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Key Publications

Abdelbaki AM, Min M, De Luca M, Marcozzi C, Hagting A, Paiardini A, Guarguaglini G, Lindon C. N-terminal SLiMs of AURKA are both necessary and sufficient for its degradation. New manuscript.

Wang RK, Roberts K, Rasmusson T, Lindon C. Targeted and selective degradation of mitotic kinase AURKA by a new PROTAC tool. New manuscript.

Naso F, Sterbini V, Crecca E, Russo AD, Asteriti IA, Cundari E, Lindon C, Rosa A, Guarguaglini G. Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit. New manuscript.

AbdelbakiAM, AkmanHB, Grant R, Poteau M, Gavet O, Guarguaglini G, Lindon C. AURKA destruction is decoupled from its activity at mitotic exit but suppresses interphase activity. https://www.biorxiv.org/content/10.1101/850917v1. Manuscript under review.

Esposito M, Akman HB, Ceregido MA, Giron P, Schepers R, Ramos-Paez LC, La Monaca E, De Greve J, Coux O, De Trez C, Lindon C, Gutierrez GJ. USP13 Controls the Stability of Aurora B Impacting Progression through the Cell Cycle. Manuscript under revision at Oncogene.

Grant R, Akman B, Abdelbaki A, Bertoldi A, Gavilan MP, Glover DM, Lindon C. (2018). Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus. Open Biology 8 170272

Ramirez J, Min M, Barrio R, Lindon C, Mayor U (2016).  Isolation of ubiquitinated proteins to high purity from in vivo samples. Methods in Molecular Biology 1449 193-202

Lindon C, Grant R, Min M (2016). Ubiquitin-mediated degradation of Aurora kinases. Frontiers in Oncology 5 307

Min M, Mevissen TE, De Luca M, Komander D, Lindon C (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell 26 4325-4332

Lipinszki Z, Wang P, Grant R, Lindon C, Dzhindzhev NS, D'Avino PP, Przewloka MR, Glover DM and Archambault V (2014).  Affinity Purification of Protein Complexes from Drosophila Embryos in Cell Cycle Studies. Methods in Molecular Biology 1170 571-588

Min M, Mayor U, Dittmar G, Lindon C (2014).
Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.  Molecular & Cellular Proteomics 13 2411-2425

Min M, Mayor U, Lindon C (2013).
Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates.  Open Biology 3 130097

Floyd S, Whiffin N, Gavilan MP, Kutscheidt S, De Luca M, Marcozzi C, Min M, Watkins J, Chung K, Fackler OT, Lindon C (2013).
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading via FHOD1.
 J. Cell Sci. 126 2845-2856

Min M, Lindon C (2012).
Substrate targeting by the ubiquitin-proteasome system in mitosis.
 Semin Cell Dev. Biol. 23 482-491

Giubettini M, Astertiti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G (2011). 
Control of Aurora-A stability through interaction with TPX2.
J. Cell Sci. 124 113-22

Astertiti I, Rensen W, Lindon C, Lavia P, Guarguaglini G (2010). 
The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme?
Biochim Biophys Acta. 1806 230-239

Elder AD, Domin A, Kaminski-Schierle GS, Lindon C, Pines J, Esposito A, Kaminski CF (2009).  
A quantitative protocol for dynamic measurements of protein interactions by FRET-sensitised fluorescence emission.
J. Royal Soc. Interface 6 S59-81

Lindon C, Di Fiore B (2009). 
Measuring proteolysis in mitosis.
Methods in Molecular Biology 545 259-70

Connell J, Lindon C, Luzio J, Reid E (2009). 
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.
Traffic 10 42-56

Floyd S, Pines J, Lindon C (2008). 
APC/CCdh1 targets Aurora kinase to control reorganization of the mitotic spindle at anaphase.
Current Biology 18 1649-58

Lindon C (2008).  Control of mitotic exit and cytokinesis by the APC/C. Biochemical Society Transactions 36 405-410

Hayes MJ, Kimata Y, Wattam SL, Lindon C, Mao G, Yamano H, Fry AM (2006).  Early mitotic degradation of nek2A depends on Cdc20-independent interaction with the APC/C. Nat. Cell Biol. 8 607-614

Pines J, Lindon C (2005). 
Proteolysis – anytime, any place, anywhere?
 Nat. Cell Biol. 7 731-735

Doucet C, Gutierrez GJ, Lindon C, Lorca T, Lledo G, Pinset C, Coux O (2005).  Multiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5. BMC Biochem. 6 27

van de Weerdt B, van Vugt M, Lindon C, Kauw J, Rozendaal M, Klompmaker R, Wolthuis, R, Medema R (2005).  Uncoupling APC/C activity from spindle assembly checkpoint control by deregulating Polo-like kinase-1. Mol. Cell. Biol. 25 2031-2044

Lindon C, Pines J (2004). 
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells.
J. Cell Biol. 164 233-241                

Lindon C, Jackman M, Nigg, EA, Pines J (2003).  Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5 143-148                       

Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A (2002).  Characterization and expression of mammalian cyclin B3, a prepachytene meiotic cyclin. J Biol. Chem. 277 41960-9                    

Lindon C, Albagli O, Pinset C and Montarras, D (2001).  Cell density-dependent induction of endogenous myogenin (myf4) gene expression by Myf5. Dev. Biol. 240 574-584                            

Montarras D, Lindon C, Pinset C and Domeyne P (2000).  Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects. Biol. Cell 92 565-572                                  

Lindon C, Albagli O, Domeyne P, Montarras D and Pinset C (2000).  Constitutive instability of muscle regulatory factor Myf5 is distinct from its mitosis-specific disappearance, which requires a D-box-like motif overlapping the basic domain. Mol. Cell. Biol. 20 8923-8932              

Albagli O, Lindon C, Lantoine D, Quief S, Puvion E, Pinset C and Puvion-Dutilleul F (2000).  DNA replication progresses on the periphery of nuclear aggregates formed by the BCL6 transcription factor. Mol. Cell. Biol. 20 8560-8570

Albagli O, Lantoine D, Quief S, Quignon F, Kerckaert J, Montarras D, Pinset C and Lindon C (1999).  Overexpressed BCL6 (LAZ3) oncoprotein associates with replication foci, delays S phase progression and induces apoptosis. Oncogene 18 5063-5070              

Lindon C, Montarras D and Pinset C (1998).  Cell cycle-regulation of the muscle determination factor Myf5 in proliferating myoblasts. J. Cell Biol. 140 111-118