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Department of Pharmacology

 

Graham studied Biochemistry at the University of Birmingham before completing a PhD in yeast pheromone signalling at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest of GPCRs. He progressed through the ranks at Warwick become an Associate Professor before leaving in 2015 to join the Department of Pharmacology at Cambridge, where he is also a Fellow of St John’s College. In 2020, he was promoted to a Readership in Receptor Pharmacology and was elected a Fellow of the British Pharmacological Society. His research group use a combination of pharmacological investigations and mathematical modelling to study factors that control agonist bias at GPCRs. These investigations have enabled him to foster strong collaborations with the pharmaceutical industry (GSK, Takeda and Firmenich) which have recently been enhanced though him being awarded a Royal Society Industry Fellowship to collaborate with AstraZeneca.

Publications

Key publications: 

1. Shaw, W.M., Yamauchi, H., Mead, J., Gowers, G.F., Oling, D., Larsson, N., Wigglesworth, M.*, Ladds, G.* and Ellis, T.* (2019) Engineering a model cell for rational tuning of GPCR signalling Cell pii: S0092-8674(19)30205-3. doi: 10.1016/j.cell.2019.02.023.

2. Bridge, L., Mead, J., Frattini, E., Winfield, I., and Ladds, G.(2018) Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. J. Theoretical. Biol.7: 44-65.

3. Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S.J., Moarec, J-C, Woodlock, D.A., Reynolds, C.A., Poyner, D.R., Watkins, H.A. and Ladds, G. (2016) RAMP-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. J. Biol. Chem.91: 21925 .

 4. Knight, A., Hemmings, J.L., Frenguelli, B.G., Dowell, S.J., Lochner, M. and Ladds, G. (2016) Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. J. Med Chem. 59: 947.

5. Weston, C., Li, J., Li, N., Barkan, G., Richards, G.O., Roberts, D., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S., Willars, G. and Ladds, G. (2015) Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290: 23009.

 

Investigator Biography

Graham studied Biochemistry at the University of Birmingham before completing a PhD in yeast pheromone signalling with John Davey at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest of GPCRs. He was appointed a lecturer at Warwick in 2006. In 2015 he was appointed to a lectureship in the Pharmacology Department, the University of Cambridge. He is a full member of the British Pharmacology Society and regularly attends meetings both in the UK and Australia. He has a long-standing collaboration with Dr Simon Dowell at GlaxoSmithKline. His group is interested in RAMP-mediated signalling bias of family B GPCRs.

Publication (Symplectic Elements)

Journal articles

2023

Integrated biorefinery approach to valorise Saccharina latissima biomass: Combined sustainable processing to produce biologically active fucoxanthin, mannitol, fucoidans and alginates

pub_doi: 
10.1016/j.eti.2023.103014
Publisher: 
Journal name: 
Environmental Technology and Innovation
pub_author_name: 
McElroy
Kopanitsa
Helmes
Fan
Attard
Simister
van den Burg
Ladds
Bailey
Gomez
Publication ID: 
1460624
pub_author_initials: 
CR
L
R
J
TM
R
S
G
DS
LD
Publication volume: 
29
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
2
pub_date_year: 
2023
pub_title: 
Integrated biorefinery approach to valorise Saccharina latissima biomass: Combined sustainable processing to produce biologically active fucoxanthin, mannitol, fucoidans and alginates

2022

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.

pub_doi: 
10.3389/fphys.2022.840763
Publisher: 
Journal name: 
Front Physiol
pub_author_name: 
Pearce
Redfern-Nichols
Harris
Poyner
Wigglesworth
Ladds
Publication ID: 
1378837
pub_author_initials: 
A
T
M
DR
M
G
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2022
pub_title: 
Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.

Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold.

pub_doi: 
10.1021/acsmedchemlett.2c00052
Publisher: 
Journal name: 
ACS Med Chem Lett
pub_author_name: 
Suchankova
Stampelou
Koutsouki
Pousias
Dhingra
Barkan
Pouli
Marakos
Tenta
Kolocouris
Lougiakis
Ladds
Publication ID: 
1393258
pub_author_initials: 
A
M
K
A
L
K
N
P
R
A
N
G
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
9
pub_date_month: 
6
pub_date_year: 
2022
pub_title: 
Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold.

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.

pub_doi: 
10.1038/s41467-022-31652-2
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Wall
Hill
Huckstepp
Barkan
Deganutti
Leuenberger
Preti
Winfield
Carvalho
Suchankova
Wei
Safitri
Huang
Imlach
La Mache
Dean
Hume
Hayward
Oliver
Zhao
Spanswick
Reynolds
Lochner
Ladds
Frenguelli
Publication ID: 
1399151
pub_author_initials: 
MJ
E
R
K
G
M
B
I
S
A
H
D
X
W
C
E
C
S
J
F-Y
D
CA
M
G
BG
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
18
pub_date_month: 
7
pub_date_year: 
2022
pub_title: 
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.

Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow.

pub_doi: 
10.1038/s41467-022-33207-x
Publisher: 
Journal name: 
Nat Commun
pub_author_name: 
Shaw
Zhang
Lu
Khalil
Ladds
Luo
Ellis
Publication ID: 
1422531
pub_author_initials: 
WM
Y
X
AS
G
X
T
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
20
pub_date_month: 
9
pub_date_year: 
2022
pub_title: 
Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow.

Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations.

pub_doi: 
10.1021/acs.jmedchem.2c01123
Publisher: 
Journal name: 
J Med Chem
pub_author_name: 
Stampelou
Suchankova
Tzortzini
Dhingra
Barkan
Lougiakis
Marakos
Pouli
Ladds
Kolocouris
Publication ID: 
1428978
pub_author_initials: 
M
A
E
L
K
N
P
N
G
A
Publication volume: 
65
Publication number: 
Edition: 
pub_date_day: 
13
pub_date_month: 
10
pub_date_year: 
2022
pub_title: 
Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations.

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists.

pub_doi: 
10.1021/acs.jmedchem.2c01414
Publisher: 
Journal name: 
J Med Chem
pub_author_name: 
Preti
Suchankova
Deganutti
Leuenberger
Barkan
Manulak
Huang
Carvalho
Ladds
Lochner
Publication ID: 
1433307
pub_author_initials: 
B
A
G
M
K
I
X
S
G
M
Publication volume: 
65
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
11
pub_date_year: 
2022
pub_title: 
Discovery and Structure-Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists.

2021 (Accepted for publication)

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

pub_doi: 
10.1021/acsptsci.0c00195
Publisher: 
American Chemical Society (ACS)
Journal name: 
ACS Pharmacology & Translational Science
pub_author_name: 
Deganutti
Barkan
Preti
Leuenberger
Wall
Frenguelli
Lochner
Ladds
Reynolds
Publication ID: 
1266522
pub_author_initials: 
G
K
B
M
M
BG
M
G
CA
Publication volume: 
Publication number: 
acsptsci.0c00195
Edition: 
pub_date_day: 
20
pub_date_month: 
1
pub_date_year: 
2021 (Accepted for publication)
pub_title: 
Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

pub_doi: 
Publisher: 
Nature Research
Journal name: 
Communications Biology
pub_author_name: 
Ladds
clark
Mullooly
Safitri
Harris
de Vries
MaassenVanDenBrink
Poyner
Gianni
Wigglesworth
Publication ID: 
1293522
pub_author_initials: 
G
A
N
D
M
T
A
D
D
M
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
11
pub_date_month: 
5
pub_date_year: 
2021 (Accepted for publication)
pub_title: 
CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

2021

Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition.

pub_doi: 
10.3390/ijms22189665
Publisher: 
Journal name: 
Int J Mol Sci
pub_author_name: 
Kopanitsa
Kopanitsa
Safitri
Ladds
Bailey
Publication ID: 
1319574
pub_author_initials: 
L
MV
D
G
DS
Publication volume: 
22
Publication number: 
Edition: 
pub_date_day: 
7
pub_date_month: 
9
pub_date_year: 
2021
pub_title: 
Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition.

