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Dr Catherine Lindon

Dr Catherine Lindon

University Lecturer


Office Phone: +44 (0) 1223 3 33964 / Lab: 7 65927

Keywords

  • Ubiquitin, APC/C, proteolysis, Aurora kinase, mitotic exit, cell fate, cancer

Topics

  • Cancer and Infectious Diseases

Key Publications

Abdelbaki AM, Akman HB, Grant R, Poteau M, Gavet O, Guarguaglini G, Lindon C. (2020). AURKA destruction is decoupled from its activity at mitotic exit but suppresses interphase activity. J. Cell Science 12 jcs243071

Grant R, Akman B, Abdelbaki A, Bertoldi A, Gavilan MP, Glover DM, Lindon C. (2018). Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus. Open Biology 8 170272

Lindon C, Grant R, Min M (2016). Ubiquitin-mediated degradation of Aurora kinases. Frontiers in Oncology 5 307

Min M, Mevissen TE, De Luca M, Komander D, Lindon C (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell 26 4325-433

Min M, Mayor U, Dittmar G, Lindon C (2014). Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells. Molecular & Cellular Proteomics 13 2411-2425

 

Investigator biography

Cath discovered her interest in cell biology at the Institut Pasteur in Paris, during postdoctoral studies of myogenic cell fate control. She returned to the UK with a Wellcome Trust Advanced Training Fellowship, to acquire expertise in live cell imaging of human cells with the Pines group at the Gurdon Institute in Cambridge. She subsequently set up her own research programme to study ubiquitin-mediated events in mitotic exit, with the support of a Career Development Award from the MRC. In 2008 she became a research group leader in the Department of Genetics and in 2015 a lecturer in the Department of Pharmacology.