J., Moarec, J-C, Woodlock, D.A., Reynolds, C.A., Poyner, D.R., Watkins, H.A. and Ladds, G. (2016) RAMP-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. J. Biol. Chem.91: 21925 .
4. Knight, A., Hemmings, J.L., Frenguelli, B.G., Dowell, S.J., Lochner, M. and Ladds, G. (2016) Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. J. Med Chem. 59: 947.
5. Weston, C., Li, J., Li, N., Barkan, G., Richards, G.O., Roberts, D., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S., Willars, G. and Ladds, G. (2015) Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290: 23009.
Investigator Biography
Graham studied Biochemistry at the University of Birmingham before completing a PhD in yeast pheromone signalling with John Davey at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest of GPCRs. He was appointed a lecturer at Warwick in 2006. In 2015 he was appointed to a lectureship in the Pharmacology Department, the University of Cambridge. He is a full member of the British Pharmacology Society and regularly attends meetings both in the UK and Australia. He has a long-standing collaboration with Dr Simon Dowell at GlaxoSmithKline. His group is interested in RAMP-mediated signalling bias of family B GPCRs.
Publication (Symplectic Elements)
2023 (No publication date)
2023
2022 (No publication date)
2021 (No publication date)
2023 (Accepted for publication)
Doi: http://doi.org/10.1007/s00125-023-06060-w
2023
Doi: 10.1111/bph.16191
Doi: http://doi.org/10.1016/j.eti.2023.103014
2022
Doi: http://doi.org/10.3389/fphys.2022.840763
Doi: http://doi.org/10.1021/acsmedchemlett.2c00052
Doi: http://doi.org/10.1038/s41467-022-31652-2
Doi: http://doi.org/10.1038/s41467-022-33207-x
Doi: http://doi.org/10.1021/acs.jmedchem.2c01123
Doi: http://doi.org/10.1021/acs.jmedchem.2c01414
2021 (Accepted for publication)
Doi: http://doi.org/10.1021/acsptsci.0c00195
2021
Doi: http://doi.org/10.1186/s13321-021-00492-5
Doi: http://doi.org/10.1021/acs.jcim.0c01331
Doi: http://doi.org/10.1038/s41598-021-89853-6
Doi: http://doi.org/10.1042/BST20201144
Doi: http://doi.org/10.3390/cancers13153780
Doi: http://doi.org/10.3390/ijms22189665
Doi: http://doi.org/10.3389/fendo.2021.792912
Doi: http://doi.org/10.1016/j.coemr.2020.07.002
2020 (Accepted for publication)
2020
Doi: http://doi.org/10.1101/2020.12.21.423730
Doi: http://doi.org/10.1016/j.bbamem.2019.183174
Doi: http://doi.org/10.1016/j.bcp.2020.113823
Doi: http://doi.org/10.1021/acs.jcim.0c00240
Doi: http://doi.org/10.1016/j.jmgm.2020.107662
Doi: http://doi.org/10.1021/acs.jmedchem.0c01416
Doi: http://doi.org/10.1038/s41586-020-2888-2
Doi: http://doi.org/10.1101/2020.10.22.350827
Doi: http://doi.org/10.1101/2020.10.14.338822
Doi: http://doi.org/10.1038/s41586-020-2999-9
2019 (Accepted for publication)
Doi: http://doi.org/10.1016/j.bbamem.2019.02.008
Doi: http://doi.org/10.1021/acs.jmedchem.9b01164
2019
Doi: http://doi.org/10.1002/stem.2954
Doi: http://doi.org/10.1016/j.cell.2019.02.023
Doi: http://doi.org/10.1101/694810
Doi: http://doi.org/10.1101/693796
Doi: 10.1073/pnas.1905561116
Doi: http://doi.org/10.1021/acs.jcim.9b00751
Doi: 10.1101/845776
2018 (Accepted for publication)
Doi: http://doi.org/10.1080/13543776.2018.1494155.
