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Department of Pharmacology





Clark, A.J., Mullooly, N., Safitri, D., Harris, M., de Vries, T., MassenVanDenBrink, A., Poyner, D.R., Gianni, D., Wigglesworth, M. & Ladds. G. (2021) CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells. Commun. Biol. 4:776.

Deganutti, G., Barkan, K., Preti, B., Leuenberger, M., Wall, M., Frenguelli, B.G., Lochner, M., Ladds, G.* & Reynolds C. A.* (2021) Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. ACS Pharmacol. Transl. Sci.  DOI: acsptsci.0c00195. (* co-corresponding authors)

Suchankova, A., Harris, M., & Ladds, G. (2021) Measuring the rapid kinetics of receptor-ligand interactions in live cells using NanoBRET. Methods Cell Bio. DOI: 10.1016/bs.mcb.2021.06.013

Deganutti, G., Barkan, K., Ladds, G. & Reynolds C. A. (2021) Multisite Model of allosterism for the Adenosine A1 Receptor. J. Chem. Inf. Model 61: 2001.

Kopanitsa, L., Kopanitsa, M.V., Safitri, D., Ladds, G & Bailey, D.S. (2021) Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition. Int. J. Mol. Sci. 22: 9665.

Kalash, L., Winfiled, I., Safitri., …Ladds, G.* & Bender A.* (2021) Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines. J. Cheminform. 13: 17. (* co-corresponding authors)

Carvalho, S., Pearce, A. & Ladds, G. (2021) Novel mathematical and computational models of G protein-coupled receptor signalling. Curr Opin. Endocrin. Metab. Res. 16: 28.

Rosa, M., Noel, T., Harris, M. & Ladds, G. (2021) Emerging roles of adhesion G protein-coupled receptors. Biochem. Soc. Trans. 20:BST20201144.

Dolezalova, N …Ladds, G., … Saeb-Parsy, K. (2021) Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Sci. Rep. 11:10418.

Shapovalov, V., Kopanitsa, L., Pruteanu, L.-L., Ladds, G. & Bailey, D.S. (2021) Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells. Cancers 13:3780.



Marti-Solano, M., Crilly, S.E., Malinverni, D., …Ladds, G. …. Babu, M.M. (2020) Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling response. Nature 588(7838):E24. doi: 10.1038/s41586-020-2999-9.

Barkan K, …Ladds G. (2020) Pharmacological characterisation of novel adenosine A 3 receptor antagonists. Sci Rep. 10:20781. 

Clark, A.J., & Ladds. G. (2020). “Adrenomedullin/Intermedin” Encyclopedia of Molecular Pharmacology 67383_0_En, (Chapter 5055-1).

Greenhalgh, J.C., Chandram, A., Harper, M.T., Ladds, G. & Rahman, T. (2020) Proposed model of the Dictyostelium cAMP receptors bound cAMP. J. Mol. Graph. Model. 100: 107662.

Safitri, D., Harris, M., …… Ladds, G. (2020) Elevated intracellular cAMP concentration mediates growth suppression in glioma cells. Biochem Pharmacol. 174:113823. doi: 10.1016/

Routledge, SJ, …… Ladds, G.* & Poyner, D.R.* (2020) Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors. Biochim Biophys Acta Biomembr. 1862: 183174. (* co-corresponding authors).

Lagarias, P., Barkan, K., … Ladds, G.* and Kolocouoris, A.* (2020) Insights to the Binding of a Selective Adenosine A3 Receptor Antagonist Using Molecular Dynamic Simulations, MM-PBSA and MM-GBSA Free Energy Calculations, and Mutagenesis. J Chem Info Model 59: 5183-5197. (* co-corresponding authors).



MacKie, D.I., Nielsen, N.R., Harris, M., Singh. S., Davis, R.B., Dy, D., Ladds, G., and Caron, K.M. (2019) RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis. Proc. Natl. Acad. Sci. In Press (accepted 21.10.19).

Stamatis, D., Lagarias, P., Barkan, K., Vrontake, E., Ladds, G.* and Kolocouoris, A.* (2019) Structural Characterization of Agonist Binding to A3Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments. J. Med. Chem. doi: 10.1021/acs.jmedchem.9b01164. (* co-corresponding authors).

