Dr Mark Bycroft

Dr Mark Bycroft completed his PhD in chemistry at the Imperial College, London, with Professor Sir Alan Fersht. He moved to the University of Cambridge, at the Department of Chemistry for his post-doctoral studies using biophysical approaches to study protein folding and stability. He established his own independent research group in 1992 as a Group Leader at the MRC Centre for Protein Engineering, and in 2011 he moved to the MRC Laboratory of Molecular Biology.

In 2018 he joined the Department of Pharmacology, where he continued his work on the Ubiquitin Proteasome System (UPS), Chromatin Remodelling Complexes and Transcription Factors.

MOLECULAR MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL CONTROL

I utilize biomolecular NMR spectroscopy and other biophysical and structural methods to understand how gene expression is regulated during cell growth and differentiation and in response to cellular stress. I exploit NMR to study weak multivalent interactions, the role of dynamics in protein function, and to investigate highly plastic systems such as IDPs/IDRs.

In particular, I focus on different components of the Ubiquitin Proteasome System (UPS), and on chromatin remodelling enzymes such as the CHD7 and SWI/SNF complexes. I also study transcription factors that play a key role in cancer such as p53 and MYC.

I collaborate widely with biologists and clinicians to apply structural methods and biophysics to a range of biomedical problems.

All publications

Please see my ORCID webpage: https://orcid.org/0000-0002-0673-2216 and my ResearchGate webage: https://www.researchgate.net/profile/Mark-Bycroft