The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation.

pub_doi: 
10.3389/fendo.2021.792912
Publisher: 
Journal name: 
Front Endocrinol (Lausanne)
pub_author_name: 
Winfield
Barkan
Routledge
Robertson
Harris
Jazayeri
Simms
Reynolds
Poyner
Ladds
Publication ID: 
1363727
pub_author_initials: 
I
K
S
NJ
M
A
J
CA
DR
G
Publication volume: 
12
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation.

Novel mathematical and computational models of G protein-coupled receptor signalling

pub_doi: 
10.1016/j.coemr.2020.07.002
Publisher: 
Elsevier
Journal name: 
Current Opinion in Endocrine and Metabolic Research
pub_author_name: 
Ladds
Carvalho
Pearce
Publication ID: 
1212388
pub_author_initials: 
G
S
A
Publication volume: 
16
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2021
pub_title: 
Novel mathematical and computational models of G protein-coupled receptor signalling

Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines.

pub_doi: 
10.1186/s13321-021-00492-5
Publisher: 
Journal name: 
J Cheminform
pub_author_name: 
Kalash
Winfield
Safitri
Bermudez
Carvalho
Glen
Ladds
Bender
Publication ID: 
1278625
pub_author_initials: 
L
I
D
M
S
R
G
A
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
3
pub_date_month: 
3
pub_date_year: 
2021
pub_title: 
Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines.

Multisite Model of Allosterism for the Adenosine A1 Receptor.

pub_doi: 
10.1021/acs.jcim.0c01331
Publisher: 
Journal name: 
J Chem Inf Model
pub_author_name: 
Deganutti
Barkan
Ladds
Reynolds
Publication ID: 
1284951
pub_author_initials: 
G
K
G
CA
Publication volume: 
61
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
4
pub_date_year: 
2021
pub_title: 
Multisite Model of Allosterism for the Adenosine A1 Receptor.

Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.

pub_doi: 
10.1038/s41598-021-89853-6
Publisher: 
Journal name: 
Sci Rep
pub_author_name: 
Dolezalova
Gruszczyk
Barkan
Gamble
Galvin
Moreth
O'Holleran
Mahbubani
Higgins
Gribble
Reimann
Surmacki
Andrews
Casey
Pampaloni
Murphy
Ladds
Slater
Saeb-Parsy
Publication ID: 
1293736
pub_author_initials: 
N
A
K
JA
S
T
K
KT
JA
FM
F
J
S
JJ
F
MP
G
NKH
K
Publication volume: 
11
Publication number: 
Edition: 
pub_date_day: 
17
pub_date_month: 
5
pub_date_year: 
2021
pub_title: 
Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.

Emerging roles of adhesion G protein-coupled receptors.

pub_doi: 
10.1042/BST20201144
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Rosa
Noel
Harris
Ladds
Publication ID: 
1309516
pub_author_initials: 
M
T
M
G
Publication volume: 
49
Publication number: 
Edition: 
pub_date_day: 
27
pub_date_month: 
8
pub_date_year: 
2021
pub_title: 
Emerging roles of adhesion G protein-coupled receptors.

Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.

pub_doi: 
10.3390/cancers13153780
Publisher: 
Journal name: 
Cancers (Basel)
pub_author_name: 
Shapovalov
Kopanitsa
Pruteanu
Ladds
Bailey
Publication ID: 
1310198
pub_author_initials: 
V
L
L-L
G
DS
Publication volume: 
13
Publication number: 
Edition: 
pub_date_day: 
27
pub_date_month: 
7
pub_date_year: 
2021
pub_title: 
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.

2020 (Accepted for publication)

Pharmacological Characterisation of Novel Adenosine A3 Receptor Antagonists

pub_doi: 
Publisher: 
Nature Publishing Group
Journal name: 
Scientific Reports
pub_author_name: 
Barkan
Lagarias
Stampelou
Stamatis
Hoare
Safitri
Klotz
Vrontaki
Ladds
Kolocouris
Publication ID: 
1230853
pub_author_initials: 
K
P
M
D
S
D
K-N
E
G
A
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
18
pub_date_month: 
9
pub_date_year: 
2020 (Accepted for publication)
pub_title: 
Pharmacological Characterisation of Novel Adenosine A3 Receptor Antagonists

2020

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells.

pub_doi: 
10.1016/j.bcp.2020.113823
Publisher: 
Journal name: 
Biochem Pharmacol
pub_author_name: 
Safitri
Harris
Potter
Yan Yeung
Winfield
Kopanitsa
Svensson
Rahman
Harper
Bailey
Ladds
Publication ID: 
1170933
pub_author_initials: 
D
M
H
H
I
L
F
T
MT
D
G
Publication volume: 
174
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
2020
pub_title: 
Elevated intracellular cAMP concentration mediates growth suppression in glioma cells.

Correction to Insights to the Binding of a Selective Adenosine A3 Receptor Antagonist using Molecular Dynamic Simulations, MM-PBSA and MM-GBSA Free Energy Calculations, and Mutagenesis.

pub_doi: 
10.1021/acs.jcim.0c00240
Publisher: 
Journal name: 
J Chem Inf Model
pub_author_name: 
Lagarias
Barkan
Tzortzini
Stampelou
Vrontaki
Ladds
Kolocouris
Publication ID: 
1187045
pub_author_initials: 
P
K
E
M
E
G
A
Publication volume: 
60
Publication number: 
Edition: 
pub_date_day: 
27
pub_date_month: 
4
pub_date_year: 
2020
pub_title: 
Correction to Insights to the Binding of a Selective Adenosine A3 Receptor Antagonist using Molecular Dynamic Simulations, MM-PBSA and MM-GBSA Free Energy Calculations, and Mutagenesis.

Proposed model of the Dictyostelium cAMP receptors bound to cAMP.

pub_doi: 
10.1016/j.jmgm.2020.107662
Publisher: 
Journal name: 
J Mol Graph Model
pub_author_name: 
Greenhalgh
Chandran
Harper
Ladds
Rahman
Publication ID: 
1214293
pub_author_initials: 
JC
A
MT
G
T
Publication volume: 
100
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
2020
pub_title: 
Proposed model of the Dictyostelium cAMP receptors bound to cAMP.

Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

pub_doi: 
10.1021/acs.jmedchem.0c01416
Publisher: 
Journal name: 
J Med Chem
pub_author_name: 
Knight
Hemmings
Winfield
Leuenberger
Frattini
Frenguelli
Dowell
Lochner
Ladds
Publication ID: 
1228349
pub_author_initials: 
A
JL
I
M
E
BG
SJ
M
G
Publication volume: 
63
Publication number: 
Edition: 
pub_date_day: 
24
pub_date_month: 
9
pub_date_year: 
2020
pub_title: 
Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

Combinatorial expression of GPCR isoforms affects signalling and drug responses.

pub_doi: 
10.1038/s41586-020-2888-2
Publisher: 
Journal name: 
Nature
pub_author_name: 
Marti-Solano
Crilly
Malinverni
Munk
Harris
Pearce
Quon
Mackenzie
Wang
Peng
Tobin
Ladds
Milligan
Gloriam
Puthenveedu
Babu
Publication ID: 
1245272
pub_author_initials: 
M
SE
D
C
M
A
T
AE
X
J
AB
G
G
DE
MA
MM
Publication volume: 
587
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
2020
pub_title: 
Combinatorial expression of GPCR isoforms affects signalling and drug responses.