Shaw, W.M., Yamauchi, H., Mead, J., Gowers, G.F., Oling, D., Larsson, N., Wigglesworth, M.*, Ladds, G.* and Ellis, T.* (2019) Engineering a model cell for rational tuning of GPCR signalling Cell. 177: 782-796. (* co-corresponding authors). (F1000Prime recommended).

Bailey, S., Harris, M……..Ladds, G.*, Poyner, D.* and Wheatley, M.* (2019) Interactions Between RAMP2 And CRF Receptors: The Effect Of Receptor Subtypes, Splice Variants And Cell Context. BBA – Biomembranes 1861: 997-1003. (* co-corresponding authors).

Neganova, I., Cotts, L., Gassner, K., Armstrong, L., Ladds, G. and Lako, M. (2019) EDG5 plays an important role in induction and maintenance of pluripotency. Stem Cell 37:318-331.

Bridge, L., Mead, J., Frattini, E., Winfield, I., and Ladds, G. (2018) Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. J. Theor. Biol. 7: 44-65.



Harris, M., Svensson, F., Kopanitsa, L., Ladds, G., and Bailey D. (2018) Emerging patents in the therapeutic areas of glioma and glioblastoma. Expert Opin. Ther. Pat. 28: 573-590.

Lazarus, K.A., …… Ladds, G., Liu, P., Evan, G., McCaughan, F., Le Quesne, J., Lee, J.H., Calado, D., and Khaled, W.T. (2018) BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma. Nat Commun. 20: 3327.



Kalash, L., Val., C., Azuaje, J., Loza, M.I., Svensson, F., Zoufir, A., Mervin, L., Ladds, G., Brea, J., Sotelo, E. and Bender, A. (2017) Computer-Aided Design of Multi-target Ligands at A1R, A2AR and PDE10A, Key Proteins in Neurodegenerative Diseases. J. Cheminform. 9(1):67.

Recino, A., Barkan ,K., Ladds, G., Cooke, A., Wong, F.S. and Wallberg, M. (2017) Hyperglycemia does not affect antigen specific activation and cytolytic killing by CD8+ T cells in vivo. Biosci Rep. 37(4): pii: BSR20171079.

Routledge, S.J., Ladds, G. and Poyner, D.R. (2017) The effects of RAMPs upon cell signalling. Mol Cell Endocrinol.  pii: S0303-7207(17)30198-3.



Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S.J., Moarec, J-C, Woodlock, D.A., Reynolds, C.A., Poyner, D.R., Watkins, H.A. and Ladds, G. (2016) Receptor activity modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. J. Biol. Chem. 91: 21925.

Hay, D.L., Walker, C.S., Gingell, J.J., Ladds, G., Reynolds, C.A. and Poyner, D.R. (2016) Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochem Soc Trans. 44: 568.

Knight, A., Hemmings, J.L., Frenguelli, B.G., Dowell, S.J., Lochner, M. and Ladds, G. (2016) Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. J. Med Chem. 59: 947.

Hennig, A., Markwart, R., Wolff, K., Schubert, K., Cui, Y., Prior, I.A., Esparza-Franco, M.A., Ladds, G. and Rubio I. (2016) Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal.14: 5.



Weston, C., Li, J., Li, N., Barkan, G., Richards, G.O., Roberts, D., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S., Willars, G. and Ladds, G. (2015) Erratum: Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290: 23009.

Shigeto, M., Ramracheya, R., Cha, C-Y., Chibalina, M., Tarasov, A., Philippaert, K., Reinbothe, T., Rorsman, N., Salehi. A., Sones, W., Vergari, E., Weston, C., Gorelik, J., Katsura, M., Nikolaev, O., Vennekens, R., Zaccolo, M., Gallione, A., Johnson, P.R.V., Kaku, K., Ladds, G. and Rorsman, P. (2015) Physiological concentrations of GLP-1 increases insulin secretion in mouse and human pancreatic b-cells by PKC-dependent activation of TRPM4 channels. J Clin Invest. 125: 4714.