2018
Doi: http://doi.org/10.1080/13543776.2018.1494155
Doi: http://doi.org/10.1101/390559
2017 (Accepted for publication)
Doi: http://doi.org/10.1186/s13321-017-0249-4
2017
Doi: http://doi.org/10.1016/j.mce.2017.03.033
Doi: http://doi.org/10.1042/bsr20171079
2016
Doi: http://doi.org/10.1074/jbc.A116.751362
Doi: http://doi.org/10.1021/acs.jmedchem.5b01402
Doi: http://doi.org/10.1186/s12964-016-0128-z
Doi: http://doi.org/10.1042/BST20150237
Doi: http://doi.org/10.1074/jbc.M116.751362
2015
Doi: http://doi.org/10.1515/hsz-2014-0257
Doi: http://doi.org/10.1002/cyto.a.22600
Doi: http://doi.org/10.1074/jbc.M114.624601
Doi: http://doi.org/10.1016/j.neuropharm.2015.03.006
Doi: http://doi.org/10.1172/JCI81975
Doi: http://doi.org/10.1007/s00285-014-0823-6
2014
Doi: http://doi.org/10.1111/bph.12716
Doi: http://doi.org/10.1016/j.bbamem.2014.08.019
2013
Doi: http://doi.org/10.1074/jbc.M113.497826
Doi: http://doi.org/10.1371/journal.pone.0065927
Doi: http://doi.org/10.1371/journal.pone.0077487
Doi: http://doi.org/10.1002/yea.2949
2011
Doi: http://doi.org/10.1007/978-1-61779-126-0_7
2010
Doi: http://doi.org/10.1091/mbc.e09-08-0743
2009
Doi: http://doi.org/10.1159/000204075
Doi: http://doi.org/10.1016/j.ejphar.2009.03.042
Doi: http://doi.org/10.1016/j.cellsig.2009.03.004
2008
Doi: http://doi.org/10.1016/j.bbrc.2008.02.064
Doi: http://doi.org/10.1016/j.cellsig.2007.10.016
2007
Doi: http://doi.org/10.1016/j.cellsig.2006.07.016
Doi: http://doi.org/10.1111/j.1742-4658.2007.06080.x
Doi: http://doi.org/10.1016/j.cellsig.2006.05.027
2006
Doi: http://doi.org/10.1002/yea.1402
Doi: http://doi.org/10.1016/j.fgb.2006.06.005
Doi: http://doi.org/10.1016/j.semcdb.2006.03.004
Doi: http://doi.org/10.1016/j.semcdb.2006.03.008
2005
Doi: http://doi.org/10.1002/yea.1330
Doi: http://doi.org/10.1002/yea.1190
Doi: http://doi.org/10.1016/j.tibtech.2005.05.007
Doi: http://doi.org/10.1016/j.bbrc.2005.09.149
Doi: http://doi.org/10.1111/j.1365-2958.2004.04394.x
2004
Doi: http://doi.org/10.1385/MB:28:3:201
2003
Doi: http://doi.org/10.1210/jc.2002-021212
Doi: http://doi.org/10.1046/j.1365-2958.2003.03336.x
2002
Doi: http://doi.org/10.1007/s00294-002-0301-3
2000
Doi: http://doi.org/10.1046/j.1365-2958.2000.02028.x
Doi: http://doi.org/10.1046/j.1365-2958.2000.01855.x
Doi: http://doi.org/10.1046/j.1365-2958.2000.02180.x
1998
Doi: http://doi.org/10.1006/scdb.1997.0215
Doi: http://doi.org/10.1006/scdb.1997.0197
1997
Doi: http://doi.org/10.1042/bst025228s
1996
Doi: http://doi.org/10.1111/j.1365-2958.1996.tb02486.x
2021
2019
2018
Doi: 10.1136/esmoopen-2018-eacr25.129
2017
2002
Doi: http://doi.org/10.1042/bst0300428
1997
Doi: http://doi.org/10.1042/bst025446s
1996
Doi: http://doi.org/10.1042/bst024210s
Doi: http://doi.org/10.1042/bst024502s
Doi: http://doi.org/10.1042/bst024504s
1995
Doi: http://doi.org/10.1042/bst023565s
2021
Doi: http://doi.org/10.1016/bs.mcb.2021.06.013
Doi: 10.1007/978-3-030-57401-7_5055
2020
Doi: 10.1007/978-3-030-21573-6_5055-1
2004
Doi: 10.1007/978-3-662-10360-9_26