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

pub_doi: 
10.1101/2020.10.22.350827
Publisher: 
Journal name: 
pub_author_name: 
Deganutti
Barkan
Preti
Leuenberger
Wall
Frenguelli
Lochner
Ladds
Reynolds
Publication ID: 
1240686
pub_author_initials: 
G
K
B
M
M
B
M
G
C
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2020
pub_title: 
Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

A Multisite Model of Allosterism for the Adenosine A1 Receptor

pub_doi: 
10.1101/2020.10.14.338822
Publisher: 
Journal name: 
pub_author_name: 
Deganutti
Barkan
Ladds
Reynolds
Publication ID: 
1240687
pub_author_initials: 
G
K
G
C
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2020
pub_title: 
A Multisite Model of Allosterism for the Adenosine A1 Receptor

Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses.

pub_doi: 
10.1038/s41586-020-2999-9
Publisher: 
Journal name: 
Nature
pub_author_name: 
Marti-Solano
Crilly
Malinverni
Munk
Harris
Pearce
Quon
Mackenzie
Wang
Peng
Tobin
Ladds
Milligan
Gloriam
Puthenveedu
Babu
Publication ID: 
1252405
pub_author_initials: 
M
SE
D
C
M
A
T
AE
X
J
AB
G
G
DE
MA
MM
Publication volume: 
588
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2020
pub_title: 
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses.

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

pub_doi: 
10.1101/2020.12.21.423730
Publisher: 
Journal name: 
pub_author_name: 
Clark
Mullooly
Safitri
Harris
de Vries
Van Den Brink
Poyner
Giani
Wigglesworth
Ladds
Publication ID: 
1261328
pub_author_initials: 
A
N
D
M
T
AM
D
D
M
G
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2020
pub_title: 
CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

pub_doi: 
10.1016/j.bbamem.2019.183174
Publisher: 
Journal name: 
Biochim Biophys Acta Biomembr
pub_author_name: 
Routledge
Simms
Clark
Yeung
Wigglesworth
Dickerson
Kitchen
Ladds
Poyner
Publication ID: 
1164956
pub_author_initials: 
SJ
J
A
HY
MJ
IM
P
G
DR
Publication volume: 
1862
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
3
pub_date_year: 
2020
pub_title: 
Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

2019 (Accepted for publication)

Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

pub_doi: 
10.1016/j.bbamem.2019.02.008
Publisher: 
Elsevier BV
Journal name: 
Biochimica et Biophysica Acta (BBA) - Biomembranes
pub_author_name: 
Bailey
Harris
Barkan
Winfield
Harper
Simms
Ladds
Wheatley
Poyner
Publication ID: 
1066180
pub_author_initials: 
S
M
K
I
MT
J
G
M
D
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
2
pub_date_year: 
2019 (Accepted for publication)
pub_title: 
Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

Structural Characterization of Agonist Binding to an A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments.

pub_doi: 
10.1021/acs.jmedchem.9b01164
Publisher: 
American Chemical Society
Journal name: 
Journal of Medicinal Chemistry
pub_author_name: 
Stamatis
Lagarias
Barkan
Vrontaki
Ladds
Kolocouris
Publication ID: 
1123834
pub_author_initials: 
D
P
K
E
G
A
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
10
pub_date_month: 
9
pub_date_year: 
2019 (Accepted for publication)
pub_title: 
Structural Characterization of Agonist Binding to an A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments.

2019

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

pub_doi: 
10.1101/845776
Publisher: 
Journal name: 
pub_author_name: 
Recino
Barkan
Schmidt-Christensen
Nilsson
Holmes
Howie
Holmberg
Larsson
Flodström-Tullberg
Laraia
Spring
Hecksher-Sørensen
Cooke
Ladds
Wållberg
Publication ID: 
1179454
pub_author_initials: 
A
K
A
J
N
D
D
P
M
L
DR
J
A
G
M
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
17
pub_date_month: 
11
pub_date_year: 
2019
pub_title: 
GLP-1R is downregulated in beta cells of NOD mice and T1D patients

Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency.

pub_doi: 
10.1002/stem.2954
Publisher: 
Journal name: 
Stem Cells
pub_author_name: 
Neganova
Cotts
Banks
Gassner
Shukurov
Armstrong
Ladds
Lako
Publication ID: 
1039174
pub_author_initials: 
I
L
P
K
A
L
G
M
Publication volume: 
37
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
3
pub_date_year: 
2019
pub_title: 
Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency.

Engineering a Model Cell for Rational Tuning of GPCR Signaling

pub_doi: 
10.1016/j.cell.2019.02.023
Publisher: 
Cell Press
Journal name: 
Cell
pub_author_name: 
Shaw
Yamauchi
Gowers
Bell
Oling
Wigglesworth
Ladds
Ellis
Publication ID: 
1072116
pub_author_initials: 
W
H
G-O
D
NL
M
G
T
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
18
pub_date_month: 
4
pub_date_year: 
2019
pub_title: 
Engineering a Model Cell for Rational Tuning of GPCR Signaling

Proposed model of the Dictyostelium cAMP receptors bound to cAMP

pub_doi: 
10.1101/694810
Publisher: 
Journal name: 
pub_author_name: 
Greenhalgh
Chandran
Harper
Ladds
Rahman
Publication ID: 
1108844
pub_author_initials: 
JC
A
MT
G
T
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2019
pub_title: 
Proposed model of the Dictyostelium cAMP receptors bound to cAMP

Pharmacological Characterisation of Novel Adenosine Receptor A<sub>3</sub>R Antagonists

pub_doi: 
10.1101/693796
Publisher: 
Journal name: 
pub_author_name: 
Barkan
Lagarias
Stampelou
Stamatis
Hoare
Klotz
Vrontaki
Kolocouris
Ladds
Publication ID: 
1108845
pub_author_initials: 
K
P
M
D
S
K-N
E
A
G
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2019
pub_title: 
Pharmacological Characterisation of Novel Adenosine Receptor A<sub>3</sub>R Antagonists

RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis.

pub_doi: 
10.1073/pnas.1905561116
Publisher: 
Journal name: 
Proc Natl Acad Sci U S A
pub_author_name: 
Mackie
Nielsen
Harris
Singh
Davis
Dy
Ladds
Caron
Publication ID: 
1139017
pub_author_initials: 
DI
NR
M
S
RB
D
G
KM
Publication volume: 
116
Publication number: 
Edition: 
pub_date_day: 
26
pub_date_month: 
11
pub_date_year: 
2019
pub_title: 
RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis.

Insights to the Binding of a Selective Adenosine A3 Receptor Antagonist Using Molecular Dynamic Simulations, MM-PBSA and MM-GBSA Free Energy Calculations, and Mutagenesis.

pub_doi: 
10.1021/acs.jcim.9b00751
Publisher: 
Journal name: 
J Chem Inf Model
pub_author_name: 
Lagarias
Barkan
Tzortzini
Stampelou
Vrontaki
Ladds
Kolocouris
Publication ID: 
1141307
pub_author_initials: 
P
K
E
M
E
G
A
Publication volume: 
59
Publication number: 
Edition: 
pub_date_day: 
23
pub_date_month: 
12
pub_date_year: 
2019
pub_title: 
Insights to the Binding of a Selective Adenosine A3 Receptor Antagonist Using Molecular Dynamic Simulations, MM-PBSA and MM-GBSA Free Energy Calculations, and Mutagenesis.