Prokic, E., Weston, C., Yamawaki, N., Hall, S., Stanford, I., Ladds, G. and Woodhall, G. (2015) Benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons alters cortical oscillatory dynamics. Neuropharmacology. 95: 192.

Weston, C., Li, J., Li, N., Barkan, G., Richards, G.O., Roberts, D., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S., Willars, G. and Ladds, G. (2015) Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290: 23009.

Hennig, A., Markwart, R., Esparza-Franco, M.A., Ladds, G. and Rubio I. (2015) Ras activation revisited: role of GEF and GAP systems. Biol. Chem. 396: 831.

Croft, W., Elliott, C.M., Ladds, G., Stinner, B., Venkataraman, C., and Weston, C. (2015) Parameter identification problems in the modelling of cell motility. J. Math Biol. 71: 399-436. Note – authors in alphabetical order.

Lockley, R., Ladds, G. and Bretschneider, T. (2015) Image based validation of dynamical models for cell reorientation. Cytometry A. 87: 471.



Weston, C., Poyner, D., Patel, V., Dowell, S. and Ladds, G. (2014) Investigating G protein signaling bias at the glucagon-like peptide-1 receptor in yeast. Brit. J. Pharmacol. 171(15):3651-65.

Lock, A., Forfar, R., Weston, C., Bowsher, L., Reynolds, C., Ladds, G., Dixon, A.M. (2014) One Motif to Bind Them: A Transmembrane Motif of Two Small Residues Affects Oligomerization, Function, Localization, and Cross-talk Between Two Yeast GPCRs. Biochim. Biophys. Acta. 1838: 3036-51.

Croft, W. Hill, C., McCann, E., Bond, M., Esparza-Franco, A., Bennett, J., Rand, D., Davey, J., Ladds, G. (2013) A Physiologically Required GPCR - RGS Interaction that Compartmentalizes RGS Activity J. Biol. Chem. 288: 27327-42.



Weston, C., Bond, M., Croft, W., and Ladds, G. (2013) Oncogenic Ras mutations inhibits Cdc42-directed cell growth. – PLOS ONE 16;8(10):e77487. doi: 10.1371/journal.pone.0077487.

Mos, M., Esparza-Franco, A., Godfrey, E.L., Richardson, K. and Ladds, G. (2013) The Role of the RACK1 Orthologue Cpc2 in Modulating Cell Cycle Arrest in Fission Yeast. PLOS ONE doi/10.1371/journal.pone.0065927.

Bond, M., Croft, W., Tyson, R., Bretschneider, T., Davey, J. and Ladds G. (2013) Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe. Yeast 30(4):145-56. doi: 10.1002/yea.2949.



Davey, J. and Ladds, G. (2011) Heterologous expression of GPCRs in fission yeast Methods Mol Biol. 746: 113-131.

A full list of publications before 2011 can be found on pubmed


Publications available on pre-print servers

Harris, M., Mackie, D., Pawlak, J.B., Carvalho, S.,  …Ladds, G* (2021) RAMPs regulate signalling bias and internalisation of the GIPR. bioRxiv 2021.04.08.436756; doi:

Wall, M.J. …Deganutti, G., …Reynolds, C. A., …Ladds, G.*, & Frenguelli, B. G.* (2020) A biased adenosine A1R agonist elicits analgesia without cardiorespiratory depression. bioRxiv 2020.04.04.023945; doi: Under revision Nat Comms. (* co-corresponding authors)

Recino, A., Barkan, K., Schmidt-Christensen, A. S., ….Ladds, G. & Wallberg, M. (2019) GLP-1R is downregulated in bet cells of NOD mice and T1D patients DOI: bioRxiv 845776; doi:

Guida, C., Miranda, C., Asterholm, I. W., Basco, D., Benrick, A., Chanclón, B., Chibalina, M., Harris, M., Kellard, J., McCulloch, L., Real, J. I., Rorsman, N., Yeung, H. Y., Reimann, F., Shigeto, M., Clark, A., Thornes, B., Rorsman, P., Ladds, G. and Ramracheya, R. (2019) Promiscuous receptor activation mediates glucagonostatic effects of GLP-1(9-36) and GLP-1(7-36). Available on BioRxiv -