Publications
Cardno A, Roberts K, Lindon C (2025). Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A. bioRxiv 2025.04.23.650020
Eapen R, Okoye C, Stubbs C, Schimpl M, Tischer T, McCall E, Zacharopoulou M, Ferrer F, Barford D, Spring D, Lindon C, Phillips C, Itzhaki L (2025). Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome. eLife 14 RP104238
Cardno A, Kennedy B, Lindon C (2025). Cellular Parameters Shaping Pathways of Targeted Protein Degradation. Commun. Bio. 8 691
Cacioppo R, Rad D, Pagani G, Gandellini P, Lindon C (2024). Post-transcriptional control drives Aurora kinase A expression in human cancers. PLoS One 19 e0310625
Cacioppo R, Lindon C (2023). Immunoprecipitation of Reporter Nascent Chains from Active Ribosomes to Study Translation Efficiency. Bio Protoc. 13 :e4821
Cacioppo R, Akman H, Tuncer T, Erson-Bensan A, Lindon C (2023). Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A. Elife 12 RP87253
Asteriti I, Polverino F, Stagni V, Sterbini V, Ascanelli C, Naso FD, Mastrangelo A, Rosa A, Paiardini A, Lindon C, Guarguaglini G (2023). AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance 6 :e202201726
Cacioppo R, Lindon C (2022). Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A. Open Biol. 12 220134
Abdelbaki A, Ascanelli C, Okoye CN, Akman B, Janson G, Min M, Marcozzi C, Hagting A, Grant R, De Luca M, Asteriti IA, Guarguaglini G, Paiardini A, Lindon C (2022). Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1. Life Sci Alliance 6 e202201372
Okoye C, Rowling P, Itzhaki L, Lindon C (2022).Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation. Frontiers in Physiology 13 913063
Vaughan N, Scholz N, Lindon C, Licchesi J (2022). The E3 ubiquitin ligase HECTD1 contributes to cell cycle progression through an effect on mitosis. Science Reports 12 13160
Boi D, Souvalidou F, Capelli D, Polverino F, Marini G, Montanari R, Pochetti G, Tramonti A, Contestabile R, Trisciuoglio D, Carpinelli P, Ascanelli C, Lindon C, De Leo A, Saviano M, Di Santo R, Costi R, Guarguaglini G, Paiardini A (2021).PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc. Int. J. Mol. Sci. 22 13122
Wang R, Ascanelli C, Abdelbaki A, Fung A, Rasmusson T, Michaelides I, Roberts K, Lindon C (2021). Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool. Commun. Biol. 4 640
Naso F, Boi D, Ascanelli C, Pamfil G, Lindon C, Paiardini A, Guarguaglini G (2021).Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer. Oncogene 40 3917-28
Scott S, Li X, Jammula S, Devonshire G, Lindon C, Fitzgerald R, D’Avino P (2021). Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments. Cell Death & Differentiation
Esposito M, Akman HB, Ceregido MA, Giron P, Schepers R, Ramos-Paez LC, La Monaca E, De Greve J, Coux O, De Trez C, Lindon C, Gutierrez GJ. (2020). USP13 Controls the Stability of Aurora B Impacting Progression through the Cell Cycle. Oncogene
Abdelbaki AM, Akman HB, Grant R, Poteau M, Gavet O, Guarguaglini G, Lindon C. (2020). AURKA destruction is decoupled from its activity at mitotic exit but suppresses interphase activity. J. Cell Science 133 jcs243071
Naso F, Sterbini V, Crecca E, Russo AD, Asteriti IA, Cundari E, Lindon C, Rosa A, Guarguaglini G. (2020). Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit. Cells 9 374
Grant R, Akman B, Abdelbaki A, Bertoldi A, Gavilan MP, Glover DM, Lindon C. (2018). Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus. Open Biology 8 170272
Ramirez J, Min M, Barrio R, Lindon C, Mayor U (2016). Isolation of ubiquitinated proteins to high purity from in vivo samples. Methods in Molecular Biology 1449 193-202
Lindon C, Grant R, Min M (2016). Ubiquitin-mediated degradation of Aurora kinases. Frontiers in Oncology 5 307
Min M, Mevissen TE, De Luca M, Komander D, Lindon C (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell 26 4325-4332
Lipinszki Z, Wang P, Grant R, Lindon C, Dzhindzhev NS, D'Avino PP, Przewloka MR, Glover DM and Archambault V (2014).Affinity Purification of Protein Complexes from Drosophila Embryos in Cell Cycle Studies. Methods in Molecular Biology 1170 571-588
Min M, Mayor U, Dittmar G, Lindon C (2014). Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells. Molecular & Cellular Proteomics 13 2411-2425
Min M, Mayor U, Lindon C (2013). Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates. Open Biology 3 130097
Floyd S, Whiffin N, Gavilan MP, Kutscheidt S, De Luca M, Marcozzi C, Min M, Watkins J, Chung K, Fackler OT, Lindon C (2013). Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading via FHOD1. J. Cell Sci. 126 2845-2856
Min M, Lindon C (2012). Substrate targeting by the ubiquitin-proteasome system in mitosis. Semin Cell Dev. Biol. 23 482-491
Giubettini M, Astertiti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G (2011). Control of Aurora-A stability through interaction with TPX2. J. Cell Sci. 124 113-22
Astertiti I, Rensen W, Lindon C, Lavia P, Guarguaglini G (2010). The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme? Biochim Biophys Acta. 1806 230-239
Elder AD, Domin A, Kaminski-Schierle GS, Lindon C, Pines J, Esposito A, Kaminski CF (2009). A quantitative protocol for dynamic measurements of protein interactions by FRET-sensitised fluorescence emission. J. Royal Soc. Interface 6 S59-81
Connell J, Lindon C, Luzio J, Reid E (2009). Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic 10 42-56
Floyd S, Pines J, Lindon C (2008). APC/CCdh1 targets Aurora kinase to control reorganization of the mitotic spindle at anaphase. Current Biology 18 1649-58