2018 (Accepted for publication)

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor

pub_doi: 
Publisher: 
Elsevier
Journal name: 
Journal of Theoretical Biology
pub_author_name: 
Bridge
Mead
Frattini
Winfield
Ladds
Publication ID: 
961849
pub_author_initials: 
L
J
E
I
GR
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
11
pub_date_month: 
1
pub_date_year: 
2018 (Accepted for publication)
pub_title: 
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

pub_doi: 
Publisher: 
Springer Nature
Journal name: 
Nature Communications
pub_author_name: 
Khaled
Lazarus
Hadi
Zambon
Bach
Santolla
Watson
Correia
Das
Ugur
Pensa
Becker
Campos
Ladds
Liu
Evan
McCaughan
Lee
Calado
Le Quesne
Publication ID: 
1007585
pub_author_initials: 
WT
K
F
E
K
M
J
L
M
R
S
L
L
G
P
G
F
J
D
J
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
15
pub_date_month: 
6
pub_date_year: 
2018 (Accepted for publication)
pub_title: 
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

Emerging Patents in the Therapeutic Areas of Glioma and Glioblastoma.

pub_doi: 
10.1080/13543776.2018.1494155.
Publisher: 
Taylor & Francis
Journal name: 
Expert Opinion on Therapeutic Patents
pub_author_name: 
Harris
Svensson
Kopanitsa
Ladds
Bailey
Publication ID: 
1012086
pub_author_initials: 
M
F
L
GR
D
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
25
pub_date_month: 
6
pub_date_year: 
2018 (Accepted for publication)
pub_title: 
Emerging Patents in the Therapeutic Areas of Glioma and Glioblastoma.

2018

Emerging patents in the therapeutic areas of glioma and glioblastoma.

pub_doi: 
10.1080/13543776.2018.1494155
Publisher: 
Journal name: 
Expert Opin Ther Pat
pub_author_name: 
Harris
Svensson
Kopanitsa
Ladds
Bailey
Publication ID: 
1012424
pub_author_initials: 
M
F
L
G
D
Publication volume: 
28
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
7
pub_date_year: 
2018
pub_title: 
Emerging patents in the therapeutic areas of glioma and glioblastoma.

Engineering a model cell for rational tuning of GPCR signaling

pub_doi: 
10.1101/390559
Publisher: 
Journal name: 
pub_author_name: 
Shaw
Yamauchi
Mead
Gowers
Öling
Larsson
Wigglesworth
Ladds
Ellis
Publication ID: 
1108846
pub_author_initials: 
W
H
J
G-O
D
N
M
G
T
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2018
pub_title: 
Engineering a model cell for rational tuning of GPCR signaling

2017 (Accepted for publication)

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases

pub_doi: 
10.1186/s13321-017-0249-4
Publisher: 
BioMed Central
Journal name: 
Journal of Cheminformatics
pub_author_name: 
Kalash
Publication ID: 
959256
pub_author_initials: 
L
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
12
pub_date_year: 
2017 (Accepted for publication)
pub_title: 
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases

2017

The effects of RAMPs upon cell signalling.

pub_doi: 
10.1016/j.mce.2017.03.033
Publisher: 
Journal name: 
Mol Cell Endocrinol
pub_author_name: 
Routledge
Ladds
Poyner
Publication ID: 
889309
pub_author_initials: 
SJ
G
DR
Publication volume: 
449
Publication number: 
Edition: 
pub_date_day: 
5
pub_date_month: 
7
pub_date_year: 
2017
pub_title: 
The effects of RAMPs upon cell signalling.

Hyperglycemia does not affect antigen specific activation and cytolytic killing by CD8+ T cells in vivo

pub_doi: 
10.1042/bsr20171079
Publisher: 
Portland Press, Biochemical Society
Journal name: 
Bioscience Reports
pub_author_name: 
Recino
Barkan
Ladds
Cooke
Wong
Wallberg
Publication ID: 
925123
pub_author_initials: 
A
K
G
A
FS
M
Publication volume: 
37
Publication number: 
BSR20171079
Edition: 
pub_date_day: 
31
pub_date_month: 
8
pub_date_year: 
2017
pub_title: 
Hyperglycemia does not affect antigen specific activation and cytolytic killing by CD8+ T cells in vivo

2016

Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

pub_doi: 
10.1021/acs.jmedchem.5b01402
Publisher: 
Journal name: 
J Med Chem
pub_author_name: 
Knight
Hemmings
Winfield
Leuenberger
Frattini
Frenguelli
Dowell
Lochner
Ladds
Publication ID: 
748071
pub_author_initials: 
A
JL
I
M
E
BG
SJ
M
G
Publication volume: 
59
Publication number: 
Edition: 
pub_date_day: 
11
pub_date_month: 
2
pub_date_year: 
2016
pub_title: 
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

Feedback activation of neurofibromin terminates growth factor-induced Ras activation.

pub_doi: 
10.1186/s12964-016-0128-z
Publisher: 
Journal name: 
Cell Commun Signal
pub_author_name: 
Hennig
Markwart
Wolff
Schubert
Cui
Prior
Esparza-Franco
Ladds
Rubio
Publication ID: 
752182
pub_author_initials: 
A
R
K
K
Y
IA
MA
G
I
Publication volume: 
14
Publication number: 
Edition: 
pub_date_day: 
9
pub_date_month: 
2
pub_date_year: 
2016
pub_title: 
Feedback activation of neurofibromin terminates growth factor-induced Ras activation.

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.

pub_doi: 
10.1042/BST20150237
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Hay
Walker
Gingell
Ladds
Reynolds
Poyner
Publication ID: 
761007
pub_author_initials: 
DL
CS
JJ
G
CA
DR
Publication volume: 
44
Publication number: 
Edition: 
pub_date_day: 
15
pub_date_month: 
4
pub_date_year: 
2016
pub_title: 
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

pub_doi: 
10.1074/jbc.M116.751362
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Weston
Winfield
Harris
Hodgson
Shah
Dowell
Mobarec
Woodlock
Reynolds
Poyner
Watkins
Ladds
Publication ID: 
794557
pub_author_initials: 
C
I
M
R
A
SJ
JC
DA
CA
DR
HA
G
Publication volume: 
291
Publication number: 
Edition: 
pub_date_day: 
14
pub_date_month: 
10
pub_date_year: 
2016
pub_title: 
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.

pub_doi: 
10.1074/jbc.A116.751362
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Weston
Winfield
Harris
Hodgson
Shah
Dowell
Mobarec
Woodcock
Reynolds
Poyner
Watkins
Ladds
Publication ID: 
962410
pub_author_initials: 
C
I
M
R
A
SJ
JC
DA
CA
DR
HA
G
Publication volume: 
291
Publication number: 
Edition: 
pub_date_day: 
2
pub_date_month: 
12
pub_date_year: 
2016
pub_title: 
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.

