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Ubiquitin-mediated signaling in cell division

Our research seeks to understand more about the cell cycle, and how cell division and cell fate decisions are shaped by ubiquitin-mediated signalling. Much of our focus is on the major cell cycle regulator Aurora A kinase (AURKA), a target of ubiquitin-dependent proteolysis by the APC/C-FZR1 ubiquitin ligase. Overexpression of AURKA is strongly associated with cancer progression. Alongside projects to understand the importance of AURKA regulation to cell cycle control and cancer, we are investigating new methods to manipulate and measure AURKA stability inside cells. We are also developing tools that will become essential for the therapeutic exploitation of intracellular protein stability. With the rapid growth in targeted protein degradation as a new therapeutic modality, this is a new and still unexplored frontier in pharmacology.

Please see our Publications page for details of our recent papers. Some of our lab members have used their time away from the bench during the Covid-19 crisis to generate graphical abstracts of their projects.

Current research in the lab is funded by the BBSRC, Royal Society, AstraZeneca, Rosetrees Foundation, Gates Foundation and the David James Trust.