2015

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

pub_doi: 
10.1172/JCI81975
Publisher: 
Journal name: 
J Clin Invest
pub_author_name: 
Shigeto
Ramracheya
Tarasov
Cha
Chibalina
Hastoy
Philippaert
Reinbothe
Rorsman
Salehi
Sones
Vergari
Weston
Gorelik
Katsura
Nikolaev
Vennekens
Zaccolo
Galione
Johnson
Kaku
Ladds
Rorsman
Publication ID: 
727191
pub_author_initials: 
M
R
AI
CY
MV
B
K
T
N
A
WR
E
C
J
M
VO
R
M
A
PRV
K
G
P
Publication volume: 
125
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2015
pub_title: 
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Parameter identification problems in the modelling of cell motility.

pub_doi: 
10.1007/s00285-014-0823-6
Publisher: 
Journal name: 
J Math Biol
pub_author_name: 
Croft
Elliott
Ladds
Stinner
Venkataraman
Weston
Publication ID: 
707523
pub_author_initials: 
W
CM
G
B
C
C
Publication volume: 
71
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2015
pub_title: 
Parameter identification problems in the modelling of cell motility.

Ras activation revisited: role of GEF and GAP systems.

pub_doi: 
10.1515/hsz-2014-0257
Publisher: 
Journal name: 
Biol Chem
pub_author_name: 
Hennig
Markwart
Esparza-Franco
Ladds
Rubio
Publication ID: 
707534
pub_author_initials: 
A
R
MA
G
I
Publication volume: 
396
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2015
pub_title: 
Ras activation revisited: role of GEF and GAP systems.

Image based validation of dynamical models for cell reorientation.

pub_doi: 
10.1002/cyto.a.22600
Publisher: 
Journal name: 
Cytometry A
pub_author_name: 
Lockley
Ladds
Bretschneider
Publication ID: 
707535
pub_author_initials: 
R
G
T
Publication volume: 
87
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2015
pub_title: 
Image based validation of dynamical models for cell reorientation.

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

pub_doi: 
10.1074/jbc.M114.624601
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Weston
Lu
Li
Barkan
Richards
Roberts
Skerry
Poyner
Pardamwar
Reynolds
Dowell
Willars
Ladds
Publication ID: 
697203
pub_author_initials: 
C
J
N
K
GO
DJ
TM
D
M
CA
SJ
GB
G
Publication volume: 
290
Publication number: 
Edition: 
pub_date_day: 
18
pub_date_month: 
9
pub_date_year: 
2015
pub_title: 
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons.

pub_doi: 
10.1016/j.neuropharm.2015.03.006
Publisher: 
Journal name: 
Neuropharmacology
pub_author_name: 
Prokic
Weston
Yamawaki
Hall
Jones
Stanford
Ladds
Woodhall
Publication ID: 
707549
pub_author_initials: 
EJ
C
N
SD
RSG
IM
G
GL
Publication volume: 
95
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2015
pub_title: 
Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons.

2014

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast.

pub_doi: 
10.1111/bph.12716
Publisher: 
Journal name: 
Br J Pharmacol
pub_author_name: 
Weston
Poyner
Patel
Dowell
Ladds
Publication ID: 
707526
pub_author_initials: 
C
D
V
S
G
Publication volume: 
171
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2014
pub_title: 
Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast.

One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.

pub_doi: 
10.1016/j.bbamem.2014.08.019
Publisher: 
Journal name: 
Biochim Biophys Acta
pub_author_name: 
Lock
Forfar
Weston
Bowsher
Upton
Reynolds
Ladds
Dixon
Publication ID: 
707527
pub_author_initials: 
A
R
C
L
GJG
CA
G
AM
Publication volume: 
1838
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2014
pub_title: 
One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.

2013

Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

pub_doi: 
10.1002/yea.2949
Publisher: 
Journal name: 
Yeast
pub_author_name: 
Bond
Croft
Tyson
Bretschneider
Davey
Ladds
Publication ID: 
707530
pub_author_initials: 
M
W
R
T
J
G
Publication volume: 
30
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
2013
pub_title: 
Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.

pub_doi: 
10.1074/jbc.M113.497826
Publisher: 
Journal name: 
J Biol Chem
pub_author_name: 
Croft
Hill
McCann
Bond
Esparza-Franco
Bennett
Rand
Davey
Ladds
Publication ID: 
707536
pub_author_initials: 
W
C
E
M
M
J
D
J
G
Publication volume: 
288
Publication number: 
Edition: 
pub_date_day: 
20
pub_date_month: 
9
pub_date_year: 
2013
pub_title: 
A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.

The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.

pub_doi: 
10.1371/journal.pone.0065927
Publisher: 
Journal name: 
PLoS One
pub_author_name: 
Mos
Esparza-Franco
Godfrey
Richardson
Davey
Ladds
Publication ID: 
707537
pub_author_initials: 
M
MA
EL
K
J
G
Publication volume: 
8
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2013
pub_title: 
The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

pub_doi: 
10.1371/journal.pone.0077487
Publisher: 
Journal name: 
PLoS One
pub_author_name: 
Weston
Bond
Croft
Ladds
Publication ID: 
707516
pub_author_initials: 
C
M
W
G
Publication volume: 
8
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2013
pub_title: 
The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

2011

Heterologous expression of GPCRs in fission yeast.

pub_doi: 
10.1007/978-1-61779-126-0_7
Publisher: 
Journal name: 
Methods Mol Biol
pub_author_name: 
Davey
Ladds
Publication ID: 
707554
pub_author_initials: 
J
G
Publication volume: 
746
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2011
pub_title: 
Heterologous expression of GPCRs in fission yeast.

2010

Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.

pub_doi: 
10.1091/mbc.e09-08-0743
Publisher: 
Journal name: 
Mol Biol Cell
pub_author_name: 
Li
Spooner
Allen
Guise
Ladds
Schnöder
Schmitt
Lord
Roberts
Publication ID: 
707519
pub_author_initials: 
S
RA
SCH
CP
G
T
MJ
JM
LM
Publication volume: 
21
Publication number: 
Edition: 
pub_date_day: 
1
pub_date_month: 
8
pub_date_year: 
2010
pub_title: 
Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.

2009

The cationic region of Rhes mediates its interactions with specific Gbeta subunits.

pub_doi: 
10.1159/000204075
Publisher: 
Journal name: 
Cell Physiol Biochem
pub_author_name: 
Hill
Goddard
Ladds
Davey
Publication ID: 
707510
pub_author_initials: 
C
A
G
J
Publication volume: 
23
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2009
pub_title: 
The cationic region of Rhes mediates its interactions with specific Gbeta subunits.

Regulators of G protein signalling proteins in the human myometrium.

pub_doi: 
10.1016/j.ejphar.2009.03.042
Publisher: 
Journal name: 
Eur J Pharmacol
pub_author_name: 
Ladds
Zervou
Vatish
Thornton
Davey
Publication ID: 
707513
pub_author_initials: 
G
S
M
S
J
Publication volume: 
610
Publication number: 
Edition: 
pub_date_day: 
21
pub_date_month: 
5
pub_date_year: 
2009
pub_title: 
Regulators of G protein signalling proteins in the human myometrium.

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.

pub_doi: 
10.1016/j.cellsig.2009.03.004
Publisher: 
Journal name: 
Cell Signal
pub_author_name: 
Smith
Hill
Godfrey
Rand
van den Berg
Thornton
Hodgkin
Davey
Ladds
Publication ID: 
707547
pub_author_initials: 
B
C
EL
D
H
S
M
J
G
Publication volume: 
21
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
7
pub_date_year: 
2009
pub_title: 
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.

2008

Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2a.

pub_doi: 
10.1016/j.bbrc.2008.02.064
Publisher: 
Journal name: 
Biochem Biophys Res Commun
pub_author_name: 
Wright
Farquhar
Aletrari
Ladds
Hodgkin
Publication ID: 
707525
pub_author_initials: 
MH
MJ
M-O
G
MN
Publication volume: 
369
Publication number: 
Edition: 
pub_date_day: 
2
pub_date_month: 
5
pub_date_year: 
2008
pub_title: 
Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2a.

Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity.

pub_doi: 
10.1016/j.cellsig.2007.10.016
Publisher: 
Journal name: 
Cell Signal
pub_author_name: 
Hill
Brownlie
Davey
Milligan
Ladds
Publication ID: 
707531
pub_author_initials: 
C
Z
J
G
G
Publication volume: 
20
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2008
pub_title: 
Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity.

2007

Interaction of PLD1b with actin in antigen-stimulated mast cells.

pub_doi: 
10.1016/j.cellsig.2006.07.016
Publisher: 
Journal name: 
Cell Signal
pub_author_name: 
Farquhar
Powner
Levine
Wright
Ladds
Hodgkin
Publication ID: 
707542
pub_author_initials: 
MJ
DJ
BA
MH
G
MN
Publication volume: 
19
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2007
pub_title: 
Interaction of PLD1b with actin in antigen-stimulated mast cells.

The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae.

pub_doi: 
10.1111/j.1742-4658.2007.06080.x
Publisher: 
Journal name: 
FEBS J
pub_author_name: 
Allen
Moore
Marsden
Fülöp
Moffat
Lord
Ladds
Roberts
Publication ID: 
707512
pub_author_initials: 
SCH
KAH
CJ
V
KG
JM
G
LM
Publication volume: 
274
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
2007
pub_title: 
The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae.

Differential effects of RGS proteins on G alpha(q) and G alpha(11) activity.

pub_doi: 
10.1016/j.cellsig.2006.05.027
Publisher: 
Journal name: 
Cell Signal
pub_author_name: 
Ladds
Goddard
Hill
Thornton
Davey
Publication ID: 
707548
pub_author_initials: 
G
A
C
S
J
Publication volume: 
19
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
1
pub_date_year: 
2007
pub_title: 
Differential effects of RGS proteins on G alpha(q) and G alpha(11) activity.

2006

Activators and regulators of G protein signalling - Introduction

pub_doi: 
10.1016/j.semcdb.2006.03.004
Publisher: 
Journal name: 
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
pub_author_name: 
Ladds
Publication ID: 
707551
pub_author_initials: 
G
Publication volume: 
17
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2006
pub_title: 
Activators and regulators of G protein signalling - Introduction

Investigating RGS proteins in yeast.

pub_doi: 
10.1016/j.semcdb.2006.03.008
Publisher: 
Journal name: 
Semin Cell Dev Biol
pub_author_name: 
Hill
Goddard
Davey
Ladds
Publication ID: 
707529
pub_author_initials: 
C
A
J
G
Publication volume: 
17
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2006
pub_title: 
Investigating RGS proteins in yeast.

Combined use of two transcriptional reporters improves signalling assays for G protein-coupled receptors in fission yeast.

pub_doi: 
10.1002/yea.1402
Publisher: 
Journal name: 
Yeast
pub_author_name: 
Das
Forfar
Ladds
Davey
Publication ID: 
707541
pub_author_initials: 
A
R
G
J
Publication volume: 
23
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
9
pub_date_year: 
2006
pub_title: 
Combined use of two transcriptional reporters improves signalling assays for G protein-coupled receptors in fission yeast.

Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.

pub_doi: 
10.1016/j.fgb.2006.06.005
Publisher: 
Journal name: 
Fungal Genet Biol
pub_author_name: 
Goddard
Ladds
Forfar
Davey
Publication ID: 
707546
pub_author_initials: 
A
G
R
J
Publication volume: 
43
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2006
pub_title: 
Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.

2005

A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

pub_doi: 
10.1111/j.1365-2958.2004.04394.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Davis
Das
Davey
Publication ID: 
707518
pub_author_initials: 
G
K
A
J
Publication volume: 
55
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
1
pub_date_year: 
2005
pub_title: 
A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

Utilisation of the budding yeast Saccharomyces cerevisiae for the generation and isolation of non-lethal ricin A chain variants.

pub_doi: 
10.1002/yea.1330
Publisher: 
Journal name: 
Yeast
pub_author_name: 
Allen
Byron
Lord
Davey
Roberts
Ladds
Publication ID: 
707540
pub_author_initials: 
SCH
A
JM
J
LM
G
Publication volume: 
22
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
12
pub_date_year: 
2005
pub_title: 
Utilisation of the budding yeast Saccharomyces cerevisiae for the generation and isolation of non-lethal ricin A chain variants.

Development of a semi-quantitative plate-based alpha-galactosidase gene reporter for Schizosaccharomyces pombe and its use to isolate a constitutively active Mam2.

pub_doi: 
10.1002/yea.1190
Publisher: 
Journal name: 
Yeast
pub_author_name: 
Goddard
Ladds
Davey
Publication ID: 
707543
pub_author_initials: 
A
G
J
Publication volume: 
22
Publication number: 
Edition: 
pub_date_day: 
15
pub_date_month: 
1
pub_date_year: 
2005
pub_title: 
Development of a semi-quantitative plate-based alpha-galactosidase gene reporter for Schizosaccharomyces pombe and its use to isolate a constitutively active Mam2.

Functional analysis of heterologous GPCR signalling pathways in yeast.

pub_doi: 
10.1016/j.tibtech.2005.05.007
Publisher: 
Journal name: 
Trends Biotechnol
pub_author_name: 
Ladds
Goddard
Davey
Publication ID: 
707515
pub_author_initials: 
G
A
J
Publication volume: 
23
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
7
pub_date_year: 
2005
pub_title: 
Functional analysis of heterologous GPCR signalling pathways in yeast.

Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.

pub_doi: 
10.1016/j.bbrc.2005.09.149
Publisher: 
Journal name: 
Biochem Biophys Res Commun
pub_author_name: 
Hiskens
Vatish
Hill
Davey
Ladds
Publication ID: 
707517
pub_author_initials: 
R
M
C
J
G
Publication volume: 
337
Publication number: 
Edition: 
pub_date_day: 
2
pub_date_month: 
12
pub_date_year: 
2005
pub_title: 
Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.

2004

Analysis of human GPCRs in fission yeast.

pub_doi: 
Publisher: 
Journal name: 
Curr Opin Drug Discov Devel
pub_author_name: 
Ladds
Davey
Publication ID: 
707521
pub_author_initials: 
G
J
Publication volume: 
7
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
9
pub_date_year: 
2004
pub_title: 
Analysis of human GPCRs in fission yeast.

An efficient bipartite PCR technique to introduce specific changes in large plasmids.

pub_doi: 
10.1385/MB:28:3:201
Publisher: 
Journal name: 
Mol Biotechnol
pub_author_name: 
Davis
Ladds
Das
Goddard
Davey
Publication ID: 
707533
pub_author_initials: 
K
G
A
A
J
Publication volume: 
28
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
2004
pub_title: 
An efficient bipartite PCR technique to introduce specific changes in large plasmids.

2003

Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins.

pub_doi: 
10.1046/j.1365-2958.2003.03336.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Davis
Hillhouse
Davey
Publication ID: 
707552
pub_author_initials: 
G
K
EW
J
Publication volume: 
47
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
2003
pub_title: 
Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins.

Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor.

pub_doi: 
10.1210/jc.2002-021212
Publisher: 
Journal name: 
J Clin Endocrinol Metab
pub_author_name: 
Blanks
Vatish
Allen
Ladds
de Wit
Slater
Thornton
Publication ID: 
707538
pub_author_initials: 
AM
M
MJ
G
NCJ
DM
S
Publication volume: 
88
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
7
pub_date_year: 
2003
pub_title: 
Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor.

2002

Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

pub_doi: 
10.1007/s00294-002-0301-3
Publisher: 
Journal name: 
Curr Genet
pub_author_name: 
Didmon
Davis
Watson
Ladds
Broad
Davey
Publication ID: 
707522
pub_author_initials: 
M
K
P
G
P
J
Publication volume: 
41
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
7
pub_date_year: 
2002
pub_title: 
Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

2000

A temperature-sensitive Krp1 allows in vivo characterization of kexin activation.

pub_doi: 
10.1046/j.1365-2958.2000.02028.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Davis
Powner
Davey
Publication ID: 
707532
pub_author_initials: 
G
K
D
J
Publication volume: 
37
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2000
pub_title: 
A temperature-sensitive Krp1 allows in vivo characterization of kexin activation.

Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe.

pub_doi: 
10.1046/j.1365-2958.2000.01855.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Davey
Publication ID: 
707511
pub_author_initials: 
G
J
Publication volume: 
36
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
2000
pub_title: 
Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe.

Identification of proteases with shared functions to the proprotein processing protease Krp1 in the fission yeast Schizosaccharomyces pombe.

pub_doi: 
10.1046/j.1365-2958.2000.02180.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Davey
Publication ID: 
707544
pub_author_initials: 
G
J
Publication volume: 
38
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
2000
pub_title: 
Identification of proteases with shared functions to the proprotein processing protease Krp1 in the fission yeast Schizosaccharomyces pombe.

1998

The processing of yeast pheromones.

pub_doi: 
10.1006/scdb.1997.0197
Publisher: 
Journal name: 
Semin Cell Dev Biol
pub_author_name: 
Davey
Davis
Hughes
Ladds
Powner
Publication ID: 
707550
pub_author_initials: 
J
K
M
G
D
Publication volume: 
9
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
2
pub_date_year: 
1998
pub_title: 
The processing of yeast pheromones.

Extracellular degradation of agonists as an adaptive mechanism.

pub_doi: 
10.1006/scdb.1997.0215
Publisher: 
Journal name: 
Semin Cell Dev Biol
pub_author_name: 
Ladds
Hughes
Davey
Publication ID: 
707509
pub_author_initials: 
G
M
J
Publication volume: 
9
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
1998
pub_title: 
Extracellular degradation of agonists as an adaptive mechanism.

1997

Sxa2, a carboxypeptidase that degrades extracellular pheromone in fission yeast.

pub_doi: 
10.1042/bst025228s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Ladds
Davey
Publication ID: 
707520
pub_author_initials: 
G
J
Publication volume: 
25
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
5
pub_date_year: 
1997
pub_title: 
Sxa2, a carboxypeptidase that degrades extracellular pheromone in fission yeast.

1996

The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe.

pub_doi: 
10.1111/j.1365-2958.1996.tb02486.x
Publisher: 
Journal name: 
Mol Microbiol
pub_author_name: 
Ladds
Rasmussen
Young
Nielsen
Davey
Publication ID: 
707553
pub_author_initials: 
G
EM
T
O
J
Publication volume: 
20
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
4
pub_date_year: 
1996
pub_title: 
The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe.

Sxa2, a carboxypeptidase that degrades extracellular pheromone in the fission yeast Schizosaccharomyces pombe

pub_doi: 
Publisher: 
Journal name: 
IMMUNOLOGY
pub_author_name: 
Ladds
Davey
Publication ID: 
707528
pub_author_initials: 
G
J
Publication volume: 
89
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
1996
pub_title: 
Sxa2, a carboxypeptidase that degrades extracellular pheromone in the fission yeast Schizosaccharomyces pombe
Theses / dissertations

2023

Drug discovery at class A and class B GPCRs

pub_doi: 
Publisher: 
University of Cambridge
Journal name: 
pub_author_name: 
Hilšer
Publication ID: 
1460209
pub_author_initials: 
A
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Ladds
pub_editor_initials: 
G
pub_date_day: 
29
pub_date_month: 
4
pub_date_year: 
2023
pub_title: 
Drug discovery at class A and class B GPCRs

2022 (No publication date)

Investigating the molecular pharmacology of class A and B G protein-coupled receptors

pub_doi: 
Publisher: 
University of Cambridge
Journal name: 
pub_author_name: 
Carvalho
Publication ID: 
1382545
pub_author_initials: 
S
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Ladds
pub_editor_initials: 
G
pub_date_day: 
4
pub_date_month: 
5
pub_date_year: 
2022 (No publication date)
pub_title: 
Investigating the molecular pharmacology of class A and B G protein-coupled receptors

2021 (No publication date)

Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors

pub_doi: 
Publisher: 
University of Cambridge
Journal name: 
pub_author_name: 
Safitri
Publication ID: 
1327255
pub_author_initials: 
D
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Ladds
pub_editor_initials: 
G
pub_date_day: 
14
pub_date_month: 
10
pub_date_year: 
2021 (No publication date)
pub_title: 
Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors

Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis

pub_doi: 
Publisher: 
University of Cambridge
Journal name: 
pub_author_name: 
Yeung
Publication ID: 
1261958
pub_author_initials: 
HY
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Ladds
pub_editor_initials: 
G
pub_date_day: 
8
pub_date_month: 
1
pub_date_year: 
2021 (No publication date)
pub_title: 
Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis

CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells

pub_doi: 
Publisher: 
University of Cambridge
Journal name: 
pub_author_name: 
Clark
Publication ID: 
1269575
pub_author_initials: 
A
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Ladds
pub_editor_initials: 
G
pub_date_day: 
8
pub_date_month: 
2
pub_date_year: 
2021 (No publication date)
pub_title: 
CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells
Book chapters

2021

Adrenomedullin/Intermedin

pub_doi: 
10.1007/978-3-030-57401-7_5055
Publisher: 
Springer International Publishing
Journal name: 
pub_author_name: 
Clark
Ladds
Publication ID: 
1362432
pub_author_initials: 
AJ
G
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Adrenomedullin/Intermedin

Measuring the rapid kinetics of receptor-ligand interactions in live cells using NanoBRET.

pub_doi: 
10.1016/bs.mcb.2021.06.013
Publisher: 
Journal name: 
pub_author_name: 
Suchankova
Harris
Ladds
Publication ID: 
1310330
pub_author_initials: 
A
M
G
Publication volume: 
166
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Measuring the rapid kinetics of receptor-ligand interactions in live cells using NanoBRET.

2020

Adrenomedullin/Intermedin

pub_doi: 
10.1007/978-3-030-21573-6_5055-1
Publisher: 
Springer International Publishing
Journal name: 
pub_author_name: 
Clark
Ladds
Publication ID: 
1430232
pub_author_initials: 
AJ
G
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2020
pub_title: 
Adrenomedullin/Intermedin

2004

Processing Proteases in S. pombe

pub_doi: 
10.1007/978-3-662-10360-9_26
Publisher: 
Springer Berlin Heidelberg
Journal name: 
pub_author_name: 
Ladds
Davey
Publication ID: 
1167999
pub_author_initials: 
G
J
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2004
pub_title: 
Processing Proteases in S. pombe

1981

'Introduction'

pub_doi: 
Publisher: 
Wiley-Blackwell
Journal name: 
pub_author_name: 
Smith
Jackson
Publication ID: 
695858
pub_author_initials: 
SJ
P
Publication volume: 
Publication number: 
Edition: 
pub_editor_name: 
Smith
Jackson
pub_editor_initials: 
S
P
pub_date_day: 
1
pub_date_month: 
1
pub_date_year: 
1981
pub_title: 
'Introduction'
Conference proceedings

2021

The Role of Receptor Activity Modifying Protein 3 in Glucagon-like Peptide-1 Receptor Signalling

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Pearce
Carvalho
Ladds
Publication ID: 
1275322
pub_author_initials: 
A
S
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
The Role of Receptor Activity Modifying Protein 3 in Glucagon-like Peptide-1 Receptor Signalling

Identification and characterisation of GIPR negative allosteric modulators

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Suchankova
Bowman
Harris
Rahman
Ladds
Publication ID: 
1275321
pub_author_initials: 
A
K
M
T
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Identification and characterisation of GIPR negative allosteric modulators

Potential modulation of protease-activated receptor4 (PAR4) Threonine120 variant signalling by receptor-activity-modifying proteins (RAMPs)

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Safitri
Qi
Harris
Ladds
Publication ID: 
1275323
pub_author_initials: 
D
H
M
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Potential modulation of protease-activated receptor4 (PAR4) Threonine120 variant signalling by receptor-activity-modifying proteins (RAMPs)

The Adenosine A(2A) Receptor Does Not Appear To Undergo Agonist-Induced Internalisation

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Carvalho
Stoddart
Kilpatrick
Sabbatini
Soave
Briddon
Hill
Ladds
Publication ID: 
1275324
pub_author_initials: 
S
L
L
A
M
S
S
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
The Adenosine A(2A) Receptor Does Not Appear To Undergo Agonist-Induced Internalisation

Receptor activity modifying proteins differentially modulate G protein activation and internalisation of the gastric inhibitory polypeptide receptor.

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Harris
Truong
Zhao
Wootten
Sexton
Ladds
Publication ID: 
1275325
pub_author_initials: 
M
T
P
D
P
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Receptor activity modifying proteins differentially modulate G protein activation and internalisation of the gastric inhibitory polypeptide receptor.

CRISPR-cas9 Interrogation of CLR signalling and the involvement of RAMPs in primary cells

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Ladds
Clark
Wigglesworth
Poyner
Publication ID: 
1275326
pub_author_initials: 
G
A
M
D
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
CRISPR-cas9 Interrogation of CLR signalling and the involvement of RAMPs in primary cells

Pharmacological and computational analysis of adenosine A(2A)R signal transduction

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Huang
Carvalho
Ladds
Publication ID: 
1275327
pub_author_initials: 
X
S
G
Publication volume: 
178
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2021
pub_title: 
Pharmacological and computational analysis of adenosine A(2A)R signal transduction

2019

RCP modulates Gas signalling of a subset of Family B GPCRs

pub_doi: 
Publisher: 
Journal name: 
BRITISH JOURNAL OF PHARMACOLOGY
pub_author_name: 
Routledge
Simms
Dickerson
Goddard
Ladds
Poyner
Publication ID: 
1110854
pub_author_initials: 
SJ
J
IM
AD
G
DR
Publication volume: 
176
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2019
pub_title: 
RCP modulates Gas signalling of a subset of Family B GPCRs

2018

PO-086 BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

pub_doi: 
10.1136/esmoopen-2018-eacr25.129
Publisher: 
Elsevier BV
Journal name: 
ESMO Open
pub_author_name: 
Lazarus
Hadi
Bach
Watson
Das
Ladds
Quesne
Lee
Calado
Khaled
Publication ID: 
1167998
pub_author_initials: 
K
F
K
J
M
G
JL
JH
D
W
Publication volume: 
3
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
6
pub_date_year: 
2018
pub_title: 
PO-086 BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

MD-assisted approach for designing multi-target ligands at A2AR and PDE10A that elevate cyclic AMP

pub_doi: 
Publisher: 
Journal name: 
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
pub_author_name: 
Kalash
Winfield
Safitri
Bermudez
Glen
Ladds
Bender
Publication ID: 
1035395
pub_author_initials: 
L
I
D
M
R
G
A
Publication volume: 
256
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2018
pub_title: 
MD-assisted approach for designing multi-target ligands at A2AR and PDE10A that elevate cyclic AMP

2017

Rational design and evaluation of multi-target ligands at A1R, A2AR and PDE10A with therapeutic potential for neurodegenerative diseases

pub_doi: 
Publisher: 
Journal name: 
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
pub_author_name: 
Kalash
Winfield
Carvalho
Ladds
Bender
Publication ID: 
986197
pub_author_initials: 
L
I
S
G
A
Publication volume: 
254
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
pub_date_year: 
2017
pub_title: 
Rational design and evaluation of multi-target ligands at A1R, A2AR and PDE10A with therapeutic potential for neurodegenerative diseases

2002

Corticotropin-releasing hormone receptors.

pub_doi: 
10.1042/bst0300428
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Hillhouse
Randeva
Ladds
Grammatopoulos
Publication ID: 
707524
pub_author_initials: 
EW
H
G
D
Publication volume: 
30
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
2002
pub_title: 
Corticotropin-releasing hormone receptors.

1997

Proteolysis of Sxa2, a carboxypeptidase involved in pheromone adaptation in yeast.

pub_doi: 
10.1042/bst025446s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Ladds
Davey
Publication ID: 
707539
pub_author_initials: 
G
J
Publication volume: 
25
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
1997
pub_title: 
Proteolysis of Sxa2, a carboxypeptidase involved in pheromone adaptation in yeast.

1996

Characterisation of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.

pub_doi: 
10.1042/bst024210s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Ladds
Davey
Publication ID: 
962900
pub_author_initials: 
G
J
Publication volume: 
24
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
5
pub_date_year: 
1996
pub_title: 
Characterisation of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.

Defining the role of Sxa1 during pheromone adaptation in Schizosaccharomyces pombe.

pub_doi: 
10.1042/bst024502s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Hughes
Ladds
Davey
Publication ID: 
707545
pub_author_initials: 
M
G
J
Publication volume: 
24
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
1996
pub_title: 
Defining the role of Sxa1 during pheromone adaptation in Schizosaccharomyces pombe.

Purification of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.

pub_doi: 
10.1042/bst024504s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Ladds
Davey
Publication ID: 
707514
pub_author_initials: 
G
J
Publication volume: 
24
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
8
pub_date_year: 
1996
pub_title: 
Purification of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.

1995

Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.

pub_doi: 
10.1042/bst023565s
Publisher: 
Journal name: 
Biochem Soc Trans
pub_author_name: 
Ladds
Rasmussen
Davey
Publication ID: 
962899
pub_author_initials: 
G
M
J
Publication volume: 
23
Publication number: 
Edition: 
pub_date_day: 
pub_date_month: 
11
pub_date_year: 
1995
pub_title: 
Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.
Datasets

2020 (No publication date)

Research Data File relating to the effect of chemokine receptor expression on receptor activity modifying protein expression

pub_doi: 
Publisher: 
Journal name: 
pub_author_name: 
Harris
Ladds
Publication ID: 
1169330
pub_author_initials: 
M
G
Publication volume: 
Publication number: 
Edition: 
pub_date_day: 
23
pub_date_month: 
1
pub_date_year: 
2020 (No publication date)
pub_title: 
Research Data File relating to the effect of chemokine receptor expression on receptor activity modifying protein expression
Professor in Receptor Pharmacology
Dr Graham  Ladds

Contact Details

+44 (0) 1223 3 34020 / Lab: 3 34028
Not available for consultancy

Affiliations

Classifications: 
Person keywords: 
G proteins, GPCRs, Signal Bias, cell signalling, RAMPs, computational modelling, RGS proteins, mathematical simulations